Organic Halides

<p>Applications 2-Bromoethylcyclopropane is used as a reagent to synthesize 22-Hydroxycholesterol (H918010) derivatives, compounds that act as serum cholesterol lowering agents. 2-Bromoethylcyclopropane is also used to prepare pyridazinones, compounds that act as cyclooxygenase 2-inhibitors (they possess anti-inflammatory and antiangiogenic effects).<br>References Chorvat, R., et al.: J. Med. Chem., 28, 194 (1985); Masferrer, J., et al.: Ann. New York Acad. Sci., 889, 84 (1999); Willoughby, D., et al.: Lancet, 355, 646 (2000)<br></p>

<p>Applications 4-Amino-2-fluorophenol is an reagent used in various synthetic preparations such as the synthesis of Amodiaquine (A634200), an antimalarial agent.<br>References O’Neill, P.M., et al.: J. Med. Chem., 37, 1362 (1994); Berg, S.S., et al.: J. Chem. Soc., 642 (1949);<br></p>

<p>Applications 2-(2,4-Difluorophenyl)-1,2,3-propanetriol is used as a reagent in the synthesis of glycerol derivatives as intermediates for antifungal phenyltriazolylpropanediol derivatives. Also an impurity of the antifungal agent Fluconazole (F421000).<br>References Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985); Yasohara, Y., et al.: PCT Int. Appl. WO 9528374 A1 19951026. Oct 26, 1995<br></p>

<p>Applications 4-Bromobutyric Acid is used in the preparation of analgesic and anti-inflammatory agents as nitroalkyl ethers. It is also used in the synthesis of Autotaxin (ENPP2) inhibitors, used in tissue fibrosis regulation, cancer cell invasion and metastasis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anzini, M. et al.: J. Med. Chem., 56, 4821 (2013); Kawaguchi, M. et al.: ACS Chem. Biol. et al.: 8, 1713 (2013);<br></p>

<p>Applications 2-Chloro-3,4-dimethoxy-β-nitrostyrene is an intermediate in the synthesis of high affinity D1 dopamine receptor ligand.<br>References Tarantino, P. A., et al.: Toxicol. App. Pharmacol., 27, 507 (1974);<br></p>

<p>Applications 2-(4-Bromophenyl)cyclohexanone is used in the synthesis of arylcyclohexanones.<br>References Zhou, L. et al.: J. Am. Chem. Soc., 134, 17023 (2012);<br></p>

<p>Applications (3-Bromopropyl)triphenylphosphonium Bromide is used in rearrangement reactions of cyclic organic molecules and in organic synthesis.<br>References Kippo, T. et al.: J. Am. Chem. Soc., 135, 632 (2013); Shi, M. et al.: J. Am. Chem. Soc., 128, 7430 (2006);<br></p>

<p>Applications (Chloromethyl)cyclohexane is a common chemical reagent used in the synthesis of imidazole inhibitors of cytokine release which suppresses the response to tumor necrosis factor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Laufer, S. et al., J. Med. Chem., 45, 1695 (2002); Rabinowitz, M. et al.: J. Med. Chem., 44, 4252 (2001);<br></p>

<p>Applications N-(Trifluoroacetyl)hexanolamine (cas# 40248-34-8) is a compound useful in organic synthesis.<br></p>

<p>Applications METHYL 2-HYDROXY-4-IODOBENZOATE (cas# 18179-39-0) is a useful research chemical.<br></p>

<p>Applications prop-1-ene-2-sulfonyl chloride (cas# 874009-75-3) is a useful research chemical.<br></p>

<p>Applications 7-Chlorokynurenic acid is an NMDA receptor antagonist and inhibitor of EAAT.<br></p>

<p>Stability Unstable in DMSO, Methanol<br>Applications 2,6-Dimethylbenzyl Bromide is a reactant used in the synthesis of spinosyns which display insecticidal activity. Also used in the preparation of pyridazine derivatives as glutamate transporter EAAT2 activators.<br>References Oliver, M. P. et al.: J. Agric. Food. Chem., 63, 5571 (2015); Xing, X. et al.: Bioorg. Med. Chem. Lett., 21, 5774 (2011);<br></p>

<p>Applications 2,5-Difluorophenylacetic acid has been used in the synthesis of 2,2-dimethyl-4-(2,5-difluorophenyl)-5-[4-(aminosulfonyl)phenyl]-3(2H)-furanone.<br>References Chin, O., et al.: J. Pharm., 44, 138 (2013)<br></p>

<p>Applications Bromosuccinic acid is prepared from Succinic acid (S688765), an important precursor in many chemicals used in the food, chemical and pharmaceutical fields. Bromosuccinic acid is also used as a reagent to prepare L-Hydrazinosuccinic acid.<br>References Gutowsky, H., et al.: J. Chem. Phys., 31, 1278 (2004); Song, H. &amp; Lee, S.: Enzyme Microb. Tech., 39, 352 (2006); Yamada, R., et al.: BBA-Prot. Struc. Mol. Enzym., 831, 82 (1985)<br></p>

<p>Applications 2-(4-Hydroxyphenyl)-N,N-dimethylethylamine*HCI(HordeninHCI) (cas# 6027-23-2) is a useful research chemical.<br></p>

<p>Applications Hydroxocobalamin Hydrochloride acts as a spin trap for radical polymerization in water when reduced with ascorbic acid.<br>References Ng, Y., et al.: Macromol. Res., 20, 473-476 (2012)<br></p>

<p>Applications 2,5-Dichlorobenzoyl Cyanide is a reagent applied for research purposes<br>References Veerareddy, A., et al.: J. Heterocyclic Chem., 51, 1311 (2014)<br></p>

<p>Applications 6,7-Dichloro-1-tetralone (cas# 25095-57-2) is a useful research chemical.<br></p>

<p>Applications methyl 4-(bromomethyl)-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (cas# 1626407-50-8) is a useful research chemical.<br></p>

<p>Applications 1-azido-4-(bromomethyl)benzene (cas# 74489-49-9) is a useful research chemical.<br></p>

<p>Applications CHLOROMETHYL ISOBUTYRATE (cas# 61644-18-6) is a useful research chemical.<br></p>

<p>Stability Volatile<br>Applications (Z)-1,2-Dichloroethene is a synthetic intermediate of solvents and chlorinated compounds. It is mainly used as a solvent for resins, fats, perfumes, dyes, paints, plastics thermosensitive, phenols, etc., also used to extract sensitive products cold to heat (caffeine, rubber, fragrant fat, etc). It is also used in some degreasing metals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mark, J.: Physical Properties of Polymer Handbook, Springer,? 2nd Edition, 1076 (2007)<br></p>

<p>Applications α-(Aminomethyl)-2-(trifluoromethoxy)benzenemethanol is an analog of α-(Aminomethyl)-3-(trifluoromethoxy)benzenemethanol (A630745); a compound that is used as a reagent in the synthesis of potent and selective ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase. It is also used as a reagent in the synthesis of 1-aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase.<br>References Jarvest, R.L., et al.: Bioorg. Med. Chem. Lett., 15, 2305 (2005); Keith, J.M., et al.: Bioorg. Med. Chem. Lett., 24, 1280 (2014)<br></p>

<p>Applications ethyl 3-(4-chlorophenyl)-3-oxopropanoate (cas# 2881-63-2) is a useful research chemical.<br></p>

<p>Applications (R)-(+)-2-Chloropropionic Acid (cas# 7474-05-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-Chlorobenzyl bromide<br></p>

<p>Applications 2-(Dimethylamino)ethanethiol Hydrochloride is a starting material for the synthesis of Echothiophate Iodide (E325800). Echothiophate Iodide is an anticholinesterase drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ashani, Y., et al.: Biochem. Pharm., 30, 2593 (1981)<br></p>

<p>Applications 3-​Bromophenylboronic Acid is a useful synthetic intermediate. It is used in oxidative cross coupling, gold salt catalyzed homocoupling and 1,4-Addition reactions with α,β-unsaturated ketones.<br>References Uchiyama, N., et al.: Chem. Comm., 47, 11671 (2011); Matsuda, T., et al.: tetrahedron Lett., 52, 4779 (2011); Berhal, F., et al.: J. Org. Chem., 76, 6320 (2011)<br></p>

<p>Applications Ethyl 6-(4-chlorophenoxy)hexanoate is used as an intermediate in the preparation of (aryl)-N-(oxooxazolidinyl)-amides as potent quorum-sensing inhibitors of Pseudomonas aeruginosa.<br>References Jiang, K., et al.: Eur. J. Med. Chem., 194, 112252 (2020);<br></p>

<p>Applications (2-Bromoethoxy)-tert-butyldimethylsilane can be used in N-alkylation with 5-piperazin-1-yl-1H-indole to synthesize 5-(4-(2-((tert-butyldimethylsilyl)oxy)ethyl)piperazin-1-yl)-1H-indole.<br>References Johnson, M., et al.: J. Med. Chem., 55, 5828 (2012)<br></p>

<p>Applications 5-Chlorohexanoic acid CAS#: 112176-22-4 is a building block used in organic synthesis.<br>References Liang, S., et al., Green Chemistry., 20, 680 (2018)<br></p>

<p>Applications 2-Chlorobenzyl cyanide was used in the synthesis of clopidogrel, platelet aggregation inhibitor. It can also be used to synthesize non-peptide CCR1 receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Huang, Y., et al.: Anhui Med. Pharm. J., 6, 007 (2009); Ng, H., et al.: J. Med. Chem., 42, 4680 (1999)<br></p>

<p>Applications 5-Aminopentanenitrile Hydrochloride is a useful research chemical.<br></p>

<p>Applications 3-(Trifluoromethoxy)aniline is reactant in the synthesis of pyrazolone-quinazolone hybrids as human hydroxyphenylpyruvate dioxygenase inhibitors which is a potential treatment for type I tyrosinemia.<br>References Xu, Y., et. al.: Bioorg. Med. Chem., 22, 5194 (2014)<br></p>

<p>Applications Methyl 5-chlorothiophene-2-carboxylate (cas# 35475-03-7) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Cyclobutylmethylamine Hydrochloride<br></p>

<p>Applications (4-Isopropoxyphenyl)hydrazine hydrochloride (cas# 104033-62-7) is a useful research chemical.<br></p>

<p>Applications 4'-(Trifluoromethyl)[1,1'-biphenyl]-4-carboxylic Acid is a reagent used in the synthesis of pharmaceuticals and pharmaceutical intermediates<br>References Zhao, D., et al.: Bioorg. Med. Chem., 25, 750 (2017); Kishino, H., et al.: Bioorg. Med. Chem. Lett., 19, 4589 (2009); Hajduk, P. J., et al.: J. Med. Chem., 40, 3144 (1997)<br></p>

<p>Stability Extremely moisture sensitive<br>Applications Highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bannwarth,W. &amp; Kung, E.: Tetrahedron Lett., 30, 4219 (1989)<br></p>

<p>Applications Ethyl 2-(2,6-Dichlorophenyl)acetate (cas# 90793-64-9) is a useful research chemical.<br></p>

<p>Applications ALLYLHYDRAZINE DIHYDROCHLORIDE (cas# 70629-62-8) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 2-Amino-5-Ethylphenol Hydrochloride (cas# 149861-22-3) is a useful research chemical.<br></p>

<p>Applications 4-Aminoresorcinol Hydrochloride is a reactant in the preparation of diethers with antiviral activity against group A and B human Rhinoviruses.<br>References Bernard, A.M., et. al.: Bioorg. Med. Chem., 22, 4061 (2014)<br></p>

<p>Applications 4-bromo-1,1-difluorobutane (cas# 1457946-33-6) is a useful research chemical.<br></p>

<p>Applications 5-Fluoronicotinamide<br></p>

<p>Applications 1-Bromo-2,4,6-trifluorobenzene<br></p>

<p>Applications 3-Phenoxypropyl Bromide is a reagent used in the synthesis of damidines in the study of myotonic dystrophy. Also used in thepreparation pf phenoxyalkylbenzimidazoles with antitubercular activity.<br>References Siboni, R. et al.: J. Med. Chem., 58, 5770 (2015); Chandrasekera, N. S. et al.: J. Med. Chem., 58, 7273 (2015);<br></p>

<p>Applications 4-Bromobenzotrifluoride is an aromatic compound that is used as a reagent to synthesize Bergenin (B318650), a compound that originates in Mallotus japonicus that exhibits hepatoprotective and antioxidant effects. 4-Bromobenzotrifluoride is also used as a reagent to prepare (±)-Preclamol, a partial dopamine D2 agonist that is used to treat Parkinson’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lim, H., et al.: Pharmacology, 63, 71 (2001); Parkan, K., et al.: Chem. Eur. J., 20, 4414 (2014); Pirtosek, Z., et al.: Clin. Neuro., 16, 550 (1993); Takahashi, H., et al.: Bioorg. Med. Chem., 11, 1781 (2003); Vasdev, N., et al.: Synapse, 60, 314 (2006)<br></p>

<p>Applications 5-Iodocytidine is an intermediate for research in the field of nucleic acids and nucleic acid-protein interactions<br></p>

<p>Applications 4-Fluoro-2-(trifluoromethl)benzonitrile is a reagent used in the synthesis of 5-substituted-1H-tetrazoles as antibacterials.<br>References Sivaguru, P. et al.: Tetrahedron Lett., 56, 2203 (2015); Shi, G et al.: Org. Lett., 17, 38 (2015);<br></p>

<p>Applications Formamidine Hydrobromide is used as a reactant in the synthesis of organometal halide perovskites (OHPs).<br>References Shi, Yifei, et al.: ACS App. Mat. &amp; Interfaces, 10(11), 9849-9857 (2018)<br></p>