Deuterated Compounds

<p>Applications 21-(3-Carboxy-1-oxopropoxy)-17-hydroxy-pregn-4-ene-3,20-dione-d4 Monosodium Salt is deuterium labelled 21-(3-Carboxy-1-oxopropoxy)-17-hydroxy-pregn-4-ene-3,20-dione Monosodium Salt (a derivative of Cortisol) and exhibits multi-site antiglucocorticoid activity in vivo.<br>References Duncan, M. R. and Duncan, G. R. J. Steroid Biochem. 10, 245 (1979)<br></p>

<p>Applications Bis(3-methylpentyl) Phthalate-d4, is the labeled analogue of Bis(3-methylpentyl) Phthalate (B486010), used as a plasticizer to impart softness and flexibility to PVC products.<br>References Pierson, J. F., et al.: Angewandte Makromolekulare Chemie, 38, 167 (1979); Kaya, T., et al.: Chem. Res. Toxic., 19 (8), 999 (2006); Matter, H., et al.: Bioorg. Med. Chem., 20 (18), 5352 (2012);<br></p>

<p>Applications Cyclopropane-1,2,2,3,3-d5-carbonyl chloride is a useful building block for organic synthesis<br></p>

<p>Applications 1-Bromoeicosane-d41 (CAS# 202480-71-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Vanillin. Occurs naturally in a wide variety of foods and plants such as orchids; major commercial source of natural vanillin is from vanilla bean extract. Synthetically produced in-bulk from lignin-based byproduct of paper processes or from guaicol.<br>References Jenner, P.M., et al.: Food Cosmet. Toxicol., 2, 327 (1964), Clark, G.S., et al.: Perfum. Flavor., 15, 45 (1990),<br></p>

<p>Applications n-Hexadecyl-d33 Alcohol (CAS# 284474-73-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications O-Toluoyl Chloride-D7 is the deuterated form of O-Toluoyl Chloride (T536250), which is used in the synthesis if quinolinone compounds as SARS CoV 3CLpro inhibitors. Also used in the synthesis of benzooxaboroles as orally active anti-inflammatory agents.<br>References Sun, Y. et al.: Chin. J. CHem., 31, 1199 (2013); Akama, T. et al.: Bioorg. Med. Chem. Lett., 23, 5870 (2013);<br></p>

<p>Applications Ditridecyl Adipate-d8 is the isotope labelled analog of Ditridecyl Adipate (D494195); a compound used as a skin conditioning or fragrance ingredient, plasticizer, solvent or emollient in cosmetics. Also used in combination with other compounds as a finisher for texturing of polyester yarns.<br>References Fiume, M.M., et al.: Int. J. Toxicol., 31, 5S (2012); Burks, P.P., et al. Finish Composition for Draw-texturing Yarn. US 3859122 A 19750107. Jan 7, 1975<br></p>

<p>Applications Ethyl-d5 4-Aminobenzoate (CAS# 1219803-76-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Propionic Acid (1-13c, 99%) (cas# 6212-69-7) is a useful research chemical.<br></p>

<p>Applications 5-(4-Hydroxyphenyl)-5-phenyl-d5-hydantoin-15N2 (CAS# 369656-71-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Aminonaphthalene-d9 (CAS# 78832-56-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Dodecyl Alcohol-d26 (CAS# 38086-03-2) is a useful isotopically labeled research compound. It can be used for neutron spin-echo spectroscopy.<br>References Yamaguchi, T., et.al., J. Phys.Chem.B., 123, 239-246,(2019);<br></p>

<p>Applications rac Desethyl Phenyl Oxybutynin-d5 is an intermediate in the synthesis of rac Desethyl Oxybutynin-d5 Hydrochloride (D289478), a labelled metabolite of the drug Oxybutynin (D289475). Used in the treatment of incontinence.<br>References Hughes, K., et al.: Xenobiotica, 22, 859 (1992); Oki, T., et al.: Biol. Pharm. Bull., 24, 491 (2001); Fetscher, C., et al.: Br. J. Pharmacol., 136, 64 (2002); Zobrist, R., et al.: Pharm. Res., 20, 103 (2003)<br></p>

<p>Applications 1,4-Diethylbenzene-d14 (CAS# 1219803-64-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromo-3-chloro-5-fluorobenzene-d3 (CAS# 1219805-00-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications (R)-(-)-Phenylephrine-2,4,6-d3 HCl (CAS# 1276197-50-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-4-Hydroxyphenyl-N'-1,2,3-thiadiazol-5-ylurea-d4 is labelled N-4-Hydroxyphenyl-N'-1,2,3-thiadiazol-5-ylurea (H949385) which is a substrate of cytokinin O-glucosyltransferase with position specificity related to receptor recognition. It is a metabolite of Thidiazuron (T344275) which is a non-purine containing urea derivative with cytokinin activity.<br>References Mok, M., et al.: Plant Physio., 137, 1057(2005); Benezet, H., et al.: Trans. Missouri Academy. Sci., 14, 75 (1980); Orlikowska, T., et al.: Plant Cell Tissue Org. Cult., 59, 95 (1999), Ray, T., et al.: Mol. Biol., 6, 35 (2005), Kanwar, J., et al.: Hort Sci., 2008, 35, 35 (2008),<br></p>

<p>Applications Pinacol-d12 is an intermediate in the synthesis of Isotope labelled Tebuconazole (T013002), which is an ergosterol biosynthesis inhibitor present in most pesticide formulations (1,2). Various uptake is observed in plants (3). Drinking water Contaminant Candidate List 3 - CCL 3 as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br></p>

<p>Applications 1,2,4,5-Tetramethylbenzene-d14 (CAS# 15502-50-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-(3,5-Diacetoxyphenyl)-1-bromoethane-13C6, is the labeled analogue of 1-(3,5-Diacetoxyphenyl)-1-bromoethane (D307562), which is an intermediate for the synthesis of Resveratrol (R150000).<br>References Powell, R.G., et al.: Phytochemistry, 35, 335 (1994), Jeandet, P., et al.: J. Phytopathol., 143, 135 (1995), Mattivi, F., et al.: J. Agric. Food Chem., 43, 1820 (1995),<br></p>

<p>Applications 2,3,6-Trimethylphenol-d11 (CAS# 347841-83-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Acetylcholine-1,1,2,2-d4 Bromide is the deuterium labelled form of Acetylcholine Bromide (A172073), which is an endogenous neurotransmitter at cholinergic synapses.<br>References Kobayashi, M., et al.: Adv. Physiol. Sci., 22, 319 (1981); Hulme, C., et al.: Biophys. J., 91, 2371 (2006);<br></p>

<p>Applications Phthalic-13C Acid is an isotope labelled version of Phthalic Acid (P384480), an organic reagent used to synthesize phthalates.<br>References Duchowicz, P.R., et al.: Bioorg. Med. Chem., 16, 7944 (2008);di Luccio, E., et al.: Biochem., 47, 4039 (2008);Lopez, Z., et al.: App. Microbiol. Biotechnol., 78, 739 (2008);Hong, Y., et al.: Toxicol. Lett., 184, 139 (2009)<br></p>

<p>Applications Indole-4,5,6,7-d4 is a labelled analogue of Indole (I577320), which can be used in perfumes and in the synthesis of tryptophan. It is also an intermediate in synthesizing Indoleacetic Acid-13C6 (I577343), which has the potential to be used in anti-cancer therapy in conjunction with horseradish peroxidase (HRP).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kawano, T. et al.: Gen. Hypo. 60, 664 (2003);<br></p>

<p>Applications Isotope labelled Propyl Paraben Sulfate (P838355) is the sulfate conjugate of Propyl Paraben (P838285), an antimicrobial agent used in cosmetic products.<br>References Kim, D.H., et al.: Biol. Pharma. Bull., 17, 1326 (1994);<br></p>

<p>Applications It is a stable isotopically labelled analog of Tasimelteon (T007740) which is a novel drug, used in the treatment of non-24 hour sleep-wake disorder. It helps to correct the circadian rhythm disorder often seen in patients who are visually impaired.<br>References Lahon, J. et al.: World. J. Pharm. Res., 3, 1521 (2014)<br></p>

<p>Applications Ammonium Formate-d5 (CAS# 65387-23-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Benzene-1,2,3,5-d4 (CAS# 14941-52-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Iodoacetic Acid-d3 (CAS# 1219799-36-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tetracosanoic-12,12,13,13-d4 Acid (CAS# 1219794-59-8) is a useful isotopically labeled research compound.<br></p>