Toxicology

Applications SN-38 4-Deoxy-glucuronide is a byproduct formed during the preparation of SN-38 Glucuronide.

Applications Terbufos-d10 (O,O-diethyl-d10) (CAS# 1276197-42-2) is a useful isotopically labeled research compound.

Applications Labelled analogue of Fenthion Sulfoxide, the sulfoxide anlogue and metabolite of the organothiophosphate insecticide Fenthion (F278000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wallnoefer, P. et al.: Pflanzensch.-Nach., 29, 236 (1976); Minelli, E.V. et al.: J. Agric. Food. Chem., 44, 936 (1996);

Applications It is a non-ergot dopamine agonist drug and is indicated for the treatment of Parkinson’s disease.
References Loschmann, P., et al.: Eur. J. Pharmacol., 166, 373 (1989), Edgar, D., et al.: J. Pharmacol. Exp. Ther., 283, 757 (1997), Ferreira, J., et al.: Lancet, 355, 1333 (2000), Arnulf, I., et al.: Neurology, 58, 1019 (2002), Wisor, J., et al.: Neuroscience, 132, 1027 (2005),

Applications Isotope labelled (2R)-3-Carboxy-2-[(9-carboxy-1-oxononyl)oxy]-N,N,N-trimethyl-1-propanaminium Inner Salt is a useful intermediate that is often used in the metabolic studies of insulin production in humans.
References Shah, S.H.; et al.: Diabetologia, 55, 321 (2012)

Applications Validamycin A is an antibiotic fungicide that inhibits trehalase activity in plants, insects, and fungi.

Applications A metabolite of Phenobarbital (P316760).
References Soine, W.H., et al.: Drug Metab. Dispos., 12, 792 (1984), Soine, W.H., et al.: J. Pharmac. Sci., 80, 99 (1991),

Stability Hygroscopic
Applications A labelled related drug of Clenbuterol (C569998), a β-agonist which can be used as a growth promoter in farm animals.
References Mosbach, K., et al.: Biotechnology, 14, 163 (1996), Rashid, B., et al.: J. Pharm. Biomed. Anal., 21, 635 (1999), Brambilla, G., et al.: Toxicol. Lett., 114, 47 (2000),

Applications 17α-Cyanomethyl-19-nortestosterone is a metabolite of Norethindrone (N676000), an progesteron used in combination with estrogen as contraceptive.
References Oettel, M., et al.: Pharmazie., 48, 541 (1993); Wong, T.C., et al.: J. Chem. Soc., Perk. Trans., 5, 765 (1988); Schubert, K., et al.: Org. Chem., 20, 143 (1985);

Applications 1-Naphthylacetyl Spermine Trihydrochloride is a poliamine amide as potent Spermidine uptake inhibitor.
References Li, Y., et al.: Cancer Res., 57, 234 (1997), Muller, T., et al.: Science, 256, 1563 (1992), Hironaka, K., et al.: J. Biol. Chem., 275, 16167 (2000),

Applications Methyl (2E)-[2-(chloromethyl)phenyl)](methoxyimino)acetate is an impurity from the pesticide active ingredient, Trifloxystrobin, a broad-spectrum foliar fungicide used in plant pritection.
References Margot, P. et al.: Bright. Crop Prot. Conf. Pest Dis., 2, 375 (1998); Karadimos, D.A. et al.: Crop Prot., 24, 23 (2005); Prom, L.K. et al.: Plant Dis., 87, 252 (2003);

Stability Air Sensitive, Light Sensitive
Applications Isotope labelled Phenserine is inhibitor of amyloid precursor protein (APP). Used in Alzheimer’s treatments.
References Nordberg, A. et al.: J. Alz. DIsease., 47, 691 (2015); Reale, M. et al.: Curr. Alzheimer. Treatments., 11, 608 (2014);

Applications 4,5-Dimethyl-N-2-propen-1-yl-3-thiophenecarboxamide is a derivative of Silthiofam (S465070(M)), which is a fungicide.
References Asrar, J., et al.: PCT Int. Appl. (2003), WO 2003026421 A1

Applications The labelled methylated analogue of Isobutyryl L-Carnitine (I780500). 2-Methylbutyryl-L-Carnitine is one of the acylcarnitines profiled from blood or plasma samples in the diagnosis of inborn errors of metabolism.
References Rashed, M.S. et al.: Pediat. Res., 38, 324 (1995); Frazier, D.M. et al.: J. Inher. Metab. Dis., 29, 76 (2006);

Applications (4S)-2-Oxoclopidogrel is an essential intermediate metabolite from which the active metabolite of Clopidogel is formed.
References Feliste, R., et al.: Thromb. Res., 48, 403 (1987), Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992), Herbert, J., et al.: Cardiovasc Drug. Rev., 11, 180 (1993), Sugidachi, A., et al.: B. J. Pharmacol., 132, 47 (2001)

Applications Fenbutatin Oxide is an organotin pesticide. Fenbutatin Oxide is widely used as an aracacide in the control of mites, in particular spider mites.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ishaaya, I. et al.: Pest. Biochem. Physiol., 6, 270 (1976); Inglesfield, C.: Bull. Environ. Contam. Toxicol., 38, 813 (1987); Riedl, H. et al.: Exp. Appl. Acarol., 11, 149 (1991);

Applications Cyprofuram
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Ethychlozate

Applications rac cis-Paroxetine N-Methyl is an impurity formed in the synthesis Paroxetine (P205750) related compounds.
References Gangula, S., et al.: Syn. Commun., 42, 3344 (2012);

Impurity Telmisartan dimer impurity
Applications An impurity of Telmisartan (T017000).

Applications Lynestrenol is an orally available progestogen hormone used in contraception to avoid hereditary angiodema as well as in treatment of ischemic stroke.
References Saule, C. et al.: Clin. Exp. Allergy, 43, 475 (2013); Beraki, S. et al.: PLoS One., 8, e69233 (2013);

Applications 3-Chloro-5-fluoro Clodinafop Propargyl is an impurity of Clodinafop Propargyl (C584515), which is a herbicide that is used for weed control in wheat.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Aliverdi, A., et al.: Weed Biol. Management, 9, 292 (2009), Hochberg, O., et al.: Weed Res., 49, 37 (2009), Liu, B., et al.: J. Agric. Food Chem., 58, 2673 (2010),

Stability Hygroscopic
Applications 4-(Trifluoromethoxy)aniline is used in the synthesis of anticancer agents and antitumor medicaments. Also, its an intermediate in the production of labelled Riluzole (R510000), a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cilibrizzi, A., et al.: J. Med. Chem., 52, 5044 (2009), Verhaeghe, P., et al.: Bioorg. Med. Chem., 17, 4313 (2009), Chandregowda, V., et al.: Eur. J. Med. Chem., 44, 3046 (2009), Wahl, F., et al.: Eur. J. Pharmacol., 230, 209 (1993) Bensimon, G., et al.: N. Engl. J. Med., 330, 585 (1994); Piras, S. et al.: Eur. j. Med. Chem., 75, 169 (2014); Vyas, V. et al.: Eur. J. Med. Chem., 82, 385 (2014);

Applications (1R)-trans-Bifenthrin is pyrethoid and a stereoisomer of B383000, which is a third generation synthetic pyrethroid. Insecticide, acaricide. Used in Pesticide detection
References Plummer, E.L., et al.: Pestic. Sci., 14, 560 (1983), Trumble, J.T., et al.: J. Econ. Entomol., 81, 608 (1988), Ross, M., et al.: Biochem. Pharmacol., 71, 657 (2006), Hillegass, J., et al.: Toxicol. Sci., 102, 413 (2008),