Toxicology

Applications Flavokavain B is a secondary metabolite of the kava plant (Piper methysticum Forst. f., Piperaceae, which has anticancer properties and demonstrated oral efficacy in murine cancer models.  Futhermore, it also has suspected roles in rare cases of kava-induced hepatotoxicity. In addition, it is a potential candidate for the development of novel antifungal phytotherapic products.
References Pinner, K. D., et al.: Pharmaceutical Biology (Abingdon, United Kingdom), 54, Epub ahead of print (2016); Rowe A., et al.: Phytotherapy Research, 26, 1768 (2012); Alves dos Santos, R., et al.: Journal of Chemistry, (2013)

Applications N7-Des[2-(1H-tetrazol-1-yl)acetyl]-N7-(tert-butylcarbonyl) Cefazolin Sodium Salt is an impurity of the semi-synthetic antibiotic Cefazolin (C242500).

Applications Physostigmine Salicylate is a cholinesterase inhibitor with the potential to improve cognitive ability in individuals with alzheimers. In addition, as a parasympathomimetic, it is used to treat glaucoma, dry mouth, and delayed gastric emptying.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Thal, L. et al.: Neurol., 47, 1389 (1996); Hedner, E. et al.: Eur. J. Oral Sci., 109, 374 (2001);

Applications (S)-1-Amino-3-chloro-2-propanol Hydrochloride is used in biological studies as an orally active male antifertility agent which is mediated by an effect on epididymal and vas deferens sperm.
References Coppola, J. A., et al.: Contraception, 9, 459 (1974);

Applications Bis(methylthio)gliotoxin (FR-49175) is an antiphagocytic metabolite.

Applications Androstenedione (A637550) analog, an aromatase inhibitor.
References Marsh, D.A., et al.: J. Med. Chem., 28, 788 (1985),

Applications Isopropyl 2-Furoate is used in the preparation of heteroarenecarboxylates.
References Luo, Wenkun. et al., Org. Lett. 22, 2093-2098(2019);

Applications Oxacyclotetradecane Erythromycin Derivatives is a useful intermediate in the preparation of erythromycin A (E649950) antibiotics and derivatives.
References Koch, W.L., et al.: Anal. Profiles Drug Subs., 8, 157 (1979), Morimoto, S., et al.: From Eur. Pat. Appl. (1988), EP 272110 A2 19880622,

Applications Intermediate for the preparation of Naratriptan and other indole sulfonamide derivatives.

Applications 1-(3-Chloro-2-methylpropyl)-4-(1,1-dimethylpropyl)benzene is a useful synthetic intermediate in the synthesis of Amorolfine Hydrochloride (A634170); a morpholine antifungal drug and topical solution for the treatment of toenail infections. 1-(3-Chloro-2-methylpropyl)-4-(1,1-dimethylpropyl)benzene is also used in the preparation of Fenpropidin (F249470); a fungicide.
References Rotta, I., et al.: JAMA Dermatol., 149, 341 (2013); Espinel-Ingroff, A., et al.: Antimicrob. Agents Ch., 26, 5 (1984); Broger, E.A., et al.: Eur. Pat. Appl. EP 492401 A1 19920701. Jul 1, 1992; Leroux, P. Walker, A.: Eur. J. Plant Path., 135, 683 (2013); Zhao, H., et. al.: Ecotox. Environ. Safe., 77, 52 (2012)

Applications Nafcillin Penilloic Acid Ester is derived from Sodium Nafcillin Monohydrate (S645800), which is used as an antibiotic, and for the treatment of gram-positive bacteria.
References Taboada, P. et al.: Langmuir. 16, 3175 (2000)

Stability Temperature Sensitive
Applications It is used in efficient synthesis of 1β-O-acyl glucuronides via regioselective acylation of allyl or benzyl D-glucuronate.Αcyl glucuronides are known metabolites of important drugs.
References Kaspersen, F., et al.: Xenobiotica, 17, 1451 (1987), Ebner, T., et al.: Drug Metab. Dispos., 27, 1143 (1999), Shipkova, M., et al.: Ther. Drug Monit., 25, 1 (2003), Stachulski, A., et al.: J. Med. Chem., 49, 6931 (2006),

Applications 6-Methyl-3,6-diazabicyclo[3.1.1]heptane is a useful research chemical.

Applications Eicosapentaenoyl Ethanolamide inhibits dietary-restriction-induced lifespan extension in wild type and TOR pathway mutant nematodes.
References Lucanic, M., et al.: Nature, 473, 226 (2011)

Applications 4-Hydroxybenzoyl Chloride is used in preparation of lysine sulfonamides as HIV-protease inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Stranix, B., et al.: Bioorg. Med. Chem. Lett., 16, 3459 (2006);

Applications Rilpivirine Amadori rearrangement Product II is an impurity of Rilpivirine(R509800) which is a novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent.
References Sun, et al.: J. Med. Chem., 41, 4648

Applications 2,3,4,6-Tetra-O-acetyl-a-D-galactopyranosyl azide (CAS# 94427-00-6) is a useful research chemical compound.

Applications Verazide is derived from Isoniazid (I821450), which is an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic).
References Brewer, G.A., et al.: Anal. Profiles Drug Subs., 6, 183 (1977), Weber, W.W., et al.: Clin. Pharmacokinet., 4, 401 (1979)