Biochemicals and Reagents

<p>Rho GTPase Activating Protein 26 (ARHGAP26) is a rho family negative regulator, used to convert G proteins RhoA and Cdc42 into their inactive forms. It can exist in multiple forms, with ARHGAP10 being a paralog gene of particular significance. As a type of GTPase-activating protein, ARHGAP26 has the capacity to enhance hydrolysis of GTPases, converting them from an active to an inactive form, therefore inhibiting signal transduction.This type of protein plays an important role in regulation of the behaviour of cancer cells, this occurs through ARHGAP26 being a GTPase-activating protein, meaning it can inhibit Rho-GTPases by promoting their hydrolytic ability. ARHGAP26 can also have an affect on tumorigenesis and tumour progression, by forming abnormal fusion genes, tumour development and progression can be both slowed down or sped up by ARHGAP. Understanding the molecular mechanisms of ARHGAP26 could help unearth its potential clinical value in cancer treatments.</p>

<p>GLG1</p>

<p>Peptide H-KSAPATGGVK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>H-GILGFVFTL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-GILGFVFTL-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-GILGFVFTL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-GILGFVFTL-OH at the technical inquiry form on this page</p>

<p>Peptide H-YNWNSFGLR^F-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-HHAAYVNNLNVTEEK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-GVFELSDEK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>The multi-functional cyclin-dependent kinase (CDK) inhibitor p21, also known as p21WAF1/Cip1 or CDKN1A functions as a cell cycle inhibitor and anti-proliferative effector. Upon DNA damage and genotoxic stress, the tumour suppressor p53 is activated and induces the expression of p21. p21 has also been implicated in nucleotide excision repair (NER), base excision repair (BER) and DNA translesion synthesis (TLS) by disrupting the proliferating cell nuclear antigen (PCNA) interaction with other DNA repair factors and promoting PCNA degradation.</p>

<p>Peptide H-DRVYI^HPFH-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Rho GTPase Activating Protein 26 (ARHGAP26) is a rho family negative regulator, used to convert G proteins RhoA and Cdc42 into their inactive forms. It can exist in multiple forms, with ARHGAP10 being a paralog gene of particular significance. As a type of GTPase-activating protein, ARHGAP26 has the capacity to enhance hydrolysis of GTPases, converting them from an active to an inactive form, therefore inhibiting signal transduction.This type of protein plays an important role in regulation of the behaviour of cancer cells, this occurs through ARHGAP26 being a GTPase-activating protein, meaning it can inhibit Rho-GTPases by promoting their hydrolytic ability. ARHGAP26 can also have an affect on tumorigenesis and tumour progression, by forming abnormal fusion genes, tumour development and progression can be both slowed down or sped up by ARHGAP. Understanding the molecular mechanisms of ARHGAP26 could help unearth its potential clinical value in cancer treatments.</p>

<p>TORC-2</p>

<p>A calcium-binding protein S100A9 inhibitor with immunomodulatory activity that reduces pathology in experimental collagenase-induced osteoarthritis.</p>

<p>Anti-PYY antibody</p>

<p>H-EPQVYTLPPSRDELTKNQ-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-EPQVYTLPPSRDELTKNQ-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-EPQVYTLPPSRDELTKNQ-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-EPQVYTLPPSRDELTKNQ-OH at the technical inquiry form on this page</p>

<p>SLC30A8</p>

<p>Inhibitor of BET bromodomain; antineoplastic</p>

<p>Vitamin D2/D3 25OH Mouse Monoclonal Antibody is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Vitamin D2/D3 25OH Mouse Monoclonal Antibody including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Glutamate is the principal excitatory neurotransmitter in the central nervous system (CNS), and imbalances in glutamatergic transmission have profound behavioural and physiological consequences. KA1 is a kainate receptor, which are atypical members of the glutamate receptor family able to signal through both ionotropic and metabotropic pathways. KA1 plays a role in memory and behaviour, and aberrant KA1 expression is seen in neurodegeneration, schizophrenia and bipolar disorder._x000D_<br>_x000D_<br>The KA1 subunit shows very limited and well-defined expression in just a few neuronal cell types after birth. In the hippocampus KA1 mRNA is expressed at high levels in the CA3 pyramidal neurons and at very low levels in granule cells in the dentate gyrus. In all other neurons in the hippocampus, KA1 is absent._x000D_<br>_x000D_<br>This antibody is conjugated to Alexa Fluor® 488. Alexa Fluor® 488 is a popular bright green fluorescent dye with high pH-stability.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Anti-ROBO1 antibody</p>

<p>Peptide H-VTSIQD^WV^Q^K^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-YVPPSSTDR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>TORC-2</p>

<p>Anti-LRP5 antibody</p>

<p>SLC30A8</p>

<p>Peptide H-DRV^YI^HPFHL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Janus kinase-2 (JAK2) is a non-receptor tyrosine kinase implicated in signalling via members of the type II cytokine receptor family (such as interferon receptors), the GM-CSF receptor family (IL-3R, IL-5R and GM-CSF-R), the gp130 receptor family (e.g., IL-6R), and the single chain receptors (e.g. Epo-R, Tpo-R, GH-R, PRL-R). The JAK/signal transducer and activator of transcription (STAT) pathway is a key cellular pathway which is involved in immunity, cell division, cell death and tumour formation. The JAK/STAT pathway is activated by leptin and the leptin receptor and results in phosphorylation of STAT3 and its translocation to the nucleus where it activates the transcription of various target genes.Mutations and gene fusions involving JAK2 have been implicated in polycythemia vera, essential thrombocythemia, and myelofibrosis as well as other myeloproliferative disorders and leukaemia.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>H-RRNIHSLTAQEREQF-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-RRNIHSLTAQEREQF-OH is provided at greater that &gt;80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-RRNIHSLTAQEREQF-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-RRNIHSLTAQEREQF-OH at the technical inquiry form on this page</p>

<p>Peptide H-DTDILAAFR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Tretinoin is a type of retinoic acid that can be used for the treatment of acne. It is a chemical inhibitor that binds to nuclear receptors and leads to an increase in apoptosis. This type of retinoic acid helps with cell detachment and increases shedding thus increasing cell turnover. Tretinoin has been shown to have antibacterial efficacy against Staphylococcus aureus, as well as synergistic effects when combined with other agents, such as cyclic lipopeptide antibiotics and quinolones. Additionally, Tretinoin is used in the research and treatment for promyelocytic leukaemia.</p>

<p>Peptide H-FAIQDISVEETSAK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-AIWNVINWENVSQR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>H-SGWMTTMFK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-SGWMTTMFK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-SGWMTTMFK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-SGWMTTMFK-OH at the technical inquiry form on this page</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Peptide H-DHIGTR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Anti-DGAT2 antibody</p>

<p>Anti-Mrgpre antibody</p>

<p>Peptide H-AEQVIFVR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-LLLEYTDSSYEEK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide Biot-GRGRGRGRGRGRG-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Rigosertib sodium is an experimental chemotherapeutic agent that is a derivative of benzyl styryl sulfone. It is synthesized chemically and functions primarily by inhibiting key signaling pathways involved in cancer cell proliferation. Specifically, Rigosertib targets the RAS signaling pathway along with the phosphatidylinositol-3-kinase/AKT and polo-like kinase 1 (Plk1) pathways, impeding the progression of the cell cycle and inducing apoptosis in malignant cells.</p>

<p>Peptide H-GLEVTAYSPLGSSDR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Dixin</p>

<p>Peptide Ac-TPYWMAPE-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Interleukin-11 (IL-11) is a multifunctional haematopoietic cytokine implicated in several normal and pathological processes. It belongs to the interleukin-6 (IL-6) family of cytokines, which affect intracellular signalling pathways via interaction with the ubiquitously expressed signal-transducing receptor, gp130 and a non-signalling cytokine-specific receptor.</p>