CAS 59-05-2

Methotrexate

Description:

Methotrexate is a potent antimetabolite and immunosuppressive agent primarily used in the treatment of certain cancers, autoimmune diseases, and ectopic pregnancies. Its chemical formula is C20H22N8O5S, and it features a pteridine ring structure, which is crucial for its mechanism of action. Methotrexate functions by inhibiting the enzyme dihydrofolate reductase, thereby disrupting the synthesis of nucleotides and ultimately affecting DNA replication and cell division. This makes it particularly effective against rapidly dividing cells, such as those found in tumors. Methotrexate is administered in various forms, including oral tablets and injectable solutions, and its pharmacokinetics can vary based on the route of administration. The drug is known for its potential side effects, which can include gastrointestinal disturbances, liver toxicity, and bone marrow suppression. Due to its immunosuppressive properties, careful monitoring is essential during treatment to manage adverse effects and interactions with other medications. Methotrexate's use in lower doses for autoimmune conditions highlights its versatility in clinical applications.

Formula: C₂₀H₂₂N₈O₅

InChI: InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1

InChI key: InChIKey=FBOZXECLQNJBKD-ZDUSSCGKSA-N

SMILES: NC=1C2=C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1

Synonyms:

• (+)-4-Amino-10-Methylfolic Acid
• (+)-Amethopterin
• (2S)-2-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]pentanedioic acid
• 4-Amino-1
• 4-Amino-4-Deoxy-N(Sup10
• 4-Amino-4-Deoxy-N(Sup10)Methylpteroylglutamic Acid
• 4-Amino-N 10-Methylpteroyl-L-Glutamic Acid
• 4-Amino-N10-methylfolic acid
• 4-Amino-N10-methylpteroylglutamic acid
• 4-Amino-N¹⁰-methylfolic acid
• 4-Amino-N¹⁰-methylpteroylglutamic acid
• <span class="text-smallcaps">L</span>-Amethopterin
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
• <span class="text-smallcaps">L</span>-Methotrexate
• Amethopterine
• Antifolan
• Caditrex
• Cl 14377
• Emt 25299
• Emtexate
• Emthexate PF
• Emtrexate
• Folex
• Folex PFS
• Folitrax
• Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, <span class="text-smallcaps">L</span>-(+)-
• Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)-
• Jylamvo
• L-(+)-Amethopterin
• L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
• L-Methotrexate
• Ledertrexate
• Merex
• Metatrexan
• Methocel
• Methocip
• Methotrexat
• Methotrexat-Ebewe
• Methotrexate LPF
• Methoxtrexate
• Methylaminopterin
• Methylaminopterine
• Methylpteroylglutamate
• Methylpteroylglutamic Acid
• Metorex
• Metotrexato
• Mexate
• Mexate-AQ
• Mtx
• N-(P-(((2,4-Diamino-6-Pteridinyl)Methyl)Methylamino)Benzoyl)-L-Glutamic Acid
• N-[4-[[(2,4-Diamino-6-Pteridinyl)Methyl]Methylamino]Benzoyl]-L-Glutamic Acid
• N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[p-[[2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">L</span>-(+)-glutamic acid
• Nordimet
• Nsc 740
• Oncotrex
• R 9985
• Remtrex
• Rheumatrex
• Trexall
• Trilem

Methotrexate

CAS: 59-05-2

Methotrexate is used as s cell cycle arresting agent that inhibits DHFR. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate is one of the most effective and widely use

Formula: C₂₀H₂₂N₈O₅

Color and Shape: Yellow or yellow-orange, Powder or crystalline powder

Molecular weight: 454.45

Ref: 02-J63075

METHOTREXATE RS

CAS: 59-05-2

METHOTREXATE RS

Formula: C₂₀H₂₂N₈O₅

Molecular weight: 454.4393

Ref: 41-ICRS0345

METHOTREXATE FOR PEAK IDENTIFICATION CRS

CAS: 59-05-2

METHOTREXATE FOR PEAK IDENTIFICATION CRS

Formula: C₂₀H₂₂N₈O₅

Molecular weight: 454.4393

Ref: 41-Y0000602

METHOTREXATE CRS

CAS: 59-05-2

METHOTREXATE CRS

Formula: C₂₀H₂₂N₈O₅

Color and Shape: Crystalline Powder. Yellow. Orange. Powder.

Molecular weight: 454.4393

Ref: 41-M1000000

Methotrexate

CAS: 59-05-2

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₂₀H₂₂N₈O₅

Color and Shape: Yellow Brown Orange Powder

Molecular weight: 454.17132

Ref: 45-1414003

Methotrexate

CAS: 59-05-2

Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR.

Formula: C₂₀H₂₂N₈O₅

Purity: 96.84% - 99.91%

Color and Shape: Orange-Brown Crystalline Powder Chemotherapy Drug That Interferes With Dna And Rna Synthesis

Molecular weight: 454.44

Ref: TM-T1485

Methotrexate

CAS: 59-05-2

Methotrexate

Formula: C₂₀H₂₂N₈O₅

Purity: By hplc: 98.13% (Typical Value in Batch COA)

Color and Shape: Yellow Solid-Powder

Molecular weight: 454.43927

Ref: 54-BIM0130

(S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid

CAS: 59-05-2

Formula: C₂₀H₂₂N₈O₅

Purity: 99%

Color and Shape: Solid

Molecular weight: 454.4393

Ref: IN-DA0039PY

Methotrexate

CAS: 59-05-2

Formula: C₂₀H₂₂N₈O₅

Color and Shape: Yellow Solid

Molecular weight: 454.45

Ref: 4Z-M-701

Methotrexate

CAS: 59-05-2

Methotrexate

Formula: C₂₀H₂₂N₈O₅

Purity: ≥95%

Molecular weight: 454.44

Ref: 54-BUP17033

Methotrexate

Controlled Product

CAS: 59-05-2

Formula: C₂₀H₂₂N₈O₅

Color and Shape: Neat

Molecular weight: 454.44

Ref: 04-C15056900

Methotrexate

CAS: 59-05-2

Color and Shape: Neat

Ref: 61-FOR0040.00

Methotrexate (Standard)

CAS: 59-05-2

Methotrexate (Standard) is a reference standard for research and analysis in studies involving Methotrexate. Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors.

Formula: C₂₀H₂₂N₈O₅

Color and Shape: Solid

Molecular weight: 454.44

Ref: TM-TMSM-3414

Methotrexate

Controlled Product

CAS: 59-05-2

Formula: C₂₀H₂₂N₈O₅

Color and Shape: Neat

Molecular weight: 454.44

Ref: 86-MM0040.00

Methotrexate

CAS: 59-05-2

(S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid

Formula: C₂₀H₂₂N₈O₅

Purity: 99% (contain ~10%water)

Molecular weight: 454.44

Ref: IN-DG43028

Methotrexate Heptaglutamate Trifluoroacetate

CAS: 59-05-2

Formula: C₅₀H₆₄N₁₄O₂₃·C₂HF₃O₂

Molecular weight: 1229.14

Ref: 4Z-M-7026

Methotrexate RS

CAS: 59-05-2

Color and Shape: From Yellow To Brownish Orange Solid Powder

Ref: 2K-116700002

Methotrexate (1.0mg/mL in Methanol with 0.1N NaOH)

CAS: 59-05-2

Formula: C₂₀H₂₂N₈O₅

Ref: TR-KIT0310-1ML

Methotrexate Heptaglutamate Trifluoroacetate

Controlled Product

CAS: 59-05-2

Formula: C₅₀H₆₄N₁₄O₂₃xC₂HF₃O₂

Color and Shape: Neat

Molecular weight: 1229.12

Ref: TR-M260690

Methotrexate

CAS: 59-05-2

Stability Hygroscopic
Applications A Folic acid antagonist. Used as a antineoplastic and antirheumatic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),

Formula: C₂₀H₂₂N₈O₅

Color and Shape: Neat

Molecular weight: 454.44

Ref: TR-M260675