Toxicology

Stability Hygroscopic, Moisture Sensitive
Applications 1-​[1-​(4-​Chlorobenzoyl)​-​5-​hydroxy-​2-​methyl-​1H-​indole-​3-​acetate]β-​D-​Glucopyranuronic Acid is an analog of Indomethacin Acyl-β-D-glucuronide a metabolite of Indomethacin (I641000). Acyl glucuronides have been implicated in the toxicity of many xenobiotics and marketed drugs.
References Abid, A., et al.: Biochem. Pharmacol., 50, 557 (1995), Gamage, N., et al.: Toxicol. Sci., 90, 5 (2006), Cerveny, L., et al.: Drug Metab. Dispos., 35, 1032 (2007), Hayeshi, R., et al.: Eur. J. Pharm. Sci., 35, 383 (2008),

Applications 6-Chloropurine 2'-Deoxy-Beta-D-ribofuranoside Diacetate is an intermediate in the synthesis of anti-hepatitis C virus agents.
References Patil, V.M., et. al.: Lett. Drug Des. Discov., 7, 139 (2010)

Applications 4-Chloro-2-isopropyl-6-methylpyrimidine, is an intermediate used for the synthesis of some novel pyrimidine derivatives, having antifungal activities.
References Sun, L., et al.: Molecules, 16, 5618 (2011);

Applications An intermediate in the preparation of HIV-integrase inhibitors
References Summa, V., et al.: J. Med. Chem., 51, 5843 (2008),

Applications Isotope Labelled 1-Cyclopropyl-8-ethoxy-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid is an impurity in the synthesis of Moxifloxacin (M745000), a fluorinated quinolone antibacterial.
References Woodcock, J.M., et al.: Antimicrob. Ag. Chemother., 41, 101 (1997), Stass, H., et al.: Antimicrob. Ag. Chemother., 42, 2060 (1998)

Applications 2-Diethylaminoethyl Hexanoate is a compound found in soybean herbicidal safeners.
References Jin, G., et al.: Faming Zhuanli Shenqing, CN 106889062 (2017);

Impurity Clobazam EP impurity E
Applications Impurity of Clobazam (C582500), a benzodiazepine psychotherapeutic agent. Clobazam (CLB) has proven efficacy against multiple seizure types. An anxiolytic; anticonvulsant and a controlled substance (depressant).
References Gastaut, H., et al.: Epilepsia, 20, 437 (1979), Guberman, A., et al.: Can J. Neurol. Sci., 17, 311 (1990), Munn, R., et al.: Pediatr. Neurol. 9, 465 (1993),

Impurity Itraconazole EP Impurity E
Applications trans-Itraconazole (Itraconazole EP Impurity E) is a geometrical isomer of Itraconazole (I937500). It is a COVID19-related research product.
References Ahn, C., et al.: J. Korean Chem. Soc., 43, 676 (1999),

Applications Darunavir N-β-D-Glucuronide Sodium Salt (90%) is a salt analogue of Darunavir N-β-D-Glucuronide (D193510), which is a metabolite of Darunavir (D193500) an inhibitor of human immunodeficiency virus (HIV) protease. It is a COVID19-related research product.
References Vermeir, M. et al.: Drug Metab. Disp., 37, 809 (2009); Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003); Arasteh, K., et al.: AIDS, 19, 943 (2005);

Applications A deuterated selective acetylcholinesterase inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bickel, U., et al.: Clin. Pharmacol. Ther., 50, 420 (1991), Maelicke, A., et al.: Drugs Dis Today, 1, 53 (1996), Sauvaltre, T., et al.: J. Med. Chem., 50, 5311 (2007),

Applications Labelled Isoproturon. Pre-and post-emergence herbicide for control of annual grasses and broad-leaved weeds. Herbicide.
References Fournier, J.-C., et al.: Chemosphere, 4, 207 (1975), Gonzales, P., et al.: Weed Res., 23, 39 (1983),

Applications Used in the preparation of Epostane (E588850).

Applications 4-Methyl-1,2,3-Thiadiazole-5-Carboxylic Acid (cas# 18212-21-0) is a useful research chemical.

Applications Itraconazole Desethylene-seco-piperazine Di-N-formyl Impurity is a by-product in the synthesis of Itraconazole Desethylene-seco-piperazine Mono-N-formyl Impurity (I937520), which is an impurity of Itraconazole (I937500). Itraconazole is an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.
References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),

Stability Hygroscopic
Applications Intermedine is an unsaturated monoester pyrrolizidine alkaloid that is extracted from the seeds of Amsinckia intermedia, a tarweed that causes enzootic hepatic cirrhosis in horses and hard liver disease in cattle. Intermedine is also a diastereomer of Lycopsamine (L487525), a pyrrolizidine alkaloid that is found in honey and in comfrey (a topical anti-inflammatory agent used to treat patients with arthritis and gout).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Culvenor, C., et al.: J. Agr. Food Chem., 29 958 (1981); Janes, D., et al.: Nat. Prod. Comm., 7, 861 (2012); Li, Y. & Stermitz, F.: J. Nat. Prod., 51, 1289 (1988); McCulloch, E.: Am. Vet. Med. Assoc., 96, 5 (1940); Pawar, R., et al.: J. Sep. Sci., 33, 200 (2010)

Applications A metabolite of Cevimeline (C283500).

Applications Deacetylvinblastine hydrazide sulfate salt is the sulfate salt of Deacetylvinblastine hydrazide, a cytotoxic vinca alkaloid often conjugated with folic acid to produce EC145, a novel folate-receptor targeted agent that is currently under development as an anti-cancer agent.
References Pribble, P. & Edelman, M.: Expert Opin. Invest. Drugs, 21, 755 (2012); Reddy, J., et al.: Cancer Res., 67, 4434 (2007); Roy, M., et al.: Dev. Biol Stand., 74, 323 (1991)

Applications Protected rac Zearalenone-d6

Applications Efavirenz penteneyne is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor and antiviral agent.
References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)

Applications Endothall-3,4,4,5,5,6-d6 Monohydrate (CAS# 1276197-30-8) is a useful isotopically labeled research compound.

Applications A bioequivalent prodrug of the DNA topoisomerase II inhibitor Etoposide (E933750). Antineoplastic used in the treatment of a wide variety of hematological malignancies and solid tumors.
References Kaul, S. et al.: J. Clin. Pharmacol., 13, 2835 (1995); J. Pharmakin. Biopharmac., 24, 313 (1996); Brooks, D.J. et al.: Anti-Cancer Drugs, 6, 637 (1995);