Toxicology

<p>Applications 4-Methylsulfonyl-2-nitrobenzoic acid is a metabolite of Mesotrione.<br>References Guengerich, F., et al.: Drug Metab. Rev., 34, 607 (2002), Kurian, J., et al.: Chem. Res. Toxicol., 19, 1366 (2006), Yang, C., et al.: Biotechnol. Lett., 29, 487 (2007), Beaudegnies, R., et al.: Bioorg. Med. Chem., 17, 4134 (2009),<br></p>

<p>Applications 17α-Testosterone-16,16,17-d3 Cypionate is the isotope labelled analog of 17α-Testosterone Cypionate (T155155); the 17α-isomer of Testosterone Cypionate (T155100) which is an anabolic steroid with androgenic properties. Also used for testosterone therapy in males with hypogonadism.<br>References Rabkin, J.G. et al.: J. Clin. Psychopharmacol., 19, 19 (1999); Hajjar, R. et al.: J. Clin. Endocrinol. Metab., 82, 3793 (1997); Rhoden, E. et al.: J. Sex Med., 7, 277 (2010)<br></p>

<p>Applications O-Desethyl O-Isopropyl Dabigatran Etexilate-d13 is the labelled form of O-Desethyl O-Isopropyl Dabigatran Etexilate (D289378). O-Desethyl O-Isopropyl Dabigatran Etexilate is an impurity of Dabigatran Etexilate Mesylate (D100150). Dabigatran Etexilate Mesylate is a nonpeptide, direct thrombin inhibitor and an Antithrombotic agent.<br>References Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002); Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002); Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005)<br></p>

<p>Applications N-Methyl Ticlopidine-13C,D3 iodide is a labelled analogue of N-Methyl Ticlopidine iodide (M330270). N-Methyl Ticlopidine iodide is a derivative of Ticlopidine (T438325), a compound that antagonizes adenosine diphosphate-stimulated platelet aggregation.<br>References Kimchi, N., et al.: Digestion, 75, 36 (2007)<br></p>

<p>Applications 3’-Dechloro-4’-chloro Bupropion is an impurity of Bupropion (B689625), a arylaminoketone based monoamine reuptake inhibitor.<br>References Soroko, F., et al.: J. Pharm. Pharmacol., 29, 769 (1977); Tucker, W.E., J. Clin. Psychiatry, 44, 60 (1983); Hsyu, P-H., et al.: J. Clin. Pharmacol., 37, 737 (1997); West, R., et al.: Expert Opin. Pharmacother., 4, 533 (2003);<br></p>

<p>Applications A Phenobarbital derivative. Anticonvulsant.<br>References Hansch, C., et al.: J. Pharm. Sci., 61, 1 (1972), Andrews, P., et al.: J. Med. Chem., 26, 1223<br></p>

<p>Applications N-Hydroxy Vortioxetine O-β-D-Glucuronide Sodium Salt, is a metabolite of Vortioxetine (V766000, HBr); a multimodal serotonergic agent which inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT.<br>References Bang-Andersen, B., et al.: J. Med. Chem., 54, 3206 (2011); Mørk, A., et al.: J. Pharmacol. Exp. Ther., 340, 666 (2012); Mørk, A., et al.: Pharmacol. Biochem. Behav. 105C, 41 (2013); Uldam, H.K., et al.: Drug Metab. Dispos., 39, 2264 (2011)<br></p>

<p>Applications 4-Chloro-2-methylphenol is a transformation/degredation product of herbicides found in the environment through landfills and runoff.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lagana, A. et al.: Anal. Chim. Acta., 462, 187 (2002); Irmak, S. et al.: App. Catal. B. Environ.., 63, 243 (2006);<br></p>

<p>Applications Clothianidin-d3 (N-methyl-d3) (CAS# 1262776-24-8) is a useful isotopically labeled research compound. This compound can be used to detect trace levels of neonicotinoid insecticides in honey bee royal jelly using ultra-sound assisted liquid-liquid extraction-UHPLC/MS.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Giroud, B., et.al., Microchemical J., 151,104249,(2019);<br></p>

<p>Applications Pentachlorophenol-13C6 is the labeled form of Pentachlorophenol (P238100), which is used as insecticide for terminate control; pre-harvest defoliant; general herbicide. Antimicrobial preservative and fungicide for wood, wood products, starches, textiles, paints, adhesives, leather, pulp, paper, industrial waste systems, building materials. Surface disinfectant.This compound is a contaminant of emerging concern (CECs).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969),<br></p>

<p>Applications Paclitaxel Succinate-d4 is the labeled analogue of Paclitaxel Succinate (P132530), which ahs been used as a reactant for the preparation of molecular hydrogelators to be used as local delivery systems for chemotherapy.<br>References Wang, H., et. al.: J. Mater. Chem., 22, 16933 (2012)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled rac-trans-N-Methyl Sertraline (M326470). rac-trans-N-Methyl Sertraline is a related compound of rac-trans Sertraline (S279980).<br>References Welch, W.M., et al.: J. Med. Chem., 27, 1508 (1984),<br></p>

<p>Stability Moisture Sensitive<br>Applications Fenquizone is a thiazide-like diuretic commonly used for antihypertensive therapy.<br>References Costa, F., et al.: J. Clin. Pharmacol., 30, 254 (1990); Maggi, G., et al.: Arzneimittel-Forsch., 35, 994 (1984);<br></p>

<p>Applications Sodium salt of Flurbiprofen (F598700) an anti-inflammatory used as an analgesic.<br>References Chalmers, et al.: Ann. Rheum. Dis., 31, 319 (1972), Nishizawa, et al.: Thromb. Res., 3, 577 (1973)<br></p>

<p>Applications Use as muscle relaxant (skeletal).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cotton, M.L., et al.: Anal. Profiles Drug Subs., 17, 41 (1988),<br></p>

<p>Applications A deuterated substrate for CYP2B6.<br>References Kabumoto, H., et al.: Biosci., Biotechnol., Biochem., 73, 1922 (2009), Maresca, A., et al.: J. Med. Chem., 53, 335 (2010), Si-Ahmed, K., et al.: J. Pharm. Biomed. Anal., 51, 225 (2010),<br></p>

<p>Applications The labelled methylated analogue of Isobutyryl L-Carnitine (I780500). 2-Methylbutyryl-L-Carnitine is one of the acylcarnitines profiled from blood or plasma samples in the diagnosis of inborn errors of metabolism.<br>References Rashed, M.S. et al.: Pediat. Res., 38, 324 (1995); Frazier, D.M. et al.: J. Inher. Metab. Dis., 29, 76 (2006);<br></p>

<p>Applications 6-Chloronicotinic Acid, is an organic building block used for the synthesis of various biologically active compounds, including inhibitors. It is an intermediate for the synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, and novel DNA-gyrase B inhibitors.<br>References Xie, Y., et al.: Bioorg. Med. Chem. Lett., 23, 2306 (2013); Shiroya, U., et al.: Med. Chem. Res., 22, 5227 (2013);<br></p>

<p>Applications Labelled 4-Dimethylaminoantipyrine(D460890). Antipyretic; analgesic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Takahashi, T., et al.: Chem. Pharm. Bull., 6, 98 (1958), Lockwood, G.F., et al.: J. Pharm. Pharmacol., 31, 787 (1979),<br></p>

<p>Applications Famoxadone is a known fungicide used in the protection of agricultural products against various fungal diseases and other biotic stresses such as pests.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Speck- Planche, A., et al.: Excotoxicol. Enviro. Safety., 80. 308 (2012).<br></p>

<p>Stability Hygroscopic<br>Applications Phenylglycyl Cefaclor Hydrochloride, is an impurity of Cefaclor (C235250), which is a second-generation cephalosporin antibiotic. Antibacterial.<br>References Gray, B.M., et al.: Antimicrob. Agents Chemother., 13, 988 (1978); Lorenz, L.J., et al.: Anal. Profiles Drug Subs., 9, 107 (1980); Hori, R., et al.: J. Pharm. Pharmacol., 40, 646 (1988);<br></p>

<p>Applications Labelled Asenapine. Asenapine is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist; structurally related to Mianserin. Antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Meltzer, H. et al.: J. Pharmacol. Exp. Ther., 251, 238 (1989); Schotte, A. et al.: Brain Res., 631, 191 (1993); Andree, B. et al.: Psychopharmacology, 131, 339 (1997); Richelson, E. et al.: Life Sci., 68, 29 (2000);<br></p>

<p>Applications Clopidogrel derivative.<br></p>

<p>Applications Fenitrooxon is an organophosphorus insecticide.<br>References Ellman, G., et al.: Biochem. Pharmacol., 7, 88 (1961), Matthews, W., et al.: Pesticide Sci., 30, 21 (1990), Escartin, E., et al.: Environ. Toxicol. Chem., 15, 915 (1996), Barata, C., et al.: Toxicology, 66, 125 (2004),<br></p>

<p>Applications It is an antiepileptic.<br>References Burchall, J., et al.: Mol. Pharmacol., 1, 126 (1965), Cody, V., et al.: J. Med. Chem., 25, 427 (1982)<br></p>

<p>Applications 2-Amino-4,6-dimethoxypyrimidine is used in the making of herbicidal compositions.<br>References Hanagan, M. A., et al.: Bioactive Heterocyclic Compound Classes, 39, (2012); Wei, W., et al.: Bioorg. Med. Chem. Lett., 27, 3365 (2017); Ma, Y., et al.: Heterocycles, 92, 829 (2016); Carles, L., et al.: J. Hazard. Mater., 354, 42 (2018)<br></p>

<p>Applications (E)-Thiothixene is an antipsychotic agent used in the treatment of psychological disorders.<br>References Andorn, A. et al.: Brain Res., 971, 66 (2003); Seeman, P. et al.: Mol. Pharmacol. 28, 391 (1985);<br></p>

<p>Applications N-Desmethyl Regorafenib-d3 is the isotope labelled analog of N-Desmethyl Regorafenib (D293270); a synthetic metabolite of Regorafenib (R143000) used for treatment and prevention of cancer.<br>References Wilhelm, S.: PCT Int. Appl. WO 2011130728 A1 20111020. Oct 20, 2011<br></p>

<p>Applications 2,3,4,5,6-Pentachlorobenzeneamine is a chemical in pesticides used to protect crops from various fungus and bacterium.<br>References Gartrell, M. et al.: J. Assoc. Off. Anal. Chem., 68, 1163 (1985); Renner, G. et al.: App. Env. Microbio. 46, 765 (1983);<br></p>

<p>Applications N-[(6-Chloropyridin-3-yl)methyl]methylamine is a metabolite of Acetamiprid (A158000), a novel neonicotinid insecticide against Holotrichia consanguinea in sugarcane.<br>References Liu, Z.H., et al.: Pest, Manage. Sci., 67, 1245 (2011); Brunet, J.L., et al.: Pest. Manage. Sci., 61, 742, (2005);<br></p>

<p>Applications Propafenone-d5 Hydrochloride is the labeled analogue of Propafenone Hydrochloride (P757500), a sodium channel blocker. Antiarrhythmic (class IC).<br>References Hollmann, M., et al.: Arzneim.-Forsch., 33, 763 (1983); Bryson, H. M., et al.:Drugs, 45, 85 (1993); Rae, A. P., et al.: Am. J. Cardiol., 82, 59N (1998)<br></p>

<p>Applications Serotonin 5HT3-receptor antagonist. Used in treatment of irritable bowel syndrome.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Camilleri, M., et al.: Lancet, 355, 1035 (2000), Nestorov, I., et al.: Drug Metab. Dispos., 30, 276 (2002), Lewis, D., et al.: Drug Metab. Rev., 35, 1 (2003), Tang, H., et al.: J. Pharm. Sci., 95, 1783 (2006), Gleeson, M., et al.: J. Med. Chem., 50, 101 (2007),<br></p>

<p>Applications Morphine Methylsulfonate is a derivative of Morphine (M652285), which is the principle alkaloid of opium and an analgesic used to treat both acute and chronic pain.<br>References Stefano, G., et. al.: Folia Biol, 58, 49 (2012);Buchwald, M.E., et al.: J. Pharmacol. Exp. Ther., 71, 197 (1941); Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 17, 259 (1988)<br></p>

<p>Applications Labelled Bexarotene (B336750). Used as an antineoplastic. A selective retinoid X receptor (RXR) agonist.<br>References Boehm, M.F., et al.: J. Med. Che., 37,2930 (1994), Gottardis, M.M., et al.: Cancer Res., 56, 5566 (1996), Mukherjee, R., et al.: Nature, 386, 407 (1997), Miller, V.A., et al.: J. Clin. Oncol., 15, 790 (1997)<br></p>

<p>Applications Labelled Eltenac (E507000). A nonsteroidal anti-inflammatory drug.<br>References Allen, A., et al.: Gut, 21, 249 (1980), Tobin, T., et al.: J. Vet. Pharmacol. Therap., 9, 1 (1986),<br></p>

<p>Applications Labelled Pelitinib (P218702). A tyrosine kinase inhibitor; it is used to prepare formulation for treating primary or secondary cancer.<br>References Veronese, M., et al.: Br. J. Cancer, 92, 1846 (2005), Hofheinz, R., et al.: Onkologie, 29, 563 (2006), Meyerhardt, J., et al.: J. Clin. Oncol., 24, 1892 (2006), Hanauske, A., et al.: Clin. Cancer Res., 13, 523 (2007),<br></p>

<p>Applications Labelled Mefenamic acid metabolite.<br>References Besunder, J., et al.: Clin. Pharmacokinet., 14, 261 (1988), Smith, P., et al.: Drug Metab. Dipos., 18, 639 (1990), Kraus, D., et al.: Clin. Pharmacol. Ther., 54, 351 (1993), Sato, J., et al.: Biol. Pharm. Bull., 16, 811 (1993),<br></p>

<p>Applications Loratadine (L469575) Impurity. An isomer of N-Methyl Desloratadine (M316500).<br>References Zhong, D., et al.: Pharmazie, 49, 736 (1994); Ruperez, F., et al.: J. Pharm. Biomed. Anal., 29, 35 (2002);<br></p>

<p>Applications 4-Chlorophenol is a halogenated phenol derivative and the building block of various pharmaceutical goods.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Strempel, S., et al.: Environ. Toxicol. Chem., 32, 1187 (2013); Arif, N.M., et al.: J. Basic. Microbiol., 53, 9 (2013);<br></p>

<p>Applications Fludiazepam is a drug which is a benzodiazepine derivative. Fludiazepam possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.<br>References Fang, S.Y., et al.: Drug. Alcohol. Depend., 104, 140 (2009); Esteki, M., et al.: Chem. Biol. Drug. Design., 72, 409 (2008);<br></p>

<p>Applications N-Lignoceroyl Taurine facilitate skin wound healing in mouse skin where it was observed that margins of a freshly inflicted wound decreases with increasing dosage of N-Lignoceroyl Taurine.<br>References Sasso, O., et al.: Proc. Natl. Acad. Sci. U. S. A., 113, E4397-E4406 (2016)<br></p>

<p>Applications Malathion (Diethyl-d10) is used as one of the substances for the clean-up step in post-harvest pesticide residue analysis.<br>References Ucles, A., et al.: Talanta, 144, 51 (2015)<br></p>

<p>Applications 1,2-Epoxy GA3, is a derivative of Gibberellic Acid (G3774500), a hormone that is found in plants which promotes the growth and elongation of cells. Gibberellic acid acts as a plant growth regulator on account of its physiological and morphological effects in extremely low concentrations. Generally Gibberellic acid affects only the plant parts above the soil surface.<br>References Bayle, J. et al.: Chem. Biol., 13, 99 (2006); Ihara, S. et al.: J. Cell Sci., 119, 500 (2006); Suh, B. et al.: Science, 314, 1454 (2006); Rinaudo, K. et al.: Nat. Biotechnol., 25, 795 (2007);<br></p>

<p>Applications Systemic fungicide for control of powdery mildew, rust in cereal crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baloch, R.I., et al.: Phytochemistry, 23, 2219 (1984), Pommer, E.-H., et al.: Pestic. Sci., 15, 285 (1984),<br></p>

<p>Applications Benzyl-alpha-alpha-d2 Chloride (CAS# 33712-34-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications A Naphthalimides with potent anticancer activity.<br></p>

<p>Applications Ethylester-m-fexofenadine is a drug analog of Fexofenadine (F322470).<br></p>

<p>Applications Triazophos-D5 is the labeled form of Triazophos(T767595). Triazophos is an organophosphorus insecticide.<br>References Bhosale, B., et al.: Pestol., 33, 38 (2009), Dash, D., et al.: J. Entomol. Res., 33, 105 (2009), Hu, Y., et al.: J. Agric. Food Chem., 58, 2801 (2010),<br></p>

<p>Applications Labeled Lauric Acid which may be used in combination with drug loading to reduce side effects, such as irritation with clarithromycin.<br>References Liu, X. et al.: Int. J. Pharma., 443, 318 (2013);<br></p>

<p>Applications A dinitroanilie heribicide used for the control of a wide range annual grass and broadleaf weeds in crops such as groundnuts, tobacco, lettuce, turf, alfalfa, clover, watermelons and sweet melons.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bradley, M.R. et al.: Exp. Horticult., 29, 35 (1977); Harvey, R.G. et al.: Weed Sci., 25, 256 (1977); Grichar, W.J. et al.: Peanut Sci., 20, 126 (1993);<br></p>

<p>Applications Nor Dihydrocodeine is a metabolite of Dihydrocodeine (D448850).This is a controlled substance.<br>References Lahti, R., et al.: Eur. J. Pharmacol., 109, 281 (1985), Schwanstecher, M., et al.: J. Neurochem., 59, 1325 (1992), Bartlett, S., et al.: Life Sci., 57, 609 (1995), Ammon, S., et al.: Brit. J. Clin. Pharmacol., 48, 317 (1999),<br></p>

<p>Stability Light Sensitive<br>Applications Isodrine is a highly toxic compound that is used as a pesticide in the agricultural industry.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.: Toxicol. Appl. Pharm., 14, 515 (1969); Walton, I., et al.: Org. Lett., 14, 2686 (2012)<br></p>

<p>Applications Protected Propofol metabolite.<br></p>

<p>Applications Tecloftalam is an agrochemical fungicide. Tecloftalam is used for the control of rice bacterial leaf blight.<br>References Nakagami, K. et al.: Nip. Noyak. Gak., 5, 511 (1980); Kirkpatrick, D. et al.: J. Agric. Food Chem., 29, 608 (1981); Takahi, Y. et al.: Jap. Past. Info., 46, 25 (1985);<br></p>

<p>Applications Labelled Azathioprine (A803350). An immunosuppressive antimetabolite. Also active as disease modifying antirheumatic drug (DMARD).<br>References Mitrou, P.S., et al.: Arzneim.-Forsch., 29, 483, 662 (1979), Ding, T.L., et al.: Drug. Metab. Dispos., 7, 373 (1979), Chan, G.L.C., et al.: Pharmacotherapy, 7, 165 (1987), Sandborn, W.J., et al.: : Scand. J. Gastroenterol., 33, Suppl. 225, 92 (1998,)<br></p>

<p>Stability Hygroscopic<br>Applications 1-Amino-3-Hydroxybenzene is used in the preparation of inhibitors of mammalian carbonic anhydrase isoforms. Also used in the preparation of quinoline tethered fluorescent carbon dots for regulated anticancer discovery.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Carta, F. et al.: Bioorg. Med. Chem., 21, 1564 (2013); Karthik, S. et al.: Chem. Comm., 49, 10471 (2013);<br></p>

<p>Stability Moisture Sensitive<br>Applications Isodimethoate is an isomer of Dimethoate (D460505), which is an organophosphate insecticide. Isodimethoate is present in usual pesticide formulations of Dimethoate that is anticholinesterase which disables cholinesterase, an enzyme essential for central nervous system function and thus is neurotoxic for humans. Isodimethoate reacts with human red blood cell acetylcholinesterase (AChE) rendering part of AChE making it non-reactivatable.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tripathy, N.K. et al.: Mut. Res. Gen. Toxicol. Test., 206, 351 (1988); Papp, A. et al.: Pest. Biochem. Physiol., 61, 21 (1998); Eyer, P., et al.: Biochem. Pharmacol., 75, 2045 (2008);<br></p>

<p>Applications Insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nishizawa, Y., et al.: Agric. Biol. Chem., 25, 605 (1961),<br></p>

<p>Applications Estradiol 4-Carboxymethyl, is a metabolite of 17β-Estradiol (E888000). Estradiol is the major estrogen secreted by the premenopausal ovary.<br>References Bucala, R., et al.: J. Clin. Endocrinol. Metab., 60, 841 (1985), Telang, N., et al.: Anticancer Res., et al.: 11, 1021 (1991), Seeger, H., et al.: Med. Sci. Res., 26, 481 (1998), Bolton, J., et al.: Chem. Res. Toxicol., 13, 135 (2000),<br></p>