Organic Halides

<p>Applications A wittig reagent.<br>References Zask, A., et al.: Bioorg. Med. Chem. Lett., 14, 4353 (2004), Seifert, A., et al.: ChemBioChem., 10, 853 (2009),<br></p>

<p>Applications 2-Iodotoluene is used as a reagent in the synthesis of aryl substituted quinones as β-secretase inhibitors.<br>References Wang, D., et al.: Russ. J. Gen. Chem., 84, 1615 (2014)<br></p>

<p>Applications 2-amino-1-(4-fluorophenyl)propan-1-ol (cas# 109515-15-3) is a useful research chemical. Also, it is an intermediate used in the synthesis of p-Fluoro-4-methylaminorex (F791850), which is a derivative of Aminorex (A629200), an anorectic stimulant drug of the 2-amino-5-aryl oxazoline class. Aminorex has been shown to have locomotor stimulant effects similar to Methamphetamine (M258795).<br>References Poos, G., et al.: J. Med. Chem., 6, 266 (1963), Watson, A., et al.: Res. Vet. Sci., 45, 411 (1988), Russell, B., et al.: Pharmacol. Biochem. Behav., 51, 375 (1995),<br></p>

<p>Applications 4-Bromo-3,5-dimethoxybenzoic acid<br></p>

<p>Applications (S)-2-Chloro-1-(3,4-difluorophenyl)ethanol is a building block used in organic synthesis including bein an intermediate in the synthesis of Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel.<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-Chloroethyl ethyl carbonate (cas# 50893-36-2) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications N,N-Dimethylphosphoramidodichloridate functions as a reagent used in the inhibition of acetylcholinestrase and butyryl cholinestrase by nerve agent surrogates. Also, the are used as reagents in the synthesis and in the antitumor activity of nonsymmetric phosphoric acid triamides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Meek, E. C., et al.: Toxicol. Sci., 126, 525 (2012); Kosykhova, L., et al.: Pharm. Chem., 34, 525 (2000)<br></p>

<p>Applications 4-Chloro-2,6-difluorophenylboronic acid<br></p>

<p>Applications (3α,5β,7α)-24-Iodo-cholane-3,7-diol Diformate is an intermediate used in the synthesis of 3α,7α-Dihydroxycoprostanic Acid-d3 (D452517), which is a labelled analogue of 3α,7α-Dihydroxycoprostanic Acid (D452515), a precursor of Cholic Acid (C432600), it undergoes side chain oxidation during the synthesis of bile acids. It was found that Zellweger’s syndrome patients have abnormal mitochondrial structure, the organelle that is responsible for the side chain oxidation, and as a consequence, excess amounts of 3α,7α-Dihydroxycoprostanic Acid.<br>References Hanson, R. F., et al.: Science (Washington, DC, U. S.), 203, 1107 (1979)<br></p>

<p>Applications 2,3-Bis(4-bromophenyl)-2-cyclopropen-1-one is useful reactant and reagent for organic reactions and synthesis.<br>References Zhao. W., et al.: Angew. Chem., 57, 6329-32 (2018); Xu, J., et al.: Org. Chem. Front., 4, 560-64 (2017);<br></p>

<p>Applications 3-Fluoropicolinonitrile<br></p>