Biochemicals and Reagents

<p>The myelin sheath which is located in both the Central Nervous System (CNS) and the Peripheral Nervous System is crucial for neural insulation and the salutatory conduction of nerve impulses. When this myelin sheath is destroyed neurodegeneration and conduction failure occur and theses occurrences can be observed in demyelinating diseases in the CNS such as: acute disseminated encephalomyelitis and multiple sclerosis and within the PNS: Guillain–Barré syndrome and Charcot–Marie–Tooth disease.<br>Myelin Basic Protein (MBP) from which this product is derived is the second most abundant protein in myelin. It has been found to be an intrinsically disordered protein and depending on the environmental conditions it can change its conformation. It also folds into ⍺-helical structures which allow MBP to bind tightly to lipid bilayer surfaces. MBP also interacts with other proteins, namely cytoskeletal proteins and calmodulin and may be involved in signalling pathways.<br>Although more research needs to be carried out, it is thought that MBP significantly contribute to the pathogenesis of multiple sclerosis. As MBP is an autoantigen it can be recognized and cleaved by autoantibodies and is a substrate for the immunoproteasome. Additional research has found that post-translational modifications of MBP such as the removal of arginine are increased and may be involved in the pathogenesis of multiple sclerosis. Therefore this protein derived from MBP can be used to mimic Neurodegenerative disease phenotypes in research and animal models.</p>

<p>As a metabolite of penicillin and a di-methly analog of cysteine, D-Penicillamine (D-Pen) has properties as a heavy metal chelator. In particular, D-Pen forms complexes with thiol groups of copper ions and so can help regulate conditions such as Wilson’s disease, contributing to the renal excretion of copper. Studies have suggested that D-Pen could be used in the treatment of Alzheimer’s disease due to a reduced activity of copper and zinc superoxide dismutases in the blood of Alzheimer’s disease patients. It can further be used to treat copper and lead poisoning cases. Although D-Pen is clinically relevant, it is important to distinguish it from its enantiomer L-Pen which has been found to be toxic and can result in neuritis and marrow damage.</p>

<p>Tenapanor is a novel antidiabetic drug that has been shown to be effective in the treatment of type 2 diabetes. Tenapanor (INN) reduces blood glucose levels by stimulating insulin release from pancreatic beta-cells and increasing insulin sensitivity in peripheral tissues. Tenapanor binds to the ATP-binding site of the phosphoinositide 3-kinase-related protein kinase 1 (PI3K1) enzyme, which is involved in glucose metabolism. It also inhibits phosphodiesterase 4D (PDE4D), an enzyme that degrades cyclic adenosine monophosphate (cAMP). This dual mechanism of action leads to increased insulin secretion and increased insulin sensitivity, which results in improved glycemic control.<br>Tenapanor has also been shown to improve long-term efficacy and reduce hypoglycemia when used as a pharmacological treatment for type 2 diabetes. The agent binds to ATP-binding sites on PI3K1, which prevents its</p>

<p>Fmoc-Val-Gly-OH is a Research Chemical that is commonly used in the field of efficient synthesis. It is an amino acyl compound that can be utilized for the synthesis of various molecules. Fmoc-Val-Gly-OH is known for its high efficiency and reliability in producing desired results. It can be easily analyzed using spectrometry techniques, allowing researchers to accurately determine its composition and purity. This versatile compound can react with azides, alcohols, and other compounds to create new chemical entities. With its efficient properties, Fmoc-Val-Gly-OH is an essential tool for scientists and researchers in their quest for innovative discoveries.</p>

<p>Hydrochloride salt</p>

<p>Acid Brown 83 is a basic dye that has been widely used in the textile industry. Acid Brown 83 contains amine groups and sodium salts, which are monomers of Acid Brown 83. This dye is water-soluble and degradable, but it can be decomposed by hydrolysis to produce lactams. Acid Brown 83 is not carcinogenic or mutagenic, but it is a skin irritant and may cause allergic reactions. It can be degraded by light exposure or by acid hydrolysis to form cleavage products, such as hydroxyl group, carboxylic acid anhydride and amide. Acid Brown 83 has been shown to have good resistance to light and heat degradation.</p>

<p>Fmoc-Gln(Trt)-Wang Resin (100-200 mesh) 1% DVB is a synthetic resin that is used as a solid phase in peptide synthesis. This resin has been shown to be an activator of the beta-adrenergic receptor, which can be used for research purposes. It also has high purity and ionic strength, which make it suitable for use in the study of ligand binding to receptors and ion channels. The Fmoc-Gln(Trt)-Wang Resin (100-200 mesh) 1% DVB is used in the study of cell biology and pharmacology, as well as antibody binding.</p>

<p>BQ-788 is a sodium salt that has high resistance to corrosion. It is effective in wastewater treatment, as it can be used as a coagulant and flocculant. BQ-788 is an electrochemical impedance spectroscopy (EIS) active ingredient that has been shown to have good thermodynamic data. This chemical substance also displays optimum concentration at 6 mM in sulfuric acid and crystalline cellulose, with a solubility of 2.5% at room temperature. The EIS measurements were performed on the locomotor activity of rats with metabolic disorders, which led to the conclusion that BQ-788 is an important factor for locomotor activity through its effects on the central nervous system and peripheral nervous system.</p>

<p>H-KINMPMSVK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-KINMPMSVK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-KINMPMSVK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-KINMPMSVK-OH at the technical inquiry form on this page</p>

<p>West Nile Virus Antigen, Uganda Strain B956 is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about West Nile Virus Antigen, Uganda Strain B956 including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Palmitoyl tetrapeptide 7 trifluoroacetate is an anticancer agent that acts as a protein kinase inhibitor. It has been shown to inhibit the growth of cancer cells and induce apoptosis in human tumors. This peptide analog has been studied extensively for its potential use in cancer therapy due to its ability to suppress the activity of kinases, which are enzymes involved in cell signaling pathways that regulate cell growth and division. Palmitoyl tetrapeptide 7 trifluoroacetate has also been found to be effective against certain strains of influenza virus, such as H1N1, by inhibiting neuraminidase activity. This compound has been isolated from Chinese urine samples and is structurally similar to oseltamivir, a drug used to treat influenza infections.</p>

<p>Neuron-Specific Enolase (NSE), Highly Purified is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Neuron-Specific Enolase (NSE), Highly Purified including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Region of GDNF protein corresponding to amino acids MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI.</p>

<p>6-Fluoro-3-indoxyl-beta-D-galactopyranoside: Experience the power of 6-Fluoro-3-indoxyl-beta-D-galactopyranoside, an exceptional antituberculosis drug from the rifamycin class. Specifically designed to combat tuberculosis infection, this active compound exhibits remarkable bactericidal activity. By binding to DNA-dependent RNA polymerase, it effectively inhibits bacterial growth, preventing transcription and replication. With its high frequency of human activity demonstrated through patch-clamp technique on human erythrocytes, this drug is proven to be highly effective. Metabolized through various metabolic transformations such as hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid, it offers a comprehensive approach to treatment. Not only does 6-Fluoro-3-indoxyl-beta-D-g</p>

<p>H-LYVDSLFFL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LYVDSLFFL-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LYVDSLFFL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LYVDSLFFL-OH at the technical inquiry form on this page</p>

<p>Kappa Free Light Chain, Highly Purified is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Kappa Free Light Chain, Highly Purified including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Purified Mouse IgG2b FITC conjugate</p>

<p>SARS-CoV-2 Nucleocapsid Antigen Goat Polyclonal Antibody, Affinity Purified is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about SARS-CoV-2 Nucleocapsid Antigen Goat Polyclonal Antibody, Affinity Purified including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Region of IL31 protein corresponding to amino acids SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T.</p>

<p>Region of Wnt1 protein corresponding to amino acids ANSSGRWWGI VNVASSTNLL TDSKSLQLVL EPSLQLLSRK QRRLIRQNPG ILHSVSGGLQ SAVRECKWQF RNRRWNCPTA PGPHLFGKIV NRGCRETAFI FAITSAGVTH SVARSCSEGS IESCTCDYRR RGPGGPDWHW GGCSDNIDFG RLFGREFVDS GEKGRDLRFL MNLHNNEAGR TTVFSEMRQE CKCHGMSGSC TVRTCWMRLP TLRAVGDVLR DRFDGASRVL YGNRGSNRAS RAELLRLEPE DPAHKPPSPH DLVYFEKSPN FCTYSGRLGT AGTAGRACNS SSPALDGCEL LCCGRGHRTR TQRVTERCNC TFHWCCHVSC RNCTHTRVLH ECL.</p>

<p>Please enquire for more information about Anti-V5 Epitope Tag antibody - 1mg/ml including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>The peptide H-Leu-Ser-Ile-Gly-Lys-Val-NH2 is a PAR3 agonist that has been shown to induce hypertension in animal models. It has also been shown to activate PAR3, which is involved in coagulation and cardiovascular diseases. The peptide is able to activate PAR3 by binding to the receptor with high affinity and selectivity. This activation induces a series of intracellular signaling events that culminate in vasoconstriction and blood clotting.<br>PAR3 agonists are being developed as a new class of antihypertensive drugs because they have shown efficacy in reducing blood pressure levels without causing adverse side effects such as dizziness or fatigue.</p>

<p>L-threo-Phenylserine is a naturally occurring amino acid that is synthesized in the human body. It can be found in the brain and muscles, where it is used for protein synthesis. L-threo-phenylserine has been shown to be an effective oxygen nucleophile and can catalyze the hydrolysis of hydrogen fluoride. This compound has also been shown to have biological activity in vitro as well as structural properties that are useful for conformational analysis and structural biology research. L-threo-phenylserine may also have potential medical applications, such as its use as a treatment for mental disorders and epilepsy.</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>H-LSVNTPNNR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LSVNTPNNR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LSVNTPNNR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LSVNTPNNR-OH at the technical inquiry form on this page</p>

<p>Bordetella Pertussis Toxin IgA /IgG Negative Human Serum is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Bordetella Pertussis Toxin IgA /IgG Negative Human Serum including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Human IgG Fc antibody was raised in goat using human IgG F(c) fragment as the immunogen.</p>

<p>H-NGQPENNYKTTPPVLDSD-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-NGQPENNYKTTPPVLDSD-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-NGQPENNYKTTPPVLDSD-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-NGQPENNYKTTPPVLDSD-OH at the technical inquiry form on this page</p>

<p>Please enquire for more information about C.I.Reactive Yellow 107 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Cy2 DiC18 (7) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Ac-Ala-Ser-Thr-Asp-AMC is a versatile building block that can be used as an intermediate in organic synthesis, a reagent, or a speciality chemical. It is also a useful scaffold for drug discovery and development. Ac-Ala-Ser-Thr-Asp-AMC has been shown to be an effective inhibitor of phosphodiesterase 3 (PDE3) and cyclic nucleotide phosphodiesterases (PDEs).</p>

<p>[Dap3]-Ghrelin (Rat) is an analog of the peptide hormone Ghrelin and is a growth-hormone releasing peptide. Ghrelin has various effects on the body, including stimulating appetite, nutrient sensing and meal initiation. It has also been found to regulate insulin resistance, diabetes and obesity and asserts its functional affects through acting as an endogenous ligand for the growth hormone secretagogue receptor (GHS-R). Its wider functions such as glucose homeostasis, energy homeostasis, cardio-protective effects, its role in bone metabolism and its potential to be a target for cancer means that it can be used to develop therapies for a whole spectrum of diseases.</p>

<p>NBQX is a competitive antagonist of ionotropic glutamate receptors of AMPA and kainate subfamilies. It has been reported anti-convulsant activity in seizures models induced by electrostimulation, drugs or genetic predisposition. It has also exhibited pro-convulsant effects in Theiler's murine encephalomyelitis virus-induced (TMEV) seizure model.</p>

<p>H-Lys(Boc)-2-ClTrt-Resin (100-200 mesh) 1% DVB is a building block that can be used for the synthesis of peptides. It is an amine resin that contains two reactive groups, one thiol and one amine. H-Lys(Boc)-2-ClTrt-Resin (100-200 mesh) 1% DVB is also a building block for alcohols and thiols.</p>

<p>ETX0282 is a covalent complex that contains an isopropyl group and a cyclic peptide. It is used to target enzymes in multidrug-resistant bacteria, such as enterobacterales, which are responsible for the development of infectious diseases. ETX0282 has been shown to be effective against gram-negative bacterial species, including Enterobacter strains. This drug has been shown to be safe for clinical use in humans and has completed phase I clinical trials. ETX0282 is an oral prodrug that is hydrolyzed by esterases or glucuronidases to release the active form, cefpodoxime proxetil. This drug targets enzymes involved in bacterial processes that are essential for cell wall biosynthesis, inhibiting protein synthesis and cell division.</p>

<p>MeOSuc-Ala-Phe-Lys-AMC is a compound that has a destabilizing effect on the vascular wall, due to its ability to inhibit proteolytic activity. It is also able to reduce the level of angiogenic factors, and thus has an anti-angiogenic effect. MeOSuc-Ala-Phe-Lys-AMC has been shown to have a macroscopic effect on vessels in tissue culture, and this can be observed through leucocyte migration. MeOSuc-Ala-Phe-Lys-AMC has also been shown to cause haemorrhagic changes in microvessels and muscle cells. This compound is also able to inhibit placental growth factor and muscle cell proliferation, as well as reducing the number of microvessels in the placenta.</p>

<p>Please enquire for more information about Anti-SARS-CoV-2 Spike protein antibody - 0.75mg/ml including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>The Propoxyphene antibody is a highly specific monoclonal antibody that is used in immunoassay methods for the detection and quantification of propoxyphene. This antibody is produced by condensation reactions between bovine serum albumin and glutaric anhydride, resulting in the formation of antibodies that specifically bind to propoxyphene. The antigen used for immunization is propoxyphene conjugated to bovine serum albumin. This antibody has been extensively validated for its specificity and sensitivity in various life science applications. It offers a reliable tool for researchers and scientists working in the field of drug analysis and toxicology.</p>

<p>H-STHGLVINIIHSLCTCSQLH-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-STHGLVINIIHSLCTCSQLH-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-STHGLVINIIHSLCTCSQLH-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-STHGLVINIIHSLCTCSQLH-OH at the technical inquiry form on this page</p>

<p>Please enquire for more information about Troponin ICT Complex, Recombinant including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Mycoplasma Pneumoniae IgM Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Mycoplasma Pneumoniae IgM Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Region of gAcrp30 protein corresponding to amino acids MKGEPGEGAY VYRSAFSVGL ETYVTIPNMP IRFTKIFYNQ QNHYDGSTGK FHCNIPGLYY FAYHITVYMK DVKVSLFKKD KAMLFTYDQY QENNVDQASG SVLLHLEVGD QVWLQVYGEG ERNGLYADND NDSTFTGFLL YHDTN.</p>

<p>Free βhCG Positive Human Serum is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Free βhCG Positive Human Serum including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Dengue virus is a member of the Flaviviridae family and is responsible for causing dengue fever in humans. It is transmitted to humans primarily via the Aedes aegypti and Aedes albopicto female mosquitoes which acquire the virus while feeding on the blood of an infected person. Although this virus can inflict asymptomatic or mild symptoms in patients, it can lead to severe infectious such as dengue hemorrhagic fever, also known as dengue shock syndrome.The envelope protein, made up of the three domains I, II and III, plays a crucial role in host cell receptor-mediated endocytosis and fusion and is therefore an ideal target for neutralizing antibody formation.  The global prevalence of dengue fever is significant and while there are numerous diagnostic tests on the market at present for dengue virus, there are few flavivirus panel assays and no specific dengue virus therapeutics available. Cymit Quimica’s biologics division is leading the field in the development of these target recombinant proteins and monoclonal antibodies. Our range of Dengue virus proteins and antibodies provides global development teams and researchers with access to vital and new raw material to test samples, in the race to diagnose patients earlier and help with vaccine development. We offer dengue virus proteins including envelope and NS1 from serotypes 1-4 and dengue virus monoclonal antibodies, for research and diagnostic purposes.</p>

<p>Peptide H-YSDYFKPFSTGK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>20 nm Colloidal Gold particle suspension</p>

<p>FMOC-Arg(Pbf)-Rink-Amide MBHA Resin is a research tool used in cell biology and pharmacology. It is an activator of ion channels and a ligand for receptors. This resin is used to study protein interactions, antibody specificity, and peptide binding properties. The resin can be used as an inhibitor of the phosphorylation of proteins in cells. FMOC-Arg(Pbf)-Rink-Amide MBHA Resin has been shown to be useful in pharmacology for the treatment of various diseases such as diabetes and hypertension.</p>

<p>Please enquire for more information about (Des-Gly10,D-Ser4,D-Leu6,Pro-NHEt 9)-LHRH trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Inhibits actin polymerization</p>