Nicotine and Nicotine Derivatives

<p>Applications S)-(-)-Nicotine-d3 is an isotope labelled compound of (S)-(-)-Nicotine (N412450). (S)-(-)-Nicotine is a prototype nicotinic acetylcholine receptor agonist. (S)-(-)-Nicotine is a naturally occurring isomer. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Geffken, D., et al.: Am. J. Epidemiol., 153, 242 (2001), Bolego, C., et al.: Cardiovasc. Res., 53, 568 (2002), Leone, A., et al.: Curr. Pharm. Des., 1, 2199 (2005),<br></p>

<p>Applications Labelled analogue of (S)-(-)-Nicotine, a prototype nicotinic acetylcholine receptor agonist. (S)-(-)-Nicotine is the naturally occurring isomer. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Geffken, D. et al.: Am. J. Epidemiol., 153, 242 (2001); Bolego, C. et al.: Cardiovasc. Res., 53, 568 (2002); Leone, A. et al.: Curr. Pharm. Des., 1, 2199 (2005);<br></p>

<p>Stability Hygroscopic<br>Applications An amino alcohol metabolite of nicotine, and precursor to NNK.<br></p>

<p>Applications A nicotine derivative.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Joyce, N.J., et al.: Heterocycles, 29, 7, 1335 (1989),<br></p>

<p>Applications 1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide, has been shown to be one of the potential novel biomarkers of peroxisome proliferation in the rat.<br>References Ringeissen, S., Biomarkers, 8, 240 (2003); Shibata, K., et al.: Biosci. Biotech. and Biochem., 77, 2105 (2013);<br></p>

<p>Applications A Nicotine metabolite. Carcinogen.<br></p>

<p>Applications Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer. It is a potent neurotoxin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ferretti, G., et al.: J. Med. Chem., 45, 4724 (2002), Guillen, M., et al.: J. Agric. Food Chem., 53, 1093 (2005), Ramunno, A., et al.: Bioorg. Med. Chem. Lett., 15, 3237 (2005), Alburges, M., et al.: Eur. J. Pharmacol., 573, 124 (2007),<br></p>

<p>Applications A major metabolite of Nicotine in humans. Carcinogen.<br>References Sugasawa, S., et al.: Pharma. Bull., et al.: 2, 39 (1954), Thompson, J.A., et al.: J. Chromatog., 231, 53 (1982); Seeman, J.I., et al.: J. Org. Chem., 51, 1548 (1986)<br></p>

<p>Applications A nicotinic receptor agonist; brain rubidium efflux pharmacol.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Alkondon, M., et al.: J. Pharmacol. Exp. Ther., 271, 494 (1994), Wang, F., et al.: J. Biol. Chem., 271, 17656 (1996), Corringer, P., et al.: J. Neurosci., 18, 648 (1998),<br></p>

<p>Stability Hygroscopic<br>Applications rac-Cotinine-d3 N-β-D-Glucuronide is a labelled racemic analogue of Cotinine N-β-D-Glucuronide (C725175), a major metabolite of Nicotine (N412420) in humans. Carcinogen.<br>References Benowitz, N., et al.: Clin. Pharmacol. Ther., 56, 483 (1994), Nakajima, M., et al.: Drug Metab. Dispos., 24, 1212 (1996), Messina, E., et al.: J. Pharmacol. Exp. Ther., 282, 1608 (1997), Oscarson, M., et al.: Hum. Mutat., 20, 275 (2002),<br></p>

<p>Applications A nicotinic receptor agonist; brain rubidium efflux pharmacol.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Alkondon, M., et al.: J. Pharmacol. Exp. Ther., 271, 494 (1994); Wang, F., et al.: J. Biol. Chem., 271, 17656 (1996); Corringer, P., et al.: J. Neurosci., 18, 648 (1998);<br></p>

<p>Applications (R)-Anabasine is a minor tobacco alkaloid from Nicotiana tabacum that is known to have nicotinic receptor agonist activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lee, S.T., et al.: Neurotoxicol. Teratol., 28, 220 (2006); Ayers, J.T., et al.: AAPS J., 4, E752 (2005)<br></p>

<p>Stability Hygroscopic, Moisture Sensitive, Temperature Sensitive<br>Applications Labelled Myosmine (M835000). Myosmine is an alkaloid found in tobacco. Myosmine has been suspected to be a tobacco-independent carcinogenic source.<br></p>

<p>Applications (S)-1-Methylnicotinium Iodide exhibits antinociceptive activity. A nicotinic receptor antagonist and a metabolite of Nicotine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Aceto, M. D., et al.: Br. J. Pharmacol., 79, 869-876 (1983); Wilkins, L. H., et al.: J. Pharm. Exp. Ther., 304, 400-410 (2003); Seeman, J.I. and Whidby, J.F.: J. Org. Chem., 41, 24, 3824 (1976), Oldendorf, W.H., et al.: Proc. Natl. Acad. Sci., USA, 90, 307 (1993)<br></p>