Deuterated Compounds

Applications 1-Bromononane-9,9,9-d3 (CAS# 1219799-20-8) is a useful isotopically labeled research compound.

Applications Sodium n-Octyl-d17 Sulfate (CAS# 1219802-16-0) is a useful isotopically labeled research compound.

Applications bis(2-Chloroethoxy)-d8-methane (cas# 93966-78-0) is a useful research chemical.

Applications DL-Phenylalanine-2-13C (CAS# 64193-01-7) is a useful isotopically labeled research compound.

Applications L-Serine (1-13c, 99%) (cas# 81201-84-5) is a useful research chemical.

Applications Ethylmethyl-d3-amine (CAS# 223459-64-1) is a useful isotopically labeled research compound.

Applications Isotope labelled Isopropyl 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]phenylcarbamate is an impurity in the synthesis of Sorafenib (S676850), a multiple kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Antineoplastic.
References Richly, H., et al.: Int. J. Clin. Pharmacol. Ther., 41, 620 (2003), Khire, U.R., et al.: Bioorg. Med. Chem. Lett., 14, 783 (2004), Wilhelm, S.M., et al.: Cancer Res., 64, 7099 (2004), Rini, B.I., et al.: Expert Opin. Pharmacother., 7, 453 (2006),

Applications iso-Propylamine-d9 DCl (CAS# 1219798-50-1) is a useful isotopically labeled research compound.
Chemical Name: iso-Propylamine-d9 DCl (CAS# 1219798-50-1) is a useful isotopically labeled research compound.

Applications Methyl 3-Amino-4-methylbenzoate-D6 is an intermediate in the synthesis of Nilotinib-d6 (N465303), which is the labeled analogue of Nilotinib (N465300), which might be useful in treatment of chronic myelogenous leukemia.
References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),

Applications 1-Bromoundecane-11,11,11-d3 (CAS# 1219805-63-6) is a useful isotopically labeled research compound.

Applications 3,5-Dibromopyridine-d3 (CAS# 1219799-05-9) is a useful isotopically labeled research compound.

Applications Piperazine-N,N'-bis(2-ethanesulfonic Acid)-d18 (CAS# 352534-95-3) is a useful isotopically labeled research compound.

Applications The four-center reactions of alkanol-alkoxide negative ions with alkyl ethers and ortho-acetates. An ion cyclotron resonance study.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 6-Hydroxy Nicorandil-d4 is the isotope labelled analog of 6-Hydroxy Nicorandil (H948550); a metabolite of the antianginal Nicorandil (N398500).
References Frydman, A., et al.: Am. J. Cardiol., 63, 25J (1989); Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008); Sudo, H., et al.: Biol. Pharm. Bull., 31, 2079 (2008); Iida, S., et al.: Brit. J. Clin. Pharmacol., 66, 352 (2008); Eguchi, Y., et al.: Ther. Res., 29, 316 (2008)

Applications 2-(3,4-Dihydroxyphenyl-13C6)ethylamine HCl (CAS# 335080-94-9) is a useful isotopically labeled research compound.

Applications 3-((2-((2-Chloroethyl)amino)ethyl)amino)propyl Ethyl Phosphate Dihydrochloride-d4, a deuterium labelled 3-((2-((2-Chloroethyl)amino)ethyl)amino)propyl Ethyl Phosphate Dihydrochloride (C984605), is a derivative of Cyclophosphamide Monohydrate (C988580), a known human carcinogen that is widely used in cancer chemotherapy because it can cross-link DNA causing strand breakage and mutation.
References Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999)

Applications Abiraterone Ethyl Ether-d5 is the labeled analogue of Abiraterone Ethyl Ether (A108525), an impurity of Abiraterone (A108490), a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.
References Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389(2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005)

Applications 4-Oxo-2,2,6,6-tetramethylpiperidine-d17 (CAS# 52168-48-6) is a useful isotopically labeled research compound.

Applications Propio-d5-phenone (CAS# 342610-99-5) is a useful isotopically labeled research compound.

Applications Hexanedioic-d8 Acid (CAS# 52089-65-3) is a useful isotopically labeled research compound.

Applications 3,5-Dimethylbenzoyl Chloride-d9 is an intermediate in the synthesis of Methoxyfenozide-d9 (M262768), deuterium labelled Methoxyfenozide (M262765). It is used primarily as an insecticide, and pesticide.
References Zhao, Q., et al.: J. Agricul, Food Chem., 56, 10799 (2008)

Applications 4-Oxo-2,2,6,6-tetramethylpiperidine-d16;1-15N-1-oxyl (CAS# 80404-14-4) is a useful isotopically labeled research compound.

Applications α-Tetralone-13C6 (cas# 189811-58-3) is a compound useful in organic synthesis.

Applications Isotope labelled 1,2-Hexanediol is used in the synthesis of sulfamidates which lead a simple route into β-amino acids. Also used in the controlled growth of GE nanowires.
References Nicolaou, K. et al.: Angew. Chem. Int. Ed., 41, 834 (2002); Lotty, O. et al.: J. Mat. Chem. C., Mat. Optic. Electro. Devices., 1, 4450 (2013);

Applications Benzyl-alpha,alpha-d2 Bromide (CAS# 51271-29-5) is a useful isotopically labeled research compound.

Applications n-Tridecyl-d27 Alcohol (CAS# 203633-18-5) is a useful isotopically labeled research compound.

Applications 3-Chloropyridine-d4 (CAS# 1001003-95-7) is a useful isotopically labeled research compound.

Applications 1-​Chloro-​2-​phenyl-diazene-13C6 is an intermediate in synthesizing N-Acetyl-S-(phenyl-13C6)-L-cysteine (A187357), a labelled N-Acetyl-S-phenyl-L-cysteine (P335600). It is an important metabolite of Benzene.
References Muller, G., et al.: Anal. Hazard. Subst. Biol. Mater., 5, 143 (1997)

Applications Cyclopropyl-2,2,3,3-d4 Methyl Ketone (CAS# 350818-63-2) is a useful isotopically labeled research compound.

Applications 1-(4-Aminophenyl)cyclopentanecarbonitrile-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is a labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);

Applications N-Acetylglycine N-Methylamide-d8 is an isotopic analog of N-Acetylglycine N-Methylamide (7606-79-3).

Applications 4-tert-Butylaniline-d15 (CAS# 1219794-71-4) is a useful isotopically labeled research compound.

Applications 3-Nitroaniline acts as an azo dye used in analytical toxicity studies. 3-Nitroaniline-2,4,5,6-d4 is the labeled version.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Garner, R.C. et al.: Mut. Res., et al 44, 9 (1977);

Applications 3-Aminobenzotrifluoride-D4 is a labelled analogue of 3-Aminobenzotrifluoride (A591720).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 1-Iodopropane-1,1,2,2-d4 (CAS# 1219804-45-1) is a useful isotopically labeled research compound.

Applications n-Heptylbenzene-d20 (CAS# 634897-84-0) is a useful isotopically labeled research compound.

Applications Isotope labelled 1-Pentene, used in the synthesis of iminosugars such as d-xylitol and l-arabinitol. Also usd in the synthesis of hydrazones of substituted salicylaldehydes.
E3
References Biela, A. et al.: Tetrahedron, 69, 3348 (2013); Ding, S. et al.: J. Coord. Chem., 66, 2023 (2013);

Applications Tolan-d10 (CAS# 19339-46-9) is a useful isotopically labeled research compound.

Applications N-Didesmethyl Loperamide-d4 is the isotope labelled analog of N-Didesmethyl Loperamide (D441135); a metabolite of the antidiarrheal Loperamide (L469450, HCl). Also a new and improved PET radiotracer for imaging P-gp function.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Stokbroekx, et al.: J. Med. Chem., 1, 782 (1973); Carter, J.E., et al.: Anal. Profiles Drug Subs., 19, 341 (1990); Rahman, A., et al.: Cancer Res., 54, 5543 (1994); Sai, Y., et al.: Xenobiotica, 30, 327 (2000); Eneroth, A., et al.: Eur. J. Pharm. Sci., 12, 205 (2001); Kim, K., et al.: Drug Metab. Dispos., 31, 1090 (2003)