Deuterated Compounds

Stability Hygroscopic
Applications Clencyclohexerol-d10 is a labelled analog of Clenbuterol, a β-agonist which can be used as a growth promoter in farm animals.
References Maistro, S., et al.: Lancet, 346, 180 (1995); Vanoosthuyze, K., et al.: J. Agric. Food Chem., 45, 3129 (1997); Fiori, M., et al.: Anal. Chim. Acta, 529, 207 (2005); Salquebre, G., et al.: J. Anal. Toxicol., 31, 114 (2007);

Applications 4-Phenanthrol-d9 has been used as a reactant for the preparation of stable isotope-labeled internal standards of PAH metabolites from urine of smokers and nonsmokers.
References Jacob, P. III, et. al.: Anal. Chem., 79, 587 (2007)

Stability Hygroscopic
Applications N-Acetylneuraminic Acid-13C,d3 is a labelled Neuraminic Acid derivative.
References Oetke, C., et al.: J. Biol. Chem., 277, 6688 (2002)

Applications Labelled 2,3-Butanedione (B690030). 2,3-Butanedione (Diacetyl), the molecule implicated in the disease known as popcorn lung, has now been implicated in amyloid-β peptide toxicity associated with Alzheimer’s disease. Diacetyl accelerates amyloid-β aggregation-a hallmark of Alzheimer’s disease. These preliminary finding raise the possibility of long-term neurological toxicity mediated by DA.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, J., et al.: Exp. Neurol., 158, 328 (1999); Brown, M., et al.: Cell, 100, 391 (2000); Heinitz, K., et al.: J. Neurochem., 98, 1930 (2006); Brody, D., et al.: Science, 321, 1221 (2008); More, S., et al.: J. Med. Chem., 52, 4650 (2009);

Applications Methyl-d3 Methanesulfonate (CAS# 91419-94-2) is a useful isotopically labeled research compound.

Applications A labelled isomer of dichloropropanol; shows metabolite toxicity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Omura, M., et al.: Bull. Environ. Contam. Toxicol., 55, 1 (1995),

Applications Labelled Fumaric Acid (F500380). Occurs in many plants. Essential to vegetable and tissue respiration. Used as an antioxidant.
References Jelitto, T., et al.: Planta, 188, 238 (1992), Son, H., et al.: J. Agric. Food Chem., 56, 8007 ( 2008),

Applications The precursor of the ubiquitous natural compound malondialdehyde.
References Basu, A.K., et al.: J. of Labelled Compounds & Radiopharmaceuticals, XX11, 11, 1175 (1985)

Applications N,N-Dimethyldodecylamine-d6 is the isotope labelled analog of N,N-Dimethyldodecylamine. N,N-Dimethyldodecylamine is used as a reagent in the synthesis of epoxy quaternary ammonium salt surfactants which exhibit potential antibacterial activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Liu, Y., et al.: J. Disper. Sci. Technol., 35, 1460 (2014)

Applications 1-Amino Hydantoin Hydrochloride (A611090), a metabolite of Nitrofuran.Environmental contaminants
References Tribalat, L., et al.: Anal. Bioanal. Chem., 386, 2168 (2006), Chu, P., et al.: J. Agric. Food Chem., 55, 2129 (2007),

Applications Nonanal-d18, is the labeled analogue of Nonanal (N649330), a component of essential oils. Nonanal possesses a strong fruity odor. Essential oils have varying effects from antibacterial activity to hypolipidemic activity.
References Zorrilla-Fontanesi, Yet al.: Plant. Phys., 159, 851 (2012): Taherkhani, M. et al.: Asian. J. Chem., 24, 1461 (2012); Ahmadvand, H. et al.: Iran. J. Pharm. Res., 11, 1219 (2012);

Applications N,N-Dimethyl-p-phenylenediamine-d6 is labelled N,N-Dimethyl-p-phenylenediamine (DMPD) (D476760) which has been used to n-dope bilayer graphene (BG) along with p-dope of tetracyanoethylene bilayer graphene to increase the band gap of DMPD/BG. N,N-Dimethyl-p-phenylenediamine (DMPD) has been shown to inhibit corrosion of mild steel in a sulphuric acid medium.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, T.H., et. al.: J. Phys. Chem. C., 117, 12873 (2013); Singh, K.U., Dubey, R.S.: Int. J. Chem., 1, 366 (2012)

Applications cis-7,10,13,16-Docosatetraenoic Acid Ethyl Ester-d5 is an isotopic analog of cis-7,10,13,16-Docosatetraenoic Acid Ethyl Ester. cis-7,10,13,16-Docosatetraenoic Acid Ethyl Ester is an ethyl analog of cis-7,10,13,16-Docosatetraenoic Acid (D494510). cis-7,10,13,16-Docosatetraenoic Acid has been identified as a protein kinase inhibitor, affecting serotonin levels in studies.
References Mirnikjoo, B. et al.: J. Biol. Chem., 276, 10888 (2001);

Stability Hygroscopic
Applications Labelled Cyromazine (C989300). Insect growth regulator. Insecticide.
References Hall, R.D., et al.: J. Econ. Entomol., 73, 564 (1980), Hart, R.J., et al.: Aust. Vet. J., 59, 104 (1982),

Applications Wittig Reagent

Applications Isotope labelled Oxacillin Sodium Salt is a semi-synthetic antibiotic related to Penicillin. Antibacterial.
References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),

Applications Oxaloacetic Acid-13C4 is labelled form of Oxaloacetic Acid (O845030) which is a four carbon dicarboxylic acid that is an intermediate in the citric acid cycle and glucogenesis. It has been shown to inhibit succinate dehydrogenase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zeylemaker, W.P. et al.: Biochim. Biophys. Acta Enzymol., 132, 210 (1967); Dalla-Betta, P. et al.: Int. J. Mol. Sci., 10, 2809 (2009);

Applications N,N-Dimethylformamide-d7 is the isotope labelled analog of N,N-Dimethylformamide. N,N-Dimethylformamide-d7 is used as a cofactor for enzymic oxidation of brassinin, which allows the transformation of dithiocarbamate group into an aldehyde equivalent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Pedras, M., et al.: Bioorg. Med. Chem., 19, 1390 (2011);

Applications 4-Bromophenol-2,3,5,6-d4 is the labelled analogue of 4-Bromophenol (B686405) which is used as a reagent in Stille reactions.
References Littke, A.F. et al.: J. Am. Chem. Soc., 124, 6343 (2002);

Applications Hexazinone-d6 (dimethyl-d6-amino) (CAS# 1219804-22-4) is a useful isotopically labeled research compound.

Applications Triethylamine (D15, 98%) (cas# 66688-79-7) is a useful research chemical.

Applications Diethyleneglycol Monoethyl-d5 Ether (CAS# 1219804-11-1) is a useful isotopically labeled research compound.

Applications Labelled Butylparaben. An antimicrobial agent used in cosmetic products.
References Gilliland, D. et al.: J. Appl. Bacteriol., 72, 258 (1992); Routledge, E. et al.: Toxicol. Appl. Pharmacol., 153, 12 (1998); Miller, C. et al.: J. Biol. Chem., 272, 32824 (1997); Nakagawa, Y. et al.: Biochem. Pharmacol., 55, 1907 (1998);

Applications Product of smoking tobacco
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Benigni, R., et al.: Env. Mol. Mutagen., 48, 754 (2007), Shin, H., et al.: Food Chem. Toxicol., 47, 192 (2009),

Applications DL-p-Hydroxyphenyllactic Acid-d3 is the isotope labelled analog of DL-p-Hydroxyphenyllactic Acid (H953665); a reagent in the synthesis of 2-O-(4-coumaroyl)-3-(4-hydroxyphenyl)lactic acid which is an important intermediate of rosmarinic acid biosynthesis.
References Matsuno, M., et al.: Chem. Pharm. Bull., 49, 1644 (2001)

Applications Labelled Benzothiazole. Various benzothiazole-benzamides synthesized were evaluated for their analgesic and antidepressant activities.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Porsolt, R., et al.: Nature, 266, 730 (1977), Foster, J., et al.: Bioorg. Med. Chem., 7, 2415 (1999), Caliendo, G., et al.: Eur. J. Med. Chem., 36, 517 (2001), Rana, A., et al.: Eur. J. Med. Chem., 43, 1114 (2008),

Applications Isotope labelled Squalane is used as an emollient and moisturizer in cosmetic applications.
References Allison, A.: Method, 19, 87 (1999)

Applications Labelled Nicotinic acid. It is a precursor of the coenzymes NAD and NADP. Widely distributed in nature; appreciable amounts are found in liver , fish, yeast and cereal grains. Dietary deficiency is associated with pellagra. The term “niacin” has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid. Vitamin (enzyme cofactor).
References Darby, W.J., et al.: Nutr. Rev., 33, 289 (1975), Black, A., et al.: Eur. J. Clin. Nutr., 54, 395 (2000), Cole, T., et al.: Br. Med. J., 320, 1240 (2000), Forshee, R., et al.: J. Nutr., 134, 2733 (2004),

Applications N-Methyl-N’-nitrosopiperazine-d4 is the isotope labelled analog of N-Methyl-N’-nitrosopiperazine (M325800), which is used as a reagent in the organic synthesis of several compounds including that of (4-methoxyphenoxy)acetic and (3,4,5-trimethoxyphenoxy)acetic acid amides and hydrazides which display antimicrobial and anthelmintic properties and may act as potential neurotropic and cardiovascular agents. N-Methyl-N’-nitrosopiperazine also diplayed strong nasal carcinogenity and genotoxicity toward nasal cells.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Valenta, V., et al.: Collect. Czech. Chem. C., 52, 3013 (1987); Klein, R., et al.: Carcinogenesis, 20, 1629 (1999);

Applications The main metabolite of Flunixin.
References Odensvik, K., et al.: Am. J. Vet. Res., 56, 489 (1995), Ngoh, M.A., et al.: J. Agric. Food Chem., 51, 4701 (2003).

Applications Labelled Methylparaben (M325660). It is used as preservative in foods, beverages and cosmetics.
References Goodwin, M., et al.: Science, 203, 559 (1979),

Applications tert-Butyl Alcohol-d10 is an isotopic analog of Tert-butyl Alcohol (T117540), an organic solvent. It is also used in the synthesis of proteosome inhibitors that are quite potent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kawamura, S. et al.: J. Med. Chem., 56, 3689 (2013); Galy, N. et al.: Tetrahedron Lett., 54, 2703 (2013)

Applications Labelled Fenhexamid (F247650). Hydroxyanilide fungicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yamashita, M., et al.: J. Phys. Chem., 88, 4451 (1984), Kende, A., et al.: Microchem. J., 84, 63 (2006),

Applications Labelled Diglyme. Solvent; it is used as reaction medium for Grignard and similar synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 4-Aminophenol-15N is an intermediate in the synthesis of Acetaminophen-13C2,15N (A161228), a labelled analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis.

Applications The labelled analogue of a versatile ethylenediamine derivative used as an intermediate in the organic synthesis of neurochemicals, antitumor agents and other pharmaceutical compounds.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Squires, R.F. et al.: Neurochem. Res., 18, 787 (1993); Murdock, K.C. et al.: J. Med. Chem., 22, 1024 (1974);

Applications Suvorexant-d6 is the labeled analog of Suvorexant (S870000), a dual (non-selective) orexin receptor antagonist in development by Merck & Co. for the treatment of insomnia. It works by turning off wakefulness rather than by inducing sleep. Users of higher doses had an increased rate of suicidal ideation.
References Cox, C., et al.: J. Med. Chem., 53, 5320 (2010); Baxter, C., et al.: Org. Process Res. Dev., 15, 367 (2011); Winrow, C., et al.: J. Neurogenet., 25, 52 (2011); Mieda, M., et al.: CNS Drugs, 27, 83 (2013); Osborne, R.: Nat. Rev. Drug Discov., 12, 492 (2013)

Applications Labelled ε-Aminocaproic Acid. Used in the preparatiom of esters of 6-aminohexanoic acid as antibacterial agents. EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo xy peptidase, plasmin, and plasminogen activator.
References Dolezal, P., et al.: Pharm. Res., 10, 1015 (1993), Vavrova, K., et al.: Curr. Med. Chem., 12, 2273 (2005), Holas, T., et al.: Bioorg. Med. Chem., 14, 7671 (2006),

Applications N6,O2'-Dimethyladenosine-d3 is an isotopic analog of N6,O2'-Dimethyladenosine (D447415), a naturally occurring modified nucleoside in RNA. It was reported in the preparation of alkylated adenosines as antihypertensive agents.
References Yamada, T., Kageyama, K.: Eur. Pat. Appl. (1988), EP 269574 A2 19880601; Aduri, R., et al.: J. Chem. Theory Comput., 3, 1464 (2007);

Applications Deuterium labelled analog of (±)-α-Bisabolol, which is found in a variety of beauty and skin care products, including compositions for skin lightening cosmetic creams, color change cosmetic compositions for makeup fused with antioxidant function and oil-to-gel makeup removing compositions.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ma, P. et al.: Faming Zhuanli Shenqing 11pp. Patent 2017 CODEN:CNXXEV; Son, T.; et al.: Repub. Korean Kongkae Taeho Kongbo 14pp.; Chemical Indexing Equivalent to 167:543596 (WO) Patent 2017 CODEN:KRXXA7; Lin, X.; et al.; Faming Zhuanli Shenqing 8pp. Patent 2017 CODEN:CNXXEV

Applications 25-Hydroxyvitamin D2 (6,19,19-D3,97%) 100 Ug/Ml In Ethanol (cas# 1217467-39-4) is a useful research chemical.

Applications A labelled imidazole, a versatile heterocycle used in the preparation of various biologically active compounds such as the amino acid histidine and is present in many antifungal medication. It is also used extensively as a corrosion inhibitor on transition metals such as copper.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Arispe, N. et al.: Biophys. J., 95, 4879 (2008); Troesken, E.R. et al.: Endo. Res., 30, 387 (2004); Otmacic Curkovic, H. et al.: Corr. Sci., 51, 2342 (2009);

Applications Fumaric Acid-d2 is the isotope labelled analog of Fumaric Acid. Fumaric acid is a compound that occurs in many plants. It is essential to vegetable and tissue respiration and also used as an antioxidant. Fumaric acid is also a metabolite of Dimethyl Fumarate (D464965), a compound used as a treatment for the relapsing forms of multiple sclerosis and psoriasis.
References Jelitto, T., et al.: Planta, 188, 238 (1992); Schimrigk, S., et al.: Eur. J. Neurol., 13, 604 (2006); Son, H., et al.: J. Agric. Food Chem., 56, 8007 (2008);

Applications Isotope labelled Nitrobenzene (N493000), used mainly in the production of the chemical precursor aniline as well as in azobenzene synthesis (1). Also may be reduced through magnetic iron oxide nanocrystals (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References 1. Yadav, G. et al.: Chem. Eng. J. 2013 Aug:221(1) pp500-5112. Cantillo, D. et al.: J. Org. Chem. 2013 May 3;78(9):4530-42.

Applications Decanoic-d19 Acid is used on platinum-on-carbon-catalyzed multiple deuterium labeling of saturated fatty acids. Cylindrocyclophane biosynthesis involves functionalization of an unactivated carbon center.
References Yamada, T., et al.: Adv. Synth. Catal., 358, 3277 (2016); Nakamura, H., et al.: J. Am Chem. Soc., 134, 45 (2012)

Applications A labelled metabolite of a mixed disulfide S-(N,N-diethyldithiocarbamoyl)-N-acetyl-L-cysteine (AC-DDTC), an antimutagenic mixed disulfide from disulfiram.
References Madan, A., et al.: Drug Metab. Dispos., 23, 1153 (1995), Lambert, D., et al.: J. Med. Chem., 48, 5059 (2005), Tsuboi, K., et al.: J. Biol. Chem., 280, 11082 (2005),

Applications Isotope labelled Acetamide (A133060) which is often used as plasticizer and as industrial solvent (1). It can also be used for the transamidation of carboxamides in 1,4-dioxane in the absence of a catalyst (2) . Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
References 1. Ma, X. et al.: Carb. Polym. 2004 Aug:57(2):197-2032. Vanjari, R. et al.: Tetrahedron. Lett. 2013 MayL54(20):2553-5

Applications Isotope labelled O,O-Diethyl Dithiophosphate-d10 is used in the synthesis of novel phosphorothioates and phosphorodithioates as cholinesterase inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Millard, C., et al.: J. Neurochem., 64, 1909 (1995), Nicolet, Y., et al.: J. Biol. Chem., 278, 41141 (2003), Casida, J., et al.: Chem. Res. Toxicol., 17, 983 (2004),

Applications Labelled analogue of Potassium Cyanide, a reagent widely used in organic synthesis for the preparation of nitriles and carboxylic acids, particularly in the von Richter reaction.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kollenz, G. et al.: Org. Prep. Proc. Int., 12, 244 (1980); Subramanian, L. R.: Sci. Synth., 19, 173 (2004);