Deuterated Compounds

Applications Labelled Doxylamine intermediate.
References Rennison, D., et al.: Bioorg. Med. Chem., 15, 2963 (2007),

Applications Labelled 4’-Bromoacetophenone (B679060). Possess activity against positive phototaxis of Chlamydomonas cells.A fundamental starting material for organic synthesis.
References Evans, S., et al.: Chem. Biol. Drug. Des., 75, 333 (2010), Rajabi, L., et al.: Lett Appl Microbiol., 40, 212 (2005),

Applications Reagent used to make labelled Catechol.

Applications Ethyl Isobutyrylacetate-d6 (cas# 1216475-83-0) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Labelled Anabaseine intermediate.

Applications Used as an animal glue liquifier, silver tarnish remover, fixing agents, manufactured resins and vulcanization accelerators. It is a known carcinogen, also causes bone marrow depression and goiters.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Butola, J., et al.: J. Plant Biol., 35, 75 (2008), Roux-Dalvai, F., et al.: Mol. Cell. Proteom., 7, 2254 (2008), Ansari, F., et al.: J. Enz. Inhibit. Med. Chem., 24, 151 (2009),

Applications Intermediate in the production of labelled Cyclophosphamide metabolites.
References Takamizawa, A., et al.: Chem. Pharm. Bull., 20, 1612 (1972),

Applications 2,6-Diamino-4-hydroxy-5-nitrosopyrimidine-13C2 is a labelled 2,6-Diamino-4-hydroxy-5-nitrosopyrimidine (D416350), used in the preparation of pterin-based inhibitors.
References Hevener, K. et al.: J. Med. Chem., 53, 166 (2010)

Applications An intermediate in the production of labelled fluorothymidine derivatives
References Roberts, G., et al.: Biochem. Pharmacol., 46, 2209 (1993), Hatano, A., et al.: Bioorg. Med. Chem., 16, 3866 (2008),

Applications 2-(2-Formamidothiazol-4-yl)acetic Acid-13C,15N2 is an intermediate used in the synthesis of Cefotiam Dihydrochloride-13C, 15N2 (C243007), which is labelled Cefotiam Dihydrochloride (C243005), which is an antibiotic product used in injections to treat bacterial infections. Cefotiam Dihydrochloride can also reduce allergic reactions and mixed with pharmaceutical carriers for medical formulations.
References Jiang, C., et al.: Faming Zhuanli Shenqing, CN 105646539 A, 20160608 (2016); Liu, X.: Faming Zhuanli Shenqing, CN 105193819 A, 20151230, (2015); Weng, Y., et al.: Faming Zhuanli Shenqing, CN 103601737 A. 20140226 (2014)

Applications 2-(2-Chloroethyl-d4)-1H-isoindole-1,3-dione (cas# 1252995-10-0) is a compound useful in organic synthesis.

Applications (Methoxymethoxy)benzene-13C6 is an intermediate in the synthesis of 2,6-Dimethylphenol-13C8 (D465859), an isotope labelled analog of 2,6-Dimethylphenol-13C8. Similar to other xylenol compounds, 2,6-dimethylphenol is used in the synthesis of anti-oxidant compounds due to the phenol moiety in the structure. In addition, this compound is used as a a reactant in the synthesis of polyphenylene ether polymers.
References Carrillo, A. et al.: ANTEC. Soc. Plas. Eng., 69, 945 (2011); Guillen, M. et al.: J. Agri. Chem., 47, 3016 (1999); Guillen, M. et al.: J. Agri. Chem., 46, 1276 (1999)

Applications 2-(n-Butyl-d9-amino)-4-chloro-6-cyclopropylamino-1,3,5-triazine (cas# 1189997-37-2) is a compound useful in organic synthesis.

Applications 5’-Deoxy-5’-iodo-2’,3’-O-isopropylidene-5-fluorouridine-13C,15N2 >95% is a compound useful in organic synthesis.

Applications 2,4,6-Trifluorobenzonitrile-15N is an intermediate in the synthesis of Bictegravir-15N, d2 (B382096), which is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.
References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;

Applications Labelled intermediate for the synthesis of Thiouric Acid.
References Levin, G., et al.: J. Org. Chem., 25, 1752 (1960), Piper, J., et al.: J. Med. Chem., 36, 4161 (1993).

Applications N-[1-(3’-Benzyloxyphenyl)ethyl]-N-(methyl-d3)amine (cas# 1189957-44-5) is a compound useful in organic synthesis.

Applications Tri-n-butylallylphosphonium Bromide-d5 is isotope labelled intermediate in the synthesis of quaternary phosphonium reversible inhibitors of cholinesterases.
References Basova, N. E., et al.: J. Evo. Biochem. Physiol., 47, 420 (2011);

Applications Cyclopropylmethanol-d4 is an isotope labelled reagent used in the addition of labelled cyclopropane.

Applications 2-(Acetylamino)butanoic Acid-d5 is an intermediate of Isotope labelled L-2-Aminobutyric Acid (A602930) Receptor antagonist.
References Porter, D.J.T., et al.: Biochem. Pharmacol., 50, 1475 (1995),

Applications Farnesalacetone-d6 is an labelled intermediate in the synthesis of intermediates in the biosynthesis of carotenoids.
References Natarajan, R. K., et al.: Adv. Biol. Res., 7, 95 (2013);

Applications N-(4-Nitrobenzoyl)-D-serine Quinine Salt is an intermediate used in the synthesis of D-Serine-2,3,3-d3 (S270977), which is derived from 2-Chlorobenzyl Chloride (C364225), which is a reagent in the synthesis of piperidine derivatives which are used as human heat shock protein 70 inhibitors for treatment of drug-resistant tumors. 2-Chlorobenzyl Chloride is also used as a reagent in the synthesis of benzothiazole derivatives bearing indole-based moiety which can exhibit anticancer activity.
References Zeng, Y., et al.: Eur. J. Med. Chem., 97, 19 (2015); Ma, J., et al.: Eur. J. Med. Chem., 96, 173 (2015)

Applications 5-[4-Bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-2-chloro-4-fluorobenzoic Acid-d3 is an intermediate in the synthesis of Fluazolate (F407500), the active ingredient in the preparation of agrochemicals and drugs in amorphous form.

Applications Acetophenone-13C8 is an intermediate in synthesizing Mandelic Acid-13C8 (M162523). It is a C13 labelled Mandelic Acid which is used as an antiseptic (urinary). It is also used as a short-term exposure biomarker in urine from styrene exposed workers.
References Pessela, B., et al.: Enzyme Microb. Technol., 40, 310 (2007); Carrasco-Lopez, C., et al.: J. Biol. Chem., 284, 4365 (2009); Fustinoni, S., et al.: Toxicol. Lett., 192, 40 (2010)

Applications 4-Pentylphenylacetylene-d7 is an isotope labelled intermediate in the synthesis of new acid ceramidase-targeted acyclic 5-alkynyl and 5-heteroaryl uracil nucleosides.
References Mescic, A., et al.: ACS. Med. Chem. Lett., 6, 1150 (2015);

Applications (4-((3-Acetamidopropyl)(tert-butoxycarbonyl)amino)butyl)(3-((tert-butoxycarbonyl)amino)propyl)carbamic Acid-d3 tert-Butyl Ester is an intermediate in the synthesis of derivatives of Spermine (S680510) which is a biogenic polyamine formed from Spermidine (S680400) that occurs in almost all tissues.
References Theoharides, T.C., et al.: Life Sci., 27, 703 (1980); Horn, Y., et al.: Cancer Res., 42, 3248 (1982)

Applications Benzophenone-2,3,4,5,6-d5 is derived from Benzene-d6 (B185282), which is an isotope labelled benzene, an organic compound that is a natural constituent of crude oil and one of the most basic petrochemicals.
References Feng, Z.X.. et al.: J. Phys. Chem. Lett. 4, 285 (2013); Pilling. M., et al.: Chem. Eng. Prog., 108, 32 (2012);

Applications (-)-(2S,3S)-Viridifloric Acid Acetonide-d7 is the isotope labelled intermediate in the synthesis of (+)-amabiline, an unsaturated pyrrolizidine alkaloid from Cynoglossum amabile.
References Senter, T. J., et al.: Org. Lett., 14, 1869 (2012);

Applications N-[(Ethylamino)thioxomethyl]-N'-phenylpropanimidamide-d5 is an intermediate in the synthesis of Ethaboxam (E675700), a fungicide used against fungal infections in crops.

Applications 4-Bromotoluene-2,3,5,6-D4 is used in the synthesis of some deuteriated benzene derivatives like isotopically labelled ZD4054 used to support the development of drug metabolism and pharmokinetics program.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bergin, J. A., et al.: Journal of Label. Compds Radiopharm., 50, 431 (2007); Renaud, R. N., et al.: Canadian J. Chem., 39, 21 (1961)

Applications An intermediate in the preparation of labelled Pipradrol Hydrochloride

Applications Used in the preparation of labelled Iopamidol. Also an intermediate in the synthesis of perylenetetracarboxylic diimide and its interactions with G-quadruplex-forming DNA
References Samudrala, R. et al.; Bioorg. Med. Chem. 15, 186 (2007)

Applications 2-Butoxyethanol-d9 is an intermediate in the synthesis of Tris(2-butyloxyethyl)phosphate-d27 (T875032), which is the isotope analog of Tris(2-butyloxyethyl)phosphate. Tris(2-butyloxyethyl)phosphate,is an organophosphate, that can be used in the preparation of flame retardant, such as viscose fiber.
References Wang, Y., et al.: Fangzhi Xuebao, 33, 16 (2012); Xiaoshan, L. et al.: Aquatic Toxicology, 114, 173 (2012);

Applications O-2-Amino-2-methylpropyl Bilastine-d6 is an intermediate used in the synthesis of Bilastine-d6 (B385002), which is labelled Bilastine. It is a novel, nonsedating H1-antihistamine developed for symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.
References Van Cauwenberge, P., et al.: Clin. Exp. Allergy, 30, 891 (2000), Bauchau, V., et al.: Eur. Respir. J., 24, 758 (2004), Lehman, J., et al.: Drugs, 66, 2309 (2006),

Applications An intermediate for the synthesis of labelled thiazolidinedione anti-diabetic drugs
References Cantello, B., et al.: Bioorg. Med. Chem. Lett., 4, 1181 (1994),

Applications A labelled intermediate of Irbesartan (I751000).
References Gillis, J., et al.: Drugs, 54, 885 (1997), Chando, T., et al.: Drug Metab. Disps., 26, 408 (1998), Hines, J., et al.: Eur. J. Pharmacol., 384, 81 (1999)

Applications 2-(Tetrazol-1-yl)acetic Acid-13C2,15N is a reactant used in the preparation of labelled β-lactam antibiotics.
References Nys, P. et al.: App. Biochem. Biotech., 88, 221 (2000); Won, J. et al.: App. Biochem. Biotech., 69, 1 (1998); Kostadinov, M. et al.: App. Biochem. Biotech., 33, 177 (1992)

Applications Isotope labelled Hexahydro-1,3-isobenzofurandione is used in the synthesis of hypotensive agents, pyridazinones. Also used in the synthesis of selective PDE4 inhibitors.
References Curran, W. et al.: J. Med. Chem., 17, 273 (1974); Van der Mey, M. et al.: J. Med. Chem., 44, 2511 (2001);

Applications Isotope labelled analog of Ethyl Cyano(ethoxymethylene)acetate, an intermediate in the synthesis of anti-inflammatory agents with gastroprotective effect in rats.
References Karoui, A., et al.: Med. Chem. Res., 23, 1591 (2014);

Applications N-Methyl-o-phenylenediamine-d3, Dihydrochloride (cas# 1246820-22-3) is a compound useful in organic synthesis.

Applications Ethyl-d5 2-Methylbutyrate is the labeled analogue of Ethyl 2-Methylbutyrate (E923200), an ester that has a sweet, apple-like aroma. Ethyl 2-methylbutyrate is naturally found in apples, cherries and orange juice.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cho, I., et al.: J. Agr. Food Chem., 54, 6332 (2006); Mattheis, J., et al.: J. Agr. Food Chem., 45, 212 (1997); Moshonas, M. & Shaw, P.: J. Agr. Food Chem., 35, 161 (1987); Willaert, G., et al.: J. Agr. Food Chem., 31, 809 (1983)

Applications Acetyl-13C2 Chloride is a labelled derivative of Acetyl chloride (A164496).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications (R)-2,3-Di(benzoyloxy)propyl-1,1-d2 4-Toluenesulfonate is an intermediate used in the synthesis of (S)-PA 824-d4 (P122502), which is a labelled novel anti-tuberculosis drug.
References Diacon, A.H. et al.: Antimicrob. Anents Chemother., 54, 3402 (2010); Dogra, M. et al.: Br. J. Pharmacol., 162, 226 (2010); Ginsberg, A.M. et al.: Antimicrob. Agents Chemother., 53, 3720 (2009);

Applications 3-Butenyl-d2 Tosylate is a proposed intermediate for the synthesis of (5S,5’S)-Dihydroxy Lysinonorleucine-d4 (D452902), which is isotope labelled (5S,5’S)-Dihydroxy Lysinonorleucine, a collagen reducible crosslink agent.
References Mizikova, I. et al.: FEBS J., 285, 3056 (2018);

Applications Labelled 2-Bromo-1,3-propanediol (B686665) derivative. 2-Bromo-1,3-propanediol is used for isolating bases by means of Reinecke's salt.
References Dudley, H., et al.: Biochem. J., 27, 157 (1933),

Applications Dithio-2,2'-bis(N-methylbenzamide)-d6 is an labelled intermediate in the synthesis of analogue of Axitinib, a tyrosine kinase inhibitor used for cancer therapy.
References Brown, D.W., et al.: Sci. Synthesis., 11, 573 (2002);

Applications N-[1-(3’-Benzyloxyphenyl)ethyl]-N-(methyl-d3)-O-ethylcarbamate (cas# 1189709-65-6) is a compound useful in organic synthesis.

Applications 4-(4-Chlorophenyl)cyclohexanol-d5 (cas# 1189961-66-7) is a compound useful in organic synthesis.