Deuterated Compounds

<p>Applications Rosiglitazone (Rosiglitazone (R693500) Rosiglitazone (R693500) ) derivative.Thiazolidinedione derivative, with antidiabetic properties.<br></p>

<p>Applications 3,5-Diamino-4-chlorobenzonitrile-15N2 is an intermediate in synthesizing Lodoxamide-15N2,d2 (L469367), a labelled form of Lodoxamide. It is an antiallergic drug that acts as a mast cell stabilizer. It is effective in the treatment of allergic conjunctivitis and in decreasing vascular permeability.<br>References Ciprandi, G., et al.: Allergy, 51(12), 946-951 (1996); Bayer, Atilla., et al.: Ophthalmologica, 217(2), 119-123 (2003)<br></p>

<p>Applications 4-(4-Chlorophenyl)-1-imidazol-1-yl-(butan-d5)-2-ol (cas# 1185063-39-1) is a compound useful in organic synthesis.<br></p>

<p>Applications A labelled metabolite of Nisoldipine.<br></p>

<p>Applications Alfuzosin labelled intermediate as potential α1-adrenoceptor antagonist.<br>References Manoury, P. M. , et al.: J. Med. Chem., 29, 19 (1986),<br></p>

<p>Applications 1-(2,5-Dichlorophenyl)ethanone-d3 is an intermediate in the synthesis of Isotope labelled Triclosan which is used as bactericide and preservative for cosmetic and detergent compositions (1). Broadly used as an antiseptic and disinfectant (2). This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br></p>

<p>Applications Phenoxy-d5-acetic Acid Ethyl Ester (cas# 1189442-18-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,1,2-Trimethyl-1H-benzo[e]indole-d6 is a labelled analogue of 1,1,2-Trimethyl-1H-benzo[e]indole (T896032). It is a useful research chemical.<br></p>

<p>Applications 6-Amino-3-methyluracil-d3 (cas# 1246820-43-8) is a compound useful in organic synthesis.<br>References Grant, D.M., et al.: Clin. Pharm. and Ther., 33, 591 (1983)<br></p>

<p>Applications 2-Pyridineacetic Acid-d6 Ethyl Ester is an labelled analogue of 2-Pyridineacetic Acid (P991750), a compound used often in nucleophilic substitution.<br>References Genicot, C., et al.: Bioorg. Med. Chem. Lett., 13, 437 (2003),<br></p>

<p>Applications 5-[2-[(3-Chloro-2-hydroxypropyl)thio]-4-thiazolyl]-2-thiophenecarboxamide-d5 is an intermediate in synthesizing Arotinolol-D5 Hydrochloride (A771502), which is a labelled analogue of Arotinolol (A771500). Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension.<br>References Kuroda, Y., et al.: Neurology, 38, 650 (1988); Miyagishi, A., et al.: Arch. Pharmacodyn. Ther., 271, 249 (1984); Wu, H., et al.: Hypertens. Res.: Off. J. Jpn. Soc. Hypertens., 24, 605 (2001);<br></p>

<p>Applications 2,4-Dichlorophenol-d3 (cas# 93951-74-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Eugenol-d3 Methanesulfonate is an intermediate in the synthesis of Labelled Eugenol (E935640), a dental compound which shows cytotoxicity to human oral squamous cell carcinoma and oral cells. When glucosylated, this compound exhibits anti-inflammatory activity.<br>References Koh, T. et al.: In Vivo, 27, 85 (2013); Zhang, P. et al.: Arch. Pharm. Res., 36, 109 (2013);<br></p>

<p>Applications N3-Tritylpyridine-2,3-diamine-d3 is an intermediate in the synthesis of Pentosidine-d3 TFA Salt which is a biochemical marker of bone turnover for management of metabolic bone diseases.<br>References Turner, W., et al.: Biol. Psychiatry, 14, 177 (1979), Miyata, T., et al.: Kidney Int., 60, 2351 (2001), Politi, P., et al.: Neurosci. Lett., 396, 163 (2006),<br></p>

<p>Applications 6-Hydroxy-8-methoxy-octanoic Acid Methyl Ester-d5 is a compound useful in organic synthesis.<br></p>

<p>Applications 5-(2-Bromoethyl-d4)-2,3-dihydrobenzofuran (cas# 1189652-25-2) is a compound useful in organic synthesis.<br></p>

<p>Applications An intermediate for the synthesis of Tamoxifen.<br>References Ruenitz, P.C., et al.: Biochem. Pharmacol., 34, 2807 (1985), Gilbert, J., et al.: J. Med. Chem., 40, 1104 (1997), Lashley, M.R., et al.: Bioorg. Med. Chem., 10, 4075 (2002),<br></p>

<p>Applications (S)-1-Boc-3-hydroxypiperidine-d4 is an intermediate in synthesizing Ibrutinib-d4 (I124971), a labelled analogue of Ibrutinib (I124970). Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)<br></p>

<p>Applications Uridine 5′-Monophosphomorpholidate 4-Morpholine-N,N′-dicyclohexylcarboxamidine Salt-13C, 15N2 is an intermediate in the synthesis of Trilithium UDP-glucuronic Acid-13C1, 15N2 (T886287), which is an isotope labelled analog of Trisodium UDP-glucuronic Acid (T886285). Trisodium UDP-glucuronic Acid is a reactant used in the enzymatic preparation of β-glucuronides.<br>References Stevenson, D.E., et. al.: Collect Czech. Chem. C., 65, 117 (2000); Robotham, S.A., Brodbelt, J.S.: Biochem. Pharmacol., 82, 1764 (2011); Kren, V., et. al.: Drug Metab. Dispos., 28, 1513 (2000)<br></p>

<p>Applications Farnesyl Pyrophosphate Triammonium Salt-13C3 is labelled Farnesyl Pyrophosphate Triammonium Salt (F102470) which is an isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular mass G proteins, including Ras.<br>References Correll, C., et al.: J. Biol. Chem., 269, 17390 (1994), Moura, I., et al.: Antimicrob. Agents Chemother., 45, 2553 (2001), Gana-Weisz, M., et al.: Clin. Cancer Res., 8, 555 (2002),<br></p>

<p>Applications Glutaronitrile-d6 (cas# 1346598-53-5) is a compound useful in organic synthesis.<br></p>

<p>Stability Volatile<br>Applications 1-Bromobutane-d3 is used in the synthesis of specifically-deuterated procaine and tetracaine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boulanger, Y., et al.: J. Labelled Comp. Radiopharm., 18, 1197 (1981),<br></p>

<p>Applications Intermediate in the synthesis of labelled heteroarotinoids.<br>References Dawson, M.I. et al.; J. Med. Chem. 27, 1516 (1984); Waugh, K.M. et al.; J. Med. Chem. 28, 116 (1985); Spruce, L.W. et al.; J. Med. Chem. 30, 1474 (1987)<br></p>

<p>Applications Labelled analogue of Potassium Cyanide, a reagent widely used in organic synthesis for the preparation of nitriles and carboxylic acids, particularly in the von Richter reaction.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kollenz, G. et al.: Org. Prep. Proc. Int., 12, 244 (1980); Subramanian, L. R.: Sci. Synth., 19, 173 (2004);<br></p>

<p>Applications Ammonium-15N hydroxide Solution is a solution prepared from ammonium-15N sulfate for studying fertilizer use efficiency and is an important fertilizer for soil fertilization of the sugarcane crop in Brazil.Ammonium-15N hydroxide Solution is also used in the preparation of isotope-labeled oligonucleotides for their use in NMR studies of protein-DNA complexes.Ammonium-15N hydroxide Solution is the 15N-labeled compound for A634020, which is used in numerous household cleaning agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bendassolli, Jose Albertino., Scientia Agricola (Piracicaba, Brazil), 59, 595-603, (2002)Kellenbach, E. R., Nucleic Acids Research, 20, 653-7, (1992)Lokshin, E.P., et al.: Russ. J. App. Chem., 86, 450 (2013)<br></p>

<p>Applications Anticonvulsant against audiogenic convulsion.<br>References Goeres, E., et al.: Acta Biol. Med. Ger., 23, 679 (1969)<br></p>

<p>Applications [3-(Dimethylamino)propyl]triphenylphosphonium-d6 Bromide is a compound useful in organic synthesis.<br></p>

<p>Applications Benzoic Acid-d5 Ethyl Ester (cas# 54354-03-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl nicotinate-2,4,5,6-d4 is a labelled form of methyl nicotinate (M323240), a useful synthetic intermediate, which can be used to prepare biarylcarboxamide inhibitors of phosphodiesterase IV and tumor necrosis factor-α in treatment of rheumatoid arthritis.<br>References Chambers, R., et al.: Bioorg. Med. Chem. Lett., 7, 739 (1997).<br></p>

<p>Applications N,N-Diisopropyl-3-(2-methoxy-5-methyl-phenyl)-3-phenylpropylamine-d14 (cas# 1795031-80-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,1,2-Trimethyl-3-(4-sulfobutyl)benz[e]indolium-d6 Inner Salt is a labelled analogue of 1,1,2-Trimethyl-3-(4-sulfobutyl)benz[e]indolium Inner Salt (T796740). It is a reactant used in the preparation of liposomally formulated indocyanine green (LP-ICG) derivatives for near infrared fluorescence imaging of lymph nodes.<br>References Toyota, T., et. al.: Bioorg. Med. Chem., 22, 721 (2014)<br></p>

<p>Applications Intermediate in the production of labelled Medetomidine<br>References Kagechika, H., et al.: J. Med. Chem., 32, 1098 (1989),<br></p>

<p>Applications N-[1-(3’-Benzyloxyphenyl)ethyl]-N,N-dimethyl-d6-amine (cas# 1190006-94-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl 4-Chlorobutyrate-d4 is an isotope labelled reagent used in the preparation of cyclopropane derivatives.<br>References Antipenko, L., et al.: Chem. Pharm. Bull., 57, 580 (2009), Kumar, A., et al.: Bioorg. Med. Chem., 17, 5285 (2009),<br></p>

<p>Applications [4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methylsulfinyl)-5-pyrimidinyl]-ethyl Ester-d6 (cas# 1189487-47-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Used in cosmetic compositions.<br>References Chasin, M., et al.: Biopharm. Manufacturing, 1, 33 (1988), Cohen, S., et al.: Pharm. Res., 8, 713 (1991), Anderson, J., et al.: Eur. J. Pharm. Biopharm., 40, 1 (1994), Park, H., et al.: Pharm. Res., 13, 1770 (1996),<br></p>

<p>Applications n-Hexyl 1-Ethylbutyl Phthalate-d4, is the labeled analogue of n-Hexyl 1-Ethylbutyl Phthalate (H296450), a phthalic acid ester (PAEs), widely used in many consumable products with potential carcinogenic properties.<br>References Wang, Zh., et al.: Guocheng Gongcheng Xuebao, 5 (6), 670 (2005);<br></p>

<p>Applications N-Methyl-d3-form-d1-amide (CAS# 110505-55-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Propyl-3,3,3-d3-amine HCl (CAS# 478702-86-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Dodecanoic-2-13C Acid (CAS# 287100-78-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Nitrotoluene-2,3,5,6-d4 (CAS# 1276197-16-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Sodium 2-Keto-4(R,S)-methyl-d3-pentanoate (CAS# 93523-67-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 6-Hydroxy Nicorandil-d4 is the isotope labelled analog of 6-Hydroxy Nicorandil (H948550); a metabolite of the antianginal Nicorandil (N398500).<br>References Frydman, A., et al.: Am. J. Cardiol., 63, 25J (1989); Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008); Sudo, H., et al.: Biol. Pharm. Bull., 31, 2079 (2008); Iida, S., et al.: Brit. J. Clin. Pharmacol., 66, 352 (2008); Eguchi, Y., et al.: Ther. Res., 29, 316 (2008)<br></p>

<p>Applications Acetophenone-d3 is an isotopic analog of acetophenone (A164015), a reagent used in the production of fragrances and resin polymers. This compound is a contaminant of emerging concern (CECs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Perez, D., et al.; Bioorg. Med. Chem., 17, 6914 (2009), Giet, J., et al.: J. Agric. Food Chem., 57, 6787 (2009), Dimoula, K., et al.: Biotechnol. J., 4, 712 (2009),<br></p>

<p>Applications 1-(3,5-Diacetoxyphenyl)-1-bromoethane-13C6, is the labeled analogue of 1-(3,5-Diacetoxyphenyl)-1-bromoethane (D307562), which is an intermediate for the synthesis of Resveratrol (R150000).<br>References Powell, R.G., et al.: Phytochemistry, 35, 335 (1994), Jeandet, P., et al.: J. Phytopathol., 143, 135 (1995), Mattivi, F., et al.: J. Agric. Food Chem., 43, 1820 (1995),<br></p>

<p>Applications The four-center reactions of alkanol-alkoxide negative ions with alkyl ethers and ortho-acetates. An ion cyclotron resonance study.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>