Nitrogen (N) Containing Building Blocks

<p>Applications 2,3-Piperazinedione is a metabolite of Ketoconazole (K186000), a broad-spectrum antifungal drug that inhibits steroid synthetic pathways and is used to treat patients with seborrheic dermatitis.<br>References Brown, M., et al.: Clin. Pharm. Ther., 37, 290 (1985); Edlund, P. &amp; Baranczewski, P.: J. Pharm. Biomed. Anal., 34, 1079 (2004); Skinner Jr., R., et al.: J. Am. Acad. Derm., 12, 852 (1985); Trachtenberg, J., et al.: J. Urology, 130, 152 (1983)<br></p>

<p>Applications 6S-Nalfurafine is a stereoisomer of Nalfurafine (N255600), a on-narcotic opioid drug for intractable itch caused by hemodialysis. It showed significant opioid κ-agonist activity and induced neither aversion nor preference in rats on the CPP (Conditioned Place Preference) test. Nalfurafine is a new therapeutic agent for the treatment of uremic pruritus in hemodialysis patients.<br>References Fujii, H., et al.: Bioorg. Med. Chem., 12, 4133 (2004); Mori, T., et al.: Life Sci., 75, 2433 (2004); Fujii, H., et al.: Curr. Med. Chem., 13, 1109 (2006); Nagase, H., et al.: Bioorg. Med. Chem. Lett., 20, 6302 (2010)<br></p>

<p>Applications 4-Ethyl-1,3-dihydro-2H-indol-2-one is an impurity of Ropinirole (R641000).<br></p>

<p>Applications 2-PHENYLNICOTINIC ACID (cas# 33421-39-5) is a useful research chemical.<br></p>

<p>Applications N-[(R)-1-Phenylethyl]acetamide (cas# 36283-44-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Hydroxyimino-3-pentanone is an intermediate in the preparation of indole derivatives.<br>References Goya, P., et al.: J. Med. Chem., 35, 3977 (1992), Masaguer, C., et al.: Chem. Pharm. Bull., 47, 621 (1999), Wu, S., et al.: Bioorg. Med. Chem. Lett., 16, 5859 (2006),<br></p>

<p>Applications (±)-1-Hydroxy Mephedrone Hydrochloride is a metabolite of Mephedrone Hydrochloride (M224200), a stimulant drug related to cathinone and methcathinone. The effects of Mephedrone are reportedly comparable to those of similar drugs such as MDMA and methylone.<br></p>

<p>Applications 2Z-Nalfurafine is a geometric isomer of Nalfurafine (N255600), a on-narcotic opioid drug for intractable itch caused by hemodialysis. It showed significant opioid κ-agonist activity and induced neither aversion nor preference in rats on the CPP (Conditioned Place Preference) test. Nalfurafine is a new therapeutic agent for the treatment of uremic pruritus in hemodialysis patients.<br>References Fujii, H., et al.: Bioorg. Med. Chem., 12, 4133 (2004); Mori, T., et al.: Life Sci., 75, 2433 (2004); Fujii, H., et al.: Curr. Med. Chem., 13, 1109 (2006); Nagase, H., et al.: Bioorg. Med. Chem. Lett., 20, 6302 (2010)<br></p>

<p>Applications Reagent used for asymmetric syntheses.<br>References Schlessinger, R., et al.: J. Org. Chem., 28, 3070 (1986)<br></p>