Deuterated Compounds

<p>Applications Propane-1,3-diylbis((3-acetamidopropyl)carbamic Acid) di-tert-Butyl Ester-d6 is an isotope labelled intermediate in the synthesis of derivatives of Spermine (S680510) which is a biogenic polyamine formed from Spermidine (S680400) that occurs in almost all tissues.<br>References Theoharides, T.C., et al.: Life Sci., 27, 703 (1980); Horn, Y., et al.: Cancer Res., 42, 3248 (1982)<br></p>

<p>Applications An intermediate in the production of labelled fluorothymidine derivatives<br>References Roberts, G., et al.: Biochem. Pharmacol., 46, 2209 (1993), Hatano, A., et al.: Bioorg. Med. Chem., 16, 3866 (2008),<br></p>

<p>Applications 3,5-Dimethylbenzoic-d9 Acid is labelled 3,5-Dimethylbenzoic Acid which is a a reagent used to synthesize 5-Benzoyl-m-xylene (B209800). It can also be used to prepare quinoline inhibitors of Dengue viral NS2B-NS3 protease.<br>References Tachibana, Y., et al.: J. Org. Chem., 71, 5093 (2006); Deng, J., et al.: J. Med. Chem., 55, 6278 (2012)<br></p>

<p>Applications Intermediate in the production of labelled Medetomidine<br>References Kagechika, H., et al.: J. Med. Chem., 32, 1098 (1989),<br></p>

<p>Applications 2,6-Diamino-4-hydroxy-5-nitrosopyrimidine-13C2 is a labelled 2,6-Diamino-4-hydroxy-5-nitrosopyrimidine (D416350), used in the preparation of pterin-based inhibitors.<br>References Hevener, K. et al.: J. Med. Chem., 53, 166 (2010)<br></p>

<p>Applications Potassium Azide-15N is a labelled intermediate in the synthesis of Tazobactam Sodium Salt-13C2,15N1, which is the labeled analogue of Tazobactam Sodium Salt (T010100), which is a β-Lactamase inhibitor, used with β-lactam antibiotics to enhance their effect.<br>References Gould, I.M., et al.: Drugs Exp. Clin. Res., 17, 187 (1991), Roland, R.K., et al.: J. Infect. Dis., 4, 226 (2000), Bonomo, R.A., et al.: Biochim. Biophys. Acta, 1547, 196 (2001),<br></p>

<p>Applications Labelled Dapsone intermediate.<br>References Tingle, M., et al.: Brit. J. Clin. Pharmacol., 30, 829 (1990), Vage, C., et al.: Toxicol. App. Pharmacol., 129, 309 (1994),<br></p>

<p>Applications (Methoxymethoxy)benzene-13C6 is an intermediate in the synthesis of 2,6-Dimethylphenol-13C8 (D465859), an isotope labelled analog of 2,6-Dimethylphenol-13C8. Similar to other xylenol compounds, 2,6-dimethylphenol is used in the synthesis of anti-oxidant compounds due to the phenol moiety in the structure. In addition, this compound is used as a a reactant in the synthesis of polyphenylene ether polymers.<br>References Carrillo, A. et al.: ANTEC. Soc. Plas. Eng., 69, 945 (2011); Guillen, M. et al.: J. Agri. Chem., 47, 3016 (1999); Guillen, M. et al.: J. Agri. Chem., 46, 1276 (1999)<br></p>

<p>Applications A labelled reactant used in the preparation of inhibitors for treatment of neurodegenerative diseases.<br></p>

<p>Applications 2-Hydroxyacetophenone-d7 (cas# 1189865-36-8) is a compound useful in organic synthesis.<br></p>

<p>Applications DMSO is a very common aprotic solvent that is used in a variety of organic chemical reactions and spectroscopic analyses.<br>References Vasseur, A. et al.: J. Org. Chem., 77, 5751 (2012); Kim, D.W. et al.: J. Org. Chem., 68, 4281 (2003);<br></p>

<p>Applications 5-Nitro-1H-imidazole-1-ethanol-d4 (cas# 1794791-19-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Bromo-6-chlorobenzene-1,2,3,4-d4 is the isotope labelled compound of (B682312) which is a reagent in the preparation of arylpiperidines and aryltetrahydropyridines as 5-HT2C agonists.<br>References Conway, R.J., et al.: Bioorg. Med. Chem. Lett., 22, 2560 (2012)<br></p>

<p>Applications (4E)-Octenedinitrile-1,8-13C2 (cas# 1185245-34-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,4,6-Trifluorobenzonitrile-15N is an intermediate in the synthesis of Bictegravir-15N, d2 (B382096), which is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.<br>References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;<br></p>

<p>Applications 4-Pentylphenylacetylene-d7 is an isotope labelled intermediate in the synthesis of new acid ceramidase-targeted acyclic 5-alkynyl and 5-heteroaryl uracil nucleosides.<br>References Mescic, A., et al.: ACS. Med. Chem. Lett., 6, 1150 (2015);<br></p>

<p>Applications Aniline-13C6 Hydrochloride is an intermediate in the synthesis of Indole-3-carboxaldehyde-13C8 (I614993), the labelled version of Indole-3-carboxaldehyde (I615020) which is a tryptophan (T947200) metabolite from Streptomyces staurosporeus and it is chemical constituent from Inula wissmanniana. Indole-3-carboxaldehyde and other tryptophan metabolites play an important role in mammalian gut immune homeostasis.<br>References Yang, S., et al.: J. Nat. Prod., 60, 44 (1997); Cheng, X. et al.: Chem. Nat. Compd., 49, 815 (2013); Zelante, T., et al,: Immunity, 39, 372 (2013)<br></p>

<p>Applications Intermediate in the production of labelled Lapatinib.<br>References Godeneche, D., et al.: Drug Metab. Disposition, 21, 93 (1993),<br></p>

<p>Applications Labelled Nitisinone intermediate.<br></p>

<p>Applications 2-Cyano-acetic Acid Sodium Salt-13C2 (cas# 1346598-51-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Fluorene-D10 is a labelled analogue of Fluorene (F462000). Fluorene is a polycyclic aromatic hydrocarbon that is ubiquitous in the urban environment, and is also a suspected carcinogen. Fluorene is used as a component of fluorescent probes that bind to human serum albumin, allowing researchers to study internal mechanisms more closely.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Harrison, R., et al.: Env. Sci. Tech., 30, 825 (1996); Park, K., et al.: Org. Biomol. Chem., 7, 4225 (2009); Weissenfels, W., et al.: Appl. Micro. Biotech., 32, 479 (1990)<br></p>

<p>Applications 5-Chloro-2-methoxy-benzoic Acid Methyl Ester-13C2,d6 (cas# 1794737-29-3) is a compound useful in organic synthesis.<br></p>

<p>Stability Volatile<br>Applications 1-Bromobutane-d3 is used in the synthesis of specifically-deuterated procaine and tetracaine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boulanger, Y., et al.: J. Labelled Comp. Radiopharm., 18, 1197 (1981),<br></p>

<p>Stability Stable<br>Applications 2,4,5-Triamino-6-pyrimidinol-13C2,15N is an intermediate in the synthesis of labelled Guanine (G836000). Guanine is on one of the five nucleobases incorporated into biological nucleic acids. Guanine, along with adenine and cytosine, is present in both DNA and RNA, whereas thymine is usually seen only in DNA, and uracil only in RNA.<br>References Geslain, R., et al.: J. Biol. Chem., 284, 27760 (2009); Manini, P., et al.: Toxicol. Lett., 190, 41 (2009); Gong, B., et al.: Biochem., 48, 11961 (2009); Sugimoto, M., et al.: J. Agric. Food Chem., 58, 374 (2010)<br></p>

<p>Applications A labelled metabolite of Nisoldipine.<br></p>

<p>Applications 2-Amino-4,6-dichloropyrimidine-13C2 (cas# 1346605-11-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Bis(2-butoxyethyl) 2-Hydroxyethyl-d4 Phosphate Triester is a labeled form of Bis(2-butoxyethyl) 2-Hydroxyethyl Phosphate Triester (B415190), which is a metabolite of Tris(2-butyloxyethyl)phosphate (T875030), an organophosphate, that is used in the preparation of flame retardant, such as viscose fiber.<br>References Wang, Y., et al.: Fangzhi Xuebao, 33, 16 (2012); Xiaoshan, L. et al.: Aquatic Toxicology, 114, 173 (2012);<br></p>

<p>Applications A deuterated intermediate in the synthesis of the metabolite of Terbinafine, an orally active, antimycotic allylamine related to naftifine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Labelled Anabaseine intermediate.<br></p>

<p>Applications Ethyl 3-Methyl-2-butenoate-d6 (cas# 53439-15-9) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications O-Demethyl Pyraclostrobin-d3 is an intermediate used in the synthesis of Pyraclostrobin-d6 (P840402), which is an isotope labelled Pyraclostrobin is a fungicide for use in seed grass and food crops.<br>References Gyldenkaerne, S., et al.: Pestic Sci., 55, 1210 (1999), Pennington, D., et al.: Environ. Sci. Technol., 39, 1119 (2005), Wang, S., et al.: Food Control., 18, 731 (2007),<br></p>

<p>Applications 4-(4-Chlorophenyl)cyclohexanol-d5 (cas# 1189961-66-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Bromopyridine-d4 is the isotope labelled analog of 3-Bromopyridine (B686740). Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Colby, J., et al.: Biochem. J., 165, 395 (1977), Damani, L., et al.: Xenobiotica, 12, 527 (1982), Balzarini, J., et al.: J. Antimicrob. Chemother., 55, 135 (2005),<br></p>

<p>Applications 2-(Benzyloxy)-1-propanol-d6 is an intermediate in the synthesis of Isotope labelled Propylene Glycol 2-Glucuronide which is a metabolite of propylene glycol, used in the synthesis of N-terminal kinase inhibitors with cellular activity. Acts as a solvent for various pharmaceutical compounds.<br>References Szczepankiewicz, B. et al.: J. Med. Chem., 49, 3563 (2006); Mateus, R. et al.: Int. J. Pharm., 444, 106 (2013);<br></p>

<p>Applications 1,3-Dihydro-N-nitro-1,3-dioxo-2H-isoindole-2-carboximidothioic acid Methyl Ester-13C is an intermediate used in the synthesis of Clothianidin-d3,13C1 (C588502), which is the isotope labelled analog of Clothianidin. Clothianidin is a neonicotinoid insecticide for use in food crops.<br>References Kamel, A., et al.: J. Agric. Food Chem., 58, 5926 (2010), Lynd, L., et al.: Energy Environ. Sci., 3, 1150 (2010), Cresswell, J., et al.: Ecotoxicology, 20, 149 (2011),<br></p>

<p>Applications [(3-Ethyl-1-cyclohexen-1-yl)oxy]trimethylsilane-d5 is an intermediate in the synthesis of metabolites of Bis(2-ethylhexyl) Phthalate (DEHP) (B433850).<br>References Denmark, S. E., et la.: J. Am. Chem. Soc., 112, 3466 (1990);<br></p>

<p>Applications N-Boc-N-methylpiperazine-d8 (cas# 1189436-83-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Eugenol-d3 Methanesulfonate is an intermediate in the synthesis of Labelled Eugenol (E935640), a dental compound which shows cytotoxicity to human oral squamous cell carcinoma and oral cells. When glucosylated, this compound exhibits anti-inflammatory activity.<br>References Koh, T. et al.: In Vivo, 27, 85 (2013); Zhang, P. et al.: Arch. Pharm. Res., 36, 109 (2013);<br></p>

<p>Applications Ammonium-15N hydroxide Solution is a solution prepared from ammonium-15N sulfate for studying fertilizer use efficiency and is an important fertilizer for soil fertilization of the sugarcane crop in Brazil.Ammonium-15N hydroxide Solution is also used in the preparation of isotope-labeled oligonucleotides for their use in NMR studies of protein-DNA complexes.Ammonium-15N hydroxide Solution is the 15N-labeled compound for A634020, which is used in numerous household cleaning agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bendassolli, Jose Albertino., Scientia Agricola (Piracicaba, Brazil), 59, 595-603, (2002)Kellenbach, E. R., Nucleic Acids Research, 20, 653-7, (1992)Lokshin, E.P., et al.: Russ. J. App. Chem., 86, 450 (2013)<br></p>

<p>Applications Reproduction of Sindbis virus strains sensitive and resistant to 1-adamantanecarboxamide.<br>References Erice, A., et al.: N. Engl. J. Med., 320, 289 (1989), Andronova, V.L., et al.: Bull. Exper. Bio. Med., 129, 74 (2000).<br></p>

<p>Applications N-Acetyl-d3-5-hydroxytryptamine is deuterium labelled N-Acetyl-5-hydroxytryptamine (A179160), which is a metabolite of Melatonin (M215000).<br>References Reiter, R.J., et al.: J. Biomed. Sci., 7, 444 (2000), Chen, Z., et al.: Am. J. Physiol, 284, 1618 (2003), Barrenetxe, J., et al.: J. Physiol. Biochem., 60, 61 (2004),<br></p>

<p>Applications 4-​(Dimethylamino)​benzoic-​2,​3,​5,​6-​d4 Acid is an intermediate in the synthesis of DMABA-d4 NHS Ester (D678402), which is a labelled DMABA NHS ester (D678400). DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids. DMABA NHS ester has been used in combination with DMABA NHS ester-d4, -d6, and -d10 to study relative changes in PE lipid abundance before and after radical oxidation.<br>References Wester, H., et al.: Nucl. Med. Bio., 23, 365 (1996), Frees, D., et al.: Mol. Microbiol., 48, 1565 (2003), Michel, A., et al.: J. Bacteriol., 188, 5783 (2006), Voelker, T., et al.: Bioorg. Med. Chem., 17, 2047 (2009),<br></p>

<p>Applications α,α-Dimethyl-1H-indole-2-acetonitrile-13C315N is an isotope labelled intermediate in the synthesis of serotonin-3 receptor antagonists.<br>References Kato, M., et al.: Chem. Pharma. Bull., 42, 2556 (1994);<br></p>

<p>Applications 5-Nitro-6-methylaminoquinoline-d3 is an isotope labelled intermediate in the synthesis of carcinogen IQ and related 3H-imidazo[4,5-f]quinolines.<br>References Ronne, E., et al.: Acta. Chem. Scandinavica., 48, 823 (1994);<br></p>

<p>Applications Cyanoacetic Acid-13C2 is an intermediate for the synthesis of Diclazuril-13C3,15N2 (D436202), which is the labelled analogue of Diclazuril (D436200). Diclazuril is a nucleotide analogue with broad-spectrum anticoccidial activity and a coccidiostat.<br>References Maes, L., et al.: J. Parasitol., 74, 931 (1988)<br></p>

<p>Applications 2-(2-Formamidothiazol-4-yl)acetic Acid-13C,15N2 is an intermediate used in the synthesis of Cefotiam Dihydrochloride-13C, 15N2 (C243007), which is labelled Cefotiam Dihydrochloride (C243005), which is an antibiotic product used in injections to treat bacterial infections. Cefotiam Dihydrochloride can also reduce allergic reactions and mixed with pharmaceutical carriers for medical formulations.<br>References Jiang, C., et al.: Faming Zhuanli Shenqing, CN 105646539 A, 20160608 (2016); Liu, X.: Faming Zhuanli Shenqing, CN 105193819 A, 20151230, (2015); Weng, Y., et al.: Faming Zhuanli Shenqing, CN 103601737 A. 20140226 (2014)<br></p>

<p>Applications N-[1-(3’-Benzyloxyphenyl)ethyl]-N,N-dimethyl-d6-amine (cas# 1190006-94-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-[2-(1-Piperidinyl)ethoxy-d4]benzoic Acid, Hydrochloride Salt (cas# 1246815-60-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl 5-Oxohexanoate-1,4,5-13C3 (cas# 1185166-61-3) is a compound useful in organic synthesis.<br></p>