Toxicology

<p>Applications Cacodylic acid is used for dermatologic treatment in cronic eczema, anemia and as a tonic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mandal, B., et al.: Talanta, 58, 201 (2002), Naranmandura, H., et al.: Chem. Res. Toxicol., 20, 616 (2007), Naranmandura, H., et al.: Toxicol. Appl. Pharmacol., 227, 390 (2008), Violin, J., et al.: J. Biol. Chem., 283, 2949 (2008),<br></p>

<p>Applications Apremilast is an oral phosphodiesterase 4 inhibitor used in the treatment of psoriatic arthritis.<br>References Gan, E., et al.: BioDrugs, 27, 359 (2013); Pathan, E., et al.: Annal. Rheum. DIs., 72, 1475 (2013);<br></p>

<p>Applications Dinosam is used in preparation of Chitosan gel and application thereof in shampoo for preventing alopecia.Also, used in methods and formulations for preventing downward migration of agricultural materials.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Qiu, Y., et al.: Faming Zhuanli Shenqing, (2020); Shieh, A., et al.: PCT Int. Appl., (2020);<br></p>

<p>Applications tert-Butyl Pitavastatin is used to prepare hemicalcium salt.<br>References Van Der Schaaf, P., et al.: PCT Int. Appl. (2004), WO 2004072040 A1 20040826.<br></p>

<p>Applications Cephalosporin Antibiotic.<br>References Murata, H., et al.: J. Hepatol., 38, 573 (2003), Osawa, M., et al.: Legal Med., 10, 143 (2008), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),<br></p>

<p>Applications A synthetic progestin largely used in hormone therapy, on the central nervous system by studying two markers of the neuroendocrine function: the neurosteroid allopregnanolone and the opioid .beta.-endorphin. Progestogen.<br>References Bernardi, F., et al.: Eur. J. Endocrinol., 138, 316 (1998), Rupprecht, R., et al.: Steroids, 64, 83 (1999), Uzunova, V., et al.: Brain Res., 976, 1 (2003), Pluchino, N., et al.: J. Steroid Biochem. Mol. Biol., 102, 205 (2006),<br></p>

<p>Applications Eszopiclone is the active stereoizomer of Zopiclone and belongs to the class of drug known as cyclopyrrones. It is a nonbenzodiazepine hypnotic agent used as a treatment for insomnia.This is a controlled substance (depressant) in the US but not in Canada.<br>References Gottesmann, C., et al.: Eur. J. Neurosci., 10, 409 (1998), Yoshimoto, M., et al.: Eur. Neuropsychopharmacol., 9, 29 (1999),<br></p>

<p>Applications Labelled Tryptamine (T894600). Occurs in plants.<br></p>

<p>Applications Tripamide is a diuretic.<br>References Ogihara, T., et al.: Hypert. Res., 32, 163 (2009)<br></p>

<p>Applications Zolmitriptan is a serotonin 5HTID-receptor agonist and used to treat migraine (1,2,3).<br>References (1) Glen, R.C., et al.: J. Med. Chem., 38, 3566 (1995)(2) Seaber, E., et al.: Brit. J. Clin. Pharmacol., 41, 141 (1996)(3) Tepper, S.J., et al.: Curr. Med. Res. Opin., 15, 254 (1999)<br></p>

<p>Applications 2-Hydroxy-5-(trifluoromethyl)pyridine (cas# 33252-63-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Allethrin is a synthetic pyrethroid derivative used as an insecticide. Allethrin is commonly used in many household insecticide products due to its low toxicity towards humans. Useful in cannabis testing kits as a component in pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dua, V.K. et al.: Bull. Environ. Contam. Toxicol., 75, 747 (2005); Jiang, M. et al.: Nanj. Nong. Dax. Xue., 18, 110 (1995);<br></p>

<p>Applications Ethirimol is a pyrimidine based fungicide with wide applications such as controlling leaf spot of sugar beet.<br>References Nougadere, A., et al.: Food. Chem. Toxicol., 49, 1484 (2011); Liu, B., et al.: J. Agri. Food. Chem., 58, 2673 (2010); Duchowicz, P.R., et al.: Bioorg. Med. Chem., 16, 7944 (2008);<br></p>

<p>Applications N-Desmethylthiamethoxam-D4 is an impurity of thiamethoxam and an isotope labelled compound of N-Desmethylthiamethoxam (D292485). Thiamethoxam is a hepatotoxic insecticide in mice.<br>References Swenson, T. L., et al.: Toxicol. Lett., 216, 139 (2013); Karmakar, R., et al.: Pest Manag. Sci, 65, 931 (2009)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Iopromide. Nonionic, injectable radio-contrast medium. Diagnostic aid (radiopaque medium).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Muetzel, W., et al.: Am.J. Neuroradiol., 4, 350 (1983), Dawson, P., et al.: Acta Radiol. Diagn., 25, 253 (1984),<br></p>

<p>Applications Tricyclazole is an common active ingredient in several commercial fungicide products used to control rice blast fungus, in transplanted and direct-seeded rice.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dhingani, J.C., et al.: J. Pure. App. Microbiol., 6, 1683 (2012); Jeong, S.A., et al.: Bull. Environ. Contamin. Toxicol., 89, 1181 (2012);<br></p>

<p>Applications A glucuronide of (Z)-4-Hydroxy Tamoxifen (or trans-4-hydroxytamoxifen), an active metabolite of Tamoxifen (T006000).<br>References Beaulieu, M., et al.: J. Biol. Chem., 271, 22855 (1996), Green, M., et al.: Drug Metab. Dispos., 26, 860 (1998), Nishiyama, T., et al.: Biochem. Pharmacol., 63, 1817 (2002),<br></p>

<p>Applications Selective pre-emergence herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bailey, G.W., et al.: Residue Rev., 10, 97 (1965), Chun, O., et al.: Food Chem. Toxicol., 41, 1063 (2003), Berrada, H., et al.: Food Control., 21, 36 (2010),<br></p>

<p>Applications (±)-Quizalofop-ethyl-d3 (propionate-3,3,3-d3) is the labelled version of Quizalofop-ethyl (Q826108(P)), which may have agricultural applications specifically in controlling plant diseases. (±)-Quizalofop-ethyl-d3 (propionate-3,3,3-d3) has been useful in analytical studies as well, particularly in the development of retention time interpolation scale for liquid chromatography.<br>References Watanabe, S., Jpn. Kokai Tokkyo Koho (2020) JP 2020125364 A; Celma, A., et al.: J. Chromatogr. A, 1568, 101 (2018)<br></p>

<p>Applications A labelled antipruritic. Antibacterial, antimicrobial agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Robinson, et al.: J. Pharm. Pharmacol., 18, 19 (1966); Abdel-Moety, E., et al.: Eur. J. Pharm. Sci., 5, 1 (1997); Basavaiah, K., et al.: Chem. Pharm. Bull., 47, 1351 (1999);<br></p>

<p>Applications Mefenacet is an acetanilide herbicide which is used for pre- and post emergence control of annual weeds in paddy oil. Mefenacet has been widely used and repeated in Asian countries and is frequently detected in river or lake water.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Saka, M., et al.: Ectoxicol. Environ. Saf., 73, 1165 (2010); Ye, Y-F., et al.: J. Environ. Sci., 16, 343 (2004);<br></p>

<p>Applications 2-Amino-6-methylpyrimidin-4(3H)-one (cas# 3977-29-5) is a useful research chemical.<br></p>

<p>Applications Simetyrn is an methylthiotriazine based herbicide used in rice paddy.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Inoue, T. et al.: J. Agri. Food. Chem., 59, 3857 (2011); Wang, S., et al.: Environ, Sci. Technol., 47, 4768 (2013);<br></p>

<p>Applications Labelled Clonazepam (C587080). Antiepileptic agent with anxiolytic and antimanic properties. Anticonvulsant.This is a controlled substance (depressant).<br>References Blum, et al.: Arzneim.-Forsch., 23, 377 (1973), Winslow, W.C., et al.: Anal. Profiles Drug Subs., 6, 61 (1977)<br></p>

<p>Stability Hygroscopic<br>Applications A 2,4-Diaminopyrimidine derivative as antimalarial agent.<br>References Andersson, K.J.I., et al.: Nature, 143, 720 (1939), Cecil, R., et al.: Biochem.J., et al.: 43, 592 (1948),<br></p>

<p>Applications Cyclobarbital has been used as an anesthetic and sedative. Controlled substance (depressant).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hofrichter, G., et al.: Arzneim.-Forsch., 17, 242 (1967),<br></p>

<p>Applications Contact herbicide used also to produce desiccation and defoliation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brian, et al.: Nature, 181, 446 (1958), Gaines, T.B., et al.: Fundam. Appl. Toxicol., 7, 299 (1986),<br></p>

<p>Applications Sumatriptan Succinate is a selective 5-HT1B/1D-receptor agonist with anticonvulsant properties (1,2). Sumatriptan Succinate is used for migraine relief (2).<br>References (1) Razzaque, Z., et al.: Br J Clin Pharmacol. 47, 75 (1999) (2) Cady, R. K., et al.: J Headache Pain. 18, 17 (2017)<br></p>

<p>Applications A structural derivative of Trimethoprim (T795615). A selective dihydrofolate reductase inhibitor; diaminopyridine antibacterial agent.<br>References Thomson, C.J. et al.: J. Chemother., 5, 458 (1993); Hawserl, S. et al.: Biochem. Pharmacol., 71, 941 (2006); Conforti, A. et al.: Br. J. Clin. Pharmacol., 44, 411 (1997);<br></p>

<p>Applications A labelled form of Etofenprox (E936400), which is a pyrethroid derivative which is used as an insecticide. Used as a standard for Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lehotay, S., et al.: J. AOAC Int., 88, 595 (2005); Paya, P., et al.: Anal. Bioanal. Chem., 389, 1697 (2007)<br></p>

<p>Applications Metazachlor Ethane Sulfonic Acid Sodium Salt is an ethanesulfonate metabolite of Metazachlor (M225855), which is a chloroacetanilide herbicide.<br>References Laue, H., et al.: Environ. Sci. Technol., 30, 1129 (1996); Matthies, M., et al.: Environ. Sci. Technol., 43, 9223 (2009); Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009); Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010); Liu, B., et al.: J. Agric. Food Chem., 58, 2673 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications Isovaleryl L-Carnitine-d9 Chloride is labelled Isovaleryl L-Carnitine Chloride (I917580) which is used to prepare carnitine benzyl esters as neuroprotectant prodrugs.<br>References Gong, X., et al.: J. Chem. Res., 6, 327 (2008)<br></p>

<p>Stability Hygroscopic<br>Applications Bis(2,3-dibromopropyl) Phosphate is a derivative of Tris(2,3-dibromopropyl) Phosphate, a widely used flame retardant in plastic and textiles.<br>References Elliott, W.C., et al.: Life. Sci., 7, 1107 (1983);<br></p>

<p>Applications An acylamino acid fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ravelo-Perez, L., et al.: Food Chem., 111, 764 (2008), Wong, J., et al.: J. Agric. Food Chem., 58, 5897 (2010),<br></p>

<p>Applications A commonly used herbicide/pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ait-Aissa, S., et al.: Toxicol., 24, 1979 (2010),<br></p>

<p>Applications Methylstenbolone is an anabolic androgenic steroid that have been studied in respect of testosterone-receptor interaction and in the development of QSAR models.<br>References Singh, D., et al.: J. Chem. Pharma. Rsch., 3, 1 (2011); McFarland, K., et al.: Science, 245, 494 (1989); Heckert, L., et al.: Mol. Endocrinol., 12, 1499 (1998); Themmen, A., et al.: Endocr. Rev. 21, 551 (2000); Kumar, R., et al.: Biol. Reprod., 65, 710 (2001)<br></p>

<p>Applications Flufenacet is an anilide based herbicide that is applied to the soil surface or incorporated before the crop is emerged. Flufenacet is often used in field corn, corn grown for silage or soybeans to control annual grasses and broadleaf weeds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hulting, A.G., et al.: Weed. Technol., 26, 230 (2012); Bailly, G.C., et al.: Crop Protect., 34, 96 (2012);<br></p>

<p>Applications A neonicotinoid insecticide. Reports show that when exposed to neonicotinid pesticides honeybees have probelms returnign home after foraging and bumblebee colonies grow poorly and produce fewer queens. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Oliver, J., et al.: J. Environ. Horticult., 28, 135 (2010), Ghosh, A., et al.: J. Entomol. Res., 34, 35 (2010), Chem. and Eng. News 90: 10 (2012)<br></p>

<p>Stability Hygroscopic<br>Applications Neuroleptic agent related structurally to thiothixene. Antipsychotic; neuroleptic agent; dopamine receptor antagonist.<br>References Nielsen, et al.: Acta Pharmacol. Toxicol., 32, 363 (1973), Post, M.L., et al.: Nature, 256, 342 (1975), Peuch, et al.: Neuropharmacology, 20, 1279 (1981),<br></p>

<p>Stability Hygroscopic<br>Applications Antipsychotic.<br>References Schafer, E.W., et al.: Toxicol. Appl. Pharmacol., 21, 315 (1972),<br></p>

<p>Applications Picloram is used as a herbicide. Studies show that Picloram can reduce seed germination rate and vigor as well as seedling growth in Bidens pilosa L.<br>References Freitas, M.R., et al.: RSC Adv., 5, 7547 (2015); Tian, X., et al.: Nongyao, 53, 485 (2014)<br></p>

<p>Applications Mono N-Desmethyl Disperse Polyester Dark Blue is a disperse dye for synthetic polyester fibers. It has good heat and light resistance and is used for thermal transfer recording.<br>References Peters A. T., et al.: J. Soc. Dyers Colour, 108(7-8), 344-8 (1992)<br></p>

<p>Applications (-)-Hycosamine-d3, is the labeled analogue of (-)-Hycosamine (H674300), a natural compound that has inhibitory activity against cholinesterases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brunhofer, G. et al.: Bioorg. Med. Chem., 20, 6669 (2012);<br></p>

<p>Applications An antimalarial; antirheumatic; lupus erythematosus suppressant. It is a COVID19-related research product.<br>References Yarden, Y., et al.: Nature, 323, 226 (1986), Seifert, R., et al.: J. Biol. Chem., 264, 8771 (1989), Gahl, W., et al.: Mol. Genet. Metab., 76, 234 (2002), Card, J., et al.: Toxicol. Sci., 75, 169 (2003),<br></p>

<p>Applications 17beta-Estradiol-16,16,17-d3 3-Benzoate (CAS# 1192354-74-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications A stable labelled selective HIV protease inhibitor Ritonavir (R535000). It is a COVID19-related research product.<br>References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994), Ammaranond, P., et al.: J. Clin. Virol., 26, 153(2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005), Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788 (2006)<br></p>

<p>Applications A metabolite of Levofloxacin.<br>References Sudo, K., et al.: Xenobiotica, 16, 72 (1986), Wong, F., et al.: Drug Metab. Dispos., 18, 1103 (1990), Aminimanizani, A., et al.: J. Clin. Pharmacokinet., 40, 169 (2001), Athamna, A., et al.: J. Antimicrob. Chemother., 53, 247 (2004), Tanaka, M., et al.: J. Pharmacol., 56, 463 (2004),<br></p>

<p>Impurity Amoxicillin EP Impurity C ; Amoxicillin USP Related Compound C<br>Applications Amoxicillin Diketopiperazine (Amoxicillin EP Impurity C) is a major metabolite of Amoxicillin (AMO)(A634235).<br>References Dewdney, J., et al.: Food Chem. Toxic, 29, 477 (1991), Connor, S., et al.: J. Pharm. Pharmacol., 46, 128 (1994), Hernandez, E., et al.: Vet. J., 170, 237 (2005),<br></p>

<p>Applications Chlorexolone is a low-ceiling sulfonamide diuretic.<br>References Goebel, C., et al.: Anal. Chimica Acta, 502, 65 (2004); Smith, E., et al.: J. Chromat., 384, 259 (1987)<br></p>

<p>Stability Light Sensitive<br>Applications Second generation tetracycline antibiotic. This compound has neuroprotective properties.<br>References Zbinovsky, V., et al.: Anal. Profiles Drug Subs., 6, 323 (1977), Oringer, R.J., et al.: J. Periodontol., 73, 835 (2002),<br></p>

<p>Impurity Cefuroxime Sodium EP Impurity A<br>Stability Hygroscopic<br>Applications Descarbamoyl Cefuroxime (Cefuroxime Sodium EP Impurity A) is a degradation product of Cefuroxime, and an intermediate for the synthesis of Cephalosporin antibiotics<br>References Nomura, H., et al.: J. Med. Chem., 17, 12 (1974), Takaya, T., et al.: J. Antibiotics, 34, 1300 (1981), Wang, D., et al.: J. Pharm. Sci., 83, 577 (1994), Okamoto, Y., et al.: J. Pharm. Sci., 85, 985 (1996),<br></p>

<p>Applications An echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall. An antifungal drug used in the treatment of invasive fungal infections.<br>References Sandhu, P. et al.: Antimicrob. Agents Chemorther., 48, 1272 (2004); Bertsche, T. et al.: Pharamaz. Zeit., 148, 34 (2003); Hoang, A.: Am. J. Health-Sys. Pharm., 58, 1206 (2001);<br></p>

<p>Applications Labelled Amprenavir, a selective HIV protease inhibitor. An analogue of Ritonavir.<br>References Adkins, J.C., et al.: Drugs, 55, 837 (1998)<br></p>

<p>Applications Digoxin derivative, a cardiotonic glycosides steroid.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yoshida, F., et al.: J. Med. Chem., 43, 2575 ( 2000), Turner, J., et al.: Pharm. Res., 21, 68 (2004), Wang, J., et al.: Anal. Chim. Acta, 601, 156 (2007),<br></p>

<p>Applications Ethametsulfuron-methyl is a regulator of the early steps of complement activation on mucosal surfaces. It can be used in combination treatment of ohmic heating with various essential oil components for inactivation of food-​borne pathogens in buffered peptone water and salsa.<br>References Kim, S. S., et al.: Food Control, 80, 29 (2017); Reichhardt, M. P., et al.: Front Immunol, 7, 85 (2016)<br></p>

<p>Stability Hygroscopic<br>Applications Mertansine-13CD3 is the isotope labelled analog of Mertansine (M257800); a cytotoxic agent used as the cytotoxic component in antibody-drug conjugates.<br>References Erickson, H., et al.: Cancer Res., 66, 4426 (2006); Kellogg, B., et al.: Bioconjugate Chem., 22, 717 (2011)<br></p>

<p>Applications De-O-ethoxy Tamsulosin is a derivative of Tamulosin (T006350), a specific α1-adrenoceptor antagonist. It is used in the treatment of benign prostatic hypertrophy.<br>References Kawabe, K., et al.: J. Urol., 144, 908 (1990), Abrams, P., et al.: Br. J. Urol., 76, 325 (1995), Michel, M.C., Expert Opin. Pharmacother., 5, 151 (2004),<br></p>

<p>Stability Hygroscopic<br>Applications 2-Hydroxyethanephosphonic acid is an substrate used in the study of 2-hydroxyethylphosphonate dioxygenase reaction mechanism. 2-Hydroxyethanephosphonic Acid is also a required intermediate in labelled Fosfomycin (F727502) biosynthesis.<br>References Hirao, H., et al.: J. Am. Chem. Soc., 133, 14550 (2011); Hidaka, T., et al.: J. Antibiot., 45, 1008 (1992); Patel, S., et al.: Drugs, 53, 637 (1997); Ribes, S., et al.: J. Antimicrob. Chemother., 57, 931 (2006);<br></p>

<p>Applications N-(Carboxymethyl)amphetamine Hydrochloride is a synthetic amphetamine-class analyte with potential pharmaceutical properties.<br>References Seiler, N. et al.: Tetrahedron Lett., 38, 4603 (1966);<br></p>

<p>Stability Hygroscopic<br>Applications Isotope labelled 1,6-Anhydro-β-D-glucopyranose (A648100), an compound that have been proven to be a valuable synthon for the preparation of various biologically important and structurally diverse products (e.g. rifamycin S, indanomycin, thromboxane B2, (+)-biotin, tetrodotoxin, quinone, and macrolide antibiotics) as well as for modified sugars.<br>References Fraser-Reid, B., et al. J. Am. Chem. Soc. 106, 731 (1984); Edwards, M.P., et al. J. Org. Chem. 49, 3503 (1984); Kelly, A.G., and Roberts, J.S. J. Chem. Soc., Chem. Commun. 228, (1980); Ogawa, T., et al. Carbohydr. Res. 57, C31 (1977); Isobe, M., et al. Tetrahedron Lett. 28, 6485 (1987);<br></p>

<p>Impurity Abacavir - In House Impurity<br>Applications Abacavir Sulfate (Abacavir - In House Impurity) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>

<p>Applications Colinesterase inhibitor. Used as insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Edson, E.F., et al.: Pharm. J., 185, 365 (1960), Pozo, O., et al.: Anal. Bioanal. Chem., 389, 1765 (2007), Mezcua, M., et al.: Anal. Chem., 81, 913 (2009),<br></p>

<p>Impurity Hydrochlorothiazide EP Impurity C<br>Applications N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide (Hydrochlorothiazide EP Impurity C) is an impurity in bulk Hydrochlorothiazide. Dimer Impurity C.<br>References Daniels, S.L., et al.: J. Pharm. Sci., 70, 211 (1981), Fang, X., et al.: Pharm. Res., 14, 691 (1997),<br></p>

<p>Applications A diuretic used to reduce menstrual pains.<br>References Varga, J., et al.: Mol. Immunol., 28, 641 (1991), Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 13, 2881 (2005), Ibrahim, H., et al.: Drug Discov. Ther., 3, 168 (2009),<br></p>

<p>Stability Moisture Sensitive<br>Applications Tetramethylphosphorodiamidic Fluoride is a type of pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hayat, K., et al.: Afr. J. Environ., 4, 666 (2010)<br></p>

<p>Applications WP 155, is a pesticide that has mutagenic effect on Saccharomyces cerevisiae and Aspergillus nidulans, which was verified by comparing with standard mutagen methylmethansulfonate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References De Bertoldi, M., et al.: Environ. Mutagen., 2, 359 (1980)<br></p>

<p>Applications Labelled Fenthion, an organothiophosphate insecticide. Fenthion is also a potent acaricide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pati, B.R. et al.: Plant Soil, 80, 215 (1984); Barros, A.T. et al.: Vet. Parasitol., 96, 243 (2001); Kyriakidis, N.V. et al.: Food Chem., 91, 241 (2005);<br></p>

<p>Applications Triallate is a pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schneider, M., et al.: J. Environ. Qual., 42, 844 (2013); Busi, R., et al.: Pest Manag. Sci., 69, 1379 (2013)<br></p>

<p>Impurity Cefoperazone EP Impurity E<br>Stability Hygroscopic<br>Applications 7-Aminocephalosporanic Acid (Cefoperazone EP Impurity E) is the starting material for semi-synthetic cephalosporins. Obtained by mild acid hydrolysis of cephalosporin C.<br>References Matsuda, A., et al.: J. Bacteriol., 169, 5815 (1987), Aramori, I., et al.: J. Ferment. Bioeng., 72, 227 (1991), Park, S., et al.: J. Biosci. Bioeng., 94, 218 (2002), Takimoto, A., et al.: Appl. Microbiol. Biotechnol., 65, 263 (2004),<br></p>

<p>Stability Hygroscopic<br>Applications Pizotifen Malate is an anti migraine drug.<br>References Serna-Jimenez. et al.,Int. J. Pharm. 492, 223-232(2015);<br></p>

<p>Applications Flutriafol is a systemic fungicide of the triazole class. Flutriafol has broad spectrum fungicidal activity and is used to control effectively cereal powdery mildew, cloud disease, leaf spot disease and rust disease.<br>References Gozzo, F. et al.: Pest. Biochem. Physiol., 40, 68 (1991); Cao, W. et al.: Jing. Huag. Zhong., 36, 33 (2006); Evans, V.J. et al.: BCPC Conf. Pests Dis., 1, 511 (2000);<br></p>

<p>Applications Ambroxol O-glucuronide is a metabolite of Ambroxol (A575900, HCl salt), a bronchosecretolytic drug.<br>References Jauch, R., et al.: Arzneim-Forsch., 13, 474 (1963)<br></p>

<p>Applications Influenza viral neuraminidase inhibitor; structural analog of the sialic acid. Antiviral.<br>References Woods, J.M., et al.: Antimicrob. Agents Chemother., 37, 1473 (1993), Pegg, M.S., et al.: Biochem. Mol. Biol. Int., 32, 851 (1994), Monto, A.S., et al.: J. Am. Med. Assoc., 282, 31 (1999),<br></p>

<p>Stability Hygroscopic<br>Applications 3-Hydroxybutyrylcarnitine is a reagent used to study acylcarnitine profile in thyroid disease.<br>References Wong, S., et al.: Clinical Biochem., 46, 180 (2013); Alu, F., et al.: Heredity, 110, 253 (2013); Adam, B., et al.: Clinical Biochem., 44, 1445 (2011)<br></p>

<p>Applications Undecanoic-d21 Acid (CAS# 60658-40-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications L-Anserine (cas# 584-85-0) is a useful research chemical.<br></p>

<p>Applications Potent inhibitor of Phosphatidylinositol 3-kinase (PI3K)<br></p>

<p>Stability Hygroscopic<br>Applications Deuterated, Memantine (M218000) which is used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>

<p>Applications A metabolite of herbicide Diuron (D494415) and Linuron (L468500). It was investigated in wheat and radish.<br>References Field, J., et al.: J. Agric. Food Chem., 45, 3897 (1997),<br></p>

<p>Applications D-p-Hydroxyphenylglycinamide is an activated side chain precursor and is an intermediate in the synthesis of 3-(4-Hydroxyphenyl)-2(1H)-pyrazinone (H951260), which is a potential impuritiy of the penicillins, ampicillin and amoxicillin, which have not been reported previously. 3-(4-Hydroxyphenyl)-2(1H)-pyrazinone impurity may be formed during the semi-synthetic preparation of these antibiotics or upon their degradation.<br>References Munro, A., et al.: J. Pharm. Sci., 67, 1197 (1978); Lebelle, M., et al.: J. Pharm. Pharmacol., 31, 441 (1979); Gabor, E., et al.: PCT Int. Appl., WO 2004111241 A1 20041223 (2004)<br></p>

<p>Applications Niclosamide is used as an anthelmintic drug (Cestodes).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Loftsson, T., et al.: J. Pharm. Sci., 85, 1017 (1996), Malik, N., et al.: Anti. Cancer Drugs, 10, 767 (1999), El-Sayed, M., et al.: Pharm. Res., 18, 23 (2001),<br></p>

<p>Stability Hygroscopic<br>Applications Phenethicillin is a semisynthetic penicillin based β-lactam antibiotic and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive bacteria.<br>References Lucien, C., et al.: Can. med. Assoc. J., 84, 535 (1961); Timmers, G.J., et al.: Clin. Microbiol. Infect., 13, 497 (2007);<br></p>

<p>Applications 3-Hydroxy Niclosamide is a metabolite of Niclosamide(N395500) which is used as an anthelmintic drug (Cestodes).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Loftsson, T., et al.: J. Pharm. Sci., 85, 1017 (1996), Malik, N., et al.: Anti. Cancer Drugs, 10, 767 (1999), El-Sayed, M., et al.: Pharm. Res., 18, 23 (2001),<br></p>