Toxicology

<p>Applications A component of pharmaceuticals used in the treatment of opioid dependence.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shiran, M., et al.: Brit. J. Clin. Pharmacol., 67, 29 (2008), Esteban, J., et al.: Drug Metab. Lett., 2, 269 (2008), Tolson, A., et al.: Drug Metab. Disposition, 37, 1887 (2009), Deeb, T., et al.: Mol. Pharmacol., 75, 908 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications Deethylterbutryne is a pollutant. It is photocatalytic degradation product of herbicide Irgarol (I764100), which is photosynthesis inhibitor.<br>References Konstantinou, I., et al.: Environ. Sci. Technol., 35, 398 (2001); Thomas, K., et al.: Sci. Total Environ., 293, 117 (2002); Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009);<br></p>

<p>Applications 2-chloro-N-(2-ethyl-6-methylphenyl)acetamide (cas# 32428-71-0) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications Bensulide, is an organophosphate acetylcholinesterase inhibitor used as an herbicide (1) in the protection of crops through pesticides (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Lisker, E. et al.: Bull. Environ. Contam. Toxicol. 2011 Oct;87(4):355-60.2. Pinkerton, T. et al.: Methods Mol. Biol. 2012;847:11-23.<br></p>

<p>Applications Used to stimulate root formation of plant clippings. Suitable for plant cell culture tested.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Handa, A., et al.: Plant Physiol., 69, 514 (1982), Polanco, C., et al.: Plant Sci., 162, 817 (2002), Rzepka-Plevnes, D., et al.: J. Food Agric. Environ., 5, 194 (2007),<br></p>

<p>Applications Gadodiamide is an apoptosis inducing agent used in chondrocytes. It is primarily used in muscoskeletal diagnosis as a contrast agent.<br>References Greisberg, J. et al.: Mag. Res. Imag., 19, 731 (2001); Hemmingsson, A. et al.: Mag. Res. Mat. Phys. Biol. Med., 12, 96 (2001);<br></p>

<p>Applications A labelled metabolite of Nabumetone (N200500). A competitive, non-selective COX inhibitor.<br>References Turpeinen et. al.: Drug Metabolism and Dispositoin, 37: 1017 (2009); Daniels, F., et al.: J. Invest. Dermatol., 44, 259 (1965), Bosca, F., et al.: Photochem. Photobiol., 71, 173 (2000),<br></p>

<p>Applications Ciprofibrate is a hypolipemic agent, related structurally to Clofibrate (C586910). Ciprofibrate is used as an antilipemic.<br>References Davison, C., et al.: Drug. Metab. Dispos., 3, 520 (1975), Arnold, A., et al.: J. Pharm. Sci., et al.: 68, 1557 (1979), Tuchman-Duplessis, H., et al.: Toxicology, 12, 1 (1979),<br></p>

<p>Applications Isotope labelled Epoxiconazole is a fungicide used to inhibit the metabolism and growth of mycelia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gromadzka, K., et al.: Cereal. Res. Commun., 40, 518 (2012); Chen, Yu,, Plant. Disease., 96, 1495 (2012); Echeverria-Saenz, S., et al.: Sci. Total. Environ., 440, 106 (2012);<br></p>

<p>Applications Carfentanil Citrate is a Fentanyl (F275000) analogue, an opioid receptor agonist. Analgesic agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zernig, G., et al.: Life Sci., 57, 2113 (1995), Bot, G., et al.: J. Pharmacol. Exper. Therap., 285, 1207 (1998), Gear, et al.: Neuroscience, 66, 5 (1995), Boronat, et al.: Br. J. Pharmacol., 125, 175 ( 1998), Ozdogan., et al.: Eur. J. Pharmacol., 460, 127 (2003),<br></p>

<p>Applications A labelled metabolite of Theophylline.<br>References ottrup, A., et al.: Pharmacol. Toxicol., 67, 340 (1990), El-Kadi, A., et al.: Drug Metab. Dispos., 28, 1112 (2000), Kim, S., et al.: J. Med. Chem., 45, 2131 ( 2002), Hansel, T., et al.: Drugs Today, 40, 55 (2004),<br></p>

<p>Applications 1-Chloro-4-[(methylsulfonyl)methyl]benzene is a metabolite of the pesticide benthiocarb (T344255).<br>References Ishikawa, K., et al.: Nippon Noyaku Gakkaishi, 1, 49 (1976); Ishii, Y., et al.: Dokl. Soobshch. - Mezhdunar. Kongr. Zashch. Rast., 8th, 3, 223 (1975); Duah-Yentumi, S., et al.: Soil Sci. Plant Nutr., 26, 541 (1980)<br></p>

<p>Applications A metabolite of Duloxetine.<br>References Lantz, R.J., et al.: Drug Dispos. Metab., 31, 1142 (2003), Detke, M., et al.: J. Clin Psy., 63, 308 (2002), Bymaster, F.P., et al.: Bioorg. Med., Chem. Lett., 13, 4477 (2003),<br></p>

<p>Stability Hygroscopic<br>Applications Ractopamine-d5 Hydrochloride is the isotope labelled analog of Ractopamine Hydrochloride (R071400); a β-adrenergic agonist and repartitioning agent.<br>References Eisemann, J.H., et al.: J. Nutr., 128, 504 (1998); Shelver, W.L., et al.: J. Agric. Food Chem., 48, 4020 (2000); Apple, J.K., et al.: J. Anim. Sci., 86, 2711 (2008)<br></p>

<p>Applications Nonsteroidal anti-inflammatory agent (NSAID).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)<br></p>

<p>Applications β-(4-Chlorophenoxy)-α-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol is a agricultural fungicide that is systemically active against powdery mildews and rusts of grains.<br>References Echeverria-Saenz, S., et al.: Sci. Total. Environ., 440, 106 (2012); Hrouzkova, S., et al.: Int. J. Environ. Anal. Chem., 92, 1546 (2012); Loos, M., et al.: Environ. Sic. Technol., 46, 9830, (2012);<br></p>

<p>Applications Monoamine oxidase inhibitor. Antidepressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 295 (1973),<br></p>

<p>Applications Ketorolac is an analgesic; anti-inflammatory.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Etman, M., et al.: Pharm. Technol., 32, 58 (2008), Chelladurai, S., et al.: Chem. Pharm. Bull., 56, 1596 (2008), Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009),<br></p>

<p>Applications Tianeptine Sodium Salt is a tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant.<br>References Malen, C., et al.: Experientia, 28, 811 (1972),<br></p>

<p>Applications Etoricoxib-d6 is the labelled analog of Etoricoxib (E934100), a specific inhibitor of COX-2 .<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McGeer, P.L., et al.: Exp. Gerontol., 37, 925 (2002), Chenevard, R., et al.: Circulation, 107, 405 (2003)<br></p>

<p>Applications Spirotetramat-​keto-​hydroxy can be used in analytical study and biological study multi-​residue method for the determination of pesticides and pesticide metabolites in honeybees by liquid and gas chromatography coupled with tandem mass spectrometry-​Honeybee poisoning incidents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kiljanek, T., et al.: J Chromtagr A, 1435, 100 (2016)<br></p>

<p>Applications Alanycarb is a oxime carbamate inseciticide with acetylcholinesterase inhibitor activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dulin, F., et al.: Ecotoxicol. Environ. Safety., 90, 183 (2013); Kawazu,K., et al.: J. App. Entomol. 135, 647 (2011);<br></p>

<p>Applications Mofebutazone is an anti-inflammatory drug used on the gastrointestinal and renal tissues.<br>References Khayyal, M.T., et al.: Int. J. Clin. Pharmacol. Res., 15, 145 (1995); Safwat, S.M., et al.: Drug. Deve. Indust. Pharm., 15, 2605 (1988);<br></p>

<p>Applications Methoxyphenone is a pesticidal compound, and it is used in preparation of Nitrones as herbicides.<br>References Campbell, Matthew J., et al:. PCT Int. Appl., (2018); Garizi, N., et al:.U.S. Pat. Appl. Publ., (2014);<br></p>

<p>Applications (R)-10-Monohydroxy-10,11-dihydro Carbamazepine-d3 is labelled (R)-10-Monohydroxy-10,11-dihydro Carbamazepine which is the metabolite of Oxcarbazepine (OXC) and Eslicarbazepine acetate, (BIA 2-093, ESL), novel central nervous system drugs.<br>References Duncan, J., et al.: Br. J. Clin. Pharmacol., 53, 123 (2002), Almeida, L., et al.: J. Clin. Pharmacol., 45, 1062 (2005), Coppola, G., et al.: CNS Drugs, 18, 133 (2004),<br></p>

<p>Applications Selective pre-emergence herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Viste, K.L., et al.: Science, 167, 280 (1970), Yoshii, K., et al.: J. Agric. Food Chem., 48, 2502 (2000), Paya, P., et al.: Anal. Bioanal. Chem., 389, 1697 (2007),<br></p>

<p>Applications Labelled (S)-Amphetamine. CNS stimulant; anorexic. More active isomer of Amphetamine. Induces release of catecholamines and serotonin by displacing the monoamines from their vesicular storage sites; blocks catecholamine reuptake.Controlled substance (stimulant).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Warren, M.R., et al.: J. Pharmacol. Exp. Ther., 85, 119 (1945), Behrendt, W.A, et al.: Arzneim.-Forsch., 13, 711 (1963), Seiden, L.S., Annu. Rev. Pharmacol. Toxicol., 32, 639 (1993),<br></p>

<p>Stability Light Sensitive<br>Applications S-Hydroprene, is an insect growth regulator used as an insecticide. It is used against cockroaches, beetles, and moths.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Environmental Protection Agency, Federal Register, 62, 61645 (1997); Bell, H. A., et al.: J. Stored Produc. Res., 35, 117 (1999);<br></p>

<p>Applications A labelled opioid analgesic. Used as a substitute to morphine for postoperative pain in children.<br>References Lundeberg, S. et al.: Acta Anaesthesiol. Scand., 54, 435 (2010); Christensen, T. et al.: Neurosci. Res. Comm., 26, 77 (2000);<br></p>

<p>Applications Calcitonin, Salmon is a calcium regulating hormone which exhibits hypocalcaemic and hypophosphatemic properties.<br></p>

<p>Applications A synthetic opioid similar in structure to Methadone (M225865). It acts as a μ-opioid receptor agonist and evokes heroin-like discriminative stimulus effects.<br>References Newman, J.L. et al.: Psychopharmacol., 164, 108 (2002); Brase, D.A. et al.: Biochem. Pharmacol., 25, 1684 (1976);<br></p>

<p>Applications 4-Amino-N-(1,1-dimethylethyl)-4,5-dihydro-3-(1-methylethyl)-5-oxo-1H-1,2,4-triazole-1-carboxamide is a triazolinone herbicide with a broad spectrum of weed control.<br>References Dayan, F., et al.: Weed Science, 57, 579 (2009); Elmore, M., et al.: Weed Technol., 27, 596 (2013)<br></p>

<p>Applications RTI-113 is a 3-phenyltropane analogue that acts as a potent and selective dopamine uptake inhibitor. RTI-113 has been shown to reduce cocaine self-administration at high occupancy of dopamine transporter. Studies suggest that RTI-113 and its analogs may be useful tools for developing potential agonist therapies for cocaine dependence.<br>References Dworkin, S. et al.: Synapse, 30, 49 (1998); Negus, S.S. et al.: Pharmacol. Biochem. Behav., 91, 333 (2009); Cook, C. et al.: Eur. J. Pharmacol., 442, 93 (2002);<br></p>

<p>Applications Allethrin is a synthetic pyrethroid derivative used as an insecticide. Allethrin is commonly used in many household insecticide products due to its low toxicity towards humans. Useful in cannabis testing kits as a component in pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dua, V.K. et al.: Bull. Environ. Contam. Toxicol., 75, 747 (2005); Jiang, M. et al.: Nanj. Nong. Dax. Xue., 18, 110 (1995);<br></p>

<p>Applications Ethirimol is a pyrimidine based fungicide with wide applications such as controlling leaf spot of sugar beet.<br>References Nougadere, A., et al.: Food. Chem. Toxicol., 49, 1484 (2011); Liu, B., et al.: J. Agri. Food. Chem., 58, 2673 (2010); Duchowicz, P.R., et al.: Bioorg. Med. Chem., 16, 7944 (2008);<br></p>

<p>Applications A novel labelled intermediate of Fexofenadine (F322470).<br>References McTavish, D., et al.: Drugs, 39, 552 (1990), Honig, P., et al.: Clin. Pharmacol. Ther., 52, 231 (1992), Yun, C., et al.: Drug Metab. Dispos., 21 403 (1993),<br></p>

<p>Applications A muscarinic receptor used as nootropic agent.<br>References Wolf-Pflugmann, M., et al.: Arzneim-Forsch./Drug Res., 39(1), 5, 539 (1989),<br></p>

<p>Applications Ezetimibe-d4 is the labeled analogue of Ezetimibe (E975000), an antihyperlipoproteinemic. A cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>