Cancer Research

<p>Stability Reacts with DMSO<br>Applications A metabolite of Cyclophosphamide (C988580).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bohnenstengel, F., et al.: Eur. J. Clin. Pharmacol., 51, 297 (1996), Busse, D., et al.: J. Clin. Oncol., 15, 188 (1997), Roy, P., et al.: Drug Metab. Dispos., 27, 655 (1999),<br></p>

<p>Applications (2R,3S)-N-Benzoyl-3-phenyl Isoserine Methyl Ester is an intermediate in the preparation of potent anticancer drug Paclitaxel (P132500) used to study the location of the binding sites.<br>References Paal, K. et al.: Bioorg. Med. Chem., 15, 1323 (2007); Krawczyk, E. et al.: J. Pharm. Pharmacol., 57, 791 (2005);<br></p>

<p>Impurity Anastrozole Monoamide Impurity<br>Applications Anastrozole Monoamide is a derivative of Anastrozole (A637425), an aromatase inhibitor. Used as an antineoplastic.<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>

<p>Applications A major metabolite of Irinotecan.<br>References Canal, P., et al.: J. Clin. Oncol., 14, 2688 (1996), Haaz, M., et al.: Cancer Res., 58, 468 (1998), Kehrer, D., et al.: Clin. Cancer Res., 6, 3451 (2000), Hanioka, N., et al.: Xenobiotica, 31, 687 (2001), Satoh, T., et al.: Drug Metab. Dispos., 30, 488 (2002),<br></p>

<p>Applications cis-Etoposide is an anticancer agent that has half-life of 2 days at pH 7.4 and 37° resulting in the loss of 90% of the active drug within 1 week during in vitro incubations.<br>References Mader, R. M., et al.: Cancer Chemotherapy and Pharmacol., 27, 354 (1991)<br></p>

<p>Applications N2'-Deacetyl-N2'-[3-(methylthio)-1-oxopropyl]-maytansine is an active metabolite of Maytansine (M197940), inhibits in vitro polymerization of tubulin and is used in the treatment of advanced breast cancer.<br>References Remillard, S., et. al.: Science, 189, 1002 (1975); Prota, A.E., et. al.: P. Natl. Acad. Sci. USA, 111, 13817 (2014)<br></p>

<p>Applications Anastrozole Acid Amide is a derivative of Anastrozole (A637425), an aromatase inhibitor. Used as an antineoplastic.<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>

<p>Applications Melphalan is an antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ross, W.C.J., et al.: Biochem. Pharmacol., 13, 969 (1964); Donelli, M.G., et al.: J. Pharm. Pharmacol., 18, 760 (1966), Furner, R.L., et al.: Cancer Treat. Rep., 64, 559 (1980),<br></p>

<p>Applications Labelled Dodecyl Phthalate (D525380). Dodecyl Phthalate is used in the preparation of Cytarabine (C998100) derivatives as anticancer agents.<br>References Aoshima, M., et al.: Cancer Res., 36, 2726 (1976), Wang, N., et al.: Bioorg. Med. Chem. Lett., 15, 4064 (2005), Marie-Helene, G., et al.: Bioorg. Med. Chem., 2009, 17, 6340 (2009),<br></p>

<p>Applications A coordination compound for treatment of cervix cancer.<br>References Jiang, M., et al.: Methods Mol. Biol., 292, 401 (2005), Fujii, T., et al.: Int. J. Oncol., 29, 541 (2006), Niu, X., et al.: Int. J. Gynecol. Cancer, 16, 743 (2006),<br></p>

<p>Applications N-Demethyl-3-methoxy-4-hydroxytamoxifen is an metabolite of Tamoxifen (T006000), a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor.<br>References Zhang, F., et al.: Chem. Rs. Toxicol., 13, 53 (2000); Sutherland, R., et al.: Nature, 267, 434 (1977); Lerner, L., et al.: Cancer Res., 50, 4177 (1990); Love, R., et al.: J. Clin. Oncol., 20 2559 (2002)<br></p>