Nicotine and Nicotine Derivatives

Applications A nicotinic receptor agonist; brain rubidium efflux pharmacol.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Alkondon, M., et al.: J. Pharmacol. Exp. Ther., 271, 494 (1994); Wang, F., et al.: J. Biol. Chem., 271, 17656 (1996); Corringer, P., et al.: J. Neurosci., 18, 648 (1998);

Applications Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer. It is a potent neurotoxin.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ferretti, G., et al.: J. Med. Chem., 45, 4724 (2002), Guillen, M., et al.: J. Agric. Food Chem., 53, 1093 (2005), Ramunno, A., et al.: Bioorg. Med. Chem. Lett., 15, 3237 (2005), Alburges, M., et al.: Eur. J. Pharmacol., 573, 124 (2007),

Applications A nicotinic receptor agonist; brain rubidium efflux pharmacol.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Alkondon, M., et al.: J. Pharmacol. Exp. Ther., 271, 494 (1994), Wang, F., et al.: J. Biol. Chem., 271, 17656 (1996), Corringer, P., et al.: J. Neurosci., 18, 648 (1998),

Applications A Nicotine metabolite. Carcinogen.

Applications Labelled Isonicotinamide is an isomeric analogue of nicotinamide and a metabolite of isonicotinic thioamide. Isonicotinamide strongly inducde apoptosis in human acute myelomonocytic leukemia cells, HL-60.
References Taguchi, H.: Furi Rajik. Rin., 14, 23 (1999); Golovinski, E. et al.: Comp. Rend. Acad. Bulg. Sci., 21, 375 (1968);

Stability Light Sensitive
Applications A metabolite of Nicotine in humans. Used for internal standardization for routine biomonitoring of nicotine metabolites.
References Sugasawa, S., et al.: Pharma. Bull., et al.: 2, 39 (1954), Thompson, J.A., et al.: J. Chromatog., 231, 53 (1982); Seeman, J.I., et al.: J. Org. Chem., 51, 1548 (1986)

Applications A nicotine derivative.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Joyce, N.J., et al.: Heterocycles, 29, 7, 1335 (1989),

Applications (±)-Cotinine-2,4,5,6-d4 (pyridine-d4) (CAS# 350818-68-7) is a useful isotopically labeled research compound.

Stability Hygroscopic
Applications A major metabolite of Nicotine in humans. Carcinogen.
References Benowitz, N., et al.: Clin. Pharmacol. Ther., 56, 483 (1994), Nakajima, M., et al.: Drug Metab. Dispos., 24, 1212 (1996), Messina, E., et al.: J. Pharmacol. Exp. Ther., 282, 1608 (1997), Oscarson, M., et al.: Hum. Mutat., 20, 275 (2002),