Deuterated Compounds

Applications 1,10-Phenanthroline-d8 (CAS# 90412-47-8) is a useful isotopically labeled research compound.

Applications 2-Tetradecylcyclobutanone-D29 is a labelled analogue of 2-Tetradecylcyclobutanone (T291540).

Applications (±)-2-Ethylhexyl-d17 Acetate (CAS# 1219802-70-6) is a useful isotopically labeled research compound.

Applications p-Xylene-d4 (ring-d4) (CAS# 16034-43-8) is a useful isotopically labeled research compound.

Applications 1,3-Di(methyl-d3)-naphthalene is the labeled analogue of 1,3-Dimethylnaphthalene (D476385), a polycyclic aromatic hydrocarbon (PAH) that has been shown to have cytochrome P 450 2A6 and 2A5 inhibitory activities.
References Wammer, K.H., Peters, C.A.: Environ. Sci. Technol., 39, 2571 (2005); Roy, K., Roy, P.P.: Eur. J. Med. Chem., 44, 1941 (2009)

Applications Cholesterol-3-d1 (CAS# 51467-57-3) is a useful isotopically labeled research compound.

Applications 4-[(Tetrahydro-2H-pyran-2-yl)oxy]-2-butyn-1-ol-1,2,3,4-13C4 is an intermediate in the synthesis of N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine-13C4 (A173713). N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine-13C4 is labelled N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (A173710), which is a metabolite of butadiene.
References Heavner, D., et al.: J. Pharm. Biomed. Anal., 40, 928 (2006); Carmella, S., et al.: Chem. Res. Toxicol., 22, 734 (2009)

Applications Di(α-tocopherol) Phosphate-d12 is labelled Di(α-tocopherol) Phosphate (T526190) which is used as a vitamin E supplement.
References Libinaki, R., et al.: Food Chem. Toxicol., 44, 916 (2006)

Applications 1-(2,6-Dichlorophenyl)piperazine-d8 Hydrochloride is the isotope analog of 1-(2,6-Dichlorophenyl)piperazine Hydrochloride. 1-(2,6-Dichlorophenyl)piperazine Hydrochloride is used in the preparation of pyrazolopyrimidones and pyrazolopyridones as tankyrase inhibitors which are useful in the treatment of cancer.
References Feng, J., et al.: PCT Int. Appl., 2013:1906020 (2013)

Applications Hexanedioyl-d8 Chloride (CAS# 284487-62-3) is a useful isotopically labeled research compound.

Applications Pentanedioic-d6 Anhydride (CAS# 1219794-53-2) is a useful isotopically labeled research compound.

Applications Chlorobenzene-4-d1 (CAS# 13122-34-4) is a useful isotopically labeled research compound.

Applications 1,4-Dibromobenzene (D4, 98%) (cas# 4165-56-4) is a useful research chemical.

Applications Isotope labelled analogue of a protected amino acid
References Villiers, B., et al.: ChemBioChem. 10, 671 (2009), Fransson, R., et al.: J. Med. Chem., 53, 2383 (2010), Watts, R., et al.: Biochem., 49, 2177 (2010),

Applications Ammonium hydrogen phosphate-15N is the labelled analogue of Ammonium hydrogen phosphate (CAS:7722-76-1), a reagent that is useful for organic synthesis.

Applications 3-Aminopropionamide-2,2,3,3-d4 HCl (CAS# 1276197-35-3) is a useful isotopically labeled research compound.

Applications N-Methylurea-d6 is the labelled form of N-Methylurea (M338175). N-Methylurea is used as a reagent in the synthesis of bis(aryl)(hydroxyalkyl)(methyl)glycoluril derivatives and is a potential byproduct of caffeine.
References Antonova, M.M., et al.: Chem. Heterocycl. Comp., 50, 503 (2014); Zarrelli, A., et al.: Sci. Total Environ., 470, 453 (2014)

Applications 3-Chlorobenzoic-d4 Acid (CAS# 2098655-72-0) is a useful isotopically labeled research compound. The compound can be used to prepare isotopically enriched analogs for treating and preventing thrombosis.
References Pandey, A., et.al., PCT Int. Appl., 51,(2017);

Applications 1,3-Dihydroxybenzene-d6 (CAS# 70938-00-0) is a useful isotopically labeled research compound.

Applications 2,6-Di-tert-butylphenol-13C6 , is the labeled analogue of 2,6-Di-tert-butylphenol (D494593).

Applications Methyl 3-Amino-4-methylbenzoate-D6 is an intermediate in the synthesis of Nilotinib-d6 (N465303), which is the labeled analogue of Nilotinib (N465300), which might be useful in treatment of chronic myelogenous leukemia.
References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),

Applications Piperazine-N,N'-bis(2-ethanesulfonic Acid)-d18 (CAS# 352534-95-3) is a useful isotopically labeled research compound.

Applications 3-((2-((2-Chloroethyl)amino)ethyl)amino)propyl Ethyl Phosphate Dihydrochloride-d4, a deuterium labelled 3-((2-((2-Chloroethyl)amino)ethyl)amino)propyl Ethyl Phosphate Dihydrochloride (C984605), is a derivative of Cyclophosphamide Monohydrate (C988580), a known human carcinogen that is widely used in cancer chemotherapy because it can cross-link DNA causing strand breakage and mutation.
References Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999)

Applications Hexanedioic-d8 Acid (CAS# 52089-65-3) is a useful isotopically labeled research compound.

Applications 4-Oxo-2,2,6,6-tetramethylpiperidine-d16;1-15N-1-oxyl (CAS# 80404-14-4) is a useful isotopically labeled research compound.

Applications Benzyl-alpha,alpha-d2 Bromide (CAS# 51271-29-5) is a useful isotopically labeled research compound.

Applications n-Heptylbenzene-d20 (CAS# 634897-84-0) is a useful isotopically labeled research compound.

Applications Tryptamine-beta,beta-d2 HCl (CAS# 362049-48-7) is a useful isotopically labeled research compound.

Applications An intermediate of Rosuvastatin (R700502). Rosuvastatin is a selective, competitive HMG-CoA reductase inhibitor.
References Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997), Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005), Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006),

Applications n-Propyl-2,2,3,3,3-d5-amine Hydrochloride is the hydrochloride salt of 1-Propyl-d5-amine (P833702); the isotope labelled analog of 1-Propylamine (P833700) which is used in the synthesis of pyrimidine derivatives as novel and highly potent PDE4 inhibitors. It is also used in the preparation of fluorenone analogs with DNA topisomerase I inhibitors.
References Goto, T. et al.: Bioorg. Med. Chem., 21, 7025 (2013); Lee, C. et al.: Bioorg. Med. Chem. 21, 7125, (2013)

Applications 1-Bromodecane-9,9,10,10,10-d5 (CAS# 1219802-02-4) is a useful isotopically labeled research compound.