Toxicology

Applications (1S,2R,6R)-6-Acetoxy-2-((bis(benzyloxy)phosphoryl)oxy)-4-(ethoxycarbonyl)cyclohex-3-en-1-yl benzoate is an intermediate in the synthesis of Shikimate-3-phosphate (S357026), an substrate for 5-Enolpyruvoyl-shikimate-3-phosphate synthase (EPSPS), the target for the board-spectrum herbicide N-(phosphonomethyl)glycine(glyphosate).
References Mooney, C.A., et al.: J. Med. Chem., 57, 3154 (2014);

Applications Simvastatin t-Butyldimethylsilyl Acyl-β-D-glucuronide-O-acrylate is an intermediate in synthesizing Simvastatin Acyl-β-D-glucuronide (S485005), a metabolite of Simvastatin.
References Billecke, S., et al.: Drug Metab. Dispos., 28, 1335 (2000); Draganov, D., et al.: J. Biol. Chem., 275, 33435 (2000); Igel, M., et al.: Eur. J. Clin. Pharmacol., 57, 357 (2001)

Applications A labelled degradation product of Desloratadine. Desloratadine impurity.
References ,Billah., et al.: Lipids, 26, 1172 (1991), Piwinski., et al.: J. Med. Chem., 34(1), 457 (1991)

Applications 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine N-β-D-Glucuronide Triacetate is an intermediate in the synthesis of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine N-β-D-Glucuronide Sodium Salt which is a carcinogenic Sodium Salt, is a metabolite of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) (A617000).
References Turesky, R., et al.: Mutat. Res., 506 187 (2002), Sugimura, T., et al.: Cancer Sci., 95, 290 (2004),

Applications A deuterated intermediate in the synthesis of Carisoprodol.

Applications S-Deoxyo-5-Hydroxy Acetate Omeprazole is an isotope labelled intermediate in the synthesis of 5-Hydroxy Omeprazole (H948863), the main metabolite of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.
References Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)

Stability Unstable in solution (DMSO or Methanol)
Applications Moxalactam Sodium is an oxacephem antibiotic. Moxalactam Sodium is more effective against Escherichia coli and Pseudomonas aeruginosa than cephalosporins.
References Yamamoto, K. et al.: Chemotherapy, 28, 1158 (1980); Toyonaga, Y. et al.: Jap. J. Antibiot., 34, 764 (1981); Nishimura, T. et al.: Jap. J. Antibiot., 34, 800 (1981):

Applications Dimethyl Succinate is used in the synthesis of antifungal agents and synthetic analogues.
References Lee, E. et al.: Ange. Chem. Int. Ed., 41, 176 (2002); Trost, B.M. et al.: J. Am. Chem. Soc., 124, 10396 (2002);

Applications Intermediate in the preparation of photolabeling and cross-linking reagent.

Applications ((2R,4R)-2-(Chloromethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-Methylbenzenesulfonate is an intermediate in the synthesis of Itraconazole (I937500), an orally active antimycotic structurally related to Ketoconazole. Antifungal.
References Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993)

Applications FR 179642 is an impurity of Micafungin (M342350), a lipopeptide compound that acts as an antifungal agent with activity against Aspergillus and Candida species.
References Denning, D., et al.: J. Infection, 53, 337 (2006); Queiroz-Telles, F., et al.: Pediatr. Infect. Dis. J., 27, 820 (2008)