Heterocycles with Nitrogen (N)

5-Hydroxyindole-2-carboxylic acid ethyl ester is a fluorescent probe that is used in the detection of hepatitis C virus by micropet assay. The compound reacts with amines and undergoes fluorescence quenching, and can be used to quantitate their concentration. 5-Hydroxyindole-2-carboxylic acid ethyl ester is also used for the determination of the kinetics of amines and other compounds that are involved in the metabolism of drugs and biogenic amines. It can be applied to chromatographic analysis or sample preparation prior to analysis by analytical chemistry methods such as gas chromatography or liquid chromatography.

6-Methylpurine is a product of the nucleotide metabolism in E. coli, which is a model organism for protein synthesis. 6-Methylpurine inhibits protein synthesis and exerts significant cytotoxicity. It has been shown to inhibit the enzyme activities of DNA polymerase alpha, DNA ligase, and RNA polymerase, as well as other enzymes involved in nitrogen metabolism. 6-Methylpurine has been shown to be an analog of adenine and has a similar reaction mechanism. The uptake of 6-methyl purine by cells is mediated by hydrogen bonds with amino acid residues on the cell membrane surface. This molecule also forms glycosidic bonds with ribose sugar groups on cellular surfaces. 6-Methylpurine plays an important role in energy metabolism through its incorporation into glucose and glycogen molecules.

1-Methylindole is a chemical compound that belongs to the group of pyrimidine compounds. It has been shown to have antibacterial activity against many types of bacteria, including methicillin-resistant Staphylococcus aureus and Clostridium perfringens. 1-Methylindole inhibits bacterial growth by binding to DNA and RNA, preventing the synthesis of proteins necessary for cell division. The high chemical stability and low redox potential make 1-methylindole an excellent candidate for use as an anticancer agent. This drug has been shown to be effective in killing cancer cells in vitro, but more research needs to be done before it can be used in vivo.

4-Cyanopiperidine is an organic compound that belongs to the class of medicines and has a cyclohexane ring with two functional groups. It is a part of the compound class of dehydrating agents. 4-Cyanopiperidine is most commonly used as an intermediate in the synthesis of other compounds, but can also be used as a medicine. 4-Cyanopiperidine has been shown to be effective against pain, cancer, and seizures. The inhibitory effect of 4-cyanopiperidine on cyclic AMP causes it to have potent inhibitory activity against cb1 receptor, which is responsible for the psychoactive effects caused by tetrahydrocannabinol (THC). This drug also has potent antagonistic effects on pethidine and related drugs such as fentanyl, morphine, and oxycodone.

Applications N-Methyl-6-(4-nitrophenoxy)-4-pyrimidinamine is an intermediate in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.
References Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);

Applications Phenyl 4-Bromo-2-cyclopropylpyridine-1(2H)-carboxylate is an intermediate in synthesizing B-(2-Cyclopropyl-4-pyridinyl)-boronic Acid (C989365), which is used in synthesis of isoindole carboxamides, pyrrolopyridine carboxamides, and similar compounds as inhibitors of phosphodiesterase type 10A for treating neurological and psychiatric disorders.
References Geneste, H., et al.: PCT Int. Appl. (2013), WO 2013000994 A1 20130103

Applications N-(Benzyloxycarbonyl)-4-piperidone

Applications 2-[(4-Bromophenyl)methyl]-4,5-dihydro-4,4-dimethyloxazole is an intermediate used in the synthesis of Bilastine-d6 (B385002), which is labelled Bilastine. It is a novel, nonsedating H1-antihistamine developed for symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.
References Van Cauwenberge, P., et al.: Clin. Exp. Allergy, 30, 891 (2000), Bauchau, V., et al.: Eur. Respir. J., 24, 758 (2004), Lehman, J., et al.: Drugs, 66, 2309 (2006),

Applications 2,6-Dibromopyridine is used as a starting material to synthesize 2,2’-bipyridines (such as 5-Cyano-1,6-dihydro-6-oxo-[3,4'-bipyridine]-2-carboxylic Acid [C979150]) via a Stille-type cross-coupling reaction. 2,6-Dibromopyridine is also used as a reagent to synthesize pyridylpyrimidine fungicides, compounds that eliminate fungi by cycling copper through the cell membrane, where it reaches toxic levels.
References Hargreaves, S., et al.: Tetrahedron Lett., 41, 1653 (2000); Heller, M. & Schubert, U.: J. Org. Chem., 67, 8269 (2002); Simkovsky, N., et al.: J. Chem. Soc. Perk. Trans. 1, 16, 1847 (2002)

Applications tert-Butyl 4-(2-(2-Oxoimidazolidin-1-yl)ethyl)piperazine-1-carboxylate is an intermediate in the synthesis of N1-[2-(1-Piperazinyl)ethyl]-1,2-ethanediamine (P481230), which is an impurity of Diethylenetriamine (D444255); a compound that is used in biological studies for polyamines inhibition to carbonic anhydrases by anchoring to the zinc-coordinated water molecule.
References Carta, F., et al.: J. Med. Chem., 53, 5511(2010)

Applications (S)-Benzyl 2-(5-Bromo-1H-indole-3-carbonyl)pyrrolidine-1-carboxylate is an intermediate in the synthesis of ent-Eletriptan (E505005), an enantiomeric impurity of the serotonin 5-HTIB/ID receptor agonist Eletriptan (E505000).
References Orita, A., et al.: Green Chem., 3, 13 (2001);

Applications 2,5-Dihydro-3-(hydroxymethyl)-2,2,5,5-tetramethyl-4-(3-pyridinyl)-1H-pyrrol-1-yloxy is an intermediate in the synthesis of highly active spin labelling reagents.
References Fawzi, N.L., et al.: J. Biomolec. NMR., 51, 105 (2011);

Applications (αS)-2-Chloro-α-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-nitro-1H-imidazole-1-ethanol is an intermediate in the synthesis of (S)-PA 824 (P122500), a novel anti-tuberculosis drug.
References Thompson, A. W., et al.: Biorg. Med. Chem. Lett., 25, 3804 (2015)

Applications 2-Chloro-3-iodopyridine (cas# 78607-36-0) is a compound useful in organic synthesis.

Applications 2-Chloro-3-cyanopyridine (cas# 6602-54-6) is a compound useful in organic synthesis.

Stability Very Moisture Sensitive
Applications Cyanoacetic Acid N-Hydroxysuccinimide Ester is used as a pharmaceutical intermediate. It is used in the preparation of substituted pyrrolopyrimidinamines as selective Janus kinase inhibitors for the treatment of autoimmune diseases and organ transplant rejection.
References Flanagan, M. E., et al.: J. Med. Chem., 53, 8468 (2010)

Applications (1-Benzyl-1H-imidazol-5-yl)(2,3-dimethylphenyl)methanone is an intermediate in the synthesis of 1-Benzyl-5-(1-(2,3-dimethylphenyl)vinyl)-1H-imidazole (B251400), an impurity of Medetomidine (M203250, HCl); an α2-adrenergic agonist, sedative, and analgesic.
References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987); Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987); Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988); Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996)

Applications 4-Iodo-1-tritylimidazole (cas# 96797-15-8) is a compound useful in organic synthesis.

Applications Hydrochloride salt of N-(β-Chloroethyl)piperidine is used in the inhibition of sickle-cell hemoglobin.
References Stubbins, J. et al.: Eur. J. Med. Chem., 14, 219 (1979);

Applications 3-Cyanopyridine N-Oxide is a useful synthetic intermediate in the synthesis of Arimoclomol Maleic Acid (A771270); an orally administered drug used to treat amyotrophic lateral sclerosis.
References Kurthy, M., et al.: New. York. Acad. Sci., 967, 482 (2002); Kalmar, B., et al.: Exp. Neurol., 184, 636 (2003)

Applications N6-(2-Chloro-6-methyl-4-pyrimidinyl)-2-methyl-4,6-quinolinediamine is an intermediate in the synthesis of NSC 23766 (N900280), which is a highly soluble and membrane permeable Rac GTPase inhibitor. NSC 23766 inhibits Rac GTPase by targeting Rac activation by guanine nucleotide exchange factor (GEF). NSC 23766 has been shown to inhibit the anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells.
References Gao, Y., et. al.: Proc. Natl. Acad. Sci. U.S.A., 101, 7618, (2004); Akbar, H., et. al.: Methods Enzymol, 406, 554 (2006)

Applications Reactant in the preparation of CB1 cannabinoid receptor agonists and brain imaging agents.
References Deng, H. et al; J. Med. Chem. 48, 6386 (2005)

Applications 4-Chloropyridine-2-carboxamide, is a versatile building block used in synthesis of various chemical compounds.

Applications N-Boc-pyrrolidine is a boc-protected cyclic amine used as a building block in the preparation of diastereomers by usually undergoing α'-lithiations and electrophilic substitution reactions.
References Beak, P. et al.: J. Org. Chem., 58, 1109 (1993);

Applications 4-Chloro-2,6-dimethoxypyrimidine (cas# 6320-15-6) is a compound useful in organic synthesis.

Applications 4,5-Dimethyl-3-isoxazolamine is an isoxazole derivative used in the preparation of a varitey of biologically active compounds such as selective ETA receptor antagonists.
References Murugesan, N. et al.: J. Med. Chem., 46, 125 (2003);

Applications Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Colby, J., et al.: Biochem. J., 165, 395 (1977), Damani, L., et al.: Xenobiotica, 12, 527 (1982), Balzarini, J., et al.: J. Antimicrob. Chemother., 55, 135 (2005),

Applications 5-{4-[2-[(5-Benzyloxypyridin-2-yl)methylamino]ethoxy]benzylidine}thiazolidine-2,4-dione (cas# 1076199-05-7) is a compound useful in organic synthesis.

Applications 5-Methylpyrimidine (cas# 2036-41-1) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 1,4-Bis(tert-boc)piperazine-d8 (cas# 1246816-49-8) is a compound useful in organic synthesis.

Applications 2-Amino-4,6-dichloropyrimidine-13C2 (cas# 1346605-11-5) is a compound useful in organic synthesis.

Applications 3-Amino-4-bromo-5-phenylpyrazole (cas# 2845-78-5) is a compound useful in organic synthesis.

Applications (R)-3-(2-Chloro-4-nitro-1H-imidazol-1-yl)-2-(4-trifluoromethoxybenzyl-d2-oxy)propyl-3,3-d2 Benzoate is an intermediate used in the synthesis of (S)-PA 824-d4 (P122502), which is a labelled novel anti-tuberculosis drug.
References Diacon, A.H. et al.: Antimicrob. Anents Chemother., 54, 3402 (2010); Dogra, M. et al.: Br. J. Pharmacol., 162, 226 (2010); Ginsberg, A.M. et al.: Antimicrob. Agents Chemother., 53, 3720 (2009);

Applications 1-Propylpiperazine dihydrobromide (cas# 64262-23-3) is a useful research chemical.

Applications 2,2,5,5-Tetramethyl-3-amino-pyrrolidine-1-oxyl Free Radical is a highly reactive spin-label compound.

Applications 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine (cas# 88964-99-2) is a compound useful in organic synthesis.

Applications 5-Nitro-1H-imidazole-1-ethanol-d4 (cas# 1794791-19-7) is a compound useful in organic synthesis.

Applications α-Methyl-2-piperidinemethanol-13C2 is a labelled analogue of α-Methyl-2-piperidinemethanol (M324830), which can be used in the preparation of substances with herbicidal activity. α-Methyl-2-piperidinemethanol-13C2 is also an intermediate in synthesizing 2-Acetyl-3,4,5,6-tetrahydropyridine-13C2 Hydrochloride (A188502), which is a labelled 2-Acetyl-3,4,5,6-tetrahydropyridine (A188500), the most important bread flavor component.
References Buttery, R.G., et al.: J. Agric. Food Chem., 43, 1878 (1995)

Applications Intermediate in the preparation of selective cyclooxygenase-2 inhibitors and calcium antagonists
References Ashimori, A., et al.: Chem. Pharm. Bull., 38, 2446 (1990), Khanna, I., et al.: J. Med. Chem., 43, 3168 (2000),

Applications Methyl 3-(Imidazol-4-yl) Propionate (cas# 31434-93-2) is a compound useful in organic synthesis.

Applications 2,6-Diamino-4-hydroxy-5-nitrosopyrimidine-13C2 is a labelled 2,6-Diamino-4-hydroxy-5-nitrosopyrimidine (D416350), used in the preparation of pterin-based inhibitors.
References Hevener, K. et al.: J. Med. Chem., 53, 166 (2010)

Applications 5-Bromo-2-(1H-tetrazol-5-yl)pyridine is a reagent in the synthesis and antibacterial activity of oxazolidinones containing pyridine substituted with heteroaromatic ring.
References Jo, Y.W., et al.: Bioorg. Med. Chem., 12, 5909 (2004)

Applications 2-Oxo-N-(pyridin-4-yl)butanamide is an intermediate in synthesizing 2-Hydroxy-N-(pyridin-4-yl)butanamide (H953495). It is a is a useful synthetic intermediate.

Applications Pyridinium Chlorochromate is used in the synthesis of potent antitumor antibiotics and agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hurley, L. et al.: Chem. Res. Toxicol., 1, 258 (1988);

Applications Used in ointments for treatment of psoriasis.
References Wetterau, J., et al.: Biochim. Biophys Acta, 1345, 136 (1997), Sorbera, L., et al.: Drugs Future, 25, 1138 (2000), Robl, J., et al.: J. Med. Chem., 44, 851 (2001), Theuns, J., et al.: Neurolog. Aging, 25, S85 (2004),

Applications 1,3-Dibromo-5,5-dimethyl-2,4-imidazolidinedione is a useful synthetic intermediate in aromatic bromination of alkoxybenzoic acids and in bromofluorination of alkenes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Olah, G., et al.: Synthesis, 7, 692 (1993); Auerbach, J., et al.: Tetrahedr. Lett., 34, 931 (1993)

Applications 3-Chloropyridine N-Oxide (cas# 1851-22-5) is a compound useful in organic synthesis.

Applications 2-Amino-5-bromo-4,6-dimethylpyridine (cas# 89856-44-0) is a compound useful in organic synthesis.

Applications 4-Chloropyridine n-oxide (cas# 1121-76-2) is a useful research chemical.

Applications Intermediate in the preparation of labelled Cycloserine (C988802).

Applications 5-Chloro-4-(3-pyridinyl)-2-pyrimidinamine is an intermediate in the synthesis of 3-((5-Chloro-4-(pyridin-3-yl)pyrimidin-2-yl)amino)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide (C179120), an impurity of Nilotinib (N465300), which might be useful in treatment of chronic myelogenous leukemia.
References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),

Applications N,1-Dimethyl-4-nitro-5-imidazolecarboxamide (cas# 858513-51-6) is a compound useful in organic synthesis.

Applications 5-Hydroxy-6-methyl-4-[[(4-methylphenyl)imino]methyl]-3-pyridinemethanol-d5 is an intermediate in the synthesis of labelled Pyridoxal phosphate.
References Sharif, S., et al.: J. Am. Chem. Soc., 129, 4440 (2007);

Applications 3-Bromopyridine-d4 is the isotope labelled analog of 3-Bromopyridine (B686740). Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Colby, J., et al.: Biochem. J., 165, 395 (1977), Damani, L., et al.: Xenobiotica, 12, 527 (1982), Balzarini, J., et al.: J. Antimicrob. Chemother., 55, 135 (2005),

Applications 4-(1,2-Benzisothiazol-3-yl)-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of Ziprasidone (Z485010) related compounds.
References Huang, M., et al.: Clin. Pharmacol. Ther., 54, 257 (1993), Prakash, C., et al.: Drug Metab. Dispos., 25, 206 (1997), Brosen, K., et al.: Eur. J. Clin. Pharmacol., 44, 349 (1993),

Applications An intermediate in the preparation of labelled Pipradrol Hydrochloride

Applications 2-AMINO-4,6-DICHLOROPYRIMIDINE (cas# 56-05-3) is a useful research chemical.

Applications 1-(4-Cyanophenyl)piperazine

Applications N-Nitro-1H-imidazol-2-amine is used as a reagent in the synthesis of Imidacloprid-olefin (I274995); a metabolite of Imidacloprid (I274990) which is an active ingredient in certain neuro-active insecticides.
References Chauzat, M., et al.: Env. Entomol., 38, 514 (2009); Patial, A., et al.: Env. Ecol., 27, 320 (2009); Fernandez-Bayo, J., et al.: J. Agric., Food Chem., 57, 5435 (2009); Tomizawa, M., et al.: J. Med. Chem., 52, 3735 (2009); Chem. and Eng. News 90: 10 (2012)

Applications A novel heterobifunctional linker for facile access to bioconjugates.
References Gait, M., et al.: Cell Mol. Life Sci., 60, 844 (2003), Hossany, R., et al.: Bioorg. Med. Chem., 12, 3743 (2004), Maurel, F., et al.: Bioorg. Med. Chem., 15, 5084 (2005),

Applications N-Acetyl-3-acetoxy-5-phenylpyrrole (cas# 100750-39-8) is a compound useful in organic synthesis.

Applications Can be used in the preparation of substances for treatment of dermatological conditions and skin protection.

Applications 2-Butyl-5-hydroxy-1H-imidazole (cas# 1026802-97-0) is a compound useful in organic synthesis.

Applications 2-(Tetrazol-1-yl)acetic Acid-13C2,15N is a reactant used in the preparation of labelled β-lactam antibiotics.
References Nys, P. et al.: App. Biochem. Biotech., 88, 221 (2000); Won, J. et al.: App. Biochem. Biotech., 69, 1 (1998); Kostadinov, M. et al.: App. Biochem. Biotech., 33, 177 (1992)

Applications 4-Piperidineethanol have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAK
References Tomita, N., et al.: Bioorg. Med. Chem., 23, 1779 (2013); Negoro, K., et al.: Bioorg. Med. Chem., 20, 6442 (2012); Giang, H.N., et al.: Macromole. Chem. Phy., 213, 982 (2012);

Impurity Abiraterone Impurity 7
Applications 3-(Diethylboryl)pyridine is an intermediate used to prepare inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. It is also used in the synthesis of trisubstituted pyrimidines from polyhalopyrimidines via Suzuki coupling.
References Charrier, J., et al.; J. Med. Pharm. Chem., 54, 2320 (2011); Large, J., et al.: Synlett., 861 (2006)

Applications 1,1'-(AZODICARBONYL)DIPIPERIDINE (cas# 10465-81-3) is a useful research chemical.

Applications 2,4-Dihydroxy-6-amino-5-diethoxyethylpyrimidine (cas# 102879-75-4) is a compound useful in organic synthesis.

Applications 4,6-Bis(4-nitrophenoxy)pyrimidine is an intermediate in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.
References Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);

Applications Methyl 4-Amino-3,6-dichloropyridine-2-carboxylate is an intermediate in the synthesis of Arylex (A794890), which exhibits potent dicot weed control; Herbicide.
References Schmitzer, P. R., et al.: ACS Symp. Ser., 1204, 247-260 (2015); Epp, J. B., et al.: Bioorg. Med. Chem., 24, 362-371 (2016); Zhao, H., et al.: J. Sep. Sci., 38, 1164-1171 (2015)

Applications 1-Phenyl-2-pyrrolidone (cas# 4641-57-0) is a compound useful in organic synthesis.

Stability Moisture Sensitive
Applications 4-Piperidinopiperidine-1-carbonyl Chloride is used as a reagent in the synthesis of Irinotecan Hydrochloride Trihydrate (I767500); a DNA topoisomerase inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kunimoto, T., et al.: Cancer Res., 47, 5944 (1987); Shimada, Y., et al.: J. Clin. Oncol., 11, 909 (1993)

Applications 2-(2-Thenylamino)pyridine is an intermediate in the synthesis of Methapyrilene Hydrochloride (M259970). Methapyrilene is used as antihistaminic agent.
References Calandre, E.P., et al.: Clin. Pharmacol. Ther., 29, 527 (1981); Eastmond, D., et al.: Mutagenesis, 24, 341 (2009); Dertinger, S., et al.: Toxicol. Sci., 115, 401 (2010)

Applications 3-Bromo-4-formyl-2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxy is an intermediate in the synthesis of highly active spin labelling reagents.
References Kalaim, T., et al: Synthesis., 10, 1702 (2010); Fawzi, N.L., et al.: J. Biomolec. NMR., 51, 105 (2011);

Applications Imidazol-1-yl-acetic Acid-15N2,13C2 (cas# 1184983-00-3) is a compound useful in organic synthesis.