Toxicology

<p>Applications A coordination compound for treatment of cervix cancer.<br>References Jiang, M., et al.: Methods Mol. Biol., 292, 401 (2005), Fujii, T., et al.: Int. J. Oncol., 29, 541 (2006), Niu, X., et al.: Int. J. Gynecol. Cancer, 16, 743 (2006),<br></p>

<p>Applications Intermediate in the preparation of Mifepristone derivatives.<br>References Jiang, W., et al.: Bioorg. Med. Chem. Lett., 17, 1471 (2007),<br></p>

<p>Applications (S)-(-)-2-Amino-3-benzyloxy-1-propanol is used as a reagent to synthesize 15-membered macrolide antibiotics. It is also used as a reagent to synthesize oxathiazinane dioxides, compounds that exhibit antiangiogenic properties.<br>References Borcard, F., et al.: Bioorg. Med. Chem. Lett., 20, 5353 (2010); Sugimoto, T., et al.: Bioorg. Med. Chem., 20, 5787 (2012)<br></p>

<p>Applications (1S,2R,6R)-6-Acetoxy-2-((bis(benzyloxy)phosphoryl)oxy)-4-(ethoxycarbonyl)cyclohex-3-en-1-yl benzoate is an intermediate in the synthesis of Shikimate-3-phosphate (S357026), an substrate for 5-Enolpyruvoyl-shikimate-3-phosphate synthase (EPSPS), the target for the board-spectrum herbicide N-(phosphonomethyl)glycine(glyphosate).<br>References Mooney, C.A., et al.: J. Med. Chem., 57, 3154 (2014);<br></p>

<p>Applications Methotrexate Disodium Salt is a folic acid antagonist which is used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>

<p>Applications S-Deoxyo-5-Hydroxy Acetate Omeprazole is an isotope labelled intermediate in the synthesis of 5-Hydroxy Omeprazole (H948863), the main metabolite of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.<br>References Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>

<p>Applications O-Benzyl Ganciclovir N-Formyl Diacetate Dimer is an intermediate used in the synthesis of Valganciclovir N3,N3'-Methylene Dimer (&gt;90%) (V092015), which is an impurity of Valganciclovir (V092000), a pro-drug of Ganciclovir (G235000) . Used in treatment of retro-virus.<br>References Acosta, E., et al.: Clin. Pharmacol. Ther., 81, 867 (2007), Nassetta, L., et al.: J. Antimicrob. Chemother., 63, 862 (2009),<br></p>

<p>Applications Labelled Azilsartan (A926900). An analgesic and antiinflammatory drugs containing angiotensin II antagonists.<br>References Kohara, Y., et al.: J. Med. Chem., 39, 5228 (1996), Plomgaard, P., et al.: Diabetes, 54, 2939 (2005), Fenton, C., et al.: Drugs, 2005, 65, 537,<br></p>

<p>Applications An impurity arising in the synthesis of Simvastatin.<br></p>

<p>Applications rac-cis-Permethrinic acid is a potent insecticide used in the agricultural industry to eliminate unwanted pests from crops. rac-cis-Permethrinic acid is also metabolite of pyrethroid compounds, a group of pesticides that are relatively low toxicity (to organisms that are not intended to be targeted) and biodegradable.<br>References Kale, M., et al.: Toxicol. Lett., 105, 197 (1999); Leszczynski, J., et al.: J. Am. Chem. Soc., 115, 5891 (1993); Sodurlund, D. &amp; Bloomquist, J.: Ann. Rev. Entomol., 34, 77 (1989)<br></p>

<p>Applications 4-Hydroxyestradiol 3-O-β-D-Glucuronide is a glucuronide derivative of 4-Hydroxy-17β-estradiol (H941895); a metabolite of Estradiol (E888000) which is the major estrogen secreted by the premenopausal ovary.<br>References Bucala, R., et al.: J. Clin. Endocrinol. Metab., 60, 841 (1985); Telang, N., et al.: Anticancer Res., et al.: 11, 1021 (1991); Seeger, H., et al.: Med. Sci. Res., 26, 481 (1998); Bolton, J., et al.: Chem. Res. Toxicol., 13, 135 (2000); Salole, E.G., et al.: Anal. Profiles Drug Subs., 15, 283 (1986); Lievertz, R.W., et al.: Am. J. Obstet. Gynecol., 156, 1289 (1987)<br></p>

<p>Applications Used as a herbicide<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Davis, V., et al.: Weed Sci., 57, 494 (2009), Bellaloui, N., et al.: J. Agric. Food Chem., 57, 9050 (2009),<br></p>

<p>Applications Paliperidone Palmitate is a long-acting injectable atypical antipsychotic used in the treatment of schizophrenia.<br>References Hough, D. et al.: Prog. Neuro-psychophamacol. Biol. Psych., 33, 1022 (2009); Samtani, M.N. et al.: Clin. Pharmacokin., 48, 585 (2009); Nasrallah, H.A. et al.: Neuropsychopharmacology, 35, 2072 (2010);<br></p>

<p>Applications 4-Bromo-2,5-dichlorophenol is a building block that has been used as a reactant in the preparation of phenoxy-nicotinamides with bile acid receptor GPBAR1 (TGR5) inhibiotory activity.<br>References Martin, R.E., et. al.: ChemMedChem, 8, 569 (2013)<br></p>