Toxicology

Applications N-[(2,4-Difluorophenyl)methyl]-2,4-difluoro-benzenemethanamine is derived from 2,4-Difluorobenzylamine (D45085), which acts as a reagent for the design of pyrazole derivatives as non-nucleoside heptatitis B virus inhibitors. It is also used as a reagent in the preparation, HIV antiviral activity, SAR, and molecular modelling of hydroxypyridonecarboxylic acids as HIV reverse transcriptase inhibitors.
References Jia, H., et al.: Eur. J. Med. Chem., 123, 202 (2016); Kankanala, J., et al.: J. Med. Chem., 59, 5051 (2016)

Impurity Nevirapine EP Impurity D
Applications Nevirapine Dimer (Nevirapine EP Impurity D) is a dimeric impurity of the antiviral Nevirapine (N391275).

Applications A metabolite of 6β-Naltrexol (N285700). Narcotic antagonist.
References Portoghese, P. et al,: J. Med. Chem., 37, 579 (1994); Ohkawa, S., et al.: J. Med. Chem., 41, 4177 (1998);

Applications Emtricitabine Isopropyl Carbamate is a derivative of Emtricitabine (E525000). Emtricitabine is a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner.
References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)

Applications Labelled Clonazepam (C587080) metabolite.
References Huang, W., et al.: J. Anal. Toxicol., 19, 333 (1995), Rittner, M., et al.: J. Anal. Toxicol., 25, 115 (2001),

Stability Hygroscopic
Applications An antibiotic related to Cephalosporin, used in the treatment of bacterial infections.
References Ahmed, A., et al.: Vet. Microbiol., 136, 397 (2009), Kim, M., et al.: J. Bacteriol. Virol., 39, 29 (2009), Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010),

Applications 4-(5-Bromothiophen-2-yl)benzonitrile (CAS# 415718-60-4) is a useful research chemical compound.

Applications 3’-O-Benzyl Sofosbuvir Desphosphate may be a metabolite of Sofosbuvir (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010);

Applications Bisphenol AP Mono-β-D-glucuronide is a metabolite of Bisphenol AP (B519485), which is used to prepare triphenylmethane derivatives as inhibitors of hepatitis C virus helicase. Bisphenol AP is a derivative of Bisphenol A (B519495) which is a monomer used for policarbonate and epoxy resins.
References Krishnan, A.V., et al.: Endocrinology, 132, 2279 (1993); Steinmetz, R., et al.: Trends Endocrinol. Metab., 9, 124 (1998); Petersen, H., et al.: Eur. Food Res. Technol., 216, 355 (2003); Chen, C., et al.: J. Med. Chem., 52, 2716 (2009);

Applications o-Carbomethoxybenzyl Sulfonamide is a useful reactant in organic synthesis.
References Jiang, Lin, et al.: Youji Huaxue, 26(2), 203-206 (2006)

Applications 12β-Deoxycholic Acid Methyl Ester 3α-Benzoate is an intermediate in the synthesis of 3α,12β-Dihydroxycholanoic Acid is a bile acid that may decrease of the toxic effects of deoxycholic acid on lipid peroxidn.
References Hino, A., et. al.: J. Biochem., 129, 683 (2001)

Applications 5-Methoxy Dapagliflozin Tetraacetate is an intermediate in the synthesis of (1S)-1,5-anhydro-1-C-[4-Chloro-3-[(4-ethoxyphenyl)hydroxymethyl]phenyl]-D-glucitol (A638185) which is an impurity of the drug Dapagliflozin (D185370), a sodium-glucose transporter 2 inhibitor.
References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)

Applications 4-Amino-1-(10-phthalimidodecyl)quinaldinium Iodide is an intermediate for the synthesis of 4-Amino-1-[10-[(2-methyl-4-quinolyl)amino]decyl]quinaldinium Iodide Hydriodide (M493250), which is an impurity of Dequalinium (D288335); the active ingredient in various medications including antiseptic and anti-malarial agents.
References Kunisada, Y., et al.: J. Biomolec. Screen., 17, 140 (2012); Zeder-Lutz., G., et al.: Anal. Biochem., 421, 417 (2012)

Applications Ceftiofur intermediate.

Applications Methyl 2-((((Benzyloxy)carbonyl)amino)methyl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate is an intermediate used in the synthesis of N-((5-Hydroxy-6-oxo-4-((2,4,6-trifluorobenzyl)carbamoyl)-1,6-dihydropyrimidin-2-yl)methyl)-1,3,4-oxadiazole-2-carboxamide (H950690), which is a derivative of Raltegravir (R100305), a potent integrase (IN) inhibitor for WT and S217Q PFV IN.
References Hare, S., et al.: Proc. Natl. Acad. Sci. U. S. A., 107, 20057 (2010); Hicks, C., et al.: Clin. Infect. Dis., 48, 931 (2009); Moss, D., et al.: Antimicrob. Agents Chemother., 56, 3020 (2012); Hare, S., et al.: Mol. Pharmacol., 80, 565 (2011)

Applications The active metabolite of Irinotecan (carboxylate form). SN-38 lactone and carboxylate may be considered pharmacokinetically distinct agents.
References Billecke, S., et al.: Drug Metab. Dispos., 28, 1335 (2000), Teiber, J., et al.: Biochem. Pharmacol., 66, 887 (2003), Ashley, G., et al.: J. Antibiot., 57, 224 (2004),

Applications Zinc salicylate trihydrate (CAS# 16283-36-6) is a useful research chemical compound.

Applications Famoxadone is a known fungicide used in the protection of agricultural products against various fungal diseases and other biotic stresses such as pests.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Speck- Planche, A., et al.: Excotoxicol. Enviro. Safety., 80. 308 (2012).

Applications N-Boc Gatifloxacin N-Oxide is an intermediate used in the synthesis of Gatifloxacin N-Oxide (G250005), which is an impurity of Gatifloxacin (G250000), an antibacterial agent.
References Bauernfeind, A.: J. Antimicro. Chemother., 40, 639 (1997), Fukuda, H., et al.: Antimicrob. Ag. Chemother., 42, 1917 (1998),

Applications di-Val-L-dC Trihydrochloride is a β-L-2'-Deoxynucleoside for treatment of resistant hepatitis B virus strains, and combination therapies.
References Standring, D. et al.: PCT Int. Appl. (2004)