Organic Halides

<p>Applications 4-Chloro-4'-hydroxybiphenyl (cas# 28034-99-3) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications (2,4-difluorophenyl)hydrazine is a reactant in the preparation of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists.<br>References Han, S., et. al.: Bioorg. Med. Chem. Lett., 25, 322 (2015)<br></p>

<p>Applications Methyl 5-cyano-2-fluorobenzoate<br></p>

<p>Applications 4-(2-Aminoethyl)-1,3-dihydro-2H-indol-2-one Hydrochloride, can be used for the synthesis of Ropinirole (R641000), which is an antiparkinsonian agent. It is also a selective dopamine D2-receptor agonist.<br>References Eden, R.J., et al.: Pharmacol. Biochem. Behav., 38, 147 (1991), Rascol, O., et al.: Mov. Disord., 13, 39 (1998),<br></p>

<p>Applications 3,4-Difluoro-1-nitrobenzene was used in the synthesis of nitrogen-carbon-linked (azolylphenyl)oxazolidinones with antibacterial activities. It was also used in the preparation of (homo)piperazinylphenyl- and piperidinylphenyl-substituted oxazolidinones with antibacterial activities.<br>References Genin, M., et al.: J. Med. Chem., 43, 953 (2000); Das, B., et al.: Bioorg. Med. Chem. Lett., 15, 4261 (2005)<br></p>

<p>Applications (3,3-Difluorocyclobutyl)methanamine hydrochloride (cas# 1159813-93-0) is a useful research chemical.<br></p>

<p>Applications Amino(3-​chlorophenyl)​acetic Acid functions as intermediate useful in the preparation of synthetic penicillins, also used in the structure-activity relationship examination of several drugs containing the benzyl moiety, their roles in biochemical and pharmacological processes.<br>References Hansch, C., et al.: J. Med. Chem., 13, 957 (1970); Holdrege, C. T., et al.: Can. (1975), CA 966853 A2 19750429;<br></p>

<p>Stability Moisture Sensitive<br>Applications Di-tert-butyl chloromethyl phosphate (cas# 229625-50-7) is a useful research chemical.<br></p>

<p>Stability Air Sensitive<br>Applications 4-IODO-2-NITROANILINE (cas# 20691-72-9) is a useful research chemical.<br></p>

<p>Applications A derivative of dioxane.<br></p>

<p>Applications 1,3,5-Tribromobenzene, is a reagent that can be used in the preparation of different inhibitors. It is also a substituted Bromobenzene, a general reagent in palladium-catalyzed reactions and in the synthesis of Grignard reagents.<br>References Miyaura, N. et al.: Synth. Commun., 11, 513 (1981); Nahm, S. et al.: Tetra. Lett., 22, 3815 (1981);<br></p>

<p>Applications 1-(4-Chlorophenyl)-2-(ethylamino)propan-1-one Hydrochloride is a derivative of Propiophenone (P827900) which is used in the preparation of pharmaceutical and organic compounds, perfumes, and the synthesis of neurochemical compounds such as ephedrines.<br>References Edkins, R.P. et al.: Quart. J. Pharm. Pharmacol., 9, 203 (1936); Sun, T.-Q. et al.: Zhong. Yiy. Gong. Zaz., 31, 534 (2000); Cherkaoui, H. et al.: Tetrahedron, 57, 2379 (2001);<br></p>

<p>Applications (3α,5β,7α)-24-Iodo-cholane-3,7-diol Diformate is an intermediate used in the synthesis of 3α,7α-Dihydroxycoprostanic Acid-d3 (D452517), which is a labelled analogue of 3α,7α-Dihydroxycoprostanic Acid (D452515), a precursor of Cholic Acid (C432600), it undergoes side chain oxidation during the synthesis of bile acids. It was found that Zellweger’s syndrome patients have abnormal mitochondrial structure, the organelle that is responsible for the side chain oxidation, and as a consequence, excess amounts of 3α,7α-Dihydroxycoprostanic Acid.<br>References Hanson, R. F., et al.: Science (Washington, DC, U. S.), 203, 1107 (1979)<br></p>