Biochemicals and Reagents

MOG (183-191) FVIVPVLGP

Lidocaine (USP grade powder) chemical reference substance

CHRAC1 antibody was raised in rabbit using the N terminal of CHRAC1 as the immunogen

Dihydrocurcumin is an analog of curcumin, a natural compound with antioxidant and anti-inflammatory properties. It has been shown to be a potent inhibitor of bacterial strains such as Salmonella enterica serovar Typhimurium and Escherichia coli O157:H7. Dihydrocurcumin binds to the bacterial target protein, which inhibits the polymerase chain reaction (PCR). This leads to decreased bacterial growth and increased sensitivity to antibiotics. Dihydrocurcumin also has low bioavailability because it is metabolized by fatty acid conjugation in vivo and is not absorbed by the gut. It has been shown to have pharmacokinetic properties that are similar to those of other curcuminoids due to its chemical similarity in structure.

A synthetic peptide for use as a blocking control in assays to test for specificity of NMT1 antibody, catalog no. 70R-2314

Mouse monoclonal NT5DC1 antibody

The Furazolidone monoclonal antibody is a highly specialized and targeted therapeutic agent used in the field of Life Sciences. This monoclonal antibody specifically targets extracellular substances found in blood plasma, making it a valuable tool in various medical applications. It has shown promising results in the treatment of leukemia and other related conditions.

Didesmethyl cariprazine is a peptide that belongs to the group of activators. It has been shown to be an inhibitor of protein interactions and a ligand for the 5-HT2A receptor. Didesmethyl cariprazine has also been found to have pharmacological effects on ion channels and cell biology, such as life science.

Purified Polyclonal HECW2 antibody

Reacts with tetrazines to produce a stable, covalent linkage, also referred to as the inverse-electron demand Diels-Alder cycloaddition reaction. This reaction is extremely fast (k > 800 M -1 s-1), selective, biocompatible, and does not require Cu-catalyst or elevated temperatures.

1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a lipid used as a research tool for studying the interactions between proteins. DMPC has been shown to inhibit antibody binding and cell signaling, suggesting that it can be used as an inhibitor or activator of protein interactions. DMPC is also used in pharmacology and life sciences to study ion channels, receptors, and ligands. It has a high purity level of 99% and is available at low cost.

Biotin-MAGE-A1 (278-286) is the N-ter biotinylated version of MAGE-A1 (278-286). Biotin-MAGE-A1 (278-286) can be used in the analysis of antigen-specific T cells. MAGE-A1 protein:
MAGE-A1 (278-286) is an epitope of Melanoma Antigen Gene A1 expressed by tumors of different histological types such as on the surface of breast carcinoma cell and is a Cancer/Testis Antigens (CTA). MAGE-A1 is a tumor antigen expressed in 40% of melanoma and contains epitope for binding HLA-A*02:01 molecules and that are recognized by cytotoxic T cells.
Applications of MAGE-A1 (278-286):
MAGE-A1 (278-286) is used to stimulate specific cytotoxic T cells in PBMCs and to analyze by ELISPOT peptide epitope specificity and cytokine production like IFN-γ. Immunogenicity of MAGE-A1 (278-286) raised the possibility of developing anticancer immunotherapies or vaccinations. MAGE-A1 is also expressed in lung adenocarcinoma and studies suggest that MAGE-A1 may serve to develop Chimeric Antigen Receptor (CAR) T cell therapy using lentiviral vector and show an encouraging tumor-inhibitory efficacy.
Sequence: Biotin-KVLEYVIKV

Selective blocker of muscular nACh receptors

SB 204990 is a growth factor that belongs to the group of fatty acid derivatives. It inhibits acetyl-CoA carboxylase and carnitine palmitoyltransferase, which are enzymes involved in fatty acid synthesis and cholesterol synthesis. SB 204990 also inhibits the activity of mitochondrial ATP synthase, which is responsible for the production of ATP. This drug has been shown to increase levels of atp in cells, which may be due to its inhibition of mitochondrial ATP synthase. SB 204990 is also known to have anti-inflammatory properties as it inhibits prostaglandin synthesis.

Human beta-defensin-2 (hBD-2), also known as skin-antimicrobial peptide 1 (SAP1) is a cysteine-rich cationic antimicrobial peptide of 41 amino acids. It was originally isolated from skin cells of psoriasis patients. hBD-2, which belongs to the defensin family, is implicated in the innate immunity thanks to its antimicrobial activity. Thus, β-defensins can play a role at the cutaneous level by limiting the use of antibiotics in severe burns and disease like psoriasis. Moreover, at the pulmonary level, defensins might be involved in the resorption of the infection in cases of cystic fibrosis.
hBD-2 is produced after stimulation of epithelial cells following their contact with some organisms like Gram-negative bacteria and Candida Albicans, fungus or cytokines such as TNF-alpha and IL-1 beta. This antimicrobial activity was shown to be microbicidal at concentrations greater than 1 µM and was lethal for E.Coli and pseudomonas (LD90 : 10 mg/mL) and Candida Albicans (LD90 : 25 mg/mL). Besides its antimicrobial activity, hBD-2 also exhibits proinflammatory properties as chemoattractants for memory T-cells, immature dendritic cells, mast cells and neutrophils.
hBD-2 has also demonstrated inhibitory activity of the voltage-gated potassium channel Kv1.3 at picomolar concentration. Kv1.3 are overexpressed by T-cells in case of autoimmune disorders.

Falipamil is a peptide that inhibits the interaction of proteins. It binds to the receptor site of the protein and blocks its activity. Falipamil is not an agonist, meaning it does not activate the receptor. It is also a ligand, which means it binds to specific receptors and activates them. Falipamil has been shown to be an excellent research tool for studying protein interactions, as well as being used in antibody production. This product can be used for life science research and has high purity with a CAS Number of 77862-92-1.

The IL17 antibody is a monoclonal antibody that targets the colony-stimulating factor, activated. It is widely used in the field of Life Sciences for research purposes. This antibody specifically binds to IL17, a cytokine that plays a crucial role in immune response and inflammation. By blocking the interaction between IL17 and its receptors, this antibody inhibits the downstream signaling pathways, leading to a reduction in inflammation. Additionally, the IL17 antibody has been shown to have potential therapeutic applications in various diseases such as rheumatoid arthritis and psoriasis. With its high specificity and potency, this antibody is an essential tool for researchers studying cytokine biology and developing novel therapies.

4-Fluoro-3-(4-hydroxypiperidin-1-yl)sulfonyl-N-(3,4,5-trifluorophenyl)benzamide is a small molecule that binds to and inhibits the activity of ion channels. It has an affinity for ligand gated ion channels, like nicotinic acetylcholine receptors (nAChRs) and serotonin type 3 receptors (5HT3). 4-Fluoro-3-(4-hydroxypiperidin-1-yl)sulfonylbenzamide is a research tool used in pharmacology and protein interaction studies. The compound is available at high purity and can be used as an inhibitor in antibody or cell biology experiments.

tert-Butyl 5-((4-ethyl-5-formyl-3-methyl-1H-pyrrol-2-yl)methyl)-3,4-dimethyl-1H-pyrrole-2-- carboxylate (BEMPC) is a potent and selective activator of the ion channel TRPV6. It has been shown to activate TRPV6 in a concentration dependent manner and at concentrations of 10 μM or lower, BEMPC activates TRPV6 with an EC50 of approximately 1 μM. This compound is also an inhibitor of protein synthesis in cells.

Protirelin – Thyrotropin-releasing hormone (TRH) (CAS: 24305-27-9)

PI3Kα and PI3Kδ inhibitor

BAY-885 is a drug development candidate that has been shown to have potent cytotoxic activity against cancer cells. BAY-885 inhibits the constitutive activation of the transcription factor NF-κB, which is involved in tumor growth, proliferation, and survival. It also inhibits the enzymatic activity of the protein caspase 3. This drug has demonstrated high potency in cell culture and animal models.

CGP 48664A is a polyamine analog that selectively inhibits the activity of two enzymes, ornithine decarboxylase and orotate phosphoribosyltransferase. It has been shown to have potent antitumor activity against solid tumours in mice, including metastatic colorectal cancer, and it has also shown to have potent anti-infectious effects against infectious diseases such as malaria. CGP 48664A has been shown to inhibit the growth of carcinoma cells in cell culture. CGP 48664A has been found to be highly selective for inhibiting the enzyme ornithine decarboxylase (ODC) and orotate phosphoribosyltransferase (OPRT), which are involved in polyamine biosynthesis. The enzyme activities of ODC and OPRT were inhibited by up to 90% when incubated with concentrations of 10 μM or higher. When the enzyme activities were inhibited by C

PF-06284674 is a potent and selective small molecule activator of the human angiotensin II type 1 receptor. Angiotensin II is a hormone that regulates blood pressure, water and electrolyte balance, and vascular tone. The activation of the angiotensin II type 1 receptor by PF-06284674 has been shown to produce vasodilation in various tissues including the kidney, heart, and brain. PF-06284674 may be useful for research purposes as an inhibitor of protein interactions or an antibody production tool.

CD9 antibody (FITC) was raised in mouse using human CD9 as the immunogen.