Deuterated Compounds

<p>Applications N,N'-Dimethyl-3,3'-dithiodipropionamide is an disulfide linked compound found in antifouling coatings and is also an intermediate in the synthesis of antimicrobial agents and biocides.<br>References Easton, C.J., et al.: J. Chem. Soc., 1, 153 (1985);<br></p>

<p>Applications Substrate for alcohol dehydrogenase<br>References Burkhard, P., et al.: J. Mol. Biol., 295, 953 (2000), Ferreira, A., et al.: J. App. Microbiol., 91, 67 (2001), Johnson, B., et al.: J. Comp. Neurol., 502, 468 (2007),<br></p>

<p>Applications 2,5-Dihydro-2-hydroxy-5-nitro-2-furanmethanediol-d3 Triacetate (cas# 1346604-22-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Acetylbutanoic-d5 Acid Ethyl Ester (cas# 141327-44-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Imidazol-1-yl-acetic Acid-15N2,13C2 (cas# 1184983-00-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Fluorene-D10 is a labelled analogue of Fluorene (F462000). Fluorene is a polycyclic aromatic hydrocarbon that is ubiquitous in the urban environment, and is also a suspected carcinogen. Fluorene is used as a component of fluorescent probes that bind to human serum albumin, allowing researchers to study internal mechanisms more closely.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Harrison, R., et al.: Env. Sci. Tech., 30, 825 (1996); Park, K., et al.: Org. Biomol. Chem., 7, 4225 (2009); Weissenfels, W., et al.: Appl. Micro. Biotech., 32, 479 (1990)<br></p>

<p>Applications Ethyl (5-Ethyl-2-pyridinyl)-1,1-d2-acetate (cas# 1189654-25-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Amino-1-pentanol-d4 Hydrochloride Salt (cas# 1216414-18-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,2-Dimethoxybenzene-3,4,5,6-d4 (CAS# 126840-15-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Amino-1-pentanol-d4 Benzyl Ether is an intermediate in the synthesis of Hydroxychloroquine-d4 Sulfate (H916902), which is an antimalarial; antirheumatic; lupus erythematosus suppressant.<br>References Yarden, Y., et al.: Nature, 323, 226 (1986), Seifert, R., et al.: J. Biol. Chem., 264, 8771 (1989), Gahl, W., et al.: Mol. Genet. Metab., 76, 234 (2002), Card, J., et al.: Toxicol. Sci., 75, 169 (2003),<br></p>

<p>Applications Isotope labelled analogue of tert-Pentyl Chloride, an alkyl chloride used as a starting material in various organic synthesis.<br></p>

<p>Applications 2-(Formylamino)-3-hydroxy-2-propenoic-13C2 Acid Ethyl Ester (cas# 1391062-48-8) is a compound useful in organic synthesis.<br></p>

<p>Applications α-Methyl-2-piperidinemethanol-13C2 is a labelled analogue of α-Methyl-2-piperidinemethanol (M324830), which can be used in the preparation of substances with herbicidal activity. α-Methyl-2-piperidinemethanol-13C2 is also an intermediate in synthesizing 2-Acetyl-3,4,5,6-tetrahydropyridine-13C2 Hydrochloride (A188502), which is a labelled 2-Acetyl-3,4,5,6-tetrahydropyridine (A188500), the most important bread flavor component.<br>References Buttery, R.G., et al.: J. Agric. Food Chem., 43, 1878 (1995)<br></p>

<p>Applications Methyl-(4-nitrophenylethyl)-4-(nitrophenoxyethyl)amine-d4 (cas# 1189869-42-8) is a compound useful in organic synthesis.<br></p>

<p>Applications (4E)-Octenedinitrile-1,8-13C2 (cas# 1185245-34-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,2-Difluoroethylamine-d2 Hydrochloride is an intermediate used in the synthesis of Flupyradifurone-d5 (F598616), which is the labeled form of Flupyradifurone (F598615), can be used as an insecticide.<br>References Anon, IP.com J., 12, 19 (2011)<br></p>

<p>Applications 2-(Benzoyloxy)ethyl-d4 Benzoate is an intermediate in the synthesis of Acyclovir-d4 (A192402), an orally active acyclic labelled nucleoside with inhibitory activity towards several herpes viruses. Antiviral.<br>References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992)<br></p>

<p>Applications Labelled Nitisinone intermediate.<br></p>

<p>Applications 2-Cyano-acetic Acid Sodium Salt-13C2 (cas# 1346598-51-3) is a compound useful in organic synthesis.<br></p>

<p>Applications (Z)-2-(Methoxyimino)-3-oxobutanoic Acid-d3 Methyl Ester (cas# 1331636-65-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Can be used in the preparation of substances for treatment of dermatological conditions and skin protection.<br></p>

<p>Applications 5,6-Diamino-2,4-dihydroxypyrimidine-13C2, Hydrochloride Salt (cas# 1346605-20-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Labelled Anisole. Anisole is used in perfumery.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Taylor, J.M., et al.: Toxicol. Appl. Pharmacol., 6, 378 (1964),<br></p>

<p>Applications N-(1-Naphthyl-d7-methyl)methylamine (cas# 1189686-07-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Hydroxy-6-methyl-4-[[(4-methylphenyl)imino]methyl]-3-pyridinemethanol-d5 is an intermediate in the synthesis of labelled Pyridoxal phosphate.<br>References Sharif, S., et al.: J. Am. Chem. Soc., 129, 4440 (2007);<br></p>

<p>Applications An impurity found in tramadol (T712500).<br>References Medvedovici, A. et al.: J. Pharmac. Biomed. Anal., 34, 67 (2004);<br></p>

<p>Applications Anticonvulsant against audiogenic convulsion.<br>References Goeres, E., et al.: Acta Biol. Med. Ger., 23, 679 (1969)<br></p>

<p>Applications α,α-Dimethyl-1H-indole-2-acetonitrile-13C315N is an isotope labelled intermediate in the synthesis of serotonin-3 receptor antagonists.<br>References Kato, M., et al.: Chem. Pharma. Bull., 42, 2556 (1994);<br></p>

<p>Applications Ammonium-15N hydroxide Solution is a solution prepared from ammonium-15N sulfate for studying fertilizer use efficiency and is an important fertilizer for soil fertilization of the sugarcane crop in Brazil.Ammonium-15N hydroxide Solution is also used in the preparation of isotope-labeled oligonucleotides for their use in NMR studies of protein-DNA complexes.Ammonium-15N hydroxide Solution is the 15N-labeled compound for A634020, which is used in numerous household cleaning agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bendassolli, Jose Albertino., Scientia Agricola (Piracicaba, Brazil), 59, 595-603, (2002)Kellenbach, E. R., Nucleic Acids Research, 20, 653-7, (1992)Lokshin, E.P., et al.: Russ. J. App. Chem., 86, 450 (2013)<br></p>

<p>Applications 2-Butyl-d3-4-chloro-5-benzyloxymethyl-1H-imidazole (cas# 1189919-69-4) is a compound useful in organic synthesis.<br></p>

<p>Applications Intermediate in the synthesis of labelled heteroarotinoids.<br>References Dawson, M.I. et al.; J. Med. Chem. 27, 1516 (1984); Waugh, K.M. et al.; J. Med. Chem. 28, 116 (1985); Spruce, L.W. et al.; J. Med. Chem. 30, 1474 (1987)<br></p>

<p>Stability Volatile<br>Applications 1-Bromobutane-d3 is used in the synthesis of specifically-deuterated procaine and tetracaine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boulanger, Y., et al.: J. Labelled Comp. Radiopharm., 18, 1197 (1981),<br></p>

<p>Applications Uridine 5′-Monophosphomorpholidate 4-Morpholine-N,N′-dicyclohexylcarboxamidine Salt-13C, 15N2 is an intermediate in the synthesis of Trilithium UDP-glucuronic Acid-13C1, 15N2 (T886287), which is an isotope labelled analog of Trisodium UDP-glucuronic Acid (T886285). Trisodium UDP-glucuronic Acid is a reactant used in the enzymatic preparation of β-glucuronides.<br>References Stevenson, D.E., et. al.: Collect Czech. Chem. C., 65, 117 (2000); Robotham, S.A., Brodbelt, J.S.: Biochem. Pharmacol., 82, 1764 (2011); Kren, V., et. al.: Drug Metab. Dispos., 28, 1513 (2000)<br></p>

<p>Applications 4-Dimethylaminobutyric Acid Hydrochloride-d6 is an intermediate in synthesizing 4-​(Dimethyloxidoamino)​butanoic Acid-d6 Hydrochloride (D447162), which is a labelled form of 4-​(Dimethyloxidoamino)​butanoic Acid (D447160). 4-​(Dimethyloxidoamino)​butanoic Acid is a metabolite of Lauramine Oxide (L178530), which is a frequently used amine oxide surfactant. It is strongly hydrophilic , and it forms normal micelles and normal liquid crystalline phases. 4-Dimethylaminobutyric Acid Hydrochloride-d6 is also a labelled analogue of 4-Dimethylaminobutyric Acid Hydrochloride (D456545), which acts as a reagent for the design, synthesis and in the biological evaluation of novel water-soluble prodrug of Docetaxel with amino acid as linkers.<br>References Kocherbitov, v., et al.: J. Molec. Struct.: Theochem., 808, 111 (2007); Kocherbitov, v., et al.: J. Phys. Chem. B., 110 (27), 13649 (2006); Turan, T.S., et al.: Xenobiotica, 11, 447 (1981); Ma, H., et al.: Chem. Biol. Drug Des. 88, 363 (2016);<br></p>

<p>Applications Methyl Valerimidate-d9 Hydrochloride (cas# 1030939-72-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Farnesyl Pyrophosphate Triammonium Salt-13C3 is labelled Farnesyl Pyrophosphate Triammonium Salt (F102470) which is an isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular mass G proteins, including Ras.<br>References Correll, C., et al.: J. Biol. Chem., 269, 17390 (1994), Moura, I., et al.: Antimicrob. Agents Chemother., 45, 2553 (2001), Gana-Weisz, M., et al.: Clin. Cancer Res., 8, 555 (2002),<br></p>

<p>Applications 6-Hydroxy-8-methoxy-octanoic Acid Methyl Ester-d5 is a compound useful in organic synthesis.<br></p>

<p>Applications N,N-Diisopropyl-3-(2-methoxy-5-methyl-phenyl)-3-phenylpropylamide-d14 (cas# 1795013-34-1) is a compound useful in organic synthesis.<br></p>

<p>Applications N3-Tritylpyridine-2,3-diamine-d3 is an intermediate in the synthesis of Pentosidine-d3 TFA Salt which is a biochemical marker of bone turnover for management of metabolic bone diseases.<br>References Turner, W., et al.: Biol. Psychiatry, 14, 177 (1979), Miyata, T., et al.: Kidney Int., 60, 2351 (2001), Politi, P., et al.: Neurosci. Lett., 396, 163 (2006),<br></p>

<p>Applications 5-(2-Bromoethyl-d4)-2,3-dihydrobenzofuran (cas# 1189652-25-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Glutaronitrile-d6 (cas# 1346598-53-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Reproduction of Sindbis virus strains sensitive and resistant to 1-adamantanecarboxamide.<br>References Erice, A., et al.: N. Engl. J. Med., 320, 289 (1989), Andronova, V.L., et al.: Bull. Exper. Bio. Med., 129, 74 (2000).<br></p>

<p>Applications Eugenol-d3 Methanesulfonate is an intermediate in the synthesis of Labelled Eugenol (E935640), a dental compound which shows cytotoxicity to human oral squamous cell carcinoma and oral cells. When glucosylated, this compound exhibits anti-inflammatory activity.<br>References Koh, T. et al.: In Vivo, 27, 85 (2013); Zhang, P. et al.: Arch. Pharm. Res., 36, 109 (2013);<br></p>

<p>Applications 5-[2-[(3-Chloro-2-hydroxypropyl)thio]-4-thiazolyl]-2-thiophenecarboxamide-d5 is an intermediate in synthesizing Arotinolol-D5 Hydrochloride (A771502), which is a labelled analogue of Arotinolol (A771500). Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension.<br>References Kuroda, Y., et al.: Neurology, 38, 650 (1988); Miyagishi, A., et al.: Arch. Pharmacodyn. Ther., 271, 249 (1984); Wu, H., et al.: Hypertens. Res.: Off. J. Jpn. Soc. Hypertens., 24, 605 (2001);<br></p>

<p>Applications (R)-1-Tosyloxy-2,3-propanediol-d2 is an intermediate used in the synthesis of (S)-PA 824-d4 (P122502), which is a labelled novel anti-tuberculosis drug.<br>References Diacon, A.H. et al.: Antimicrob. Anents Chemother., 54, 3402 (2010); Dogra, M. et al.: Br. J. Pharmacol., 162, 226 (2010); Ginsberg, A.M. et al.: Antimicrob. Agents Chemother., 53, 3720 (2009);<br></p>

<p>Applications 2-Pyridineacetic Acid-d6 Ethyl Ester is an labelled analogue of 2-Pyridineacetic Acid (P991750), a compound used often in nucleophilic substitution.<br>References Genicot, C., et al.: Bioorg. Med. Chem. Lett., 13, 437 (2003),<br></p>

<p>Applications 2,4-Dichlorophenol-d3 (cas# 93951-74-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 6-Amino-3-methyluracil-d3 (cas# 1246820-43-8) is a compound useful in organic synthesis.<br>References Grant, D.M., et al.: Clin. Pharm. and Ther., 33, 591 (1983)<br></p>

<p>Applications 2-Amino-5-chlorobenzophenone Oxime-d5 is an intermediate in synthesizing N-Demethyl Chlordiazepoxide-d5 (D230827), a deuterium labelled analogue of N-Demethyl Chlordiazepoxide (D230825), which is the main metabolite of anxiolytic drug Chlordiazepoxide (C327050).<br>References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 15 (1972); Greenblatt, D.J., et al.: Clin. Pharmacokinet., 3, 381 (1978); Barbone, F., et al.: Lancet, 352, 1331 (1998); Miki, A., et al.: J. Anal. Toxicol., 26, 87 (2002)<br></p>