Biochemicals and Reagents

Applications Tipiracil Hydrochloride serves as a treatment for metastatic colorectal cancer (mCRC). A thymidine phosphorylase inhibitor.
References Sugita, K., et al.: Oncol., 91, 224-230 (2016); van der Velden, D. L., et al.: Clin. Cancer Res., 22, 2835-2839 (2016)

Applications S 3304, is a novel matrix metalloproteinases (MMP) inhibitor specific for MMP-2 and MMP-9.
References Chiappori, A. A. et al.: Clin Cancer Res. 2007 Apr 1;13(7):2091-9.;

Applications The preparation and incorporation of 2-[2-[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]acetic Acid into the bilayers of liposomal constructs used for immunization with synthetic peptides.
References Frisch, B., et al.: Bioconjugate Chem., 7, 180-186 (1996)

Applications Allergosil is used in preparation of Sulfonic Acid Magnesium Chloride Salts as Sulfur-based electrolyte solution for Magnesium secondary batteries.
References Mori, G., et al.: PCT Int. Appl., (2020);

Applications L-Proline-N-Fmoc is N-Fmoc protected L-Proline (P755995) which is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles. It is important in wound healing.
References Bondarenko, L.B., et al.: Int. J. Peptides., 2, 1687 (2012); Rimer, T., et al.: Biomacromolecules, 13, 2110 (2012);

Applications 4-Chloro-1,2-benzenediamine is a useful reagent for the synthesis of novel calix[4]arene p-benzazole derivatives.
References Ozkan, S. C., et al.: RSC Adv., 10, 38695 (2020)

Applications SR 1078 is a selective agonist of RORα and RORγ that stimulates ROR transcriptional activity in HEK293 cell reporter assays.
References Wang, Y., et al.: ACS Chem. Biol., 5, 1029 (2010); Wang, Y., et al.: PLoS One, 7, 1 (2012)

Applications Acelarin is a phosphoramidate transformation of the pancreatic and ovarian cancer chemotherapy Gemcitabine; and the first anti-cancer ProTide to enter the clinic.
References Sarr, A., et al.: Sci. Rep., 9, 1 (2019); Blagden, S. P., et al.: Br. J. Cancer, 119, 815 (2018)

Applications N-2-Pyridinyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide is a reagent used in the synthesis of a compound applied as a Bruton tyrosine kinase inhibitor and its use for treating or relieving BTK-mediated disease.
References Li, Y. et al.: PCT Int. Appl. 108 pp., (2018)

Applications A dueterated isotope of Methylamine (M285560) a common chemical reagent used in the synthesis of 2-aminoquinolines as potent and selective inhibitors of neuronal nitric oxide synthase for neurodegenrative disorders.
References Cinelli, M. et al.: J. Med. Chem., 58, 8694 (2015);

Applications N4-Ethyl-2’-deoxycytidine avoids self-dimerization of fluorescent DNA probes.
References Ikeda, S., et al.: Org. Biomol. Chem., 8, 546-551 (2010)