Biochemicals and Reagents

MOG(97-108) corresponds to amino acids 97 to 108 of the myelin oligodendrocyte glycoprotein (MOG).

Bombesin (BBN) is a 14-amino acid neuropeptide originally isolated from the skin of Bombina bombina. The bombesin-related family comprises three other peptides, the amphibian homologs alytesin and Neuromedin C (NMC), and the mammalian peptide named Gastrin-Releasing Peptide (GRP). Bombesin and bombesin-related peptides are characterized by a region of homology at the carboxy-terminus ending with Gly-His-Leu-Met-NH2, in which resides their biological activity.
Bombesin is active in mammals and affects a broad range of biological functions including smooth muscle contraction, cell growth, blood pressure, plasma glucose, as well as gastric secretions2. These effects are mediated by the interaction of Bombesin peptide with G protein-coupled receptors (GPCRs) called bombesin receptors that are well represented in the gastrointestinal tract and in the central nervous system (CNS).
Bombesin peptide is a potent natural agonist of the mammalian Gastrin Releasing Peptide Receptor (GRPR) also know as bombesin receptor 2 (BB2), whose endogenous ligand is the Gastrin Releasing Peptide (GRP). Bombesin has demonstrated a high affinity for human Gastrin-Releasing Peptide Receptors (hGRPR) in both human cells containing native GRP receptors and murine cells stably expressing human GRP receptors (IC50 = 0.17±0.01 nM and 0.07 ± 0.01 nM, respectively).There is increased interest in targeting the bombesin receptors to explore their roles in pathophysiological processes, and for diagnostic imaging of human cancers over-expressing Gastrin-Releasing Peptide Receptors (GRPR), such as prostate, breast, and small-cell lung carcinoma. Bombesin peptide is investigated as targeting peptide to deliver radiotracers and therapeutic agents into tumors. Moreover, many synthetic agonist analogs of the biologically active COOH terminus of bombesin-related peptides have been synthesized to develop more metabolically stable and selective ligands for Bombesin receptors.

SIL peptide for Infliximab detection and quantification

Secondary SIL peptide for Dupilimab detection and quantification

Simian Parainfluenza Virus type 5
V5 peptide is an epitope peptide of Simian Parainfluenza Virus type 5 (SV5) belonging to the Paramyxovirus family. SV5 causes some common human diseases, such as pneumonia, bronchiolitis, measles and mumps.
V5 peptide
V5 peptide represents amino acids 95-108 of SV5 corresponding to RNA polymerase alpha subunit and non-structural protein V. V5 peptide sequence was chosen because high-affinity antibodies can be produced in many different species. V5 peptide is useful as tag for protein purification and detection such as Western blotting, ELISA assays, immunofluorescence, immunoprecipitation assays and for protein purification.

Insecticidal peptide against Spodoptera frugiperda

Primary SIL peptide for Dupilimab detection and quantification

MiniAP-4 peptide is a short nontoxic derivative of apamin (a neurotoxin from bee venom) used as a blood-brain barrier (BBB) shuttle peptide.

KLPGF peptide is a sequence from egg white albumen. This peptide have recently shown interest for Alzheimer’s disease.

Bis-dPEG®5, Half Benzyl Half NHS Ester is a heterobifunctional cross-linking reagent, which is derived from discrete poly(ethylene glycol) chemistry. It features a benzyl group on one end and an N-hydroxysuccinimide (NHS) ester on the other. The NHS ester is a well-known active ester that facilitates the formation of stable amide bonds with primary amines, commonly found on proteins and peptides. By doing so, it enables the covalent attachment of biomolecules, enhancing solubility, stability, and overall bioavailability.