Toxicology

<p>Applications 17β-neriifolin could be considered a candidate for the treatment of hepatocellular carcinoma. It can also work as an inhibitor of hERG channel trafficking.<br>References Zhao, Q., et al.:Fitoterapia, 82, 735 (2011); Wang, L., et al.: J. Pharmacol. Exper. Ther., 320, 525 (2007)<br></p>

<p>Applications Cloticasone is an intermediate in the synthesis of Fluticasone Propionate.<br>References Meltzer, E.O., et al.: J. Allergy Clin. Immunol., 86, 221 (1990), Mitchison, H.C., et al.: Gut, 32, 260 (1991), Phillipps, G.H., et al.: J. Med. Chem., 37, 3717 (1994)<br></p>

<p>Applications Phenindione is a proton pump inhibitor and traditional nonsteroidal anti-inflammatory drug used for acute interstitial nephritis and acute kidney injury.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Leonard, C.E., et al.: Pharmacoepidemiol. Drug. Safety., 21, 1155 (2012); Moda, T.L., et al.: Bioorg. Med. Chem. Lett., 22, 2889 (2012); Dhareshwar, S.S., et al.: J. Pharma. Sci., 99, 2711 (2010);<br></p>

<p>Applications 4-Hydroxy Flecainide is an analogue of Flecainide (F390000).<br>References Blom, Y., et al.: J. Chromatogr., 653, 138 (1993),<br></p>

<p>Applications 1-Chloro-1-desmethylpiperazinyl-bosutinib is a useful intermediate in the green preparation of the anti-tumor agent Bosutinib (B676095). It is a COVID19-related research product.<br>References Mao, Y., et al.: Synthesis, 47, 3133 (2015); Chen, H., et al.: Zhongguo Yiyao Gongye Zazhi, 44, 1086 (2013); Yin, X. J., et al.: Molecules, 4261 (2010)<br></p>

<p>Stability Acid Sensitive<br>Applications 17β-(Trimethylsiloxy)testosterone is an anabolic steriod, and a derivative compound of Testosterone (T155000), Principal hormone of the testes, produced by the interstitial cells. Major circulating androgen; converted by 5α-reductase in androgen-dependent target tissues to 5α-dehydrotestosterone which is required for normal male sexual differentiation. Also converted by aromatization to Estradiol.Testerone is a controlled substance (anabolic steroid). Androgen.<br>References McFarland, K., et al.: Science, 245, 494 (1989), Heckert, L., et al.: Mol. Endocrinol., 12, 1499 (1998), Themmen, A., et al.: Endocr. Rev. 21, 551 (2000), Kumar, R., et al.: Biol. Reprod., 65, 710 (2001),<br></p>

<p>Applications (3R,5S)-5-(6-Cyclopropyl-10-fluoro-7,8-dihydrobenzo[k]phenanthridin-8-yl)-3,5-dihydroxypentanoic Acid Sodium Salt is an impurity of Pitavastatin (P531000), a competitive inhibitor of HMG-CoA reductase. Antilipemic.<br>References Aoki, T., et al.: Arzneim.-Forsch., 47, 904 (1997); Yamada, I., et al.: Xenobiotica, 33, 789 (2003); Park, S., et al.: Clin. Ther., 27, 1074 (2005)<br></p>

<p>Applications N-Desmethyl analog of Rosuvastatin Lactone (R700550); an intermediate in the production of Rosuvastatin (R700500) derivatives.<br></p>

<p>Stability Light Sensitive, Moisture Sensitive, Temperature Sensitive<br>Applications A major metabolite of Irinotecan.<br>References Canal, P., et al.: J. Clin. Oncol., 14, 2688 (1996), Haaz, M., et al.: Cancer Res., 58, 468 (1998), Kehrer, D., et al.: Clin. Cancer Res., 6, 3451 (2000), Hanioka, N., et al.: Xenobiotica, 31, 687 (2001), Satoh, T., et al.: Drug Metab. Dispos., 30, 488 (2002),<br></p>

<p>Impurity Levonorgestrel EP Impurity D<br>Applications 13-Ethyl-18,19-dinor-17α-pregn-4-en-20-yn-17-ol (Levonorgestrel EP Impurity D) is an impurity of Levonorgestrel.<br>References McGinty, D., et al.: Endocrinology, 24, 829 (1939), Belanger, A., et al.: Steroids, 37, 361 (1981), Nieman, L., et al.: J. Clin. Endocrinol. Metab., 61, 536 (1985), Klebe, G., et al.: J. Med. Chem., 37, 4130 (1994),<br></p>

<p>Applications Fipexide Hydrochloride is one of five potential drug candidates to overcome the melphalan-induced vascular toxicity.<br>References Yang, Y., et al.: Tumour Biol., 37, 6709-6718 (2016);<br></p>

<p>Stability Light Sensitive<br>Applications alpha-Tocotrienol is an antioxidant.<br></p>

<p>Applications Dydrogesterone (D826000) intermediate. Used in the preparation of 10α-steroids.<br></p>

<p>Applications D-2'-Deoxyribopyranosyl-3-guanylurea (α/β-Mixture) can be obtained from 5-Aza-2’-deoxy Cytidine (A796950) which can be used as cancer treatment, in particular to inhibit the growth of pancreatic endocrine tumor cell lines.<br>References Deng, T., et al.: Life Sci., 84, 311 (2009), Horne, H., et al.: Mol. Cancer Res., 7, 199 (2009), Zinner, R., et al.: Mol. Cancer Ther., 8, 521 (2009),<br></p>

<p>Stability Light Sensitive<br>Applications Prifinium Bromide is a synthetic antispasmodic drug; parasympatholytic. Prifinium Bromide is used as a quartenary anticholinergic agent.<br>References Kumada, S. et al.: Arzneim.-Forsch., 20, 237 (1970); Nakai, T. et al.: Arzneim.-Forsch., 20, 1112 (1970); Bettini, V. et al.: Farm. Ed. Prat., 33, 392 (1978);<br></p>

<p>Stability Hygroscopic<br>Applications Atorvastatin impurity in bulk drug and tablets.<br>References Posvar, E., et al.: J. Clin. Pharmacol., 36, 728 (1996), Lea, A., et al.: Drugs, 53, 828 (1997), Miao, X., et al.: J. Chromatogr., 998, 133 (2003),<br></p>

<p>Stability Hygroscopic<br>Applications The hydrochloride salt of AZ 5104 (A795170), which is a derivative of AZD 9291 (A808075) and a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).<br>References Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);<br></p>

<p>Applications A metabolite of Cholesterol.<br>References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969), Nestel, P., et al.: Metabolism, 24, 189 (1975), Ellegard, L., et al.: Eur. J. Clin. Nutr., 45, 451 (1991), Pedersen, A., et al.: J. Lipid Res., 41, 1901 (2000),<br></p>

<p>Applications 3-Ethyl 3,5-Didemethyl Memantine is an impurity of Memantine (HCl salt, M218000) which is used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>

<p>Applications N3-Methanethiosulfonylethyl Lumiflavin is a derivative of the Lumiflaviin (L473900), a toxic photolysis product of vitamin B2.<br></p>

<p>Applications Forsythoside A is used as an antiinflammatory agent in traditional Chinese medicine.<br>References Li, H. et al.: Phytother. Res., 25, 338 (2011);<br></p>

<p>Impurity Fluticasone EP Impurity D<br>Applications Ticabesone Propionate is an impurity of Fluticasone, an antiallergic, anti-asthmatic and anti-inflammatory agent.<br>References Marrero-Ponce, Y., et al.: Europ. J. Med. Chem., 46, 5736 (2011); Dalvi, P., et al.: J. Chem., 20, 187 (2008);<br></p>

<p>Applications Prostanozol (P838700) derivative.<br></p>

<p>Applications Sodium 4-Hydroxybutyrate-2,2,3,3-d4 (CAS# 1251763-08-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled steroid hormone with weak androgenic activity. It is metabolized from Testosterone (T155000) in the liver and is used in doping analysis to detect testosterone misuse. Controlled Substance.<br>References Park, J., et al.: J. Anal. Toxicol., 14, 66 (1990),; Palonek, E., et al.: J. Steroid Mol. Biol., 55, 121 (1995); Aguilera, R., et al.: Clin. Chem. 47, 292 (2001); Flenker, U., et al.: Steroids, 73, 408 (2008); Saudan, C. et al.: Steroids, 70, 179 (2005);<br></p>

<p>Applications Methylamine-d5 DCl (CAS# 14779-55-6) is a useful isotopically labeled research compound.<br>Chemical Name: Methylamine-d5 DCl (CAS# 14779-55-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications (±)-Carisoprodol-d7 (iso-propyl-d7) (CAS# 1218911-01-3) is a useful isotopically labeled research compound. As a deuterated drug analog, this compound can be used for inter-patient variability.<br>References Gant, T., et.al., U.S. Pat. Appl. Publ., 28,(2010);<br></p>

<p>Applications L-Propoxyphene-d5 Hydrochloride is the isotope labelled analog and L-isomer of Propoxyphene Hydrochloride (P831500); a controlled substance (opiate) and analgesic (narcotic). The α-DL-and D-diastereoisomers possess marked analgesic activity in contrast to the β-diastereoisomers which are substantially inactive. Oral administration of L-Propoxyphene Hydrochloride enhances the analgesic activity of D-Propoxyphene Hydrochloride.<br>References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971); McEwan, B., et al.: Anal. Profiles Drug Subs., 1, 301 (1972); Murphy, P.J., et al.: J. Pharmacol. Exp. Ther., 199, 415 (1976)<br></p>

<p>Applications (±)-Zopiclone-d3 (N-methyl-d3) (CAS# 1398066-10-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Testosterone-2,2,4,6,6-d5 Benzoate is a useful isotopically labeled compound of Testosterone Benzoate (T155015)<br></p>

<p>Applications Chloramphenicol-3-O-sulfate Sodium Salt is a salt version of Chloramphenicol-3-O-sulfate (CAS 116512-90-4) which can be used in study for evidence for new metabolic pathways of Chloramphenicol in the duck. Metabolite of the drug Chloramphenicol (C325030).<br>References Cravedi, J. P., et al.: Drug Metab Dispos, 22, 578 (1994)<br></p>

<p>Applications Fenbendazole-Amine Sulfoxide is a highly effective inhibitor of the helminth-specific enzyme, fumarate reductas in Ascaris suum. Also, it inhibits the polymerization of tubulin into microtubules in vitro.<br>References Barrowman, M. M., et al.: Biosci. Rep., 4, 879-883 (1984); Barrowman, M. M., et al.: Biochem. Pharmacol., 33, 3037-3040 (1984);<br></p>

<p>Applications 2-Fluoroimidazole is a chemical reagent used in the synthesis of cephalosporins.<br>References Jung, F. et al.: J. Antibio., 46, 992 (1993);<br></p>

<p>Applications 4-Chlorophenyl Benzoate is used as a reagent in the synthesis of phenstatin analogs via Fries rearrangement and Friedel-Crafts reaction. These biaryl analogs are antitubulin compounds.<br>References Tozatti, C., et al.: Quim. Nova, 35, 1758 (2012)<br></p>

<p>Applications Hexahydrocurcumin is a reagent in the synthesis of Gingerenone A (G387500) which is an antifungal and antiparasitic diarylheptenone that is isolated from Zingiber officinale (more commonly known as ginger), a medicinal plant that is used to treat inflammation and musculoskeletal disorders.<br>References Ali, B., et al.: Food Chem. Toxicol., 46, 409 (2008); Bordia, A., et al.: Prost. Leuk. Ess. Fat. Acids, 56, 379 (1997); Choi, W., et al.: J. Appl. Biomed., 11, 15 (2013); Riaz, T., et al.: Nat. Prod. Res., 24, 1131 (2010); Srivastava, K. &amp; Mustava, T.: Med. Hypoth., 39, 342 (1992)<br></p>

<p>Applications 1-Chloro-4-(methylsulfonyl)-2-nitrobenzene (cas# 97-07-4) is a useful research chemical.<br></p>

<p>Impurity Emtricitabine Impurity 14<br>Applications An intermediate in the synthesis of Emtricitabine (E525000). A reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500). Emtricitabine Impurity 14.<br>References Schinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. Infec. Dis., 182, 599 (2000)<br></p>

<p>Applications (4-(3-Methylbutan-2-yl)phenyl)methanol is an intermediate used in the synthesis of 1-Desmethyl-2-methylpropyl Amorolfine (D292315), which is an analogue of Amorolfine Hydrochloride (A634170). Amorolfine hydrochloride is a salt of Amorolfine which is a morpholine antifungal drug. It is a topical solution for the treatment of toenail infections.<br>References Rotta, I., et al.: JAMA Dermatol., 149, 341 (2013); Espinel-Ingroff, A., et al.: Antimicrob. Agents Ch., 26, 5 (1984)<br></p>

<p>Applications Ophenyl-[4”-(Pentyloxy)[1,1’:4’,1”-terphenyl]-4-yl]carbonyl] Anidulafungin is an impurity of Anidulafungin (A673000) which is used as an antifungal drug.<br>References Denning, D. W., et al.: J. Antimicrob. Chemother, 40, 611 (1997); Vazquez, J. A., et al.: Clin. Ther., 27(6), 657 (2005);<br></p>

<p>Applications 1,9-Dihydro-9-[[2-hydroxy-1-[[(4-methoxyphenyl)diphenylmethoxy]methyl]ethoxy]methyl]-2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6H-purin-6-one is an intermediate used in the synthesis of Ganciclovir Triphosphate Triethylamine Salt (G235030), which is an inhibitor of hepatitis B virus DNA polymerase and has shown potent antiviral activity against herpes viruses and hepadnaviruses.<br>References Rubsam, L.Z., et al.: Cancer. Res., 59, 669 (1999); Shaw, T., et al.: Hepatol., 24, 996 (1996);<br></p>

<p>Applications 4-(2-methyl-1,3-oxazol-4-yl)benzene-1-sulfonyl chloride (cas# 1086376-81-9) is a useful research chemical.<br></p>

<p>Applications 2-Nonyn-1-ol is a Propargyl alcohol (P762550) derivative that is used as a reagent to synthesize Microcarpalide, a microfilament disrupting agent that is weakly cytotoxic to mammalian cells. 2-Nonyn-1-ol is also thought to have potential antifungal properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gershon, H., et al.: J. Pharm. Sci., 73, 1840 (1984); Ratnayake, A., et al.: Org. Lett., 3, 3479 (2001); Tamao, K., et al.: Tetrahedron Lett., 29, 6955 (1988)<br></p>

<p>Applications 4-Nitrophenyl-methoxycarbonylamino Amoxicillin is an intermediate used in the synthesis of N-(Penicillan-6-yl) Open Ring Amoxicillinamide Disodium Salt (P223050), which is an impurity of Amoxicillin (A634235); a semi-synthetic antibiotic related to Penicillin (P233500). Antibacterial.<br>References Brogden, R.N., et al.: Drugs, 18, 169 (1979); Bird, A.E., et al.: Anal. Profiles Drug Subs. Excip., 23, 1 (1994)<br></p>

<p>Applications Flucloxacillin-O-ethylacetate is an intermediate used in the synthesis of 6-APA Flucloxacillin (A726105), which is an impurity of Flucloxacillin (F419200), which is a new semi-synthetic penicllin.<br>References Markovich, M., et al.: Antibiot. Med. Biotekhnol., 31, 603 (1986), Rahman, M., et al.: Biochem. Pharmacol., 46, 1721 (1993), Silva, D., et al.: Med. Biol. Res., 37, 963 (2004)<br></p>

<p>Applications AHR 10240 Dimer is a dimer of 7-(4-Bromobenzoyl)-1,3-dihydro-2H-indol-2-one (B680190); a cyclic metabolite of Bromfenac (B678550).<br>References Osman, M.A. et al.: J. Chrom. Biomed. Appl., 489, 452 (1989); Isaka, M. et al.: Yakub. Dot., 14, 32 (1999)<br></p>

<p>Applications Quinolin-8-yl 2,2,5,5-Tetramethylthiazolidine-4-carboxylate is an intermediate in the synthesis of D,L-Penicillamine O-Lactose Adduct (P223020), which is an impurity of D-Penicillamine (P223000), a Penicillin metabolite used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.<br>References Marti-Prats, L., et al.: Neurosci. Lett., 483, 143 (2010); Singh, A., et al.: J. Pharm. Sci., 99, 3931 (2010); Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010);<br></p>

<p>Applications Desoxymycin is a derivative of streptomycin(S687223) which is an antibiotic produced by aerobic fermentation. Antibacterial (tuberculostatic).<br>References Weiss, et al.: Antibiot. Chemother., 7, 374 (1957), Umezawa, et al.: J. Antibiot., 27, 997 (1974), Mossa, J., et al.: Anal. Profiles Drug Subs., 16, 507 (1986),<br></p>