Organic Halides

<p>Applications Methyl 6-Chloronicotinate is used in the determination of Acetamiprid (A150800) and its metabolites in crop and soil.<br>References Tokieda, M., et al.: Nippon Noyaku Gakkaishi, 24, 115 (1999)<br></p>

<p>Applications Ethyl 4-Fluorophenylglyoxylate (cas# 1813-94-1) is a compound useful in organic synthesis.<br></p>

<p>Applications (±)-Tetrahydrofurfuryl Bromide is a general chemical reagent used in the synthesis of tubulin polymerization inhibitors.<br>References Colley, H. et al.: J. Med. Chem., 58, 9309 (2015);<br></p>

<p>Applications Methyl 5-Chloro-3-(Chlorosulfonyl)Thiophene-2-Carboxylate (cas# 126910-68-7) is a useful research chemical.<br></p>

<p>Applications Methyl 4-Bromophenylacetate (cas# 41841-16-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(1,3-Dioxolan-2-yl)ethyltriphenylphosphonium Bromide (cas# 86608-70-0) is a useful research chemical.<br></p>

<p>Applications 3,4-Dichloro-6-aminotoluene is an building block reagent used in the synthesis of various drug analogues and pharmaceutical goods.<br>References PCT Int. Appl. (2013), WO 2013030138 A1 20130307.; Shimada, I., et al.: Bioorg. Med, Chem., 16, 1966 (2008);<br></p>

<p>Applications Benzyltrimethylammonium dichloroiodate is used in the mechanism of oxidation.<br>References Srinivasan, N., et al.: Tetrahedron, 30, 419 (1974), Sankhla, R., et al.: J. Chem. Res., 0465 (2002),<br></p>

<p>Applications 2,4-dibromo-1-iodobenzene (cas# 19393-94-3) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-Hydroxybenzenesulfonyl Chloride is useful for the preparation of amino acid derivatives with anticancer activity.<br>References Kim, S., et al.: PCT Int. Appl. (2020), WO 2020204548 A1<br></p>

<p>Applications Methyl 2-Chloro-6-(trifluoromethyl)nicotinate (cas# 1073129-57-3) is a useful research chemical.<br></p>

<p>Applications Bromomethyl Methyl Ether acts as a reagent in the synthesis and evaluation of hydroxymethyl-aminocyclitols as glycosidase inhibitors, preparation of pyridine derivatives for minimizing CYP2C9 inhibition for cancer therapy. Also a reagent in the discovery of GBT 440, an orally bioavailable R state stabilizer of sickle cell Hb.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Trapero, A., et al.: J. Org. Chem., 80, 3512 (2015); Zak, M., et al.: J. Med. Chem., 59, 8345 (2016); Metcalf, B.; et al.: ACS Med. Chem. Lett., 8, 321 (2017)<br></p>

<p>Applications 2,3,4,5-Tetrafluorobenzoic Acid is used in the synthesis of diterpenoid analogs as antitumor compounds. Also used in the synthesis of novel quinoline lactones.<br>References Li, D. et al.: Eur. J. Med. Chem., 64, 215 (2013); Zheng, H. et al.: Lett. Org. Chem., 10, 252 (2013);<br></p>

<p>Applications 2-Fluoro-5-nitroanisole<br></p>

<p>Applications 4-Fluorobenzyl Bromide is a substituted benzyl bromide reagent used in the preparation of wide range of biologically active compounds such as bronchodialators, neurochemicals and antibacterials.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hardtmann, G.E. et al.: J. Med. Chem., 18, 447 (1975); Bartl, V. et al.: Coll. Czechoslov. Chem. Comm., 45, 3182 (1980);<br></p>

<p>Applications 4-fluorobutanoic acid (cas# 462-23-7) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-Fluoro-2-iodoaniline is a useful reactant for the synthesis of cyclohepta[b]indole scaffold via annulative two-carbon ring-expansion.<br>References Tymann, D. C., et al.: Chem. Eur. J, 26, 11974 (2020)<br></p>

<p>Applications 1-(2-Chloroethyl)-4-Fluorobenzene (cas# 332-43-4) is a useful research chemical.<br></p>

<p>Applications 2,3-Dibromopropene is used in preparation of Quaternary Ammonium Salt derivatives for use as Trimethylamine production inhibitors.Also, used in preparation of Boron containing compounds as Phosphodiesterase PDE4 inhibitors.<br>References Nudel, K., et al.:PCT Int. Appl., (2020); Strohbach, Joseph W., et al.: PCT Int. Appl., (2020);<br></p>

<p>Applications 3-​Bromopropanoyl Isocyanate is a reagent used in the preparation of pharmaceuticals. It is prepared successfully through the rearrangement of N-Bromosuccinimide.<br>References Zhang, Y. et al.: Can. J. Chem., 68, 1668 (1990);<br></p>

<p>Applications 4-Amino-5-trifluoromethylbenzoic Acid (cas# 400-76-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Chloro-3-nitrobenzoic Acid is used in rapid, efficient and selective reduction of aromatic nitro compounds with hydrazine hydrate in the presence of the plain and supported platinum nanoparticles as catalysts as reactant/reagent.<br>References Mehdizadeh, S., et al.: J. Iran. Chem. Soc., 11, 1587-1592 (2014)<br></p>

<p>Applications 1-Bromo-3,5-difluorobenzene is used in the synthesis of selective antagonists of GluN2C/GluN2D is used in the synthesis of COX-2 inhibitors as anti-inflammatory agents and anti-cancer agents.<br>References Khanna, I. et al.: J. Med. Chem., 40, 1634 (1997); Pommery, N. et al.: J. Med. Chem., 47, 6195 (2004);<br></p>

<p>Applications (1R,3S)-3-(4-Bromophenyl)cyclopentanamine is used in the synthesis of pharmaceutical agents.<br></p>

<p>Stability Light Sensitive<br>Applications Ethyl 1-Bromocyclobutanecarboxylate is a reactant in the preparation of aroylindole-substituted phenoxyacetic acid derivatives, which has PPARγ and PPARα agonist activity, pharmacokinetics, and glucose and triglyceride lowering properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, W., et al.: J. Med. Chem., 52, 14 (2009)<br></p>

<p>Applications 2-Bromo-4-aminobenzoic Acid (cas# 2486-52-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Bromo-1-cyclopropylethanone is an intermediate used to prepare pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A3 adenosine receptor antagonists. It is also used to synthesize indolizine derivatives incorporating a cyclopropylcarbonyl group against Hep-G2 cancer cell line.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baraldi, P., et al.: J. Med. Chem., 48, 4697 (2005); Shen, Y., et al.: Eur. J. Med. Chem., 45, 3184 (2010)<br></p>

<p>Applications A 3-aryl substituted Azetidine (A813000) used in the preparation opioid receptor modulators.<br></p>

<p>Applications (Bromomethyl)cyclohexane is a reagent that is used in the synthesis of cyano thiouracils as SecA inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chaudhary, A. S., et al.: Bioorg. Med. Chem., 23, 105 (2015);<br></p>

<p>Applications Methyl 3-(bromomethyl)cyclobutanecarboxylate (cas# 89892-95-5) is a useful research chemical.<br></p>

<p>Applications 2,2-Difluoro-1,3-benzodioxole is used in the synthesis of Kv3 inhibitors as well as in the preparation of renin inhibitors.<br></p>

<p>Stability Light and Moisture sensitive<br>Applications (Diacetoxyiodo)benzene is a hypervalent iodine reagent that is used in conjunction with catalytic amount of sodium azide in acetonitrile, which enables oxidative decarboxylation of 2-aryl carboxylic acid into the corresponding aldehydes, ketones and nitriles.<br>References Telvekar, V.N., et al.: Synlett., 2778 (2012); Liu, W.B., et al.: Beilstein. J. Org. Chem., 8, 244 (2012);<br></p>

<p>Applications 3-(2-Chloroethynyl)-2,2-dimethylcyclopropanecarboxylic Acid is a useful intermediate for the preparation of pesticidal and insecticidal formulations.<br>References Farooq, S., et al.: From Ger. Offen. (1980), DE 2925570 A1 19800117; Nishida, N., et al.: From Jpn. Kokai Tokkyo Koho (2002), JP 2002069039 A 20020308<br></p>

<p>Applications 2,4-dihydroxy-3,5,5-bromobiphenyl is a useful building block and reactant.<br></p>

<p>Applications 2-(4-Hydroxyphenyl)-N,N-dimethylethylamine*HCI(HordeninHCI) (cas# 6027-23-2) is a useful research chemical.<br></p>

<p>Stability Unstable in DMSO, Methanol<br>Applications 2,6-Dimethylbenzyl Bromide is a reactant used in the synthesis of spinosyns which display insecticidal activity. Also used in the preparation of pyridazine derivatives as glutamate transporter EAAT2 activators.<br>References Oliver, M. P. et al.: J. Agric. Food. Chem., 63, 5571 (2015); Xing, X. et al.: Bioorg. Med. Chem. Lett., 21, 5774 (2011);<br></p>

<p>Applications 2-Iodotoluene is used as a reagent in the synthesis of aryl substituted quinones as β-secretase inhibitors.<br>References Wang, D., et al.: Russ. J. Gen. Chem., 84, 1615 (2014)<br></p>

<p>Applications 3-​[2-​(Trifluoromethyl)​phenyl]​propionic Acid is a reactant used in the synthesis of small molecule inhibitors of anthrax toxin.<br>References Williams, J. et al.: Bioorg. Med. Chem., 22, 419 (2014);<br></p>

<p>Applications Hydrochloride salt of (S)-1-Cyclopentylethanamine, used in the preparation of renin inhibitors.<br></p>

<p>Applications 1-Chloroanthraquinone is used to characterize anthraquinone intercalators as carrier molecules for second-generation platinum anticancer drugs.<br>References Gibson, D., et al.: J. Med. Chem., 34, 414 (1991); Gibson, D., et al.: Eur. J. Med. Chem., 32, 823 (1997); Alderden, R., et al.: Biochem. Pharmacol., 71, 1136 (2006)<br></p>

<p>Applications 2-Acetamido-4-(trifluoromethyl)phenylboronic acid, pinacol ester<br></p>

<p>Applications A Wittig reagent.<br></p>

<p>Applications 3-FLUORO-PROPYLAMINE HCL (cas# 64068-31-1) is a useful research chemical.<br></p>

<p>Applications Colestipol Hydrochloride (cas# 37296-80-3) is a useful research chemical.<br></p>

<p>Applications 2-amino-5-oxohexanoic acid hydrochloride (cas# 1394040-02-8) is a useful research chemical.<br></p>

<p>Stability Very Very Moisture sensitive<br>Applications Chloroformic Acid Chloromethyl Ester is used as a reagent in the synthesis of carbamates and carbonates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Safadi, M. et al.: Pharm. Res. 10, 1350 (1993); Loren, J.C. et al.: Synlett, 18, 2847 (2005);<br></p>

<p>Applications (2-Chloroethoxy)methyl Chloride (cas# 1462-33-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Bromo-4-hydroxybenzonitrile is a reactant that has been used in the preparation of tetrazoles.<br>References Kumar, S., et. al.: Tetrahedron. Lett., 55, 6034 (2014)<br></p>

<p>Applications 4-Dimethylaminobut-2-ynoic Acid Hydrochloride, is used as a reactant in the synthesis of quinazoline derivatives such as (2Z)-Afatinib (A355305) which may be used in the treatment of some cancers.<br>References Tsou, H., et. al.: J. Med. Chem., 44, 2719 (2001)<br></p>

<p>Applications 2-Amino-4-chlorophenol is a widely used reagent in the synthesis of various drugs, dyes and pesticides. A reagent in the synthesis of aggrecanase-2 inhibitors based on acylthiosemicarbazide zinc-binding, used in the treatment of osteoarthritis.<br>References Arora, P. et al.: Microb. Cell Fact., 11, 150 (2012); Maingot, L. et al.: Eur. J. Med. CHem., 69, 244 (2013);<br></p>

<p>Applications 2,4,6-Tribromotoluene acts as a reagent in the synthesis of non-proteinogenic α-amino acids.<br>References Lecointe, L., et al.: J. Pept. Res., 55, 300 (2000)<br></p>

<p>Applications 4-Cyanophenylhydrazine Hydrochloride (cas# 2863-98-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,2-Diiodopropane is used in studying the Raman effect (isomerism rotation) and is used as a reagent in some synthetic preparations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kahovec, L., et al: Z. Physik. Chem., B47, 48 (1940); Charette, A., et al: Synlett, 1, 176 (2002)<br></p>

<p>Applications 3-(trifluoromethyl)oxetan-3-ol (cas# 1403676-72-1) is a useful research chemical.<br></p>

<p>Applications trans-2-(Chloromethyl)cyclohexanemethanol is an impurity of Lurasidone Hydrochloride (L474920), an antipsychotic used for treatment of schizophrenia.<br>References Ishiyama, T., et al.: Eur. J. Pharmacol., 572, 160 (2007); Cole, P., et al.: Drugs of the Fut., 33, 316 (2008)<br></p>

<p>Applications Ethyl 7-Chloro-2-oxoheptanoate is a reagent used in the synthesis of selective BCL-XL inhibitor A1155463 used in the treatment of cancer.<br>References Tao, Z. et al.: ACS Med. Cem. Lett., 5, 1088 (2014);<br></p>

<p>Applications 2-(2-bromo-6-chlorophenyl)acetic acid (cas# 37777-77-8) is a useful research chemical.<br></p>

<p>Applications 1-Bromo-3-(trifluoromethyl)benzene is used in the synthesis of calcium channel inhibitors for inflammatory and neuropathic pain.<br>References Beebe, X. et al.: Bioorg. Med. Chem. Lett., 23, 4857 (2013);<br></p>

<p>Applications It is reported that Dibutylcarbamoyl Chloride is used as a reagent for the preparation of 7-azaindole-1,3-dicarboxamide hydroxyethylamine which exhibited potent BACE-1 enzyme inhibition. Also it is used for the preparation of copper salicylaldehyde semicarbazone complex which showed cytotoxicity in human cancer cells.<br>References Marcin, L., et al.: Bioorg. Med. Chem. Lett.,21,537(2011); Lee, W., et al.:Metallomics,2,694(2010)<br></p>

<p>Applications 3-Fluoro-4-phenylphenol (cas# 477860-13-2) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications o-Bromophenoxyacetic acid<br></p>