Organic Halides

<p>Applications 4-Bromo-1-cyclopentene is an intermediate used in the synthesis of Cyclopentobarbital (C992020), which is a barbiturate derivative that has sedative and anticonvulsant properties, and was used primarily as an anaesthetic in veterinary medicine.<br>References Martin, J.R., et al.: Psychopharmacological Agents. Kirk-Othmer Encyclopedia of Chemical Technology (2000); Vander Brook, M.J., et al.: Journal of Pharmacology And Experimental Therapeutics, 80, 119-125 (1944);<br></p>

<p>Applications Octafluoroadiponitrile (cas# 376-53-4) is a useful research chemical.<br></p>

<p>Applications 1-Bromo-2-phenoxyethane (cas# 589-10-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Fluoro-4-phenylphenol (cas# 477860-13-2) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Chlormefos<br></p>

<p>Applications GAMMA-CHLOROCROTONIC ACID (cas# 26340-58-9) is a useful research chemical.<br></p>

<p>Applications 4-Cyano-3,5-difluorophenylboronic acid<br></p>

<p>Applications Methyl-2-bromo-4-bromomethylbenzoate<br></p>

<p>Applications 5-Chloropent-1-yne is an intermediate in the synthesis of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>

<p>Applications 2,3-Dimethylbutyl Chloroformate is used to prepare phenyl(piperazinylphenyl)pyrazolo[1,5-a]pyrimidinylamine derivatives for use as Lck inhibitors.<br>References Buehlmayer, P., et al.: PCT Int. Appl. (2008), WO 2008037459 A1 20080403<br></p>

<p>Applications N-(4-amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide (cas# 10558-45-9) is a useful research chemical.<br></p>

<p>Applications 4-Nitrobenzyl Bromide is used in the synthesis of di and tri-substituted azoles. Also used in the preparation of N6-Benzyladenosine-5’-uronamides as selective A3 adenosine agonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gallo-Rodriguez, C. et al.: J. Med. Chem., 37, 636 (1994); Appukkuttan, P. et al.: Org. Lett., 6, 23 (4223);<br></p>

<p>Stability Light Sensitive<br>Applications 5-Iodo-2’-deoxytubercidin is a derivative of 7-Iodo-7-deazadenine designed to be incorporated into DNA by primers extension by using Vent(exo-) polymerase. Possesses photophysical properties.<br>References Macickova-Cahova, H., et al.: Chem. Eur. J., 17, 5833-5841 (2011); Saito, Y., et al.: Tetrahedron Lett., 52, 4726-4729 (2011)<br></p>

<p>Applications Methyl 2-Chloro-1-cyclopentenecarboxylate is a versatile reactant that can be synthesized from Methyl 2-Cyclopentanonecarboxylate (M294705), which is used in the preparation of functionalized ketones.<br>References Mashima, K. et al.: J. Org. Chem., 59, 3064 (1994); Hamashima, Y. et al.: J. Am. Chem. Soc., 124, 11240 (2002);<br></p>

<p>Applications 5-azetidin-3-yl-3-(trifluoromethyl)-1,2,4-oxadiazole hydrochloride (cas# 1426290-78-9) is a useful research chemical.<br></p>

<p>Applications (2S)-pentan-2-amine hydrochloride (cas# 216237-52-4) is a useful research chemical.<br></p>

<p>Applications 4-Deiodo-amidotrizoic Acid can be obtained from 3,5-Dinitrobenzenemethanol. It can also be used in biological study for quality environmental risk assessment of photolytic transformation products of iodinated X-ray contrast agent diatrizoic acid.<br>References Rastogi, T., et al.: Sci. Total Environ., 482-483, 378-388 (2014);<br></p>

<p>Applications Reagent used in Phthalimidooxy alylation.<br>References Yoda, R., et al.: Chem. Pharm. Bull., 42, 686 (1994), Kim, M., et al.: Bioorg. Med. Chem. Lett., 6, 2077 (1996),<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-Morpholinylsulfur Trifluoride is a chemical reagent used in the preparation of proline analogs. Also used in the preparation of difluoropiperidines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mykhailiuk, P. et al.: Tetrahedron 67, 3091 (2011); Surmont, R. et al.: Synlett., 12, 1933 (2009);<br></p>

<p>Applications Geranyl Bromide is a chemical reagent used in the synthesis of natural and semisynthetic napthoquinones showing growth inhibitory activity for cancer cell lines. Also used in the synthesis of saicylic acid derivatives showing antimicrobial activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fiorito, S. et al.: Bioorg, Med. Chem. Lett., 24, 454 (2014); Kraus, G. et al.: Nat. Prod. Comm., 8, 911 (2013);<br></p>

<p>Applications 9-Fluorenone-D8 is a labelled analogue of 9-Fluorenone (F462780). 9-Fluorenone is a polycyclic aromatic ketone that has photosensitizing properties and also has the ability to undergo electrochemical polymerization. 9-Fluorenone is used in industry as an initiator in visible-light cured resin systems. 9-Fluorenone has potentially toxic effects on humans, as exposure can cause DNA mutations.<br>References Cihaner, A., et al.: J. Elec. Chem., 568, 151 (2004); Li, Y., et al.: J. Biomed. Mater. Res. Part B-A, 84, 58 (2008); Okamoto, H., et al.: Org. Lett., 13, 2758 (2011)<br></p>

<p>Applications Ethyl Succinoyl Chloride, used in the synthesis of bivalent ligands for D2/D3 dopamine receptors. Also used in the preparation of antimicrobial pyrrolo-isoquinolinones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gogoi, S. et al.: ACS Med. Chem. Lett., 3, 991 (2012);<br></p>

<p>Applications 4-(Chloromethyl)benzoic Acid has been used in the synthesis of dihydroxy stilbene derivatives.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jung, M., et al.: Bioorg. Med. Chem. Lett., 16, 4481-4486 (2007);<br></p>

<p>Applications 4-Fluorobenzoylacetonitrile is used as a reagent in the synthesis of Blonanserin (B595850); a 5-HT2 serotonin receptor and D2 dopamine receptor antagonist, used as an antipsychotic. 4-Fluorobenzoylacetonitrile is also used in the preparation of pyrazolopyrimidines as potential antimicrobial and antioxidant agents.<br>References Oka, T., et al.: Life Sci., 76, 225 (2004), Singh, A., et al.: Int. Med. J., 12, 175 (2005); Ochi, T., et al.: Bioorg. Med. Chem., Lett., 15, 1055 (2005); El-Borai, M.A., et al.: J. Applicable Chem., 3, 1526 (2014)<br></p>

<p>Applications 2-[3-(trifluoromethyl)phenoxymethyl]oxirane (cas# 585-45-5) is a useful research chemical.<br></p>

<p>Applications 1-Bromo-5-chloropentane is a chemical reagent used in the synthesis of novel imidazole derivatives as heme-oxygenase (HO-1 and HO-2) inhibitors for use as cytotoxic agents against cancer cell lines.<br>References Salerno, L. et al.: Eur. J. Med. Chem., 96, 162 (2015);<br></p>

<p>Applications 4-(Trichloromethyl)benzonitrile, is a building block used in various chemical syntheis such as in preparation of Betrixaban (B329500), a novel anticoagulant, and an oral direct inhibitor of factor Xa (FXa) for use in the prevention of venous thromboembolism (VTE).<br>References Turpie, A.G.G. et al.: Thromb. Haemost., 101, 68 (2009); Gomez-Outes, A. et al.: Curr. Vasc. Pharmacol., 7, 309 (2009);<br></p>

<p>Applications 2,3-Dimethylbutanoyl Chloride is an intermediate used in the synthesis of 3-Chloro-2-methylbutane (Contains CCl4) (C990505), which is a generic chemical reagent used in the synthesis of alkylthioalkylmalonic esters as antimicrobial agents for the inhibition of microorganisms.<br>References Saitkulova, F. et al.: Khim. Farmat. Zhur., 20, 319 (1986)<br></p>

<p>Applications 3-Fluoro-4-(trifluoromethyl)benzonitrile is a reactant in the synthesis of amino-acetonitrile derivatives. as a new class of synthetic anthelmintic compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ducray, P., et. al.: Bioorg. Med. Chem. Lett., 18, 2935 (2008)<br></p>

<p>Applications 3-(3,4,5-trimethoxyphenyl)acryloyl chloride (cas# 89652-61-9) is a useful research chemical.<br></p>

<p>Applications 4-Bromo-N,N-dimethylaniline is an internal standard used in the determination of iodine present as iodide in pharmaceuticals and iodate in iodized table salt.<br>References Das, P., et al.: J. Chromat. A, 1023, 33 (2004);<br></p>

<p>Applications (2-Chloro-3-trifluoromethylphenyl)amine, cna be used in synthesis of various compounds, such a S676850 (S676850), and its derivatives.<br>References Wu, L. et al.: Huaxue Shiji, Vol. 38, issue5, P: 488-490 (2016);<br></p>

<p>Applications 2-Fluoro-5-nitrobenzoic Acid (cas# 7304-32-7) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications Methyl (chlorosulfonyl)acetate<br></p>

<p>Applications p-Phthalamidine Dihydrochloride is a reactant that has been used in the preparation of (phenylene)bis[pyrimidine], benzenedicarboximidamide and benzenetricarboximidamide.<br>References Felix, O., et. al.: New J. Chem., 21, 285 (1997)<br></p>

<p>Applications 3-Fluoro-4-(trifluoromethoxy)phenylboronic acid<br></p>

<p>Applications Fluorosulfonyl Isocyanate is an intermediate used in the synthesis of 5-Chloro Acesulfame (C363250), which is an impurity of Acesulfame (A132500), the artificial sweetener, and a new sweet-tasting oxathiazinone dioxides. Acesulfame Potassium Impurity B<br>References Clauss, K., et al.: Liebigs Annalen der Chemie,4, 494 (1980); Armenta, S., et al.: J. Agric. Food Chem., 52, 7798 (2004);<br></p>

<p>Stability Air Sensitive, Moisture Sensitive, Temperature Sensitive<br>Applications 5-Chlorosaligenyl-N,N-diisopropylphosphoramidite (cas# 1620086-77-2) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications Dimorpholinophosphinyl Chloride is an condensing reagent in the synthesis of Dexamethasone Phosphate (D298835), a pro-drug of Dexamethasone (D298800), an anti-inflammatory glucocorticoid.<br>References Stefancich, G., et al.: J. Heterocycle. Chem., 30, 529 (1993);<br></p>

<p>Applications 4-Bromobiphenyl is used as a reagent in the synthesis of spirooxindole derivatives for use as AMPK activators. 4-Bromobiphenyl is also used as a reagent in the preparation of indenoindole derivatives as organic electroluminescent device materials.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Madanahalli Ranganath Rao, J., et al.: PCT Int. Appl. WO 2014202580 A1 20141224. Dec 24, 2014; Nagaoka, M., et al.: PCT Int. Appl. WO 2014196556 A1 20141211. Dec 11, 2014<br></p>

<p>Stability Hygroscopic<br>Applications Cyclobutylmethylamine Hydrochloride<br></p>

<p>Applications 3-(Chloromethyl)-2,4,6-trimethylbenzoic Acid (cas# 52411-49-1) is a useful research chemical.<br></p>

<p>Applications 9,9-Dihexylfluorene (cas# 123863-97-8) is a useful research chemical.<br></p>

<p>Stability Unstable in solution. Small amounts of precipitate should have no effect on use.<br>Applications 1-Chloro-N,N-2-trimethylpropenylamine acts as a reagent in the synthesis and antitumor activity of (-)-bassianolide in human cancer cells through cell cycle arrest. Enantioselective total synthesis of nannocystins A and A0 as elongation factor 1 inhibitors. Total synthesis of (-)-caprazamycin A with antibacterial activity against Mycobacterium tuberculosis (TB) via diastereoselective aldol reaction.<br>References Mun, B., et al.: Bioorg. Chem., 69, 64 (2016); Huang, J., et al.: Org. Lett., 18, 4702 (2016); Nakamura, H., et al.: Angew. Chem., Int. Ed., 54, 3136 (2015)<br></p>

<p>Applications 4-Fluorobenzamide<br></p>

<p>Applications 3-Bromotetrahydrofuran<br></p>

<p>Applications 3-Fluoro-5-trifluoromethylbenzonitrile is a reagent used in the synthesis of cholesteryl ester transfer protein (CETP) inhibitors in the treatment of high cholesterol. Also used in the preparation of substituted pyrimidines with dithioacetals for antimicrobial activity.<br>References Qiao, J. et al.: J. Med. Chem., 58, 9010 (2015); Gami, S. et al.: J. Hetero. Chem., 52, 751 (2015);<br></p>

<p>Applications 1-Iodopropane is used in the synthesis of a new class of cesium selective ionophores. Also used to preparation of secondary amines and diamines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Casnati, A. et al.: J. Am. Chem. Soc., 117, 2767 (1995); Fukuyama, T. et al.: Tetrahedron Lett., 38, 5831 (1997);<br></p>

<p>Applications 2-amino-4-fluoro-5-nitrobenzoic acid (cas# 1194097-41-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications (5-Carboxypentyl)triphenylphosphonium Bromide (cas# 50889-29-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Chloro-4'-nitrobenzanilide (cas# 55501-45-6) is a compound useful in organic synthesis.<br></p>

<p>Applications tert-Butyl 2,2,2-trichloroacetimidate is used in the conversion of alcohols and carboxylic acids to their respective ethers and esters.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wessel, H., et al.: J. Chem. Soc., Perkin Trans. 1, 2251 (1985); Armstrong, A., et al.: Tetrahedron Lett., 29, 2483 (1988)<br></p>

<p>Applications 4-Chlorobutyronitrile (cas# 628-20-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Tetrachlorothiophene is chlorinated derivative of Thiophene (T368080), which is used as a building block of various organic molecules and pharmaceuticals providing functional properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prasad, B. et al.: Chem. Comm., 48, 10434 (2012); Freitas, V. et al.: Struct. Chem., 24, 661 (2013);<br></p>

<p>Applications 3-Bromophthalic anhydride<br></p>

<p>Applications cyclopent-2-en-1-amine hydrochloride (cas# 91469-54-4) is a useful research chemical.<br></p>

<p>Applications Ethyl trans-2-(4-aminocyclohexyl)acetate, HCl<br></p>

<p>Stability Moisture Sensitive<br>Applications BROMO-PEG3-BROMIDE (cas# 31255-10-4) is a useful research chemical.<br></p>

<p>Applications 2-Bromobutane is used in the various organic synthesis, existing as a grignard reagent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Girard, P. et al.: J. Am. Chem. Soc., 102, 2693 (1980); Apsel, B. et al.: Nat. Chem. Biol., 4, 691 (2008);<br></p>

<p>Applications 1,3-Diiodobenzene is a common chemical reagent used in the synthesis of multinuclear complexes of large porphyrinoids. Also used in the synthesis of small molecular probes as sensors with low viscosity values.<br>References Miguel, D. et al.: Org. Lett., 17, 2844 (2015);<br></p>

<p>Applications (2-Carboxyethyl)-triphenylphosphonium Chloride (cas# 36626-29-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Di(p-anisyl)iodonium Tetrafluoborate (cas# 1426-58-0) is a compound useful in organic synthesis.<br></p>

<p>Applications (R)-N-Ethyl-N,N-dimethyl-2-(phenyl(o-tolyl)methoxy)ethanaminium Chloride is an impurity in the synthesis of Orphenadrine (O695300). muscle relaxant (skeletal); antihistaminic.<br>References Harms, N., et al.: J. Med. Pharm. Chem., 2, 57 (1960),<br></p>

<p>Applications Hydrobromide salt of Triphenylphosphine, used in the preparation of uridine derivatives as substrate donor analogs of UDP-sugars for glycosyltransferases. Also used in the preparation of tensioactive and antibacterial deoxyglycoside compounds via catalysis.<br>References Wandzik, I. et al.: Bioorg. Chem., 37, 211 (2009); Martins, A. et al.: Eur. J. Org. Chem., 2014, 1448, 2013<br></p>

<p>Applications 2-Bromoiodobenzene was used in the synthesis of diarylamines. It was also a reactant used in Suzuki Coupling reactions.<br>References Buden, M., et al.: J. Org. Chem., 74, 4490 (2009); Wolfe, J., et al.: J. Am. Chem. Soc., 121, 9550 (1999)<br></p>

<p>Applications N-Hydroxybenzylamine Hydrochloride, is a versatile intermediate for the synthesis of various pharmaceutical compounds. It is used for the preparation of Ticagrelor (T437700) derivatives as novel antiplatelet agents.<br>References Zhang, H., et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012); Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007);<br></p>

<p>Applications 3-Fluoropropan-1-ol is used as a reagent to synthesize fluorinated amino acids (e.g. DL-erythro-4-Fluoroglutamine [F591630]). 3-Fluoropropan-1-ol is also used as a reagent to synthesize labelled N-desmethyl-loperamide analogues, compounds that have potential use as imaging radiotracers.<br>References Bao, X. &amp; Duliang, L.: Tetrahedron Lett., 54, 1412 (2013); Drouet, F., et al.: Eur. J. Org. Chem., 2014, 1195 (2014)<br></p>

<p>Applications ALLYLHYDRAZINE DIHYDROCHLORIDE (cas# 70629-62-8) is a useful research chemical.<br></p>

<p>Applications 4'-(Trifluoromethyl)[1,1'-biphenyl]-4-carboxylic Acid is a reagent used in the synthesis of pharmaceuticals and pharmaceutical intermediates<br>References Zhao, D., et al.: Bioorg. Med. Chem., 25, 750 (2017); Kishino, H., et al.: Bioorg. Med. Chem. Lett., 19, 4589 (2009); Hajduk, P. J., et al.: J. Med. Chem., 40, 3144 (1997)<br></p>

<p>Applications (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium Bromide is used as a reactant in the synthesis of ketolides methyloxoerythromycins with antibacterial activity as highly potent against macrolide-resistant and susceptible respiratory pathogens.<br>References Agouridas, C., et al.: J. Med. Chem., 41, 4080 (1998);<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-Chlorobenzyl Chloride is a benzylchloride derivative used in the preparation of various biologically active compounds such as bronchodilators and antibacterial agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Adams, M. et al.: Synth. Comm., 29, 2419 (1999); Foroumadi, A. et al.: Arch. Pharm. Res., 30, 138 (2007);<br></p>