Toxicology

<p>Applications Morphazinamide is an anti-tuberculosis agent. Also, it is derived from Pyrazinamide (P840600), which is an anti-bacterial (tuberculostatic).<br>References Gennaro, M. C., et al.: J. Chromatogr. B Biomed. Sci. Appl., 754, 477-486 (2001); Weiner, I.M., et al.: J. Pharmacol. Exp. Ther., 180, 411 (1972), Feldner, E., et al.: Anal. Profiles Drug Subs., 12, 433 (1983)<br></p>

<p>Applications 4-​[3-Fluoro-​4-​(methoxycarbonyl)​phenyl]​-​1,​1-​dimethylethyl Ester 1-​Piperazinecarboxylic Acid is used in the binding envelope of cytochrome P 450 51 inhibitors targeting Trypanosoma cruzi with 4-aminopyridyl-based sulfonamide derivatives.<br>References Vieira, Debora F. et al., ChemBioChem. 8,1111-1120(2014);<br></p>

<p>Applications Chlorflurenol-methyl is an auxin polar transport inhibitor that effects elongation growth of the excised fourth internode of tulips. As well as a pesticide.<br>References Wegrzynowicz-Lesiak, E., et al.: J. Hort. Res., 21, 31-39 (2013);<br></p>

<p>Applications Protected Rosuvastatin (R700500).<br></p>

<p>Applications A Quinidine labelled metabolite.<br>References Small, D.L., J. Chem. Med., 22,1014 (1979), Guentert, T.W., et al.: Eur. J. Drug Metab. Pharmacokinet., 7, 31 (1982), Chang, Y.F., et al.: Neurochem. Res., 13, 455 (1988),<br></p>

<p>Applications 4,4'-Dichlorodiphenyltrichloroethane - D8 is a synthetic organochlorine insecticide. 4,4'-Dichlorodiphenyltrichloroethane - D8 functions by opening sodium ion channels in the insects’ neurons, causing them to fire spontaneously which in turn leads to death. 4,4'-Dichlorodiphenyltrichloroethane - D8 is banned for agricultural use in North America, it is still commonly used in some countries and particularly as a means of malaria control.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Balkew, M. et al.: Paras. Vect., 3, No pp. given (2010); Kikankie, C.K. et al.: Malaria J., 9, No pp. given. (2010); Battu, R.S. et al.: Sci. Total Environ., 78, 173 (1989).<br></p>

<p>Stability Hygroscopic<br>Applications Atorvastatin impurity in bulk drug and tablets.<br>References Posvar, E., et al.: J. Clin. Pharmacol., 36, 728 (1996), Lea, A., et al.: Drugs, 53, 828 (1997), Miao, X., et al.: J. Chromatogr., 998, 133 (2003),<br></p>

<p>Applications Propachlor ESA Sodium Salt is an amido sulfonate compound used as an analytical standard.<br>References Cheng, X., et al.: J. Agric. Food Chem., 58, 4588-4593 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications The hydrochloride salt of AZ 5104 (A795170), which is a derivative of AZD 9291 (A808075) and a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).<br>References Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);<br></p>

<p>Applications trans-Methacrifos is used as a pesticide used to protect crops and vegetation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tigar, B. et al.: Pest. Sci., 25, 175 (1989);<br></p>

<p>Applications Contolled substance. Testosterone (T155000) derivative.<br></p>

<p>Applications 5-Hydroxytryptophol Sulfate is a metabolite of serotonin (S274980), a monoamine neurotransmitter.<br>References Kuraishi, Y., et al.: Biol. Pharm. Bull., 31, 2143 (2008); Morera, E., et al.: Bioorg. Med. Chem. Lett., 19, 6806 (2009); Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010);<br></p>

<p>Applications Prothioconazole S-Glucuronide is derived from Prothioconazole (P838830), which is an antifungal metabolite used in agricultural fungicides and herbicides.<br>References Aristimuno Ficoseco, M.E., et al.: Nat. Prod. Res (2016)<br></p>

<p>Stability Hygroscopic<br>Applications Diquafosol Sodium Salt, is a dinucleoside derivative of uridine that acts as a selective P2Y2 receptor agonist. Diquafosol is used as a therapeutic agent in the treatment of dry eye syndrome.<br>References Peral, A. et al.: Drugs News Pers., 2, 166 (2008); Vallejo, C.G. et al.: Biochim. Biophys. Acta Enzymol., 438, 304 (1976);<br></p>

<p>Applications 2-Butyl-2-(2,4-dichlorophenyl)oxirane is an impurity of Hexaconazole (H293555), a fungicide of the triazole class. Hexaconazole has a broad spectrum antifungal activity and is commonly used in the control of apple, coffee and peanut diseases.<br>References Brown, M.C. et al.: Bright. Crop Prot. Conf. Pest. Dis., 1, 229 (1988); Gozzo, F. et al.: Pest. Biochem. Physiol., 40, 68 (1991)<br></p>

<p>Applications A metabolite of Cholesterol.<br>References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969), Nestel, P., et al.: Metabolism, 24, 189 (1975), Ellegard, L., et al.: Eur. J. Clin. Nutr., 45, 451 (1991), Pedersen, A., et al.: J. Lipid Res., 41, 1901 (2000),<br></p>

<p>Stability Hygroscopic<br>Applications Dopexamine is a synthetic dopamine analog and acts as a a β2-adrenergic receptor agonistt as well as an agonist at peripheral dopamine receptors. Dopexamine has been used to improve myocardial and renal performance in patients suffering from low cardiac output states.<br>References Brown, R.A. et al.: Br. J. Pharmacol., 85, 599 (1985); Napoleone, P. et al.: Nephron, 65, 385 (1993);<br></p>

<p>Applications Lupeol-d3 is the isotope labelled analog of Lupeol (L474850); a pentacyclic triterpene that is used as a therapeutic and chemopreventive agent for the treatment of inflammation and cancer.<br>References Geetha, T., et al.: J. Ethnopharmacol., 76, 77 (2001); Saleem, M., et al.: Cancer Lett., 285, 109 (2009)<br></p>

<p>Stability Moisture Sensitive<br>Applications trans-Crotoxyphos is an organophosphorous insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nillos, M.G., et. al.: Environ. Toxicol. Chem., 26, 1949 (2007); Miller, J.A., et. al.: J. Control Release, 8, 73 (1988)<br></p>

<p>Applications 1,1,2,3,4,5,6-Heptachlorocyclohexane is an organochloride which is one of the isomers of hexachlorocyclohexane and is an byproduct of insecticide Lindane (L465990).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bist, R., et al.: Int. J. Pharm. Pharma. Sci., 4, 117 (2012); Heinz, M., et al.: Human. Health. Handbook., 1, 355 (2012); Bay, S.M., et al.: Enviro. Toxciol. Chem., 31, 2711 (2012);<br></p>

<p>Applications Systemic fungicide for control of powdery mildew, rust in cereal crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baloch, R.I., et al.: Phytochemistry, 23, 2219 (1984), Pommer, E.-H., et al.: Pestic. Sci., 15, 285 (1984),<br></p>

<p>Applications Clopidogrel derivative.<br></p>

<p>Applications Benzyl-alpha-alpha-d2 Chloride (CAS# 33712-34-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Bromoaniline is a brominated aniline used as a building block in the preparation or pharmaceutial and organic compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abdel-M. et al.: J. Org. Chem., 61, 3849 (1996); Sridhar, S.. et al.: Eur. J. Med. Chem., 36, 615 (2001);<br></p>

<p>Applications rel-(R*,R*)-Bicalutamide Sulfoxide is an diastereomeric bicalutamide (B382000) derivative.<br>References Li, Wei., et al.: Chirality., 21, 578 (2009);<br></p>

<p>Applications Protected Propofol metabolite.<br></p>

<p>Applications Tecloftalam is an agrochemical fungicide. Tecloftalam is used for the control of rice bacterial leaf blight.<br>References Nakagami, K. et al.: Nip. Noyak. Gak., 5, 511 (1980); Kirkpatrick, D. et al.: J. Agric. Food Chem., 29, 608 (1981); Takahi, Y. et al.: Jap. Past. Info., 46, 25 (1985);<br></p>