Toxicology

<p>Applications (2R,4R)-Itraconazole (Mixture of Diastereomers) is an enantiomer of Itraconazole (I937500), an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.<br>References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),<br></p>

<p>Applications A labelled impurity of Gatifloxacin.<br>References Naber, C., et al.: Antimicrob. Agents Chemother., 45, 293 (2001), Herzler, M., et al.: J. Anal. Toxicol., 27, 233(2003), Pragst, F., et al.: Clin. Chem. Lab. Med., 42, 1325 (2004),<br></p>

<p>Applications 5-epi Emtricitabine is an epimer of Emtricitabine (E525000), a nucleoside reverse transcriptase inhibitor approved for treatment of human immunodeficiency virus (HIV) 1, and also has antagonistic activity against the hepatitis B virus. 5-epi Emtricitabine is also used as a reagent for the synthesis of β-L-(2R,5S)- and α-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential HIV agents.<br>References Jeong, L., et al.: J. Med. Chem., 36, 181 (1993); Lim, S. et al.: Arch. Intern. Med., 166, 49 (2006); Smith, K., et al.: AIDS, 23, 1547 (2009)<br></p>

<p>Applications Deschloroacetylmetolachlor Propanol is a pesticide that is detected in drinking water.<br>References Hladik, Michelle L. et al., Water Research. 42, 4905-4914(2008);<br></p>

<p>Applications Furamidine is a diphenylfuran compound belonging to an important class of antimicrobial and antiparasitic agents. Furamidine and its analogues also display antitumor activities and showed antiproliferative activities against various tumor cell lines.<br>References Lansiaux, A. et al.: Cancer Res., 62, 7219 (2002); Steck E.A. et al.: Exp. Parasitol., 52, 404 (1981); Balzarini, J. et al.: Incest. New Drugs, 1, 103 (1983);<br></p>

<p>Applications 6-Methyl-3,6-diazabicyclo[3.1.1]heptane is a useful research chemical.<br></p>

<p>Applications Intermediate in the preparation of antifungal agents.<br>References Saksena, A., et al.: Bioorg. Med. Chem. Lett., 4, 2023 (1994),<br></p>

<p>Applications N-Oxacilloilyl (+)-6-Aminopenicillanic Acid Disodium Salt is a derivative of Oxacillin which is used as an antibiotic related to Penicillin. Antibacterial.<br>References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971);<br></p>

<p>Applications 6-Hydroxy Albaconazole-d3, is the labeled analogue of 6-Hydroxy Albaconazole (H761395), a metabolite of Albaconazole (H761395), an antifungal agent as neuroprotectant.<br>References Pujol, I., et al.: J. Antimicrob. Chemother., 39, 163 (1997), Gilgado, F., et al.: J. Clin. Microbiol., 43, 4930 (2005), Raad, I., et al.: Clin. Infect. Dis., 42, 1398 (2006), Nucci, M., et al.: Clin. Microbiol. Rev., 20, 695 (2007),<br></p>

<p>Applications A protected metabolite of Testosterone (T155000) in humans and animals.<br>References Demisch, K. et al.: Eur. J. Biochem., 8, 284 (1969); Fernandez, C. et al.: J Chrom. B Biomed. Appl., 677, 363 (1996); Capolongo, F. et al.: J. Vet. Pharmacol. Therap., 26, 160 (2003);<br></p>

<p>Applications 17α-Testosterone-16,16,17-d3 Cypionate is the isotope labelled analog of 17α-Testosterone Cypionate (T155155); the 17α-isomer of Testosterone Cypionate (T155100) which is an anabolic steroid with androgenic properties. Also used for testosterone therapy in males with hypogonadism.<br>References Rabkin, J.G. et al.: J. Clin. Psychopharmacol., 19, 19 (1999); Hajjar, R. et al.: J. Clin. Endocrinol. Metab., 82, 3793 (1997); Rhoden, E. et al.: J. Sex Med., 7, 277 (2010)<br></p>

<p>Stability Light Sensitive<br>Applications Efavirenz 1-Desamine is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>

<p>Applications A key intermediate in production of HCV (Hepatitis C virus) antivirals.<br>References McGowan, D., et al.: Bioorg. Med. Chem. Lett., 19, 2492 (2009), Birch, A., et al.: J. Med. Chem., 52, 1558 (2009),<br></p>

<p>Applications An anti-inflammatory corticosteroid.<br>References Weber, D., et al.: J. Pharm. Sci., 61, 689 (1972), Biagi, G., et al.: J. Med. Chem., 18, 873 (1975),<br></p>

<p>Applications Eicosapentaenoyl Ethanolamide inhibits dietary-restriction-induced lifespan extension in wild type and TOR pathway mutant nematodes.<br>References Lucanic, M., et al.: Nature, 473, 226 (2011)<br></p>

<p>Applications An amine reactive trifunctional cross linker.<br></p>

<p>Applications (S)-10-Monohydroxy-10,11-dihydro Carbamazepine-D3 is a labelled analogue of (S)-10-Monohydroxy-10,11-dihydro Carbamazepine (M546510), a metabolite of Eslicarbazepine acetate (E659000) a novel central nervous system drug.<br>References Duncan, J., et al.: Br. J. Clin. Pharmacol., 53, 123 (2002), Almeida, L., et al.: J. Clin. Pharmacol., 45, 1062 (2005), Coppola, G., et al.: CNS Drugs, 18, 133 (2004),<br></p>

<p>Impurity Fluconazole EP Impurity A<br>Applications Iso Fluconazole (Fluconazole EP Impurity A) is an impurity of Fluconazole (F421000). Fluconazole USP impurity A.<br>References Rogers, T., et al.: Antimicrob. Agents Chemother., 30, 418 (1986), Itoh, H., et al.: Chem. Pharmaceut. Bull., 48, 1148 (2000),<br></p>

<p>Applications 17α-Testosterone Cypionate is the 17α-isomer of Testosterone Cypionate (T155100); an anabolic steroid with androgenic properties. Also used for testosterone therapy in males with hypogonadism.<br>References Rabkin, J.G. et al.: J. Clin. Psychopharmacol., 19, 19 (1999); Hajjar, R. et al.: J. Clin. Endocrinol. Metab., 82, 3793 (1997); Rhoden, E. et al.: J. Sex Med., 7, 277 (2010)<br></p>

<p>Applications 1,2-benzisoxazol-3-amine (cas# 36216-80-5) is a useful research chemical.<br></p>

<p>Applications 4-(8-Chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl Benzoate is an protected intermediate in the synthesis of Desloratadine (D290250), an nonsedating-type histamine H1-receptor antagonist.<br></p>

<p>Applications 13-O-Ethylamphotericin B is an analogue of 13-O-Methylamphotericin B (M287440), an antifungal. 13-O-Methylamphotericin B is a derivative of Amphotericin B (A634250), a polypeptide antibiotic active against gram positive bacteria. Antifungal.<br>References Taylor, A.W., et. al.: J. Antibiot., 46, 486 (1993); Asher, I.M., et al.: Anal. Profiles Drug Subs., 6, 1, (1977)<br></p>

<p>Applications An impurity of Docetaxel (D494420).<br>References Zamir, L., et al.: Tetrahedron Lett., 33, 5173 (1992), Gueritte-Voegelein, F., et al.: J. Med. Chem., 34, 992 (1993), Volk, K., et al.: J. Chromatogr., 696, 99 (1997),<br></p>

<p>Applications (17β)-9-Hydroperoxyestradiol is an intermediate in the synthesis of [1S-(1α,3aβ,4β,7aα)]-4-[2-(2,5-Dihydroxyphenyl)ethyl]octahydro-1-hydroxy-7a-methyl-5H-inden-5-one (D458310), an estradiol impurity.<br></p>

<p>Applications Malonic Acid-2-13C is labelled Malonic Acid (M158005) which is a small bioactive molecule, that can be used in variuos reactions. It is the classic example of a competitive inhibitor, which acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain.<br>References Weiner, N., "Malonic acid", Org. Synth.; Coll. Vol. 2: 376;<br></p>

<p>Applications Estradiol 6-N3-Adenine is a depurinating adduct that is created by the interaction of specific metabolites of estrogens in the body with DNA. Unfortunately, these adducts are endogeneous initiators of various human cancers, such as breast &amp; prostate.<br>References Yang, L., et al.: Prostate, 69, 41 (2009); Zahid, M., et al.: Chem. Res. Toxicol., 19, 164 (2006); Zhang, Y., et al.: Metabol. Clin. Exp., 56, 887 (2007)<br></p>

<p>Applications Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir is an intermediate for the synthesis of Atazanavir (A790051) and the preparation of some peptide analogs.<br>References Martin, J., et al.: Prog. Med. Chem., 32, 239 (1995), Jadhav, P., et al.: J. Med. Chem., 40, 181 (1997), Bold, G., et al.: J. Med. Chem., 41, 3387 (1998);<br></p>

<p>Applications β-Amyrin is used as a protein tyrosine phosphatase 1B inhibitor with potential treatment towards diabetes. Also used in the synthesis of HIV-1 integrase inhibitory compounds based upon plant extracts.<br>References Zhang, Y. et al.: Bioorg, Med. Chem., 16, 8697 (2008); Tewtrakul, S. et al.: Phytother. Res., 17, 232 (2003);<br></p>

<p>Applications 5-Chloro-2-furancarbonyl Fluticasone Furoate is a Fluticasone Furoate(F599510) raw material impurity which is a synthetic corticosteroid derived from fluticasone for treatment of seasonal allergic rhinitis.<br>References DeWester, J., et al.: Allergy Asthma Proc., 24, 331 (2003), Hughes, S., et al.: Drug Metab. Dispos., 36, 2337 (2008), Meltzer, E., et al.: Clin. Drug Investig., 29, 79 (2009),<br></p>

<p>Applications Linear Daptomycin Hydrochloride Salt is the hydrochloride salt of L466470, which is the open-conformation of Daptomycin (D193350), cyclic lipopeptide antibiotic derived from a fermentation product of Streptomyces roseosporus; disrupts plasma membrane function in gram-positive bacteria. Antibacterial. Daptomycin Impurity<br>References Allen, N.E., et al.: Antimicrob. Agents Chemother., 31, 1093 (1987), Tully, F.P., et al.: Expert Opin. Invest. Drugs, 8, 1223 (1999),<br></p>

<p>Applications N2-Acetyl Acyclovir Benzoate-d5 is the isotope labelled analog of N2-Acetyl Acyclovir Benzoate (A167975); a derivative of Acyclovir (A192400) which is an orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. Also an antiviral.<br>References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992); Ashton, D.S., et al.: J. Chromatogr. A, 707, 367 (1995)<br></p>

<p>Applications 2-O-Methyl-β-D-N-acetylneuraminic Acid Sodium Salt, is a model compound for studies of binding of influenza virus hemaglutinin and metal ions.<br>References Sauter, N.K., et al.: Biochemistry, 28, 8388 (1989), Sharon, N., et al.: Science, 246, 227 (1989), Nagy, J.O., et al.: J. Med. Chem., 35 (23), (1992), Knibbs, R.N., et al.: J. Biol. Chem., 268 (25), 18524 (1993)<br></p>

<p>Applications N-[(1R,2R)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of 1-epi-Darvunavir (D193505), a second generation HIV-1-protease inhibitor.<br></p>

<p>Applications 2-Nitromorphine is an intermediate in the synthesis of 3-O-(Codein-2-yl)morphine (C634500), an impurity of Codeine (C634075).<br>References Chatterjie, N., et al.: Syn. Commun., 9, 647 (1979);<br></p>