Organic Halides

Applications 2-Chloro-4-fluorobenzoic Acid s a useful synthetic intermediate. It can be used to prepare aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists. It can also be used to synthesize (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as arginine vasopressin V2 receptor agonists.
References Barnett, H., et al.: Bioorg. Med. Chem. Lett., 19, 158 (2009); Tsukamoto, I., et al.: Bioog. Med. Chem., 16, 9524 (2008)

Applications Bis(2,4,5-tribromophenyl)iodonium Hydrogen Sulfate is an intermediate in the synthesis of 2,2',4,4',5,6'-Hexabromodiphenyl ether (H290745), which is a hepatotoxic polybrominated diphenyl ester (PBDE) that is commonly used as a flame retardant. 2,2',4,4',5,6'-Hexabromodiphenyl ether is also sometimes found in food and meats as well, posing a significant risk to humans (especially during pregnancy) and/or animals that consume it. One of the new POPs under the Stockholm Convention
References Johnson, P., et al.: Sci. Total Environ., No vol. given, 445 (2013); Scott, L., et al.: Organo. Comp., 74, 1109 (2012); Zhao, Y., et al.: Env. Sci. Tech., 47, 5939 (2013)

Applications Nonafluoropentanoic Anhydride is a useful compound in silicon-based energy storage devices.
References Ji, L., & Benjamin, Y.: U.S. Pat. Appl. Publ. (2020), US 20200203711 A1

Applications 1,3,5-Trichloro-2-nitrobenzene is a building block for organic synthesis.

Applications (4-(BROMOMETHYL)PHENYL)METHANOL (cas# 71831-21-5) is a useful research chemical.

Applications Isobutyryl chloride is a useful intermediate commonly used in synthetic chemistry. Isobutyryl chloride is also a potential inducer of pulmonary adenomas in strain A mice.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Theiss, J., et al.: Cancer Res., 39, 391 (1979)

Applications A phenylhydrazone derivative with fungicidal activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 1,2-Dibromo-4,5-dimethylbenzene is used as a reagent in the synthesis of Thalidomide (T338850); an inhibitor of FGF-induced angiogenesis and replication of human immunodeficiency virus type 1. Also a teratogenic sedative and immunomodulatory agent used primarily in combination with dexamethasone to treat multiple myeloma.
References Chen, J., et al.: Org. Biomol. Chem., 12, 5578 (2014); D’Amato, r.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 4082 (1994); Makonkawkeyoon, S., et al.: Proc. Natl. Acad. Sci. USA, 90, 5974 (1993); Schumacher, H., et al.: J. Pharmacol. Exp. Therap., 160, 189 (1968)

Applications 2,4-Dibromophenol Acetate (cas# 36914-79-1) is a compound useful in organic synthesis.

Applications 4-Chloro-2-nitrobenzenediazonium Chloride is reduced in the presence of hypophosphorous acid and carbon powder resulting in functionalized carbon powder with chloronitrophenyl groups attached on carbon particle surface;Also, it is an intermediate used in the synthesis of 2,4-Di-tert-butyl-6-(5-chloro-2H-benzotriazol-2-yl)phenol-d20 (D428017), which is an isotope labelled form of 2,4-Di-tert-butyl-6-(5-chloro-2H-benzotriazol-2-yl)phenol (D428015), which is a UV absorber.
References Pandurangappa, M., et al.: J. Solid State Electrochem., 12, 1411-1419 (2008); Moisan, J.: Eur. Polymer J., 16, 979 (1980); Nakata, H., et al.: Environ. Sci. Technol.,43, 6920 (2009)

Applications O-((Perfluorophenyl)methyl)hydroxylamine Hydrochloride functions as one of the substances used in the identification of stable cytotoxic factors in extracts of cigarette smoke and in the pharmacological characterization of their cytotoxicity.
References Noya Y., et al.: Toxicology, 314, 1 (2013)

Stability Store FROZEN
Applications Material that was assayed to be approximately 80% pure was diluted to 5% in benzene.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 4-Bromo-1-butyl Acetate is a useful synthetic intermediate. It was used in the synthesis of 9-alkylguanine derivative. It can also be used to prepare potent heat shock protein 90 inhibitors.
References Kjellberg, J., et al.: Tetrahedron Lett. 27, 877 (1986); Zhang, L., et al.: J. Med. Chem., 49, 5352 (2006)

Applications TETRABUTYLPHOSPHONIUM BROMIDE (cas# 3115-68-2) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-Bromoacetic Acid Phenylmethyl Ester is used in the synthesis of somatostatin analogues with tumor-targeting properties . Also used in the synthesis of inhibitors of phospholipase A2, indolizine and indene derivatives.
References Heppeler, A. et al.: Chem. A. Eur. J., 5, 1974 (1999); Hagishita, S. et al.: J. Med. Chem., 39, 3636 (1996);

Applications 2-Bromo-1-(4-chlorophenyl)propan-1-one

Applications 1-(4-CHLOROPHENYL)CYCLOBUTANAMINE HYDROCHLORIDE (cas# 1228878-71-4) is a useful research chemical.

Applications 1,1,1-Trifluoro-2-iodoethane (cas# 353-83-3) is a compound useful in organic synthesis.

Stability Hygroscopic
Applications 5-Chloro-2-Thiophenecarbonyl Chloride is a reagent in the synthesis of indolinyl-thiazole based inhibitors of cellular lipid uptake. Also used in the preparation of anticoagulants and such related promising drug candidates.
References Dockendorff, C. et al.: ACS Med. Chem. Lett.., 6, 375 (2015);

Applications (R)-(+)-2-Chloropropionic Acid (cas# 7474-05-7) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-Bromo-4-chloroanisole has been used as a reactant in the preparation of naphthyl phenyl ethers as nonnucleoside HIV-1 reverse transcriptase inhibitors.
References Gu, S., et. al.: Bioorg. Med. Chem., 19, 4220 (2011)

Applications 3-Aminobenzotrifluoride is a known human toxin that can cause bacterial mutation and hepatocyte unscheduled DNA synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Reinhold, D., et al.: T. ASAE, 49, 2077 (2006); Thompson, C., et al.: Environ. Mutagen., 5, 803 (1983)

Applications 1-Azido-3-chloro-2-propanol, Technical Grade (cas# 51275-91-3) is a compound useful in organic synthesis.

Applications [4-(Cyclopropylmethyl)phenyl]methanamine Hydrochloride is a useful research chemical for organic synthesis.

Applications (Chloromethyl)cyclopropane is a used as a reagent to synthesize 6-alkylamino-9-alkylpurines, compounds that have potential to be antipsychotic agents. (Chloromethyl)cyclopropane is also used as a reagent to prepare acylmorphinans, a class of compounds that have analgesic effects in rats.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kelley, J., et al.: J. Med. Chem., 40, 3207 (1997); Mohacsi, E., et al.: J. Med. Chem., 28, 1177 (1985)

Applications 3,5-Difluorobenzoic Acid can be used as reactant/reagent in Rh(III)-catalyzed regioselective heterocyclization of benzoic acids with acrylates to give phthalides with water as the solvent
References Zhu, Y., et al.: Eur J Org Chem, 2017, 806 (2017)

Applications 1-BROMODOCOSANE (cas# 6938-66-5) is a useful research chemical.

Applications Methyl 2-(4-Bromophenyl)-2,2-dimethylacetate (cas# 154825-97-5) is a compound useful in organic synthesis.

Applications Reagent used in the preparation of fluorescent dyes and indicators.
References Link, J., et al.: J. Med. Chem., 48, 5295 (2005), Martin, V., et al.: Bioorg. Med. Chem. Lett., 15, 1851 (2005),

Applications (Z)-Ethyl 4-(2-(tert-butoxy)-2-oxoethoxy)-2-(2-chlorobenzylidene)-3-oxobutanoate is an intermediate for the synthesis of O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine (D289480), which is the metablolite of Amlodipine (A633495), a long-acting calcium channel blocker that is commonly used as an anti-hypertensive in the treatment of cardiovascular conditions.
References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986), Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987), Haria, M., et al.: Drugs, 50, 560 (1995)

Applications 1-Bromo-2,4,6-trifluorobenzene

Applications 9-Fluorenemethanol is used in the design and in the synthesis of novel type somatostatin analogs with antiproliferative activities on A431 tumor cells.
References Miyazaki, A., et al.: Tetrahedron Lett., 45, 6323 (2004)

Applications 4,4-diethylcyclohexan-1-amine hydrochloride (cas# 1087747-58-7) is a useful research chemical.

Applications 2-[(Benzyloxycarbonyl)amino]-4,4,4-trifluorobutanoic acid is used in the preparation of benzamides and nicotinamides as spleen tyrosine kinase inhibitors.
References Jia, Z., et al.: PCT Int. Appl., 359 (2012)