Toxicology

<p>Applications Tebuconazole is an ergosterol biosynthesis inhibitor present in most pesticide formulations (1,2). Various uptake is observed in plants (3). Drinking water Contaminant Candidate List 3 - CCL 3 as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants. Useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Grimalt S. et al.: Anal Bioanal Chem. 2015 Apr;407(11):3083-912. Gent, D. et al.: Plant Dis. 2003 May:87(5) p591-5973. Wang, C. et al.: Pest. Biochem. Physiol. 2007 Jan:87(1) p1-8<br></p>

<p>Applications Labelled analog of Nilotinib (AMN1O7), which might be useful in treatment of chronic myelogenous leukemia. It is a COVID19-related research product.<br>References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>

<p>Applications Quinmerac-3,8-dicarboxylic Acid is a impurity of Quinmerac (Q696500(P)) which is a Auxin-type herbicide.<br>References Grossmann, K., et al.: J. Exp. Bot., 52, 1811 (2001),<br></p>

<p>Applications A cell division factor found in various plant parts and in yeast. A plant growth regulator. Augments growth of microbial cultures.<br>References Fry, D.W., et al.: Science, 265, 1093 (1994), Vesely, J., et al.: Eur. J. Biochem., 224, 771 (1994),<br></p>

<p>Applications Olanzapine is a serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity. Antipsychotic. Neuroprotective product.<br>References Moore, N.A., et al.: Curr. Opin Invest. Drugs, 2, 281 (1993), Baldwin, D.S. and Montgomery, S.A.: Int. Clin. Psychopharmacol., 10, 239 (1995), Tohen, M., et al.: Am. J. Psychiatry, 156, 702 (1999)<br></p>

<p>Applications Rabeprazole-d4 is the labeled analogue of Rabeprazole (R070500), a partially reversible gastric proton pump inhibitor.<br>References Morii, M., and Takeguchi, N.: J. Biol. Chem., 268, 21553 (1993); Yasuda, S., et al.: Int. J. Clin. Pharmacol. Ther., 32, 466 (1994); Cloud, M.L., et al.: Dig. Dis. Sci., 43, 993 (1998)<br></p>

<p>Applications Dimepiperate is a pesticide used for weed control in rice.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Saeki, M.: PCT Int. Appl. (2007), WO 2007046440 A1 20070426. Apr 26, 2007<br></p>

<p>Applications Insecticide; acaricide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freitas, E., et al.: Exper. App. Acarol., 53, 189 (2011), Riviere, J., et al.: Toxicol. Sci., 119, 224 (2011),<br></p>

<p>Stability Moisture Sensitive<br>Applications Phosphoric Acid Tributyl Ester is used as a solvent in the solvent-detergent method for production of immunoglobulin for inactivation of viruses with lipid envelope on the model of duck hepatitis B virus. It is also used as a ligand in the extraction of lanthanide ions from solid and liquid materials by supercritical CO2.This compound is a contaminant of emerging concern (CECs).<br>References Zubkova, N., et al.: Bull. Exp. Biol. Med., 155, 821 (2013); Lin, Y., et al.: Anal. Chem., 66, 1971(1994)<br></p>

<p>Applications Labelled ester analog of Rapamycin.<br>References Raymond, E., et al.: J. Clin. Oncol., 22, 2336 (2004), Galanis, E., et al.: J. Clin. Oncol., 23, 5294 (2005)<br></p>

<p>Stability Hygroscopic<br>Applications A labelled form of Clofentezine which is used in agriculture for the protection of ornamentals, food and non-food crops in the field. Used as a standard for Pesticide detection. Clofentezine is used in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bakirci, G.T., et al.; Food. Chem., 135, 1901 (2012); Ay, R., et al.: Insect. Sci., 18, 503 (2011);<br></p>

<p>Applications The active labelled carboxylic acid metabolite of Ebastine.<br>References Hashizume, T., et al.: Drug Metab. Dispos., 29, 798 (2001), Hashizume, T., et al.: J. Pharmacol. Exp. Ther., 300, 298 (2002), Matsumoto, S., et al.: Xenobiotica, 33, 615 (2003), Chaikin, P., et al.: Br. J. Clin. Pharmacol., 59, 346 (2005),<br></p>

<p>Stability Moisture Sensitive<br>Applications Fensulfothion Oxon is a metabolite of the insecticide fensulfonthion (F265490), an inhibitor of cholinesterase activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rainsford, K.D., et al.: Pest. Biochem. Physiol., 8, 302 (1978); Iverson, F., et al.: Can. J. Biochem., 54, 918 (1976);<br></p>

<p>Applications Labelled Tolperisone, a muscle relaxant.<br></p>

<p>Stability Air Sensitive<br>Applications Used for detecting the presence of hydrolytic analytes, such as leukocytes, esterase, and protease. The detection of leukocytes is especially important in medical diagnostics.<br>References Jackson, D.S., et al.: Arch. Biochem. Biophys., 20, 323(1), 108 (1995)<br></p>

<p>Applications Tesofensine, is a serotonin–noradrenaline–dopamine reuptake inhibitor from the phenyltropane family of drugs, which is currently in clinical development for the treatment of obesity.<br>References Hansen, H., et al.: Pharmacology, Biochemistry and Behavior, 110, 265 (2013);<br></p>

<p>Stability Unstable in Methanol<br>Applications Tadalafil is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003), Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005), Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005),<br></p>

<p>Applications 1-Chloro-4-(chlorophenylmethyl)benzene is used in the synthesis of novel benzhydrylpiperazine derivatives as cytotoxic compounds in the treatment of various cancers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gurdal, E. et al.: Drug Res., 63, 121 (2013); Yarim, M. et al.: Int. J. Mol. Sci., 13, 8071 (2013);<br></p>

<p>Applications N-(Propyl(2-(2,4,6-trichlorophenoxy)ethyl)carbamoyl)formamide is a Prochloraz (P755280) metabolite.<br>References Needham, D., Challis, I.R.: Xenobiotica, 21, 1473 (1991); Debrauwer, L., et. al.: J. Agr. Food Chem., 49, 3821 (2001)<br></p>

<p>Applications Anti-inflammatory.<br>References Carson, et al.: J. Med. Chem., 14, 646 (1971), Wong, S., et al.: J. Pharmacol. Exp. Ther., 185, 127 (1973), Brogden, R.N., et al.: Drugs, 15, 429 (1978),<br></p>

<p>Applications Hexachlorobenzene is a fungicide that was formerly used as a seed treatment especially on wheat to control the fungal disease bunt.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Munoz, E. et al.: J. AOAC. Int., 95, 1777 (2012)<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of NNAL.<br>References Hecht, S.S., et al.: Chem. Res. Toxicol., 14, 555 (2001)<br></p>

<p>Applications N-Methyltaurine can be used as a counter ion in the formation of soaps.<br>References Miyahara, Reiji, et al.: J. of Oleo Sci., 50(10), 823-830 (2001)<br></p>

<p>Applications A glucuronide metabolite of Chlorpyrifos (C425300).<br>References Barron, M.G., et al.: Environ. Toxicol. Chem., 12, 1469 (1993), Tang, J., et al.: Drug Metab. Dispos., 29, 1201 (2001),<br></p>

<p>Applications N-Isopropyl quaternary salt of Atropine. Nonselective muscarinic acetylcholine receptor antagonist; bronchodilator.<br>References Groeben, H., et al.: Anesthesiology, 85, 867 (1996), Haddad, et al.: Br. J. Pharmacol., 127, 413 (1999), Barnes, P. J., et al.: Chest, 117, 63S (2000),<br></p>

<p>Stability Hygroscopic<br>Applications Isotope labelled analog of aminomethanephosphonic acid (A617340), a degradation product of glyphosate (G765000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Goupe, R.H., et al.: Pest. Manag. Sci., 68, 16 (2012); Saxton, M.A., et al.: J. Great. Lakes. Res., 37, 683 (2011);<br></p>

<p>Stability Hygroscopic<br>Applications Hexanoyl-L-carnitine-(N-methyl-d3) Chloride, is the labeled analogue of Hexanoyl-L-carnitine Hydrochloride (H294440), which is used as reactant in the synthesis of carnitine benzyl esters as prodrugs.<br>References Gong, X., et. al.: J. Chem. Res., 6, 327 (2008)<br></p>

<p>Applications 1,2,4-Triazol-4-amine is an intermediate used to prepare potent, selective, and orally active cyclooxygenase-​2 inhibitors. It is also used to synthesize hydroxyphenacyl azoles and related azolium derivatives as antifungal agents.<br>References Song, Y., et al.: J. Med. Chem., 42, 1151 (1999); Emami, S., et al.: Bioorg. Med. Chem. Lett., 18. 141 (2008)<br></p>

<p>Applications It is listed as a known human carcinogen. Used in manufacturing of dyes, as antioxidant in rubber.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References IARC Monographs, 4, 97 (1974),<br></p>

<p>Applications Picolinafen-d4 is deuterium labelled Picolinafen (P436800), a pesticide. It is a molecule for selective post emergence weed control in wheat and barley.<br>References Wang, J., et al.: Anal. Bioanal. Chem., 396, 1513 (2010); Sinclair, C., et al.: Environ. Sci. Technol., 40, 7283 (2006); Magnani, D., et al.: Atti, Giornate fitopatologiche, Perugia, 2, 405 (2000)<br></p>

<p>Applications Labelled Tamoxifen (T006000). A nonsteroidal estrogen antagonist of interest in the treatment of some forms of breast cancer. Tamoxifen is a protein kinase C inhibitor, and induces apoptosis in human malignant glioma cell lines.<br>References Sutherland, R., et al.: Nature, 267, 434 (1977), Lerner, L., et al.: Cancer Res., 50, 4177 (1990), Love, R., et al.: J. Clin. Oncol., 20 2559 (2002),<br></p>

<p>Applications Butachlor is a pre-emergent chloroacetanalide herbicide. Butachlor is commonly used for weed control in rice as well as cotton, maize, wheat and other crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References De Datta, S.K. et al.: Weed Res., 11, 41 (1971); Nadagoudar, B.S. et al.: Ind. J. Weed Sci., 13, 129 (1981); Yu, Y. et al.: Tur. Xueb., 39, 575 (2002);<br></p>

<p>Applications 4-Fluoroaniline is a degradation product of Ezetimibe (E975000). 4-Fluoroaniline is used as an analytical reagent in the enzymic detection of glucose.<br>References El-Moghazy, S.M. et al.: J. Chin. Chem. Soc., 56, 360 (2009); Gorski, L. et al.: Anal. Bional. Chem., 389, 533 (2007);<br></p>

<p>Applications A peripheral benzodiazepine GABAA receptor ligand, a new anxiolytic.<br>References Min, D., et al.: Pharmacotherapy, 12, 68 (1992), Rothwell, C., et al.: J. Toxicol. Sci., 27, 35 (2002), Gonzalez-Diaz, H., et al.: Bioorg. Med. Chem. Lett., 15, 1651 (2005), Boelsterli, U., et al.: Curr. Drug Metab., 7, 715 (2006), Rietjens, I., et al.: Chem. Res. Toxicol., 19, 977 (2006),<br></p>

<p>Applications Etofenprox is a pyrethroid derivative which is used as an insecticide. Used as a standard for Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lehotay, S., et al.: J. AOAC Int., 88, 595 (2005); Paya, P., et al.: Anal. Bioanal. Chem., 389, 1697 (2007)<br></p>

<p>Applications Acetaminophen-13C2, 15N1 is doubly labeled Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)<br></p>

<p>Applications Dihexadecyldimethylammonium Chloride is used in hair cosmetic as a emulsion agent.<br>References Guimaraes, J. P. D., et al., PCT Int. Appl. (2020), WO 2020257889 A1;<br></p>

<p>Applications Copper is a metal with a number of properties and uses, some of which include metal-organic framework-driven copper/carbon polyhedron which describes the synthesis, characterization and the role of copper in electrochemistry properties. Copper is used in electrochemical, radiational, and thermal energy technology studies.<br>References Qiao, Lulu., Journal of Materials Science, 53, 7755-7766, (2018)<br></p>

<p>Applications Movento is a synergistic insecticide. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Byrne, F., et al.: Crop. Prot., 25, 831 (2006), Kanrar, B., et al.: Bull Environ. Contam. Toxicol., 77, 631 (2006), Venkateswarlu, P., et al.: Food Chem., 105, 1760 (2007), Khay, S., et al.: Biomed. Chromatogr., 22, 581 (2008),<br></p>