Organic Halides

<p>Applications 2-Bromo-4-(1,1,3,3-tetramethylbutyl)phenol is a useful reagent for the preparation of spiroboronates.<br>References Woodgate, P. D., et al.: J. Organomet. Chem., 590, 52 (1999)<br></p>

<p>Applications Chlorocyclohexane, is a building block used in various chemical synthesis.<br></p>

<p>Applications (2,4-Difluorophenoxy)acetic acid<br></p>

<p>Applications Methyl 4-(trifluoromethoxy)benzoate<br></p>

<p>Applications Methyl 4-Chlorobenzoate is a reactant used in the synthesis of ataxia-telangiectasia mutated (ATM) kinase, a target for novel radiosensitizing agents. As well, used as a reactant in the synthesis of aminopyridine functionalized polyacrylonitrile fibers.<br>References Min, J. et al.: J. Med. Chem., 59, 559 (2016);<br></p>

<p>Applications 2,4-Dichloroquinazoline has been used as a reactant for the preparation of 1-methyl-1H-imidazole derivatives as Jak2 inhibitors.<br>References Su, Q., et. al.: J. Med. Chem., 57, 144 (2014)<br></p>

<p>Applications Bromomethyl Methyl Ether acts as a reagent in the synthesis and evaluation of hydroxymethyl-aminocyclitols as glycosidase inhibitors, preparation of pyridine derivatives for minimizing CYP2C9 inhibition for cancer therapy. Also a reagent in the discovery of GBT 440, an orally bioavailable R state stabilizer of sickle cell Hb.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Trapero, A., et al.: J. Org. Chem., 80, 3512 (2015); Zak, M., et al.: J. Med. Chem., 59, 8345 (2016); Metcalf, B.; et al.: ACS Med. Chem. Lett., 8, 321 (2017)<br></p>

<p>Applications 1,3-Dichloropropane is an intermediate used to prepare analogs of tamoxifen with improved calmodulin antagonism.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hardcastle, I., et al.: J. Med. Chem., 38, 241 (1995);<br></p>

<p>Applications 2-Bromo-4-nitrotoluene<br></p>

<p>Applications 2,2-Dihydroxy-3,5,5-bromobiphenyl is a useful building block and reactant.<br></p>

<p>Applications (1-Fluorovinyl)methyldiphenylsilane acts as a reagent for the preparation of fluoro C-glycosyl asparagine from C-formyl glucoside by fluorovinylation and Claisen rearrangement for the construction of α-amino acid moiety.<br>References Usuki, Y., et al.: ITE Lett. Batter., New Technol. Med., 7, 63 (2006)<br></p>

<p>Applications 2-Chloroethyl Ethyl Sulfide is used as a reagent in the synthesis of furfuryl xanthines as adenosine receptor antagonists. It is also used as a reagent in the synthesis of methoxypropyl xanthines as putative A2B receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Balo, M.C., et al.: Bioorg. Med. Chem., 17, 6755 (2009); Nieto, M.I., et al.: Bioorg. Med. Chem., 17, 3426 (2009)<br></p>