Toxicology

<p>Applications Fenoxanil (cas# 115852-48-7) is an amide fungicide<br></p>

<p>Applications 1-[5-Chloro-2-(2,4-dichlorophenoxy-13C6)phenyl]ethanone is an intermediate in the synthesis of Triclosan-13C6 (T774253). Isotope labelled Triclosan is used as bactericide and preservative for cosmetic and detergent compositions (1). Broadly used as an antiseptic and disinfectant (2). This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br></p>

<p>Applications Ertapenem N-tert-Butyloxycarbonyl 4-Nitrophenyl Methyl Ester is an protected analog of Ertapenem (E635000), an antibacterial agent belonging to group 1 carbapenem antibiotic.<br></p>

<p>Applications Used in the preparation of triazole antifungal agents.<br></p>

<p>Applications 3-Benzyloxy-2-(2-hydroxy-2-phenylethyl)-4H-pyran-4-one is an intermediate in the synthesis of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor.<br></p>

<p>Applications 3-[[(1,1-Dimethylethyl)diphenylsilyl]oxy] Ergosta-7,24(28)-diene is an intermediate in the synthesis of Episterol which is a compound influencing ergosterol biosynthesis, and thus acting as an antifungal agent.<br>References Mallory, J. et al.: Pharmacol., 3, 179 (2012); Mueller, C. et al.: Steroids, 78, 483 (2013);<br></p>

<p>Applications Protected metabolite of Chloramphenicol (C325030).<br>References Simons, P., et al.: Xenobiotica, 22, 1267 (1992), Kaji, H., et al.: Drug Metab. Dispos., 33, 60 (2005),<br></p>

<p>Applications 5H-Pyrido[1,2,3-de]-1,4-benzoxazine-D3 Boron Derivative is an intermediate in the synthesis of (R)-Ofloxacin-d3 (O245742), which is a labelled fluorinated quinolone antibacterial. An enantiomer of Levofloxacin (L360000).<br>References Hwangbo, H.J. et al.: Eur. J. Pharmac. Sci., 18, 197 (203); Gascon, A.R. et al.: J. Clin. Pharmacol, 40, 869 (2000); Monk, J.P., et al.: Drugs, 33, 346 (1987); Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990);<br></p>

<p>Applications An intermediate in the preparation of heteropolycyclic quinolones.<br>References Dogan, J. et al.: Heterocycles, 41, 1659 (1995)<br></p>

<p>Applications Isotope labelled analogue of Thiothiamine, an impurity of Thiamine (T344185). Thiothiamine inhibits the activity of glutamate decarboxylase and decreases the concentration of GABA in brain tissue. Thiamine Impurity A;<br>References Koval'chuk, V.G. et al.: Tezisy Dokl.- Konf. Beloruss. Biokhim. O-va., 2, 135 (1974); Ostrovskii, Y. et al.: Biokhimiya, 34, 488 (1969);<br></p>

<p>Applications (9Z)-Erythromycin A Oxime is a metabolite of Roxithromycin (R700850) in humans.<br>References Zhong, D. et al.: Drug Metab. Dispos., 28, 552 (2000)<br></p>

<p>Applications ((2S,4S)-2-(Chloromethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-Methylbenzenesulfonate is an intermediate in the synthesis of Itraconazole (I937500), an orally active antimycotic structurally related to Ketoconazole. Antifungal.<br>References Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993)<br></p>

<p>Applications Clindamycin Cyclomonophosphate is a by-product during the synthesis of Clindamycin Phosphatidyl Anhydride (C580110), an impurity of Clindamycin (C580000), which is an antibiotic prepared from Lincomycin (L466200), used to treat various infections.<br>References Birkenmeyer, R.D., et al.: J. Med. Chem., 13, 616 (1970); Oesterling, et al.: J. Pharm. Sci., 59, 63 (1970); Gray, J.E., et al.: Toxicol. Appl. Pharmacol., 21, 516 (1972); Brown, L.W., et al.: Anal. Profiles Drug Subs., 10, 75 (1981)<br></p>

<p>Applications 6-Quinoxalinecarboxylic Acid is an intermediate used in the production of antiprotozoal agents.<br>References Kim, D., et al.: Eur. J. Med. Chem., 44, 568 (2009), Lyne, P., et al.: Bioorg. Med. Chem. Lett., 19, 1026 (2009),<br></p>

<p>Applications 3-Phenyl-3-hydroxypropanenitrile (cas# 17190-29-3) is a compound useful in organic synthesis.<br></p>

<p>Applications (S)-Carnitine Mesylate, Mesylate Salt (cas# 161886-60-8) is a compound useful in organic synthesis.<br></p>