Nicotine and Nicotine Derivatives

Stability Hygroscopic
Applications trans-3'-Hydroxy Cotinine is a metabolite of Nicotine (N412450, (S)-(-)-Nicotine).
References Benowitz, N., et al.: J. Pharmcol. Exp. Ther., 268, 296 (1994); Horning, E., et al.: Life Sci., 13, 1331 (1973), Desai, D., et al.: Chem. Res. Toxicol., 3, 47 (1990), Kitagawa, K., et al.: J. Biol. Chem., 276, 17830 (2001),

Stability Air Sensitive
Applications β-Nornicotyrine (cas# 494-98-4) is a compound useful in organic synthesis.
References Beckett, A., et al.: J. Pharm. Pharmacol., 24, 115 (1972), Zwickenpflug, W., et al.: Chem. Res. Toxicol., 19, 150 (2006),

Applications A potent inhibitor of gluconeogenesis.
References Blank, B., et al.: J. Med. Chem., 17, 1065 (1974), Memoli, K.A., Tetrahedron Letters, 37, 21, 3617 (1996)

Stability May Turn Brown on Exposure to Light or Air
Applications Labelled rac-Nicotine (N412420). Nicotine is an alkaloid isolated from plants. Nicotine is an active stimulant, having both addictive and carcinogenic properties. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ferretti, G., et al.: J. Med. Chem., 45, 4724 (2002), Guillen, M., et al.: J. Agric. Food Chem., 53, 1093 (2005), Ramunno, A., et al.: Bioorg. Med. Chem. Lett., 15, 3237 (2005), Alburges, M., et al.: Eur. J. Pharmacol., 573, 124 (2007),

Stability Hygroscopic
Applications A tobacco alkaloid as risk factor of human cancer.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Stepanov, I., et al.: Cancer Res., 69, 8236 (2009), Maertens, R., et al.: Chem. Res. Toxicol., 22, 1406 (2009), Gaworski, C., et al.: Toxicol., 269, 54 (2010),

Applications An amino ketone metabolite of nicotine, and precursor to NNK.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Stephen S. Hect, Sharon E. Murphy, et. al. , Proc. Natl. Acad. Sci. USA, Oct. 24, 2000.

Stability Light Sensitive
Applications The S-enantiomer metabolite of tobacco, a specific N-nitrosamines with carcinogenic activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hoffmann, D., et al.: Cancer Res., 39, 2505 (1979), Hecht, S., et al.: Chem. Res. Toxicol., 11, 559 (1998), Hecht, S., et al.: Mutation. Res., 424, 127 (1999), Wang, M., et al.: Chem. Res. Toxicol., 16, 616 (2003),

Applications Labelled Nudifloramide (N925500). Nudifloramide is a metabolite of Niacin (or Nicorinic acid).
References Felsted, R., et al.: J. Biol. Chem., 242, 1274 (1967), Igel, M., et al.: Eur. J. Clin. Pharmacol., 57, 357 (2001), Kashyap, M., et al.: Am. J. Cardiol., 89, 672 (2002), Bottorff, M., et al.: Am. J. Cardiol., 97, 27 (2006),

Stability Hygroscopic
Applications (R,S)-Norcotinine-pyridyl-d4 (cas# 1020719-70-3) is a compound useful in organic synthesis.

Applications 3-Pyridylacetic Acid is a metabolite of Nicotine (N412420). 3-Pyridylacetic Acid is an antilipemic.
References Baer, T.A., et al.: J. Med. Chem., 16, 85 (1973); Kyerematen, G. A., et al.: Drug Metab. Dispos., 16, 125 (1988);

Stability Hygroscopic
Applications A labelled major metabolite of nicotine in humans. Carcinogen.
References Sugasawa, S., et al.: Pharma. Bull., et al.: 2, 39 (1954), Thompson, J.A., et al.: J. Chromatog., 231, 53 (1982); Seeman, J.I., et al.: J. Org. Chem., 51, 1548 (1986)

Applications A metabolite of Nicotine.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Labelled rac-Nicotine (N412420). Nicotine is an alkaloid isolated from plants. Nicotine is an active stimulant, having both addictive and carcinogenic properties. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Guillen, M., et al.: J. Agric. Food Chem., 53, 1093 (2005), Alburges, M., et al.: Eur. J. Pharmacol., 573, 124 (2007), Roy, K., et al.: Eur. J. Med. Chem., 44, 1941 (2009),

Applications Trigonelline (chloride) is an alkaloid found in plants and coffee. Trigonelline is a product of niacin metabolism that is excreted in urine.

Applications Isotope labelled Nicotelline is a Nicotine (N412420) related metabolite with potential as an inhibitor of human cytochrome P-450 2A6.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Denton, T. et al.: Biochem. Pharm., 67, 751 (2004); Gorrod, J. et al.: Anal. Det. Nic. Rel. Comp. Metab., 69, (1999);

Impurity Nicotine USP Related Compound F (3-(pyrrolidine-2-yl)pyridine)
Stability Light Sensitive
Applications (RS)-Nornicotine is a tobacco alkaloid and the major Nicotine (N412420) metabolite in brain. Nornicotine appears to activate different nAChR subtypes, has a better pharmacokinetic profile, and produces less toxicity than Nicotine. Nornicotine shows a significant analgesic activity. Nicotine USP Related Compound F (3-(pyrrolidine-2-yl)pyridine).
References Hecht, S., et al.: Carcinogenesis, 9, 875 (1988), Rivenson, A., et al.: Cancer Res., 48, 6912 (1988), Hoffmann, D., et al.: Chem. Res. Toxicol., 14, 767 (2001), Kool, J., et al.: J. Med. Chem., 49, 3287 (2006), Kool, J., et al.: Drug Metab. Dispos., 35, 640 (2007),

Stability Hygroscopic
Applications rac-Cotinine-d3 N-β-D-Glucuronide is a labelled racemic analogue of Cotinine N-β-D-Glucuronide (C725175), a major metabolite of Nicotine (N412420) in humans. Carcinogen.
References Benowitz, N., et al.: Clin. Pharmacol. Ther., 56, 483 (1994), Nakajima, M., et al.: Drug Metab. Dispos., 24, 1212 (1996), Messina, E., et al.: J. Pharmacol. Exp. Ther., 282, 1608 (1997), Oscarson, M., et al.: Hum. Mutat., 20, 275 (2002),