Deuterated Compounds

Applications 2-Butoxyethanol-d9 is an intermediate in the synthesis of Tris(2-butyloxyethyl)phosphate-d27 (T875032), which is the isotope analog of Tris(2-butyloxyethyl)phosphate. Tris(2-butyloxyethyl)phosphate,is an organophosphate, that can be used in the preparation of flame retardant, such as viscose fiber.
References Wang, Y., et al.: Fangzhi Xuebao, 33, 16 (2012); Xiaoshan, L. et al.: Aquatic Toxicology, 114, 173 (2012);

Applications A useful reactant in the preparation labelled Carbazeran (C175792), a phosphodiesterase inhibitor drug.

Applications (Methoxymethoxy)benzene-13C6 is an intermediate in the synthesis of 2,6-Dimethylphenol-13C8 (D465859), an isotope labelled analog of 2,6-Dimethylphenol-13C8. Similar to other xylenol compounds, 2,6-dimethylphenol is used in the synthesis of anti-oxidant compounds due to the phenol moiety in the structure. In addition, this compound is used as a a reactant in the synthesis of polyphenylene ether polymers.
References Carrillo, A. et al.: ANTEC. Soc. Plas. Eng., 69, 945 (2011); Guillen, M. et al.: J. Agri. Chem., 47, 3016 (1999); Guillen, M. et al.: J. Agri. Chem., 46, 1276 (1999)

Applications Isotope labelled Ammonium Chloride is used as a main component and source of nitrogen in fertilizer.
References Crill, P. et al.: Soil Biol. Biochem., 26, 1331 (1994); Zaman, M. et al.: Biol. Fert. Soils, 29, 178 (1999);

Applications (-)-(2S,3S)-Viridifloric Acid Acetonide-d7 is the isotope labelled intermediate in the synthesis of (+)-amabiline, an unsaturated pyrrolizidine alkaloid from Cynoglossum amabile.
References Senter, T. J., et al.: Org. Lett., 14, 1869 (2012);

Applications Ethyl-d5 2-Methylbutyrate is the labeled analogue of Ethyl 2-Methylbutyrate (E923200), an ester that has a sweet, apple-like aroma. Ethyl 2-methylbutyrate is naturally found in apples, cherries and orange juice.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cho, I., et al.: J. Agr. Food Chem., 54, 6332 (2006); Mattheis, J., et al.: J. Agr. Food Chem., 45, 212 (1997); Moshonas, M. & Shaw, P.: J. Agr. Food Chem., 35, 161 (1987); Willaert, G., et al.: J. Agr. Food Chem., 31, 809 (1983)

Applications (R)-2,3-Di(benzoyloxy)propyl-1,1-d2 4-Toluenesulfonate is an intermediate used in the synthesis of (S)-PA 824-d4 (P122502), which is a labelled novel anti-tuberculosis drug.
References Diacon, A.H. et al.: Antimicrob. Anents Chemother., 54, 3402 (2010); Dogra, M. et al.: Br. J. Pharmacol., 162, 226 (2010); Ginsberg, A.M. et al.: Antimicrob. Agents Chemother., 53, 3720 (2009);

Applications Reagent used in labelled pyrimidine and purine synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Das, S., et al.: J. Med. Chem., 52, 5937 (2009), Kim, K., et al.: Bioorg. Med. Chem. Lett., 19, 5225 (2009),

Applications 5,6-Diamino-2,4-dihydroxypyrimidine-13C2, Hydrochloride Salt (cas# 1346605-20-6) is a compound useful in organic synthesis.

Applications An impurity found in tramadol (T712500).
References Medvedovici, A. et al.: J. Pharmac. Biomed. Anal., 34, 67 (2004);

Applications N-[(Ethylamino)thioxomethyl]-N'-phenylpropanimidamide-d5 is an intermediate in the synthesis of Ethaboxam (E675700), a fungicide used against fungal infections in crops.

Applications An intermediate of Rosuvastatin (R700500).

Applications Reagent used in the addition of labelled cyclopropane.
References Cave, C., et al.: Eur. J. Med. Chem., 25, 75 (1990), Kiyama, R., et al.: Chem. Pharm. Bull., 43, 960 (1995), Humphries, P., et al.: Bioorg. Med. Chem. Lett., 16, 6120 (2006)

Applications 5-[2-[(3-Chloro-2-hydroxypropyl)thio]-4-thiazolyl]-2-thiophenecarboxamide-d5 is an intermediate in synthesizing Arotinolol-D5 Hydrochloride (A771502), which is a labelled analogue of Arotinolol (A771500). Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension.
References Kuroda, Y., et al.: Neurology, 38, 650 (1988); Miyagishi, A., et al.: Arch. Pharmacodyn. Ther., 271, 249 (1984); Wu, H., et al.: Hypertens. Res.: Off. J. Jpn. Soc. Hypertens., 24, 605 (2001);

Applications Isotope labelled Quinoline (Q700380), which is a starting material that may be transformed by bacteria and fungi to produce intermediates useful for the synthesis of drugs. Used in the synthesis of tertiary alcohol modulators of RORγ (1) which appears to have various biological functions. Also derivatives of quinoline have been seen to promote anticancer, antibacterial and antiviral activity, however quinoline itself is often seen as an environmental contaminant (2,3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
References 1. Kummer, D. et al.: Bioorg. Med. Chem. Lett. 2017 Feb 21.2. Ramirez-Prada, J. et al.: Eur J Med Chem. 2017 Mar 16;131:237-254.3. Mestankova, H. et al.: Water Res. 2016 Apr 15;93:110-20

Applications N-(2-Bromoethyl-d4)phthalimide is the labeled analogue of N-(2-Bromoethyl)phthalimide (B683975), a building block that has been used as a reactant for the preparation of β-Cyclodextrin derivatives. N-(2-Bromoethyl-d4)phthalimide is an intermediate in the synthesis of (E)-Fluvoxamine-d4 Maleate (F603503), the labeled analogue of (E)-Fluvoxamine Maleate (F603500), a selective serotonin reuptake inhibitor (SSRI) used as an anti-depressant. Antiobsessional.
References Karginov, V.A., et. al.: Bioorg. Med. Chem., 14, 33 (2006); Claassen, V., et al.: Br. J. Pharmacol., 60, 505 (1977); Koran, L.M., et al.: J. Clin. Psychopharmacol., 16, 121 (1996); Ware, M.R., et al.: J. Clin. Psychiatry, 58, Suppl. 5, 15 (1997); Inazu, M., et al.: Neurochem. Int., 39, 39 (2001)

Applications Ethyl 3-Methyl-2-butenoate-d6 (cas# 53439-15-9) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 4-Chloro-6-nitrosoresorcinol-13C6 (cas# 953390-33-5) is a compound useful in organic synthesis.

Applications 4-(4-Chlorophenyl)cyclohexanol-d5 (cas# 1189961-66-7) is a compound useful in organic synthesis.

Applications Dithio-2,2'-bis(N-methylbenzamide)-d6 is an labelled intermediate in the synthesis of analogue of Axitinib, a tyrosine kinase inhibitor used for cancer therapy.
References Brown, D.W., et al.: Sci. Synthesis., 11, 573 (2002);

Applications 3-Butenyl-d2 Tosylate is a proposed intermediate for the synthesis of (5S,5’S)-Dihydroxy Lysinonorleucine-d4 (D452902), which is isotope labelled (5S,5’S)-Dihydroxy Lysinonorleucine, a collagen reducible crosslink agent.
References Mizikova, I. et al.: FEBS J., 285, 3056 (2018);

Applications 1,4-Bis(tert-boc)piperazine-d8 (cas# 1246816-49-8) is a compound useful in organic synthesis.

Applications Octahydro-6-(phenylmethyl)-1H-Pyrrolo[3,4-b]pyridine-d4 is an isotope labelled intermediate in the synthesis of moxifoxacin (M745000), a fluorinated quinolone antibacterial.
References Somisetti, N. et al.: Org. Chem. Indian J., 7, 123 (2011);

Applications 5-Nitro-6-methylaminoquinoline-d3 is an isotope labelled intermediate in the synthesis of carcinogen IQ and related 3H-imidazo[4,5-f]quinolines.
References Ronne, E., et al.: Acta. Chem. Scandinavica., 48, 823 (1994);

Applications N-Phenethylbenzamide-d5 is an isotope labelled intermediate in the synthesis of deteurerium-labeled amides within microreactors.
References Hooper, J., Watts, P.: J. Labelled Compd. Rad., 50, 189 (2007)

Applications N-[1-(3’-Benzyloxyphenyl)ethyl]-N-(methyl-d3)-O-ethylcarbamate (cas# 1189709-65-6) is a compound useful in organic synthesis.

Applications N-Methyl-o-phenylenediamine-d3, Dihydrochloride (cas# 1246820-22-3) is a compound useful in organic synthesis.

Applications Iodobenzene-d5 (cas# 7379-67-1) is a useful research chemical.

Applications 2-(Tetrazol-1-yl)acetic Acid-13C2,15N is a reactant used in the preparation of labelled β-lactam antibiotics.
References Nys, P. et al.: App. Biochem. Biotech., 88, 221 (2000); Won, J. et al.: App. Biochem. Biotech., 69, 1 (1998); Kostadinov, M. et al.: App. Biochem. Biotech., 33, 177 (1992)

Applications A labelled intermediate of Irbesartan (I751000).
References Gillis, J., et al.: Drugs, 54, 885 (1997), Chando, T., et al.: Drug Metab. Disps., 26, 408 (1998), Hines, J., et al.: Eur. J. Pharmacol., 384, 81 (1999)

Applications O-2-Amino-2-methylpropyl Bilastine-d6 is an intermediate used in the synthesis of Bilastine-d6 (B385002), which is labelled Bilastine. It is a novel, nonsedating H1-antihistamine developed for symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.
References Van Cauwenberge, P., et al.: Clin. Exp. Allergy, 30, 891 (2000), Bauchau, V., et al.: Eur. Respir. J., 24, 758 (2004), Lehman, J., et al.: Drugs, 66, 2309 (2006),

Applications Tri-n-butylallylphosphonium Bromide-d5 is isotope labelled intermediate in the synthesis of quaternary phosphonium reversible inhibitors of cholinesterases.
References Basova, N. E., et al.: J. Evo. Biochem. Physiol., 47, 420 (2011);

Applications Methyl 4-(Dimethylamino)benzoate-D4 is an intermediate in the synthesis of DMABA-d4 NHS Ester (D678402), which is a labelled DMABA NHS ester (D678400). DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids. DMABA NHS ester has been used in combination with DMABA NHS ester-d4, -d6, and -d10 to study relative changes in PE lipid abundance before and after radical oxidation.
References Wester, H., et al.: Nucl. Med. Bio., 23, 365 (1996), Frees, D., et al.: Mol. Microbiol., 48, 1565 (2003), Michel, A., et al.: J. Bacteriol., 188, 5783 (2006), Voelker, T., et al.: Bioorg. Med. Chem., 17, 2047 (2009),

Applications Labelled Anabaseine intermediate.

Applications 2-​Pyrimidin-​4,​6-​d3-​amine is a byproduct in the synthesis of 2-Chloropyrimidine-d3 (C380852), which was used in the study of IR vibrational spectroscopy of [Ru(bpy)2(bpm)]2+ and [Ru(bpy)3]2+ in the excited triplet state.
References Mukuta, T., et al.: Inorg. Chem., 53, 2481 (2014)

Applications 3,5-Dimethyl-1-hexyn-3-ol-d5 is an isotope labelled intermediate in the synthesis of acetylene glycol derivative used in water-based coatings and has both antifoaming and surfactant properties.
References Schwartz, J. et al.: J. Coat. Tecnhol., 67, 21 (1995); Chinoy, N.F. et al.: Polym. Paint Colour J., 175, 438 (1985);

Applications O-Methyloxime Guanosine-13C15N2 is an isotope labelled intermediate in the preparation of nucleotide analogs.
References Robins, M. J., et al.: J. Am. Chem. Soc., 105, 4059 (1983);

Stability Hygroscopic
Applications Tiglylcarnitine-d3 is labelled Tiglylcarnitine (T793780), a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Tiglylcarnitine can be diagnostic for a number of ß-oxidation defects.
References Adams, S., et al.: J. Nutrition, 139, 1073 (2009); Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)

Applications 4-[2-(1-Piperidinyl)ethoxy-d4]benzoic Acid, Hydrochloride Salt (cas# 1246815-60-0) is a compound useful in organic synthesis.

Applications Trimethylphenylammonium-d9 Iodide (cas# 88278-22-2) is a compound useful in organic synthesis.
References Dorweiler, J., et al.: Biochem., 42, 14653 (2003),

Applications Adenose N-Oxide and its derivatives are used as an active ingredient in the preparation of therapeutic agents for inflammatory diseases and inhibitors of adenosine kinase.
References Long, M. & Parker, W.: Biochem. Pharmacol., 71, 1671 (2006)

Applications Labelled 4’-Bromoacetophenone (B679060). Possess activity against positive phototaxis of Chlamydomonas cells.A fundamental starting material for organic synthesis.
References Evans, S., et al.: Chem. Biol. Drug. Des., 75, 333 (2010), Rajabi, L., et al.: Lett Appl Microbiol., 40, 212 (2005),

Applications 2-Bromoethyl-d4-amine HBr (CAS# 918633-70-2) is a useful isotopically labeled research compound.

Applications (R)-3-Benzoyloxy-2-(4-trifluoromethoxybenzyl-d2-oxy)propyl-1,1-d2 4-Toluenesulfonate is an intermediate used in the synthesis of (S)-PA 824-d4 (P122502), which is a labelled novel anti-tuberculosis drug.
References Diacon, A.H. et al.: Antimicrob. Anents Chemother., 54, 3402 (2010); Dogra, M. et al.: Br. J. Pharmacol., 162, 226 (2010); Ginsberg, A.M. et al.: Antimicrob. Agents Chemother., 53, 3720 (2009);

Applications Phenoxy-d5-acetic Acid Ethyl Ester (cas# 1189442-18-9) is a compound useful in organic synthesis.

Applications 6-Amino-3-methyluracil-d3 (cas# 1246820-43-8) is a compound useful in organic synthesis.
References Grant, D.M., et al.: Clin. Pharm. and Ther., 33, 591 (1983)

Applications 2-Pyridineacetic Acid-d6 Ethyl Ester is an labelled analogue of 2-Pyridineacetic Acid (P991750), a compound used often in nucleophilic substitution.
References Genicot, C., et al.: Bioorg. Med. Chem. Lett., 13, 437 (2003),

Applications 2-(tert-Butylamino)-4-chloro-6-cyclopropylamino-1,3,5-triazine-d9 (cas# 1189419-70-2) is a compound useful in organic synthesis.

Applications Eugenol-d3 Methanesulfonate is an intermediate in the synthesis of Labelled Eugenol (E935640), a dental compound which shows cytotoxicity to human oral squamous cell carcinoma and oral cells. When glucosylated, this compound exhibits anti-inflammatory activity.
References Koh, T. et al.: In Vivo, 27, 85 (2013); Zhang, P. et al.: Arch. Pharm. Res., 36, 109 (2013);