Nicotine and Nicotine Derivatives

<p>Stability Light Sensitive<br>Applications (±)-Nicotine-d7 (N-methyl-d3; pyridine-d4) is the labelled version of Nicotine (N412420(M)) is an alkaloid isolated from plants. Nicotine is an active stimulant, having both addictive and carcinogenic properties. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.<br>References Ferretti, G., et al.: J. Med. Chem., 45, 4724 (2002), Guillen, M., et al.: J. Agric. Food Chem., 53, 1093 (2005), Ramunno, A., et al.: Bioorg. Med. Chem. Lett., 15, 3237 (2005), Alburges, M., et al.: Eur. J. Pharmacol., 573, 124 (2007),<br></p>

<p>Applications Nicotine analog.<br>References Yamamoto, I., et al.: Agr. Biol. Chem., 27, 446 (1963)<br></p>

<p>Applications A nicotine metabolite.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kool, J., et al.: J. Med. Chem., 49, 3287 (2006), Newman, D., et al.: J. Nat. Prod., 70, 461 (2007), Kool, J., et al.: Drug Metab. Dispos., 35, 640 (2007),<br></p>

<p>Applications (±)-Cotinine-2,4,5,6-d4 (pyridine-d4) (CAS# 350818-68-7) is a useful isotopically labeled research compound.<br></p>

<p>Stability Hygroscopic<br>Applications Nicotine-N-(4-deoxy-4,5-didehydro)-β-D-glucuronide is a possible metabolite of Nicotine (N412420).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-Chloro-6-nitrosoresorcinol-d1 is the labeled analogue of 4-Chloro-6-nitrosoresorcinol (C374860). 4-Chloro-6-nitrosoresorcinol-d1 is an intermediate in the synthesis of 6-Hydroxy Chlorzoxazone-d2 (H825123), a labeled analogue of 6-Hydroxy Chlorzoxazone (H825120), A major metabolite of chlorzoxazone and formed by the actions of cytochrome P450IIE1.<br>References Twele, et al.: Arzneim.-Forsch., 32, 759 (1982); Peter, et al.: che. Res. Toxicol., 3, 566 (1990)<br></p>

<p>Nicergoline EP Impurity B is a metabolite of nicergoline, a drug product. It has been synthesized for use as an impurity standard for analytical and pharmacopoeia purposes. Nicergoline EP Impurity B is not found in nature and has been shown to be metabolically stable in vitro. It can be used as a reference substance for the determination of nicergoline concentrations in human plasma samples.</p>