Deuterated Compounds

<p>Applications 2-(3,4-Dihydroxyphenyl-13C6)ethylamine HCl (CAS# 335080-94-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-((2-((2-Chloroethyl)amino)ethyl)amino)propyl Ethyl Phosphate Dihydrochloride-d4, a deuterium labelled 3-((2-((2-Chloroethyl)amino)ethyl)amino)propyl Ethyl Phosphate Dihydrochloride (C984605), is a derivative of Cyclophosphamide Monohydrate (C988580), a known human carcinogen that is widely used in cancer chemotherapy because it can cross-link DNA causing strand breakage and mutation.<br>References Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999)<br></p>

<p>Applications Abiraterone Ethyl Ether-d5 is the labeled analogue of Abiraterone Ethyl Ether (A108525), an impurity of Abiraterone (A108490), a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.<br>References Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389(2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005)<br></p>

<p>Applications 4-Oxo-2,2,6,6-tetramethylpiperidine-d17 (CAS# 52168-48-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Propio-d5-phenone (CAS# 342610-99-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Hexanedioic-d8 Acid (CAS# 52089-65-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications α-Tetralone-13C6 (cas# 189811-58-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Isotope labelled 1,2-Hexanediol is used in the synthesis of sulfamidates which lead a simple route into β-amino acids. Also used in the controlled growth of GE nanowires.<br>References Nicolaou, K. et al.: Angew. Chem. Int. Ed., 41, 834 (2002); Lotty, O. et al.: J. Mat. Chem. C., Mat. Optic. Electro. Devices., 1, 4450 (2013);<br></p>

<p>Applications Benzyl-alpha,alpha-d2 Bromide (CAS# 51271-29-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Tridecyl-d27 Alcohol (CAS# 203633-18-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Chloropyridine-d4 (CAS# 1001003-95-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-​Chloro-​2-​phenyl-diazene-13C6 is an intermediate in synthesizing N-Acetyl-S-(phenyl-13C6)-L-cysteine (A187357), a labelled N-Acetyl-S-phenyl-L-cysteine (P335600). It is an important metabolite of Benzene.<br>References Muller, G., et al.: Anal. Hazard. Subst. Biol. Mater., 5, 143 (1997)<br></p>

<p>Applications Cyclopropyl-2,2,3,3-d4 Methyl Ketone (CAS# 350818-63-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-(4-Aminophenyl)cyclopentanecarbonitrile-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is a labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.<br>References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>

<p>Applications 4-tert-Butylaniline-d15 (CAS# 1219794-71-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Nitroaniline acts as an azo dye used in analytical toxicity studies. 3-Nitroaniline-2,4,5,6-d4 is the labeled version.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Garner, R.C. et al.: Mut. Res., et al 44, 9 (1977);<br></p>

<p>Applications 3-Aminobenzotrifluoride-D4 is a labelled analogue of 3-Aminobenzotrifluoride (A591720).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications n-Heptylbenzene-d20 (CAS# 634897-84-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Didesmethyl Loperamide-d4 is the isotope labelled analog of N-Didesmethyl Loperamide (D441135); a metabolite of the antidiarrheal Loperamide (L469450, HCl). Also a new and improved PET radiotracer for imaging P-gp function.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stokbroekx, et al.: J. Med. Chem., 1, 782 (1973); Carter, J.E., et al.: Anal. Profiles Drug Subs., 19, 341 (1990); Rahman, A., et al.: Cancer Res., 54, 5543 (1994); Sai, Y., et al.: Xenobiotica, 30, 327 (2000); Eneroth, A., et al.: Eur. J. Pharm. Sci., 12, 205 (2001); Kim, K., et al.: Drug Metab. Dispos., 31, 1090 (2003)<br></p>

<p>Applications N-Desmethyl Nefopam-D5 is deuterium labelled analogue of N-Desmethyl Nefopam (D422355), which is the main metabolite of Nefopam (N389418), which is a non-opioid non-steroidal centrally acting analgesic.<br>References Chawla, J., et al.: Ther. Drug Monit., 25, 203 (2003); Aymard, G., et al.: Pharmacol. Toxicol., 92, 279 (2003); Yoon, J., et al.: Korean J. Anesthesiol., 69, 161 (2016); Petrault, M., et al.: Fundam. Clin. Pharmacol., 31, 194 (2017);<br></p>

<p>Applications 1-Bromododecane-d25 (CAS# 204259-66-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications p-Toluic-2,3,5,6-d4 Acid (CAS# 1219798-71-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications A volatile lactone found in fruits giving ripe produce their aroma.<br>References Tavori, H., et al.: Bioorg. Med. Chem., 16, 7504 (2008), Pandit, S., et al.: J. Sci. Food Agric., 89, 2071 (2009), Xiang, D., et al.: Biochem., 48, 2237 (2009), Pandit, S., et al.: Food Chem., 114, 363 (2009),<br></p>

<p>Applications Acetophenone-d3 is an isotopic analog of acetophenone (A164015), a reagent used in the production of fragrances and resin polymers. This compound is a contaminant of emerging concern (CECs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Perez, D., et al.; Bioorg. Med. Chem., 17, 6914 (2009), Giet, J., et al.: J. Agric. Food Chem., 57, 6787 (2009), Dimoula, K., et al.: Biotechnol. J., 4, 712 (2009),<br></p>

<p>Applications Heptanoic-5,5,6,6-d4 Acid (CAS# 352431-36-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tetradecanoic-2,2-d2 Acid (CAS# 30719-21-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromohexane-1,1,2,2-d4 (CAS# 1219802-83-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Phenyltrimethyl-d9-ammonium Methane-d3-sulfonate is an intermediate in the synthesis of Oxycodone-d3 (O870603), a labelled Oxycodone (O870600), a controlled substance (opiate). Analgesic (narcotic).<br>References Mendelson, J., et al.: Clin. Pharmacol. Ther., 60, 105 (1996); Fudala, P., et al.: N. Engl. J. Med., 349, 949 (2003); Alho, H., et al.: Drug Alcohol Depend., 88, 75 (2007)<br></p>

<p>Applications Tryptamine-beta,beta-d2 HCl (CAS# 362049-48-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications O-(2,3,4,5,6-Pentafluorobenzyl-alpha,alpha-d2)hydroxylamine HCl (CAS# 358730-85-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Fluoro-N-isopropylaniline-13C6 is an intermediate for the synthesis of Flufenacet-13C6 (F599422), labelled Flufenacet (F599420) which is an anilide based herbicide that is applied to the soil surface or incorporated before the crop is emerged. Flufenacet is often used in field corn, corn grown for silage or soybeans to control annual grasses and broadleaf weeds.<br>References Hulting, A.G., et al.: Weed. Technol., 26, 230 (2012); Bailly, G.C., et al.: Crop Protect., 34, 96 (2012)<br></p>

<p>Applications Propionitrile-3,3,3-d3 (CAS# 24300-21-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Nonanoic-2,2-d2 Acid (CAS# 62689-94-5) is used as a tracer for detecting metabolic pathways in anaerobic alkane degradation in methane production. It can be used for NMR analysis.<br>References Chen, D., et.al., Can. J. Chem, 55, 2404-2410, (1977); Mou, B., et.al., Faming Zhuanli Shenqing, 5,(2012);<br></p>

<p>Applications n-Hexylbenzene-2,3,4,5,6-d5 (CAS# 1219799-07-1) is a useful isotopically labeled research compound.<br></p>