Deuterated Compounds

<p>Applications 1,5-Dinitronaphthalene-d6 (CAS# 1219804-48-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Prednisolamate-D10 is a labelled analogue of Prednisolamate (P703715).<br></p>

<p>Applications 2-Bromo-4'-fluoroacetophenone-2',3',5',6'-d4 (CAS# 1219803-30-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,4-Dimethyl-d6-nitrobenzene (CAS# 1398065-58-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Desacetyl Diltiazem-d4 Hydrochloride is the labeled analogue of Desacetyl Diltiazem Hydrochloride (D289335), a metabolite of Diltiazem Hydrochloride (D460620), a calcium channel blocher with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV).<br>References Shallcross, H., et al.: Br. Med. J., 295, 1236 (1987); Yeung, P.K.F., et al.: Drug Metab. Dispos., 18, 1055 (1990); Cashman, J.R., et al.: J. Med. Chem., 34,2049 (1991); Sato, et al.: Arzneim.-Forsch., 21, 1338 (1971); Smirnov, S.R.: Eur. J. Pharmacol., 360, 81 (1998); Hansson, L., et al.: Lancet, 356, 359 (2000)<br></p>

<p>Applications Diethyl-d6-amine has been used as a reactant for the analysis of the sequential oxidation of N-nitrosoalkylamines to aldehydes and carboxylic acids by human cytochrome P 450 2A6.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chowdhury, G., et. al.: J. Bio. Chem., 285, 8031 (2010)<br></p>

<p>Applications 1,2,3-Trichloropropane-d5 (CAS# 203578-27-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications (±)-Propafenone-d7 HCl (n-propyl-d7) (CAS# 1219799-06-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Aceclofenac-d4 is deuterium labelled Aceclofenac (A130400), which is an anti-inflammatory and analgesic drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yscla, A., et al.: Drugs Exp. Clin. Res., 14, 491 (1988); Ballesteros, R., et al.: Clin. Trials J., 27, 12 (1990)<br></p>

<p>Applications Butyronitrile-d7 (CAS# 352431-11-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromodecane-1,1,2,2-d4 (CAS# 1219805-58-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Cyproheptadine Hydrochloride-d3 is the isotope labelled analog of Cyproheptadine (C989200, HCl,H2O); a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. Also a 5-HT2/5-HT1C serotonin receptor antagonist, H1 histamine receptor antagonist, and antipruritic.<br>References Marchei, E., et al.: J. Pharm. Biomed. Anal., 41, 1633 (2006); de-Benedictis, F., et al.: Allergy, 63, 1395 (2008); Feas, X., et al.: J. Pharm. Biomed. Anal., 50, 1044 (2009); Yu, C., et al.: Talanta, 2011, 83, 1376 (2011)<br></p>

<p>Applications 1,2-Dibromobenzene-d4 (CAS# 1643577-34-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Mebeverine Alcohol, a metabolite of Mebeverine (M202490), an antispasmodic.<br>References Greenwood, B. et al.: Eur. J. Pharmacol., 211, 143 (1992); van Outryve, M. et al.: J. Clin. Pharm. Ther., 20, 277 (1995); Kraemer, T. et al.: Drug Metab. Disp., 28, 339 (2000);<br></p>

<p>Applications 2-(1-Oxo-2(1H)-naphthalenylidene)-hydrazinecarboxamide-d4 is labelled 2-(1-Oxo-2(1H)-naphthalenylidene)-hydrazinecarboxamide (N359270) which is a novel anti-anflammatory agent as well as an anti-proliferative agent due to its 1,2-napthoquinone substructure.<br>References Marrero-Ponce, Y. et al.: Eur. J. Med. Chem., 46, 5736 (2011);<br></p>

<p>Applications 8-Nitro-1-pyrenol is a urinary hydroxylated metabolites used as a biomarkers of exposure of polycyclic aromatic hydrocarbons. This is the labeled analog.<br>References Toriba, A., et al.: J. Health. Sci., 53; 631 (2007); Chae, Y.H., et al.: Cancer Res., 59, 1473 (1999); Sangaiah, R., et al.: Poly. Aro. Comp., 11, 283 (1996);<br></p>