Biochemicals and Reagents

<p>Peptide H-IPTGQEYAAK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>CPI 444 is a monoclonal antibody that binds to the adenosine receptor. It has been shown to inhibit the growth of tumor cells in mice, with an IC50 of 1.3 mg/kg. CPI 444 has also been shown to inhibit the proliferation of tumor cells in vitro by blocking cell cycle progression through G1 phase and arresting cells in G2 phase. This drug is being investigated as a potential treatment for cancer, including urothelial carcinoma and renal cell cancer, as well as other solid tumours. The mechanism of action of CPI 444 is not clear but may be due to its ability to induce death protein-mediated apoptosis or alter the microenvironment by binding to toll-like receptors on immune cells.</p>

<p>POLDIP3 is preferentially associated with CBC-bound spliced mRNA-protein complexes during the initial round of mRNA translation. POLDIP3 is deposited at the exon junction during pre-mRNA splicing. It becomes part of the exon junction complex (EJC), which then facilitates the recruitment of S6K1 to the spliced RNA to boost the translation efficiency of the spliced mRNA. In addition, POLDIP3 is involved in nuclear mRNA export mediated by association with the TREX complex._x000D_<br>_x000D_<br>POLDIP3 interacts with DNA polymerase Pol Ύ and PCNA depending on its modifications. This creates a distinct regulatory role for POLDIP3 during DNA synthesis.</p>

<p>Ferritin antibody was raised in goat using ferritin from the human Liver as the immunogen.</p>

<p>Pomalidomide is an immunomodulatory agent that inhibits transcriptional regulation by interacting with the pomalidomide-binding protein, which prevents its interaction with RNA polymerase II and thereby prevents DNA transcription. The study with U266 cells demonstrated that pomalidomide targets CRBN, part of an E3 ligase complex, and inhibits its autoubiquinitation and supresses a critical gene (IRF4, interferon regulatory factor 4) for myeloma cell growth with concentrations up to 10 μM.In vitro assays have shown that pomalidomide has inhibitory effects on cell signaling pathways, such as the NF-κB pathway. Pomalidomide also decreases the production of proinflammatory cytokines, such as TNFα and IL-1β, by inhibiting their synthesis or their release from activated monocytes. Recently, the promoting effect of pomalidomide, as its analog lenalidomide, on erythropoiesis (production of red blood cells) has been investigated, demonstrating positive results for its use as a potential new therapy agent for β-hemoglobinopathies.</p>

<p>Human IgG gamma antibody was raised in sheep using human IgG (Fc Fragment) as the immunogen.</p>

<p>HSV2 gD antibody was raised in mouse using purified HSV from strain BH as the immunogen.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Dixin</p>

<p>HBeAg antibody was raised in mouse using hepatitis B Virus as the immunogen.</p>

<p>HBE1 antibody was raised in Rabbit using Human HBE1 as the immunogen</p>

<p>Anti-MINK1 antibody</p>

<p>H-STSTAHMHLSDLR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-STSTAHMHLSDLR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-STSTAHMHLSDLR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-STSTAHMHLSDLR-OH at the technical inquiry form on this page</p>

<p>Mycophenolic acid is an immunosuppressant metabolite present in drug formulations that are used to prevent rejections after organ transplants. Mycophenolic acid is a selective inhibitor of inosine monophosphate dehydrogenase (IMPDH) which blocks the conversion of inosine-5-phosphate and xanthine-5-phosphate to guanosine-5-phosphate. This drug inhibits de novo purine biosynthesis. It has also shown to have antibacterial and antifungal properties.</p>

<p>H-PENGFFGVAPGTSASTNPNA-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-PENGFFGVAPGTSASTNPNA-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-PENGFFGVAPGTSASTNPNA-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-PENGFFGVAPGTSASTNPNA-OH at the technical inquiry form on this page</p>

<p>Rabbit polyclonal Rabies Virus Glycoprotein G antibody</p>

<p>H-YRNIEFFTKNSAFPK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-YRNIEFFTKNSAFPK-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-YRNIEFFTKNSAFPK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-YRNIEFFTKNSAFPK-OH at the technical inquiry form on this page</p>

<p>ATPase antibody was raised in rabbit using highly purified Na+, K+ ATPase from rabbit kidney, enzymatically denatured, as the immunogen.</p>

<p>Anti-GFP antibody</p>

<p>Anti-TRPA1 antibody</p>

<p>hCG Beta antibody was raised in mouse using hCG beta as the immunogen.</p>

<p>Dopamine reuptake inhibitor; ligand of sigma receptors</p>

<p>Activates CFTR channels</p>

<p>Anti-DYRK3 antibody</p>

<p>The SARS Coronavirus Antibody is a specific antibody that targets the SARS-CoV virus. It has been extensively tested and proven to bind specifically to the virus, inhibiting its replication and spread. This monoclonal antibody is produced using advanced techniques such as polymerase chain reaction (PCR) and transcription-polymerase chain reaction (RT-PCR). It specifically targets the α subunit of the virus, which is crucial for its survival and replication.</p>

<p>Consisting of the disulfide Bonds: Cys6- Cys22, Cys9-Cys12, Cys10- Cys18, and Cys13-Cys21 and of the trifluoroacetate salt form, this product can be used as an internal standard for Hepcidin assays.Hepcidin-24 is a peptide hormone that plays a key role in the regulation of iron metabolism in the body. It is produced by the liver and is secreted into the bloodstream, where it interacts with cells in the intestine and other tissues to control the absorption and distribution of iron.<br>Hepcidin acts as a negative regulator of iron uptake and release by binding to and inhibiting the activity of ferroportin, a protein that facilitates the export of iron from cells into the bloodstream. When hepcidin levels are high, ferroportin activity is reduced, leading to decreased iron absorption from the diet and reduced iron release from cells. When hepcidin-24 levels are low, ferroportin activity is increased, leading to increased iron absorption and release.<br>Imbalances in hepcidin levels can lead to a variety of disorders, including iron-deficiency anemia, hemochromatosis (an iron overload disorder), and anemia of chronic disease. Therefore, hepcidin-24 is a key target for the development of treatments for these and other iron-related disorders.<br>In addition to its role in iron metabolism, hepcidin has been shown to have antimicrobial properties, as it can inhibit the growth of certain bacteria and fungi. It may also be involved in the regulation of immune function and inflammation.</p>

<p>Together with IL12B, IL23A forms part of the heterodimeric cytokine IL-23 which functions in innate and adaptive immunity. IL-23 is a member of the IL-12 family of cytokines that includes IL-12, IL-35, IL-27, and IL-39. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R and activates the Jak-Stat signaling cascade. IL-23 is a key driver of Th17-mediated immune response during infection and inflammation and its over production is involved in several cancers._x000D_<br>_x000D_<br>IL23A expression is induced by several mechanisms including Tumour necrosis factor (TNF)/NF-kB, mitogen-activated protein kinase (MAPK) signalling and the formation of a transcriptional enhancer complex consisting of proto-oncogene c-Jun (c-Jun), RELA proto-oncogene NF-kB subunit (RelA), RUNX family transcription factor 1 (RUNX1), and RUNX3. Collectively, these proteins induced IL23A secretion._x000D_<br>_x000D_<br>IL-23 is produced by dendritic cells and macrophages as well as keratinocytes and gastric; intestinal; lung and ovarian epithelial cells.</p>

<p>Apo E</p>

<p>H-FYYIDDPK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-FYYIDDPK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-FYYIDDPK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-FYYIDDPK-OH at the technical inquiry form on this page</p>

<p>Vegfb</p>

<p>ANP (Rat, 1-28) is a peptide that is the active fragment of atrial natriuretic peptide. It has been shown to activate ion channels and inhibit protein interactions. ANP (Rat, 1-28) has also been used as a research tool for studies on receptor biology and pharmacology.</p>

<p>PDEs are a family of phosphohydrolyases, used to catalyse hydrolysis of 3 €™ cyclic phosphate bonds in the second messengers adenosine and guanine 3 €™, 5 €™ cyclic monophosphates (cAMP and cGMP). Physiologically, Pde2a is a locus for communication between cAMP and cGMP signalling pathways, regulating this process through degradation of cAMP and cGMP. This is particularly noteworthy in cells where cAMP and cGMP regulate opposing cell functions.Pde2a is expressed both in the periphery and central nervous system, but is found in highest concentration in the brain; implying that Pde2a is necessary in regulation of interneuronal cAMP and cGMP involved in emotion, sensory perception and memory. Alteration in cyclic nucleotide signalling is shown cause depression, bipolar disorder and schizophrenia; hence Pde2a, a molecule used to break down cyclic nucleotides, has the potential to be a novel biomarker or therapeutic target for such psychiatric conditions.</p>

<p>H-CGGSGNDRRQSERLTGDSG-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-CGGSGNDRRQSERLTGDSG-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-CGGSGNDRRQSERLTGDSG-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-CGGSGNDRRQSERLTGDSG-OH at the technical inquiry form on this page</p>

<p>Inhibitor of Src and Abl tyrosine kinases; anti-proliferative; anti-migratory</p>

<p>Nafamostat is a broad-spectrum serine protease inhibitor produced by chemical synthesis. Nafamostat is effective through its antioxidant and anti-inflammatory activity. This drug is involved in inhibiting various enzyme systems such as coagulation and fibrinolytic systems.</p>

<p>Rabbit anti-Human IgG4 monoclonal antibody</p>

<p>H-LTGLSEISQR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LTGLSEISQR-OH is provided at greater that Flashpure (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LTGLSEISQR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LTGLSEISQR-OH at the technical inquiry form on this page</p>

<p>ICOS</p>

<p>Endoglin is a protein that is encoded by the ENG gene and is expressed in most tissues. It has been shown to be an antagonist of angiopoietin-1 and angiopoietin-2, which are proteins that regulate the growth of blood vessels and act as a tumor suppressor. Endoglin has also been found to be expressed in neoplastic cells, including cancer cells. The physiological role of endoglin is not well understood, but it may play a role in cell migration and invasion, angiogenesis, or other cellular functions.</p>

<p>Glycogen Synthase Kinase 3 beta (GSK3β) is a multifunctional serine/threonine kinase widely expressed in most mammalian cells. GSK3β is highly active under basal conditions and acts downstream of phosphoinositide 3-kinase (PI3K) signalling. PI3K activation results in Akt phosphorylation and the subsequent phosphorylation of GSK3β at serine-9 and its inactivation. GSK3β in turn activates the production of pro-inflammatory cytokines including IL-1β, IL-6, IL-12, IL-17, TNFα and IFNγ, and supresses the production of IL-10, IL-1Ra, and IFNβ by immune cells.</p>

<p>Prolactin antibody was raised in mouse using purified human prolactin as the immunogen.</p>

<p>6-Thioguanine is a purine analog used in the therapy for leukemia and for remission consolidation in patients with acute nonlymphocytic anemia. This drug also has antimetabolite action. It replaces guanine during DNA replication. This substitution disrupts the accurate pairing of DNA bases, leading to errors in DNA replication and hinders cell division.</p>

<p>MIF antibody was raised in mouse using recombinant human MIF (1-114 aa) purified from E. coli as the immunogen.</p>

<p>Glut-4</p>

<p>Etodolac is a non-steroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis and rheumatoid arthritis. It is also used to treat acute pain. This drug works by inhibiting prostaglandin synthesis from the inhibition of the enzyme cyclooxygenase.</p>

<p>Sheep Red Blood Cells (SRBC) are widely used in various research applications. SRBC contain prodigiosin, a red pigment that can be used as a marker for cell labeling and tracking. They are often used in studies involving messenger RNA (mRNA) analysis, electrophoresis, and the characterization of metal-binding proteins. In veterinary applications, SRBC can be used as an anticoagulant to prevent blood clotting during procedures. Additionally, SRBC have been utilized in studies related to adipose tissue, liver microsomes, midbrain dopaminergic neurons, interferon production, and the development of monoclonal antibodies with neutralizing properties. With their versatility and wide range of applications, SRBC are essential tools in life sciences research.</p>

<p>Slc34a3</p>

<p>JAK3</p>

<p>Peptide H-AGEVQEPELR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>BRDU antibody was raised in mouse using bromodeoxyuridine as the immunogen.</p>