Deuterated Compounds

Applications Used in the preparation of cosmetic and pharamceutical products.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 4-Fluoroanisole-2,3,5,6-d4 (CAS# 1219802-94-4) is a useful isotopically labeled research compound.

Applications Vinyl Acetate-d6 (CAS# 189765-98-8) is a useful isotopically labeled research compound.

Applications Tuberculostearic Acid Ethyl-d5 Ester is labelled Tuberculostearic Acid Ethyl Ester (T897095), the ethyl ester of Tuberculostearic Acid (T897090) which is a saturated fatty acid produced by Actinomycetales bacteria.
References Frencha, G., et al.: The Lancet, 330, 117 (1987)

Applications 4-Chlorohippuric Acid-d4 is the isotope labelled analog of 4-Chlorohippuric Acid (C367420); a derivative of Hippuric Acid (H356700) and the major metabolite in human urine.
References Köppel, C., et al.: Arzneimittel-Forsch., 36, 1116 (1986); Oelschläger, H., et al.: Die Pharmazie, 53, 620 (1998)

Stability Moisture Sensitive
Applications 1-Oxyl-2,2,5,5-tetramethyl-∆3-(methanesulfonyloxymethyl)pyrroline is an intermediate in the synthesis of 3-Iodomethyl-(1-oxy-2,2,5,5-tetramethylpyrroline)-15N the isotope labelled analog of 3-Iodomethyl-(1-oxy-2,2,5,5-tetramethylpyrroline) (I709500); a thio-reactive spin label.
References Qin, P.Z., et al.: Biochemistry, 40, 6929 (2001);

Applications N-Butyrylglycine-2,2-d2 (CAS# 1219799-10-6) is a useful isotopically labeled research compound.

Applications Isotope Labelled analogue of D-Glucose is a aldohexose sugar that is very rare in nature but has been found in archaea, bacteria and other eukaryotes. Gulose is the C-3 Epimer of galactose (G155250).
References Sun, Y.X., et al.: Biosci. Biotech. Biochem., 70, 598 (2006); Bhuiyan, S.H., et al.: J. Biosci. Bioengin., 88, 567 (1999);

Applications Tetrahydro-2-(2-methoxyethoxy)-2H-pyran-d7 is an intermediate used in the synthesis of Roxithromycin-d7 (R700852), which is a semisynthetic labeled Erythromycin derivative. Antibacterial.
References Jones, R.N., et al.: Antimicrob. Agents Chemother., 24, 209 (1983), Barry, A.L., et al.: Eur. J. Clin. Microbiol., 5, 536 (1986), Grassi, C., et al.: Chemioterapia, 6, 41 (1987),

Applications 2-Hydroxy-2-phenyl-d5-1H-indene-1,3(2H)-dione is the labeled analogue of 2-Hydroxy-2-phenyl-1H-indene-1,3(2H)-dione (H949575), an impurity of phenindione (P297250), a proton pump inhibitor and traditional nonsteroidal anti-inflammatory drug used for acute interstitial nephritis and acute kidney injury.
References Haywood, P.A., et. al.: P. Anal. Div. Chem. Soc., 15, 332 (1978); Leonard, C.E., et al.: Pharmacoepidemiol. Drug. Safety., 21, 1155 (2012); Moda, T.L., et al.: Bioorg. Med. Chem. Lett., 22, 2889 (2012); Dhareshwar, S.S., et al.: J. Pharma. Sci., 99, 2711 (2010)

Applications 2,6-Diethylaniline-15N (CAS# 287488-24-8) is a useful isotopically labeled research compound.

Applications 1-(4-Amino-3,5-dichlorophenyl)-2-((4-hydroxycyclohexyl-D10)amino)ethanone is an intermediate in the synthesis of Clencyclohexerol-d10 (C572502), which is a labelled analog of Clenbuterol, a β-agonist which can be used as a growth promoter in farm animals.
References Maistro, S., et al.: Lancet, 346, 180 (1995); Vanoosthuyze, K., et al.: J. Agric. Food Chem., 45, 3129 (1997); Fiori, M., et al.: Anal. Chim. Acta, 529, 207 (2005); Salquebre, G., et al.: J. Anal. Toxicol., 31, 114 (2007);

Applications (±)-1-Amino-2-propanol-1,1,2,3,3,3-d6 (CAS# 1219795-13-7) is a useful isotopically labeled research compound.

Applications Labelled analogue of Potassium Cyanide, a reagent widely used in organic synthesis for the preparation of nitriles and carboxylic acids, particularly in the von Richter reaction.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kollenz, G. et al.: Org. Prep. Proc. Int., 12, 244 (1980); Subramanian, L. R.: Sci. Synth., 19, 173 (2004);

Applications (2E)-3-(Phenyl-d5)-2-propenoic Acid is labeled (2E)-3-(Phenyl)-2-propenoic Acid (P336185) which is used in the synthesis of amides and esters through coupling reactions involving carboxylic acids and amines. Also used in the N-methylation of amides and O-methylation of carboxylic acids.
References Kunishima, M. et al.: Tetrahedron, 55, 13159 (1999); Xia, Q. et al.: Org. Lett., 15, 3326 (2013);

Applications n-Hexadecyl-16,16,16-d3 Alcohol (CAS# 75736-52-6) is a useful isotopically labeled research compound.

Stability Volatile
Applications Isotope labelled Acetonitrile is used as a polar aprotic solvent in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hu, H.H., et al.: Phy. Chem. Phys., 15, 7666 (2013); Kim, J.Y., et al.: J. Mater. Chem. A., et al.: 1, 5982 (2013);

Applications Cyclopropane-d5-carboxylic Acid (CAS# 1219804-09-7) is a useful isotopically labeled research compound.

Applications 2,3-Dihydro-2-[3-(2-phenoxyethoxy)phenyl]-4(1H)-quinazolinone-D5is the isotopic labelled analog of 2,3-Dihydro-2-[3-(2-phenoxyethoxy)phenyl]-4(1H)-quinazolinone.

Applications 1-Bromooctane-3,3,4,4-d4 (CAS# 1219803-37-8) is a useful isotopically labeled research compound.

Applications 1-[5-Chloro-2-(2,4-dichlorophenoxy)phenylethanone]-d2 Major (cas# 1189477-14-2) is a compound useful in organic synthesis.

Applications 1-Chlorohexane-d13 (CAS# 1219798-45-4) is a useful isotopically labeled research compound.

Applications 4-Aminobenzoic-​2,​3,​5,​6-​d4 Acid Methyl Ester is an intermediate in the synthesis of DMABA-d4 NHS Ester (D678402), which is a labelled DMABA NHS ester (D678400). DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids. DMABA NHS ester has been used in combination with DMABA NHS ester-d4, -d6, and -d10 to study relative changes in PE lipid abundance before and after radical oxidation.
References Wester, H., et al.: Nucl. Med. Bio., 23, 365 (1996), Frees, D., et al.: Mol. Microbiol., 48, 1565 (2003), Michel, A., et al.: J. Bacteriol., 188, 5783 (2006), Voelker, T., et al.: Bioorg. Med. Chem., 17, 2047 (2009),

Applications 2,2-Dimethyloctanoic Acid-d3 is the isotope analog of 2,2-Dimethyloctanoic Acid. 2,2-Dimethyloctanoic Acid is used in biological studies as benzyl dimethyloctanoate metabolite of sewage bacteria.
References Millier, A., et al.: Bull. Environ. Contam. Toxicol., 28, 113 (1982);

Applications 1-Propyl-d5-amine is labelled 1-Propylamine (P833700) which is used in the synthesis of pyrimidine derivatives as novel and highly potent PDE4 inhibitors. It is also used in the preparation of fluorenone analogs with DNA topisomerase I inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Cresyl Diphenyl Phosphate-d7 Isomer 3 is the deuterated form of Cresyl Diphenyl Phosphate (C783015), which is a phosphorus flame retardant additive.
References van der Veen., et al.: Chemosphere, 88, 1119 (2012);

Applications N-Acetylglycine-d5 is an isotopic analog of N-Acetyl-glycine (A178260), a derivative of Glycine (G615990). It is an intermediate used to synthesize rac 3-O-Methyl DOPA (M303805) which is an impurity of Levodopa.
References Tabar, et al.: Pharmacol. Biochem. Behav., 33, 139 (1989), De Souza Silva, et al.: J. Neurochem., 68, 233 (1997), Feigin, A., et al.: Neurology, 57, 2083 (2001), Perera, A., et al.: J. Labelled Comp. Radiopharm., 46, 389 (2003),

Applications An intermediate for the synthesis of Labelled Ketoprofen.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Derewenda, Z., et al.: J. Mol. Biol., 227, 818 (1992), Grochulski, P., et al.: J. Biol. Chem., 268, 12843 (1993).

Applications Labelled Isopentenyl Pyrophosphate. Used for the preparation of antitumor agents phosphohalohydrins.
References Dhe-Paganon, S., et al.: Biochem., 33, 13355 (1994), Tanaka, Y., et al.: Nature, 375 155 (1995), Wesch, D., et al.: Eur. J. Immunol., 27, 952 (1997),

Applications N,N-Bis-desethyl, N-Methyl Entacapone-d3 is the isotope analog of N,N-Bis-desethyl, N-Methyl Entacapone which is an impurity of Entacapone (E558500). The (E)-Isomer of Entacapone which is a polymorphic form A. Peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.
References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),

Applications (3,4,5-Trimethoxyphenyl)acetic-alpha,alpha-d2 Acid (CAS# 344299-45-2) is a useful isotopically labeled research compound.

Applications Potassium Dodecanoate-d23 (CAS# 51732-20-8) is a useful isotopically labeled research compound.

Stability Volatile
Applications Acetonitrile (15n, 98%+) (cas# 14149-39-4) is a useful research chemical.

Applications Labelled N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide (F595365). Rosuvastatin intermediate.