Biochemicals and Reagents

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Glutaryl-Phe-AMC is a fluorophore that has been used to study dental plaque. It is an amide of glutaryl-Phe and AMC, which is a water molecule. Glutaryl-Phe-AMC is a synthetic molecule that can be deprotonated by histidine in the presence of d-homoserine. The fluorescence of this compound increases when it binds to the enzyme substrates, 7-amino-4-methylcoumarin (AMC) and water molecules. This assay can be used for studying proteolytic activity on enzymes such as protease and amylase.</p>

<p>Please enquire for more information about Amyloid beta-Protein (22-35) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Please enquire for more information about Amyloid beta/A4 Protein Precursor770 (740-770) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>SB 258585 hydrochloride is a positron-emitting radiotracer that binds to dopamine D2 receptors in the brain. It has been used for positron emission tomography (PET) imaging studies of the human brain. SB 258585 hydrochloride is taken up by the brain and specifically targets striatal regions. It can be used in clinical development as an unlabelled surrogate marker of dopamine D2 receptors. This drug has been validated for use in macaque models and shown to be a molecular imaging agent with high sensitivity, specificity, and good pharmacokinetic properties.</p>

<p>Please enquire for more information about Fmoc-Lys(Boc)-Cys(Psi(Dmp,H)pro)-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>H-Glu-Glu-OH is an organic acid that has proteolytic and gene product properties. It is a hyperactive compound that can be used as a sample preparation reagent for the detection of glutamic acid in proteins. H-Glu-Glu-OH inhibits protein synthesis by binding to ribosomes, which are responsible for the production of proteins in the cell, and prevents their function. Magnetic resonance spectroscopy has been used to investigate the uptake of H-Glu-Glu-OH into mammalian cells and ovarian follicles.</p>

<p>Trinexapac is a fungicide that belongs to the group of systemic, acylated triazoles. It is used for protecting perennial ryegrass against diseases caused by fungi. Trinexapac has been shown to inhibit fatty acid synthesis and cause an accumulation of monocarboxylic acids in plant tissue. This effect is due to its ability to inhibit the enzyme acylation reaction, which converts acetyl-CoA into fatty acids. Trinexapac also inhibits the production of ethylene and other essential oils in plants, as well as inhibiting sporulation in mollusks. Trinexapac is applied as a liquid or granular formulation and can be detected using analytical methods such as liquid chromatography or gas chromatography.</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>BRD6688 is a protein inhibitor that binds to and inhibits the activity of GABA transporters. It is a potent inhibitor of the gaba transporter (GAT) with an IC50 of 0.2 μM. BRD6688 has been shown to inhibit the acetylation of histone proteins, which are important for transcriptional regulation and gene expression. BRD6688 also has a thermodynamic inhibitory constant (Ki) of 1.4 μM and a kinetic inhibitory constant (Ki) of 0.3 μM, indicating that it binds tightly to GATs and does not dissociate easily from it. The Ki values were determined by measuring the inhibition of GAT-mediated chloride transport in cells cultured in vitro. This drug also inhibits antigen presentation in T cells by inhibiting protein synthesis and cell division, as well as histone methylation during mitosis, leading to downregulation of cell-surface antigens on B cells.</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Please enquire for more information about H-Ile-2-chlorotrityl resin (200-400 mesh) (Low Substitution) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Berubicin is an anthracycline-based chemotherapeutic agent, which is a semi-synthetic derivative sourced primarily from the bacterium Streptomyces peucetius. It operates by intercalating into DNA strands, disrupting the replication and transcription processes, which ultimately induces apoptosis in rapidly dividing tumor cells.</p>

<p>20-Azido-3,6,9,12,15,18-hexaoxaicosanoic acid is a synthetic ligand that binds to the receptor for lysophosphatidic acid. It has been shown to inhibit the activity of ion channels and receptor tyrosine kinases. This compound also activates protein kinase C and inhibits phospholipase A2. 20-Azido-3,6,9,12,15,18-hexaoxaicosanoic acid is soluble in water and has a purity of &gt;99%.</p>

<p>Please enquire for more information about Fluorescein-6-carbonyl-Leu-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Fmoc-Tyr(tBu)-Wang resin (100-200 mesh) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Avibactam descarbonyl is a medicinal compound that has shown promise as an anticancer agent. It is an analog of kinase inhibitors, which are known to have potent anticancer activity. Avibactam descarbonyl has been shown to induce apoptosis in cancer cells and inhibit the growth of tumors in Chinese hamsters. This compound has also been found in urine samples from patients receiving avibactam therapy, suggesting that it may be a metabolite of this drug. Avibactam descarbonyl is a cyclin-dependent protein kinase inhibitor, which means that it can prevent the proliferation of cancer cells by blocking cell cycle progression. This compound has potential for use in cancer treatment due to its potent anticancer activity and ability to induce apoptosis in tumor cells.</p>

<p>Please enquire for more information about rec Serum Amyloid A Protein (human) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Peptide Lv (rat) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Z-Ala-Glu-OH is an amino acid with a glutamate residue. It is a synthetic amino acid that has been shown to have excitotoxic effects in the brain. The mechanism of action is thought to involve the activation of ionotropic glutamate receptors and the inhibition of voltage-gated potassium channels, leading to neuronal cell death. This compound has been found to be a sweetener in biochemical reactions. Z-Ala-Glu-OH was shown to undergo proteolytic degradation, which may be due to aminopeptidases present in the gut or enzyme preparations used during digestion. This amino acid was also shown to have neurodegenerative properties when given orally to mealworms, as well as profiles that are similar to those found in humans with neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis.</p>

<p>Please enquire for more information about Z-Gly-Gly-Trp-OH TFA including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Dooku1 is a synthetic biochemical compound designed for advanced research applications. It is derived through a complex series of organic synthesis processes that utilize specialized reactants and catalysts to achieve high purity and specificity. The compound functions by selectively binding to molecular targets, allowing researchers to investigate cellular pathways and molecular interactions with greater precision.</p>

<p>Please enquire for more information about H-Gly-2-chlorotrityl resin (200-400 mesh) (Low Substitution) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Z-Phe-Val-OH is an optical isomer of the molecule Z-Val-OH. It can be synthesized from the reactants Isobutyl, Chloroformate, and Hydrophobic. This synthetic product has been shown to have high yields and specificities. The chiral center in this molecule causes it to rotate light in one direction or another, which means that it can be used to create a spectrum of colors. The synthesis of this molecule takes place in a kinetically controlled manner. When mixed with amines, carboxylic acids, and tripeptides, this compound will form a tripeptide bond with two amino acids on either side of the peptide chain.</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Inhibitor of MDM2 E3 ubiquitin-protein ligase and MRP1 transporter</p>

<p>Please enquire for more information about Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Monoclonal antibody against RANKL; anti-resorptive agent for osteoperosis treatment</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Please enquire for more information about Fluorescein-6-carbonyl-Leu-Glu(OMe)-His-DL-Asp(OMe)-fluoromethylketone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 5,6-Dehydro finasteride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Bpoc-Gly-OH·DCHA including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Biotinyl-epsilonAhx-Amyloid b-Protein (1-42) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Amyloid beta-protein (Aβ) is a peptide that is associated with the development of Alzheimer's disease. The Aβ(16-20) trifluoroacetate salt (ATF) has been used in the diagnosis of Alzheimer's disease by fluorescence microscopy. This compound binds to hyaluronic acid and has been used as a coating for optical fibers and other materials, such as coatings for mitochondria for use in live cell imaging. The ATF also interacts with mitochondria and alters mitochondrial membrane potential, which may be due to its ability to displace cardiolipin from the inner mitochondrial membrane. ATF binds to unsymmetrical dimethylarginine (DMA), an endogenous nitric oxide synthase inhibitor, and selectively inhibits only cancer cells that have elevated levels of DMA. ATFP also induces spontaneous apoptosis in human carcinoma cells when bound to these cells via a photoconjugation reaction with bioconjugate chemistry.</p>

<p>Glp-1(7-36), amide acetate is a peptide that is used as a research tool in cell biology and pharmacology. It has been shown to activate the GLP-1 receptor, which can lead to inhibition of food intake and glucose production by pancreatic beta cells. Glp-1(7-36), amide acetate binds to the GLP-1 receptor and inhibits the binding of agonists such as exendin-4. This binding blocks the activation of G proteins, leading to an increase in intracellular calcium levels. The high purity of this product makes it ideal for use in research settings where trace impurities may interfere with results.</p>

<p>GSK2193874 is a potent and selective small molecule for the treatment of chronic cough. It inhibits the activation of TRPV4, which is a member of the transient receptor potential cation channel family, in primary cells by pharmacological agents and in vitro by intracellular Ca2+ levels. GSK2193874 has been shown to inhibit acetylcholinesterase activity and to increase cytosolic calcium levels in atrial myocytes. This drug also has effects on congestive heart failure (CHF) patients, such as an increase in left ventricular function and improved pulmonary hemodynamics. GSK2193874 also binds to toll-like receptor 4 (TLR4), which may be a therapeutic target for the treatment of chronic cough.</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Please enquire for more information about Fmoc-Tyr(tBu)-Ser(Psi(Me,Me)Pro)-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Parathyroid hormone receptor agonist</p>

<p>Please enquire for more information about α-Azacitidine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>JNJ-64619178 is a novel small molecule that targets the methyltransferase domain of the protein PRMT5. The compound has been shown to induce apoptosis in cancer cells, and is currently being evaluated for safety and efficacy in clinical trials. This drug has been shown to have a favorable safety profile and shows no adverse effects on erythropoiesis. JNJ-64619178 is an investigational drug that belongs to the class of compounds that bind to the target site on PRMT5, which is involved in regulating gene expression. It binds to enzymes with methyltransferase activity and inhibits RNA splicing, leading to cell death by apoptosis.</p>

<p>15:0 Lyso PC is a lipid with a fatty acid backbone. It is found in the blood and tissue of mammals, such as humans and cows. 15:0 Lyso PC is produced by the liver, where it plays an important role in cholesterol metabolism. This lipid can be used as a diagnostic marker for chronic kidney disease and heart disease. It also has been shown to have a positive correlation with blood pressure levels. Hippuric acid is another potential diagnostic marker for cirrhosis diagnosis and prognosis.</p>

<p>Please enquire for more information about Z-D-Arg-Gly-Arg-pNA dihydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (Met(O)35)-Amyloid b-Protein (1-40) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Edelfosine is a phospholipid that selectively binds to nuclear DNA, leading to apoptosis. It also binds to the G-protein coupled receptors and inhibits the release of Ca2+ from intracellular stores. Edelfosine has been shown to inhibit the growth of Leishmania in vitro as well as in vivo. This drug is being studied for its potential use in inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis.</p>

<p>Please enquire for more information about (Gly21)-Amyloid b-Protein (1-40) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Edelfosine is a phospholipid analog that has been shown to inhibit insulin-induced glucose uptake in adipocytes. It is a potent inhibitor of the insulin receptor tyrosine kinase and can also act as an allosteric inhibitor of protein kinase C (PKC). Edelfosine inhibits the growth of mammary carcinomas by inhibiting PKC, which leads to a decrease in cell proliferation. This drug also interacts with sulfonic acids, forming hydrogen bonds, which may be the reason for its high-performance liquid chromatography. The molecular weight of edelfosine is 582.3 g/mol.</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Please enquire for more information about Aloc-DL-Orn (Boc)-OH·DCHA including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Enalaprilat is a prodrug that is converted to the active drug enalapril in vivo. It is a potent angiotensin-converting enzyme (ACE) inhibitor that prevents the conversion of angiotensin I to angiotensin II, which leads to vasodilatation and reduced blood pressure. Enalaprilat has been shown to be effective in lowering blood pressure in patients with cardiac insufficiency or hypertension. It also has been shown to decrease the production of endogenous bradykinin, which acts on its receptor B2, leading to vasodilatation and reduced blood pressure. The most common side effect of enalaprilat therapy is cutaneous reactions such as erythema, rash, or pruritus.</p>

<p>Please enquire for more information about Amyloid beta-Protein (12-28) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Gly-Amyloid b-Protein (15-25)-Gly-epsilon-aminocaproyl(-Lys)6 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>AG-270 is a small molecule that binds to the extracellular domain of the human angiotensin II type 1 receptor. It inhibits the receptor from binding with angiotensin II and prevents the activation of downstream signaling pathways, thereby blocking the effects of angiotensin II. AG-270 is a research tool that can be used in cell biology and pharmacology studies.</p>

<p>H-Leu-Arg-OH acetate salt is a cyclase inhibitor that is used to treat cancer. It has been shown to inhibit soluble guanylate cyclase, which is an enzyme that converts guanosine triphosphate (GTP) into the second messenger molecule, cyclic guanosine monophosphate (cGMP). Inhibition of this enzyme results in a decrease in the production of cGMP and blood pressure. H-Leu-Arg-OH acetate salt also inhibits delta opioid receptors, which are found on the surface of cells in the brain. This drug binds competitively with delta opioid receptors and blocks the effect of endogenous or exogenous ligands such as enkephalins.</p>

<p>Please enquire for more information about (2-Methylindol-1-yl)acetic acid·DCHA including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(Leu16)-Amyloid b-Protein (16-19) is the carboxyl-terminal peptide of amyloid b protein, a component of the amyloid plaques that are found in Alzheimer's disease. The sequence is found in the blood and cerebrospinal fluid of healthy individuals as well as those with Alzheimer's disease. The peptide is a tetrapeptide that is cleaved from the full length protein by hydrogenolysis. This peptide can also be synthesized by condensation of an activated amino group and an esterified l-phenylalanine. The carboxyl group at position 16 can be removed using carbodiimide to produce a lysine residue.</p>

<p>Inhibitor of FGF tyrosine kinase</p>

<p>BMY 7378 Dihydrochloride is a selective 5-HT1A receptor antagonist, which is synthetically derived for specialized research purposes. This compound is known for its ability to bind exclusively to the 5-HT1A receptor, inhibiting the action of serotonin. Its mechanism of action involves a high-affinity blockade of serotonin at this receptor site, making it a valuable tool for understanding serotonergic signaling pathways.</p>

<p>(Asn7)-Amyloid b-Protein (1-40) trifluoroacetate salt H-Asp-Ala-Glu-Phe-Arg-His-Asn-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys<br>The product is a compound that has been shown to inhibit the formation of beta amyloid peptides in the brain. It binds to the beta amyloid peptide and prevents its aggregation, thereby preventing the formation of plaques and inhibiting neuronal cell death. The product contains no detectable levels of trehalose, which makes it ideal for use in brain imaging studies. This product may also be used as a predictive biomarker for Alzheimer's disease because it can be detected in cerebrospinal fluid and plasma.</p>

<p>H-Pro-Phe-OH is a synthetic peptide that is used in the treatment of high blood pressure. It has been shown to decrease blood pressure by increasing the production of nitric oxide and by decreasing activity of angiotensin converting enzyme, which are factors that have an influence on blood pressure. H-Pro-Phe-OH has been shown to be effective for treating HIV infection and amyloidosis. H-Pro-Phe-OH binds to collagen and increases its production in tissues, which may be responsible for its antihypertensive effects. It also inhibits the growth of bacteria by binding to their cell walls and inhibiting their protein synthesis. The metabolic products of H-Pro-Phe-OH are not yet known, but it is thought that they may contain hydroxyproline or hydroxylysine residues.</p>

<p>H-D-Arg(Me)-OH is a peptide that has been shown to inhibit the proliferation of cancer cells in culture. It inhibits the growth of tumor cells by blocking the activity of the oxytocin receptor, which regulates cell adhesion and migration. The H-D-Arg(Me)-OH acetate salt has also been shown to promote the differentiation of basophilic leukemia cells into normal myeloid cells. This peptide is used as a control for incubated cell cultures, such as liver cells, and can be used to study protein synthesis.</p>

<p>Please enquire for more information about PEN–SP9–Cy3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Abz-Amyloid beta/A4 Protein Precursor770 (669-674)-EDDnp trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Ala-Ala-bNA is a substrate for dipeptidyl aminopeptidase I (cathepsin C)</p>

<p>Policosanol is a natural substance that is obtained from sugar cane. It is a mixture of various alcohols, including octacosanol, hexacosanol, heptacosanol, and octacosanol. Policosanol has been studied for its potential to treat high cholesterol levels in the blood by reducing low-density lipoprotein-cholesterol (LDL-C) and triglycerides. Animal studies have shown that policosanol can lower LDL-C and reduce the risk of heart disease by preventing the formation of plaque in the arteries. Policosanol also reduces the risk of heart attack and stroke by lowering blood pressure and decreasing platelet aggregation. It may also be used as an antioxidant or anti-inflammatory agent.</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Lariciresinol is a natural compound that has been shown to have antioxidative properties and inhibit the growth of cancer cells in vitro. It has also been shown to reduce the metastatic potential of colorectal cancer cells by inhibiting fatty acid synthesis. Lariciresinol has synergistic effects when combined with other natural compounds, such as resveratrol, for example. This compound inhibits the proliferation of cancer cells by inducing apoptosis through a multivariate logistic regression analysis. The mechanism of lariciresinol-mediated apoptosis includes inhibition of transcriptional regulation and mitochondrial membrane potential, which leads to an increase in reactive oxygen species (ROS) and reactive nitrogen species (RNS). Lariciresinol also inhibits bacterial growth by binding to DNA gyrase and topoisomerase IV and interfering with transcription through RNA polymerase.</p>

<p>Selective and potent inhibitor of lysine acetyltransferases KAT6A and KAT6B with IC50 values in low nanomolar range. The compound is a reversible competitor of acetyl coenzyme A domain of KAT6A/B enzymes. It inhibits MYST-catalysed histone acetylation and was shown to arrest lymphoma progression in mice models. The compound opened the door to a new class of cancer therapeutics that could potentially direct the cancer cells in senescence or permanent dormancy.</p>

<p>Please enquire for more information about (Asn23)-Amyloid b-Protein (1-40) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>