Deuterated Compounds

Applications 2-Aminofluorene-d11 (CAS# 347841-44-5) is a useful isotopically labeled research compound.

Applications Sodium Propionate-3,3,3-d3 (CAS# 1210410-35-7) is a useful isotopically labeled research compound. This compound can be used to demonstrate intereactions between ergosterol and amphotericin B in lipid bilayers using NMR spectroscopy to exert antifungal activity.
References Matsumori, N.,et.al., J.Am.Chem.Soc., 131,11855-11860,(2009);

Applications N2-Acetyl Acyclovir-d4 is the isotope labelled analog of N2-Acetyl Acyclovir (A168015); an impurity of Acyclovir (A192400) which is an orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. Also an antiviral.
References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992)

Applications 1-Bromodecane-d21 (CAS# 98195-39-2) is a useful isotopically labeled research compound.

Applications Labelled 2-[(Ethylamino)methyl]-4-nitrophenol (E898825). 2-[(Ethylamino)methyl]-4-nitrophenol is used in synthesis of some novel amodiaquine analogs as potential antimalarial and antifilarial compounds.

Applications (±)-1-Phenylethan-1,2,2,2-d4-ol (CAS# 90162-44-0) is a useful isotopically labeled research compound.

Applications Diethyl L-(+)-Tartrate-13C8 is the isotope labelled analog of Diethyl L-(+)-Tartrate. Diethyl L-(+)-Tartrate is used as a chiral reagent in a host of chemical reactions, such as the synthesis of isoquinoline alkaloids and arundic acid, which has been used in acute ischemic stroke therapy.
References Ziolkowski, M. et al.: Tetrahedron Lett., 41, 1963 (2000); Fernandes, R. et al.: Tetrahedron Lett. 50, 5903 (2009);

Stability Volatile
Applications Cyclohexene-d10 is a labelled organic solvent. It has also been used in the synthesis of adipic acid.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Reed, S. et al.: J. Chem. Educ. 77, 12 (2000)

Applications 4-Hydroxy-2,2,6,6-tetramethylpiperidine-d17-1-oxyl (CAS# 100326-46-3) is a useful isotopically labeled research compound.

3-MCPD-d5 is a deuterated fatty acid ester that is used to measure the level of 3-monochloropropane-1,2-diol (3-MCPD) in food products.

Trideuteriomethylbenzene is a chemical compound that contains three deuterium atoms. It is a member of the class of compounds called alkyl-deuteriomethylbenzenes, which are used as proton donors in chemical reactions. It has been shown to be an effective supercritical solvent for the separation of long-chain alcohols from hydrocarbons. Trideuteriomethylbenzene may also be used as a photoelectron donor for the determination of time constants and depression constants by electron diffraction.

4-Aminobiphenyl is a chemical compound that belongs to the group of aromatic amines. It is a human carcinogen and has been shown to cause cancer in animals. 4-Aminobiphenyl has been detected in the environment as an environmental pollutant and can be found in small quantities at low levels in food, air, and water. 4-Aminobiphenyl can be hydrolyzed by acid or alkaline hydrolysis to form its hydrolysate, which contains nitroarenes that are not present in the original compound. The DNA modification caused by 4-aminophenol may be due to its ability to modify DNA bases through reactive metabolites such as nitroarenes.

Diethylene glycol d8 is a deuterated analog of diethylene glycol. It is synthesized from ethylene oxide and diethylene glycol by substitution of one hydrogen atom with deuterium. The sequences of this molecule have been determined, yielding a traceless product that can be used as a synthetic intermediate in the production of imidazoles. Diethylene glycol d8 is also used to study anions, acidic materials, and isotopic labeling. This compound has been methylated, butylated, or solvented to form different derivatives for use in studies on other molecules.

Benzidine D8 is a benzidine compound that has been shown to be carcinogenic. It is used in the production of dyes and colorants, and it is found in wastewater from dyeing factories. Benzidine D8 has been detected in human urine, which may be due to occupational exposure. This chemical can also be found in the environment as a result of industrial discharge. The carcinogenicity of benzidine D8 is mediated by its ability to produce reactive metabolites that bind to DNA, forming adducts. These adducts inhibit DNA replication and transcription, leading to cell death through inhibition of protein synthesis. Benzidine D8 undergoes metabolism via oxidative reactions with amines or hydrolysis with hydrophilic compounds such as alcohols or phenols, which are present at high levels in the bladder tissue. The risk of bladder cancer increases when benzidine D8 binds to these amines or hydrophilic compounds, resulting in the formation of reactive metabolites that can bind to DNA

3-Amino-2-oxazolidinone-d4 is a methanol solvent that can be used to analyze the muscle tissue. 3-Amino-2-oxazolidinone-d4 can be synthesized by reacting oxalyl chloride and 2 nitrobenzaldehyde in acetonitrile. It can also be prepared by dehydrating and analyzing the synthesis of 3 amino 2 oxazolidinones in chloroform and bromoacetic acid. 3 - Amino - 2 - oxazolidinone - d4 is deuterated, which means it has an extra neutron in its nucleus.

24,25-Dihydroxy vitamin D2 is a form of vitamin D that has been shown to be effective in the treatment of biliary cirrhosis and neonatal cirrhosis. It is synthesized from 25-hydroxyvitamin D3 by the enzyme 24-hydroxylase. The assay sensitivity for this compound is 10 ng/mL. This form of vitamin D has been shown to have an effect on serum bilirubin levels in patients with biliary cirrhosis. 24,25-Dihydroxy vitamin D2 can also be used to treat patients with chronic renal failure who are deficient in vitamin D3. The plasma concentration of 24,25-dihydroxyvitamin D2 is lower than that of 25-hydroxyvitamin D2 and 1,25-dihydroxyvitamin D2 because it is more rapidly metabolized by the liver.

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