Organic Halides

<p>Applications Benzyltrimethylammonium dichloroiodate is used in the mechanism of oxidation.<br>References Srinivasan, N., et al.: Tetrahedron, 30, 419 (1974), Sankhla, R., et al.: J. Chem. Res., 0465 (2002),<br></p>

<p>Applications 3-Phenylpropionyl Chloride is a derivative of phenylpropionic acid used in the preparation of a wide range of pharmaceutical compounds such as antivirals and antitumor agents.<br>References Ermolova, G.I. et al.: Khim.-Farm. Zh., 24, 35 (1990); Bernier, J.L. et al.: J. Med. Chem., 28, 497 (1985); Jung, J.-C. et al.: Bioorg. Med. Chem. Lett., 14, 5527 (2004);<br></p>

<p>Impurity Darifenacin 5 Carboxymethyl Impurity/ Darifenacin Bromo Impurity<br>Applications 5-(2-Bromoethyl)-2,3-dihydrobenzofuran (cas# 127264-14-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,3-Dimethylbenzotrifluoride (cas# 80245-28-9) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-Chlorobutyroyl Chloride is used in the preparation of mitosene and mitosane analogs of Mitomycin C (M371900), an antitumor antibiotic. .<br>References Verboom, W. et al.: Anti-Canc. Drug Des., 2, 271 (1987); Kinoshita, S., et al.: J. Med. Chem., 14, 13 (1971), Beijnen, J.H., et al.: Anal. Profiles Drug Subs., 16, 361 (1986),<br></p>

<p>Applications 2,4-dibromo-1-iodobenzene (cas# 19393-94-3) is a useful research chemical.<br></p>

<p>Applications 4-Amino-5-trifluoromethylbenzoic Acid (cas# 400-76-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Pyrenemethylamine Hydrochloride is used for labelling of various biomolecules. It is used as a reactant in self-assembling vancomycin-pyrene derivatives as hydrogel with potential medical applications. Also used in the preparation of 25,27-bis(ethylacetoethoxy)-26,28-dipropyloxycalix[4]arene.<br>References Xing, B., et al.: J. Am. Chem. Soc., 124, 14846 (2002); Kim, S., et al.: J. Am. Chem. Soc., 126, 16499 (2004);<br></p>

<p>Applications (1-Chloropropan-2-yl)dimethylamine Hydrochloride is used in the convenient synthesis of phenothiazine drugs.<br>References Galons, H., et al.: Chem. Pharm. Bull., 33, 5108 (1985);<br></p>

<p>Applications 3-chloro-N-(3-hydroxyphenyl)propanamide (cas# 50297-40-0) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications TRISPHENYL(3,3,3-TRIFLUOROPROP-1-YL)PHOSPHONIUM IODIDE (cas# 128622-15-1) is a useful research chemical.<br></p>

<p>Applications 2-(Chloromethoxy)-1,1,3,3,3-pentafluoro-1-propene is a reagent used as a fluoride source in halogen-exchange reactions<br>References Rozov, L.A., et al.: J. Fluorine Chem., 88, 51 (1998)<br></p>

<p>Applications 1-(2-Hydroxyethyl)lepidinium Bromide (cas# 26468-13-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(4-Bromo-3-formylphenoxy)benzonitrile (cas# 906673-54-9) is a useful research chemical.<br></p>

<p>Applications 2-Bromo-4-chloroanisole has been used as a reactant in the preparation of naphthyl phenyl ethers as nonnucleoside HIV-1 reverse transcriptase inhibitors.<br>References Gu, S., et. al.: Bioorg. Med. Chem., 19, 4220 (2011)<br></p>

<p>Applications 2-nitroso-5-dimethylaminophenol hydrochloride (cas# 41317-10-6) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-Hydroxybenzenesulfonyl Chloride is useful for the preparation of amino acid derivatives with anticancer activity.<br>References Kim, S., et al.: PCT Int. Appl. (2020), WO 2020204548 A1<br></p>

<p>Applications (2-Bromoethyl)trimethylsilane has been used as a reactant in the synthesis of strychnine, norfluorocurarine, dehydrodesacetylretuline and valparicine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Martin, D.B., et. al.: J. Org. Chem., 77, 17 (2012)<br></p>

<p>Applications Methyl 2-Chloro-6-(trifluoromethyl)nicotinate (cas# 1073129-57-3) is a useful research chemical.<br></p>

<p>Applications (3-Fluorophenyl)methanesulfonyl chloride<br></p>

<p>Applications tert-butyl 2-(4-(bromomethyl)phenyl)acetate (cas# 77292-91-2) is a useful research chemical.<br></p>

<p>Applications 2,3,4,5-Tetrafluorobenzoic Acid is used in the synthesis of diterpenoid analogs as antitumor compounds. Also used in the synthesis of novel quinoline lactones.<br>References Li, D. et al.: Eur. J. Med. Chem., 64, 215 (2013); Zheng, H. et al.: Lett. Org. Chem., 10, 252 (2013);<br></p>

<p>Applications Ethyl 6-(4-chlorophenoxy)hexanoate is used as an intermediate in the preparation of (aryl)-N-(oxooxazolidinyl)-amides as potent quorum-sensing inhibitors of Pseudomonas aeruginosa.<br>References Jiang, K., et al.: Eur. J. Med. Chem., 194, 112252 (2020);<br></p>

<p>Stability Hygroscopic<br>Applications 3-Amino-2-chloro-propenal is a chemical reagent in the synthesis of a COX-2 specific inhibitor.<br>References Davies, I. et al.: J. Org. Chem., 65, 8415 (2000);<br></p>

<p>Applications 4-Fluorotoluene<br></p>

<p>Applications 2-Chloro-3,4-dimethoxy-β-nitrostyrene is an intermediate in the synthesis of high affinity D1 dopamine receptor ligand.<br>References Tarantino, P. A., et al.: Toxicol. App. Pharmacol., 27, 507 (1974);<br></p>

<p>Applications 4-Fluorobenzyl Bromide is a substituted benzyl bromide reagent used in the preparation of wide range of biologically active compounds such as bronchodialators, neurochemicals and antibacterials.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hardtmann, G.E. et al.: J. Med. Chem., 18, 447 (1975); Bartl, V. et al.: Coll. Czechoslov. Chem. Comm., 45, 3182 (1980);<br></p>

<p>Applications 5-Bromopentylboronic Acid<br></p>

<p>Applications 4-fluorobutanoic acid (cas# 462-23-7) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygrscopic<br>Applications N-(2,6-Dimethylphenyl)-2,2-dichloroacetamide is an intermediate used to prepare Ranolazine (R122500), an antianginal agent.<br>References Aalla, S., et al.: Org. Proc. Res. Dev.,16, 748 (2012)<br></p>

<p>Applications Colestipol Hydrochloride (cas# 37296-80-3) is a useful research chemical.<br></p>

<p>Stability Very Very Moisture sensitive<br>Applications Chloroformic Acid Chloromethyl Ester is used as a reagent in the synthesis of carbamates and carbonates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Safadi, M. et al.: Pharm. Res. 10, 1350 (1993); Loren, J.C. et al.: Synlett, 18, 2847 (2005);<br></p>

<p>Applications 2-Amino-4-trifluoromethoxyphenylboronic acid pinacol ester<br></p>

<p>Applications 2-(4-Bromophenyl)cyclohexanone is used in the synthesis of arylcyclohexanones.<br>References Zhou, L. et al.: J. Am. Chem. Soc., 134, 17023 (2012);<br></p>

<p>Applications 2-Iodo-3-Oxo-4-aza-5α-androst-17β-carboxylic Acid is a reactant in the synthesis of Duasteride (D735000), a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.<br>References Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),<br></p>

<p>Applications 3-Amino-1,1,1-trifluoropropan-2-ol<br></p>

<p>Stability Volatile<br>Applications 3-chlorooxolane (cas# 19311-38-7) is a useful research chemical.<br></p>

<p>Applications Di-[2-(4-pyridyl)ethyl]sulfide Dihydrochloride is a compound useful in organic synthesis.<br></p>

<p>Applications tert-Butyl-(3-iodo-1,1-dimethyl-propoxy)-dimethyl-silane (cas# 105262-85-9) is used as a reagent in the preparation of Methyl Acetoacetate.<br>References Heslin, J. C., et al.: J. Chem. Soc. [Perkin 1]. 6, 1417 (1988)<br></p>

<p>Applications Methyl 12-Aminododecanoate Hydrochloride (cas# 4271-86-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Chloro-1-butanol is a reagent used in the preparation of pharmaceutical compounds such as canthine analogues for their activity against HeLa cervical cells. Also used in the preparation of novel and highly potent Bryostatin, another anti-cancer agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Naik, P. et al.: Tetrahedron, 69, 6545 (2013); Wender, P. et al.: J. Am. Chem. Soc., 124,13648 (2002);<br></p>

<p>Applications 5-Ethyl-2-fluorophenylboronic acid<br></p>

<p>Applications 4,4'-Dichlorodiphenyl Ether is a standard for environmental testing and research. Substance for the QSPR/QSAR models for prediction of physico-chemical properties and biological activity of polychlorinated diphenyl ethers.<br>References Xu, H., et al.: Chemosphere, 80, 665 (2010)<br></p>

<p>Applications 4-Nitrobenzoyl Chloride is used inorganic syntheses such as Michael additions. Also used in the synthesis of polysubstituted furanonaphthoquinoines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhong, J. et al.: Catal. Comm., 32, 18 (2013); Wu, Z. et al.: Org. Biomol. Chem., 11, 828 (2013);<br></p>

<p>Applications (1R,3S)-3-(4-Bromophenyl)cyclopentanamine is used in the synthesis of pharmaceutical agents.<br></p>

<p>Applications 2,3-Dichlorobenzal Chloride is used in the biological study of plant growth-promoting activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kemp, M. S., et al.: Ann. Appl. Biol., 80, 311-15 (1975)<br></p>

<p>Applications 4-Amino-2-fluorophenol is an reagent used in various synthetic preparations such as the synthesis of Amodiaquine (A634200), an antimalarial agent.<br>References O’Neill, P.M., et al.: J. Med. Chem., 37, 1362 (1994); Berg, S.S., et al.: J. Chem. Soc., 642 (1949);<br></p>

<p>Applications 4-Nitrobenzyl Bromide is used in the synthesis of di and tri-substituted azoles. Also used in the preparation of N6-Benzyladenosine-5’-uronamides as selective A3 adenosine agonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gallo-Rodriguez, C. et al.: J. Med. Chem., 37, 636 (1994); Appukkuttan, P. et al.: Org. Lett., 6, 23 (4223);<br></p>

<p>Stability Light Sensitive<br>Applications Ethyl 1-Bromocyclobutanecarboxylate is a reactant in the preparation of aroylindole-substituted phenoxyacetic acid derivatives, which has PPARγ and PPARα agonist activity, pharmacokinetics, and glucose and triglyceride lowering properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, W., et al.: J. Med. Chem., 52, 14 (2009)<br></p>

<p>Stability Moisture Sensitive, Toxic<br>Applications Benzyl Chloromethyl Ether is a reagent in the preparation of benzoyl-hydroxypyrimidine-diones, which are dual inhibitors of HIV reverse transcriptase and integrase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tang, J., et al.: Bioorg. Med. Chem. Lett., 21, 2400 (2011); Berkley, S., et al.; Nat. Med. 16, 981 (2010)<br></p>

<p>Applications 2-Bromo-4-aminobenzoic Acid (cas# 2486-52-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-chloro-2,4-dimethylnicotinonitrile (cas# 101251-72-3) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Chloro-1,1,1-trimethoxyethanen is a reactant in the synthesis of α-chloro-β-aminosulfinyl imidates as chiral building blocks<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Col0paert, F., et. al.: J. Org. Chem., 76, 2204 (2011)<br></p>

<p>Applications 1,1-dimethylguanidine hydrochloride (cas# 22583-29-5) is a useful research chemical.<br></p>

<p>Applications 2-Bromo-1-(3,5-dichlorophenyl)-1-propanone is an intermediate in the synthesis of 5-Chloro Bupropion Fumarate (C364765). A 5-chloro substitued analogue of Bupropion (B689625) used in the preparation of compounds for indirect dopamine agonist pharmacotherapy for treating cocaine, methamphetamine, nicotine, and other drugs of abuse addiction.<br>References Carroll, F.I. et al.: J. Med. Chem., 52, 6768 (2009)<br></p>

<p>Applications 4-(4-Fluorophenyl)aniline<br></p>

<p>Applications N-​Methylcyclopropanami​ne Hydrochloride can be used as reactant/reagent in preparation of substituted benzazinones as antibacterial compounds.<br>References Jin, Q., et al.: PCT Int. Appl., WO 2017098440 A1 20170615 (2017)<br></p>

<p>Applications 2-(4-Fluoro-2-hydroxyphenyl)isonicotinic acid<br></p>

<p>Applications 2,7-Diacetylfluorene is used as a reactant in the synthesis of (dioxaborine)fluorene derivatives for light-emitting diodes (LEDs).<br>References Domercq, B., et al.: J. Phys. Chem. B, 108, 8647 (2004);<br></p>

<p>Applications 3,5-DIAMINOBENZOTRIFLUORIDE (cas# 368-53-6) is a useful research chemical.<br></p>

<p>Applications 7-Fluoro-2,3,4,5-tetrahydro-1H-3-benzazepine is a metabolite of Lorcaserine (L469890), which is a novel selective 5-HT2C-receptor agonist for the treatment of obesity.<br>References Pauli, M., et al.: Formulary, 45, 180 (2010), Ioannides-Demos, L.L., et al.: J. Obesity, 18, 179674 (2011),<br></p>

<p>Impurity Anastrozole 1,3-Dibromomethyl Impurity<br>Applications 1,​3-​Bis(bromomethyl)​-​5-​methylbenzene is a reagent used in the synthesis of sphingosine kinase 2 inhibitors. Anastrozole 1,3-Dibromomethyl Impurity<br>References Congdon, M. et al.: Bioorg. Med. Chem. Lett., 25, 4956 (2015);<br></p>

<p>Applications CHLOROMETHYL ISOBUTYRATE (cas# 61644-18-6) is a useful research chemical.<br></p>

<p>Applications 2-Aminoacetohydrazide Hydrochloride has been used in the preparation of hydrazidones that exhibit antihypertensive activity.<br>References Cave, C., et. al.: Eur. J. Med. Chem., 29, 389 (1994)<br></p>

<p>Applications Didechloropyoluteorin is an intermediate in the synthesis of Pyoluteorin (P840375). Pyoluteorin is a pesticide used in the protection of crops from bacteria.<br>References Bakthavatchalu, S. et al.: J. Biol., 37, 289 (2013); Kumar, A.. et al.: Env. Microbiol., 15, 764 (2013)<br></p>

<p>Applications 3-Cyanophenylhydrazine Hydrochloride<br></p>

<p>Applications 2-Chloroethyl (2,6-Dimethylphenyl)-carbamic Acid Ester is an intermediate used in the synthesis of Dimethachlor Ethane Sulfonic Acid Sodium Salt (D460283), which is a pesticide metabolite pollutant found in groundwater, surface water, and wastewater.<br>References Huntscha, S., et al.: J. Chromatogr. A, 1268, 74 (2012); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013);<br></p>

<p>Applications 6-Trifluoromethyltetralin-1-one is derived from 4-Bromobenzotrifluoride (B680525), which is an aromatic compound that is used as a reagent to synthesize Bergenin (B318650), a compound that originates in Mallotus japonicus that exhibits hepatoprotective and antioxidant effects. 4-Bromobenzotrifluoride is also used as a reagent to prepare (±)-Preclamol, a partial dopamine D2 agonist that is used to treat Parkinson’s disease.<br>References Lim, H., et al.: Pharmacology, 63, 71 (2001); Parkan, K., et al.: Chem. Eur. J., 20, 4414 (2014); Pirtosek, Z., et al.: Clin. Neuro., 16, 550 (1993); Takahashi, H., et al.: Bioorg. Med. Chem., 11, 1781 (2003); Vasdev, N., et al.: Synapse, 60, 314 (2006)<br></p>