Heterocycles with Nitrogen (N)

<p>Stability Very Moisture Sensitive<br>Applications Cyanoacetic Acid N-Hydroxysuccinimide Ester is used as a pharmaceutical intermediate. It is used in the preparation of substituted pyrrolopyrimidinamines as selective Janus kinase inhibitors for the treatment of autoimmune diseases and organ transplant rejection.<br>References Flanagan, M. E., et al.: J. Med. Chem., 53, 8468 (2010)<br></p>

<p>Applications 6-Ethyl-4-(1-piperazinyl)thieno[2,3-d]pyrimidine Hydrochloride is an intermediate used in the synthesis of 6-Ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]thieno[2,3-d]pyrimidine Hydrochloride (E926745), which is an inhibitor of fusion protein interaction of menin-mixed lineage leukemia (menin-MLL). Menin-MLL inhibitors downregulate the expression of target genes required for MLL fusion protein oncogenic activity and thus effectively reverse MLL fusion protein-mediated leukemic transformation.<br>References Grembecka, J. et al.: Nat. Chem. Biol., 8, 277 (2012);<br></p>

<p>Applications Ethyl N-Boc-piperidine-4-carboxylate is used as a reagent to synthesize 3-amino-1-(5-indanyloxy)-2-propanol derivatives as sodium channel blockers to treat stroke patients. Ethyl N-Boc-piperidine-4-carboxylate is also used as a reagent to prepare inhibitors of tumour necrosis factor alpha-converting enzyme.<br>References Levin. J.: Heterocycles, 70, 691 (2006); Seki, M., et al.: Chem. Pharm. Bull., 60, 488 (2012)<br></p>

<p>Applications 2-Butyl-d3-4-chloro-5-benzyloxymethyl-1H-imidazole (cas# 1189919-69-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Chloropyridine N-Oxide (cas# 1851-22-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(2,3-Dichlorophenyl)piperazine 1-Oxide is an intermediate in the synthesis of Aripiprazole (A771000) related compound.<br>References Satyanarayana, Bollikonda. et al., Heterocyclic. Commun., 11, 485 (2005);<br></p>

<p>Applications 5H,6H,7H-cyclopenta[b]pyridine-7-carboxylic acid hydrochloride (cas# 1610919-99-7) is a useful research chemical.<br></p>

<p>Applications 1,3-Dibutyl-3,6-dihydropyrimidin-1-ium Bromide is a byproduct in the synthesis of Carboplatin-d4 (C177502), which is an analog of Cisplatin with reduced nephrotoxicity. Antineoplastic.<br>References Harland, S.J., et al.: Cancer Res., 44, 1693 (1984), Smith, I.E., et al.: Cancer Treat. Rep., 69, 43 (1985), Lygidakis, N.J., et al.: Interferon Cytokine Res., 15, 467 (1995),<br></p>

<p>Applications N-Boc-N-methylpiperazine-d8 (cas# 1189436-83-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Bromo-3-hydroxypyridine (cas# 161417-28-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(1,2-Benzisothiazol-3-yl)-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of Ziprasidone (Z485010) related compounds.<br>References Huang, M., et al.: Clin. Pharmacol. Ther., 54, 257 (1993), Prakash, C., et al.: Drug Metab. Dispos., 25, 206 (1997), Brosen, K., et al.: Eur. J. Clin. Pharmacol., 44, 349 (1993),<br></p>

<p>Applications A useful synthetic intermediate for solid phase synthesis of polyamides containing imidazole.<br>References Baird., E.E. and Dervan, P.B.: J. Am. Chem. Soc., 118, 6141 (1996)<br></p>

<p>Applications 1-Cyclohexyl-1-(4-benzyloxycyclohexyl)-2-(2-pyridinyl)ethanol-d11_x000D_(Mixture of Diastereomers) (cas# 1189891-05-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Piperonylpiperazine (cas# 32231-06-4) is a compound useful in organic synthesis.<br>References Min, J. Z. et at., Biom. Chrom. 24, 1287 (2010); Mitrea, N. et al., Bioanalysis 2, 1211 (2010)<br></p>

<p>Applications 2-[[(3aR,4S,6R,6aS)-6-[7-Chloro-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol is used as a reagent in the synthesis of Ticagrelor (T437700); an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.<br>References Springthorpe, B., et al.: Bioorg. Med. Chem. Lett., 17, 6013 (2007)<br></p>

<p>Applications α-Methyl-2-piperidinemethanol-13C2 is a labelled analogue of α-Methyl-2-piperidinemethanol (M324830), which can be used in the preparation of substances with herbicidal activity. α-Methyl-2-piperidinemethanol-13C2 is also an intermediate in synthesizing 2-Acetyl-3,4,5,6-tetrahydropyridine-13C2 Hydrochloride (A188502), which is a labelled 2-Acetyl-3,4,5,6-tetrahydropyridine (A188500), the most important bread flavor component.<br>References Buttery, R.G., et al.: J. Agric. Food Chem., 43, 1878 (1995)<br></p>

<p>Applications 1-(N,N-Dimethylsulfamoyl)-1H-imidazole-15N2 is a labelled imidazole (I350202) derivative, used in the preparation of Histamine H3 Receptor Agonists and druglike angiotensin II compounds with affinity for the AT2 receptor.<br>References Wijtmans, M. et al.: J. Med. Chem., 51, 2944 (2008); Georgsson, J. et al.: J. Med. Chem., 50, 1711 (2007)<br></p>

<p>Applications N,1-Dimethyl-4-nitro-5-imidazolecarboxamide (cas# 858513-51-6) is a compound useful in organic synthesis.<br></p>

<p>Applications An intermediate for the synthesis of labelled thiazolidinedione anti-diabetic drugs<br>References Cantello, B., et al.: Bioorg. Med. Chem. Lett., 4, 1181 (1994),<br></p>

<p>Applications 2-Amino-4,6-dihydroxy-5-nitropyrimidine (cas# 80466-56-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(2-Chloroethyl)-2-imidazolidinone (cas# 2387-20-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Bromopyridine-d4 is the isotope labelled analog of 3-Bromopyridine (B686740). Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Colby, J., et al.: Biochem. J., 165, 395 (1977), Damani, L., et al.: Xenobiotica, 12, 527 (1982), Balzarini, J., et al.: J. Antimicrob. Chemother., 55, 135 (2005),<br></p>

<p>Applications 4-Chloro-2,6-dimethoxypyrimidine (cas# 6320-15-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Cyanopyrimidine (cas# 40805-79-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl 4-Amino-3,6-dichloropyridine-2-carboxylate is an intermediate in the synthesis of Arylex (A794890), which exhibits potent dicot weed control; Herbicide.<br>References Schmitzer, P. R., et al.: ACS Symp. Ser., 1204, 247-260 (2015); Epp, J. B., et al.: Bioorg. Med. Chem., 24, 362-371 (2016); Zhao, H., et al.: J. Sep. Sci., 38, 1164-1171 (2015)<br></p>

<p>Applications (5-Bromopyridin-2-yl)[2-(tert-butyldimethylsilyloxy)ethyl]methylamine (cas# 326496-01-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Imidazol-1-yl-acetic Acid-15N2,13C2 (cas# 1184983-00-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-[(5-Benzyloxypyridin-2-yl)methylamino]ethanol-d4 (cas# 1794786-87-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Benzoyl-4-(2,3-dichlorophenyl)piperazine 4-Oxide is an intermediate in the synthesis of Aripiprazole (A771000) related compound.<br>References Satyanarayana, Bollikonda. et al., Heterocyclic. Commun., 11, 485 (2005);<br></p>

<p>Applications 5-Nitro-1-(phenylmethyl)-1H-imidazole is an intermediate in the synthesis of nitroimidazole based compounds.<br>References Vidakovic, M., et al.: Antimicrob. Agents Chemother., 47, 302 (2003);<br></p>

<p>Applications 2-(tert-Butylamino)-4-chloro-6-cyclopropylamino-1,3,5-triazine-d9 (cas# 1189419-70-2) is a compound useful in organic synthesis.<br></p>

<p>Stability Stable<br>Applications 2,4,5-Triamino-6-pyrimidinol-13C2,15N is an intermediate in the synthesis of labelled Guanine (G836000). Guanine is on one of the five nucleobases incorporated into biological nucleic acids. Guanine, along with adenine and cytosine, is present in both DNA and RNA, whereas thymine is usually seen only in DNA, and uracil only in RNA.<br>References Geslain, R., et al.: J. Biol. Chem., 284, 27760 (2009); Manini, P., et al.: Toxicol. Lett., 190, 41 (2009); Gong, B., et al.: Biochem., 48, 11961 (2009); Sugimoto, M., et al.: J. Agric. Food Chem., 58, 374 (2010)<br></p>

<p>Applications N-Boc-pyrrolidine is a boc-protected cyclic amine used as a building block in the preparation of diastereomers by usually undergoing α'-lithiations and electrophilic substitution reactions.<br>References Beak, P. et al.: J. Org. Chem., 58, 1109 (1993);<br></p>

<p>Applications Protected N-Benzylpiperazine-d8<br>References Bannwarth, W., et al.: Bioorg. Med. Chem., Lett., 6, 1525 (1996), Greenwald, R., et al.: J. Med. Chem., 43, 475 (2000), Wills, A., et al.: Curr. Opin. Chem. Biol., 7, 346 (2003), Heidler, P., et al.: Bioorg. Med. Chem., 13, 585 (2005),<br></p>

<p>Applications 1,1'-(AZODICARBONYL)DIPIPERIDINE (cas# 10465-81-3) is a useful research chemical.<br></p>

<p>Applications 2-Amino-4,6-dihydroxypyrimidine-13C2 is an intermediate in the production of antimicrobial guanylsulfonamides.<br>References Barrett, O., et al.: ChemBioChem., 7, 1882 (2006), Patel, P., et al.: Bioorg. Med. Chem. Lett., 17, 6610 (2007), Gasser, L., et al.: Environ. Sci. Technol., 41, 2445 (2007)<br></p>

<p>Applications 5-Bromo-2-(1H-tetrazol-5-yl)pyridine is a reagent in the synthesis and antibacterial activity of oxazolidinones containing pyridine substituted with heteroaromatic ring.<br>References Jo, Y.W., et al.: Bioorg. Med. Chem., 12, 5909 (2004)<br></p>

<p>Applications 2,6-Diamino-4-hydroxy-5-nitrosopyrimidine-13C2 is a labelled 2,6-Diamino-4-hydroxy-5-nitrosopyrimidine (D416350), used in the preparation of pterin-based inhibitors.<br>References Hevener, K. et al.: J. Med. Chem., 53, 166 (2010)<br></p>

<p>Applications 1-Benzyl-3-(3-(dimethylamino)propoxy)-1H-pyrazole-5-carboxylic Acid Hydrochloride is an intermediate for the synthesis of CFM 1571 Hydrochloride (C291720), which acts as a soluble guanylyl cyclase (sGC) activator while ignoring adenylyl cyclase. Inhibits collagen-stimulated platelet aggregation in vitro.<br>References Kotzki, S. et al.: J. Pharm. Exp. Ther., 346, 424 (2013); Selwood, D&gt; et al.: J. Med. CHem., 44, 78 (2001)<br></p>

<p>Applications 1-(4-Cyanophenyl)piperazine<br></p>

<p>Applications 4-[2-(1-Piperidinyl)ethoxy]-benzenemethanol is an intermediate in the synthesis of Pipendoxifene (P479850), a 2-Ph indole selective estrogen receptor modulator (SERM) that exhibits an excellent preclin. pharmacol. profile and was selected for further development as a treatment for metastatic breast cancer.<br>References Cotreau, M., et al.: J. Clin. Pharm., 42, 157 (2002); Greenberger, L., et al.: Clin. Cancer Res., 7, 3166 (2001)<br></p>

<p>Applications 2,2,6,6-Tetramethyl-4-piperidinone (cas# 826-36-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Amino-4-chloro-5-nitropyridine (cas# 24484-96-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Used in the preparation of piperazine-1-carboxamide derivatives as fatty acid amide hydrolase (FAAH) inhibitors.<br>References Glorius, F., et al.: Org. Biomol. Chem., 3, 4171 (2005),<br></p>

<p>Applications An intermediate in the preparation of CDK inhibitors<br>References Jakobsen, P., et al.: Bioorg. Med. Chem., 8, 2803 (2000), Chu, X., et al.: J. Med. Chem., 49, 6549 (2006),<br></p>

<p>Applications (S)-1-Nitrosopiperidin-3-ol-d4 is an intermediate in synthesizing Ibrutinib-d4 (I124971), a labelled analogue of Ibrutinib (I124970). Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.<br>References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)<br></p>

<p>Applications 2,3,7,8-Tetrachloro-[1,4]dioxino[2,3-b:5,6-b']dipyridine is used in analytical studies for the presence and formation of dioxin-like compounds in heat-treated chlorpyrifos herbicide, a potential precursor of pyridine analog of 2,3,7,8-Tetrachloro-p-dioxin (T291370).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sakiyaama, T., et al.: Organohalogen Compounds, 73, 146 (2011);<br></p>

<p>Impurity Abiraterone Impurity 7<br>Applications 3-(Diethylboryl)pyridine is an intermediate used to prepare inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. It is also used in the synthesis of trisubstituted pyrimidines from polyhalopyrimidines via Suzuki coupling.<br>References Charrier, J., et al.; J. Med. Pharm. Chem., 54, 2320 (2011); Large, J., et al.: Synlett., 861 (2006)<br></p>

<p>Applications 2-Bromopyridine n-oxide hydrochloride<br></p>

<p>Applications 2-(n-Butyl-d9-amino)-4-chloro-6-cyclopropylamino-1,3,5-triazine (cas# 1189997-37-2) is a compound useful in organic synthesis.<br></p>

<p>Applications (4R)-3-(1-Oxo-3-buten-1-yl)-4-(phenylmethyl)-2-oxazolidinone is an intermediate in the synthesis of emericellamide A, a secondary metabolite of marine cyclic depsipeptide with antimicrobial properties.<br>References Ma, J. Y., et al.: Synlett., 8, 1307 (2009);<br></p>

<p>Applications 2,2,5,5-Tetramethyl-3-amino-pyrrolidine-1-oxyl Free Radical is a highly reactive spin-label compound.<br></p>

<p>Applications 2-(Tetrazol-1-yl)acetic Acid-13C2,15N is a reactant used in the preparation of labelled β-lactam antibiotics.<br>References Nys, P. et al.: App. Biochem. Biotech., 88, 221 (2000); Won, J. et al.: App. Biochem. Biotech., 69, 1 (1998); Kostadinov, M. et al.: App. Biochem. Biotech., 33, 177 (1992)<br></p>

<p>Applications 2,4-Dinitro-3-pyridinol is an impurity in the synthesis of 2,6-Diamino-5-hydroxy-3-(phenylazo)pyridine which is a novel metabolite of Phenazopyridine (P313751).<br>References Bailey, K., et al.: Drug Metab. Dispos., 11, 277 (1983), Thomas, B. H., et al.: J. Pharm. Sci., 79, 321 (1990), Thomas, B.H., et al.: Xenobiotica, 23, 99 (1993),<br></p>

<p>Applications 2-Cyano-3-chloropyridine (cas# 38180-46-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Amino-3-(1-naphthyl)-4-cyano-1-tert-butylpyrazole (cas# 221243-34-1) is a compound useful in organic synthesis.<br>References Bishop, A.C., et al.: J. Am. Chem. Soc., 121, 627 (1999)<br></p>

<p>Applications (1S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic Acid 2,5-Dioxo-1-pyrrolidinyl Ester is an intermediate in the synthesis of ((R)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)((S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone (P309025). ((R)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)((S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone is a possible impurity of solifenacin (S676700) which is a muscarinic M3 receptor antagoinst. Solifenacin is used in treatment of urinary incontinence.<br>References Ikeda K., et al.: Arch. Pharmacol., 366, 97, (2002); Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004); Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004); Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005); Habb, F., et al.: Eur. Urol. 47, 376 (2005); Payne, C.K., et al.: Drugs, 66, 175 (2006)<br></p>

<p>Applications Reagent used to synthesize many pyrrole derivatives<br></p>

<p>Applications (αS)-2-Chloro-α-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-nitro-1H-imidazole-1-ethanol is an intermediate in the synthesis of (S)-PA 824 (P122500), a novel anti-tuberculosis drug.<br>References Thompson, A. W., et al.: Biorg. Med. Chem. Lett., 25, 3804 (2015)<br></p>

<p>Applications 2,6-Dibromopyridine is used as a starting material to synthesize 2,2’-bipyridines (such as 5-Cyano-1,6-dihydro-6-oxo-[3,4'-bipyridine]-2-carboxylic Acid [C979150]) via a Stille-type cross-coupling reaction. 2,6-Dibromopyridine is also used as a reagent to synthesize pyridylpyrimidine fungicides, compounds that eliminate fungi by cycling copper through the cell membrane, where it reaches toxic levels.<br>References Hargreaves, S., et al.: Tetrahedron Lett., 41, 1653 (2000); Heller, M. &amp; Schubert, U.: J. Org. Chem., 67, 8269 (2002); Simkovsky, N., et al.: J. Chem. Soc. Perk. Trans. 1, 16, 1847 (2002)<br></p>

<p>Applications An intermediate in the preparation of labelled Pipradrol Hydrochloride<br></p>

<p>Applications 3-Amino-4-bromo-5-phenylpyrazole (cas# 2845-78-5) is a compound useful in organic synthesis.<br></p>

<p>Applications (1-Benzyl-1H-imidazol-5-yl)(2,3-dimethylphenyl)methanone is an intermediate in the synthesis of 1-Benzyl-5-(1-(2,3-dimethylphenyl)vinyl)-1H-imidazole (B251400), an impurity of Medetomidine (M203250, HCl); an α2-adrenergic agonist, sedative, and analgesic.<br>References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987); Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987); Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988); Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996)<br></p>

<p>Applications An intermediate of Rosuvastatin (R700500).<br></p>

<p>Applications 2,4-Dihydroxy-6-amino-5-diethoxyethylpyrimidine (cas# 102879-75-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Chloro-4-(3-pyridinyl)-2-pyrimidinamine is an intermediate in the synthesis of 3-((5-Chloro-4-(pyridin-3-yl)pyrimidin-2-yl)amino)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide (C179120), an impurity of Nilotinib (N465300), which might be useful in treatment of chronic myelogenous leukemia.<br>References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>

<p>Applications 2,4-Dichloro-5-nitropyrimidine (cas# 49845-33-2) is a compound useful in organic synthesis.<br></p>

<p>Applications (S)-5-Chloro-3-(cyclopropylethynyl)-3-(trifluoromethyl)-1,3-dihydrobenzo[c]isoxazole is a proposed intermediate in the synthesis of (4S)-6-Chloro-4-(3-((4-chloro-2-((S)-4-cyclopropyl-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl)phenyl)amino)pent-1-yn-1-yl)-4-(trifluoromethyl)-1H-benzo[d][1,3]oxazin-2(4H)-one (Mixture of Diastereomers) (C360045) which is an impurity of Efavirenz (E425000) which is a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>

<p>Applications 4,6-Bis(4-nitrophenoxy)pyrimidine is an intermediate in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.<br>References Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);<br></p>

<p>Applications 2-Hydroxy-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of (E)-6-Amino-2-hexenoic Acid (A609990), used in the preparation of anti-collagenase active agent.<br>References Schmidt, A. M., et al: Org. Biomolec. Chem., 3, 2333 (2005);<br></p>

<p>Applications 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine (cas# 88964-99-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Used in ointments for treatment of psoriasis.<br>References Wetterau, J., et al.: Biochim. Biophys Acta, 1345, 136 (1997), Sorbera, L., et al.: Drugs Future, 25, 1138 (2000), Robl, J., et al.: J. Med. Chem., 44, 851 (2001), Theuns, J., et al.: Neurolog. Aging, 25, S85 (2004),<br></p>

<p>Applications A useful reactant in the preparation labelled Carbazeran (C175792), a phosphodiesterase inhibitor drug.<br></p>

<p>Applications Methyl 3-(Imidazol-4-yl) Propionate (cas# 31434-93-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-(Chloromethyl)pyridine Hydrochloride has been used as a reactant for the synthesis of (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-one derivatives as Polo-like kinase 4 (PLK4) inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Laufer, R., et. al.: J. Med. Chem., 56, 6069 (2013)<br></p>

<p>Applications Reactant used in the preparation of labelled Camptothecin derivatives.<br></p>

<p>Applications 2-Butyl-5-hydroxy-1H-imidazole (cas# 1026802-97-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-[[2-(tert-Butyldimethylsilyloxy)ethyl]methylamino]pyridin-3-ol (cas# 326496-02-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Hydrochloride salt of N-(β-Chloroethyl)piperidine is used in the inhibition of sickle-cell hemoglobin.<br>References Stubbins, J. et al.: Eur. J. Med. Chem., 14, 219 (1979);<br></p>

<p>1-(3-Methylbenzyl)piperazine (MBZP) is a piperazine-type stimulant drug that has been used recreationally as an antidepressant or anorectic. MBZP can affect the levels of catecholamines, which are neurotransmitters that play a role in mood and appetite control. It is believed that MBZP works by blocking the reuptake of catecholamines, prolonging their presence in synapses and increasing the likelihood of stimulation.</p>

2-(Hydroxymethyl)pyridine is a metal chelate that has been shown to be a potent inhibitor of picolinic acid amidohydrolase. This enzyme is responsible for the conversion of picolinic acid to nicotinamide adenine dinucleotide (NAD), which is a cofactor in the citric acid cycle. The 2-(hydroxymethyl)pyridine-picolinic acid complex inhibits the activity of this enzyme, blocking the conversion of NAD into nicotinamide adenine dinucleotide phosphate (NADP). This inhibition leads to higher levels of NAD and lower levels of NADP, which may lead to an increase in metabolic activity by increasing the availability of ATP. 2-(Hydroxymethyl)pyridine has been shown to have immunosuppressive properties, as well as anti-inflammatory properties. It also has been shown to be effective against bowel disease and infectious diseases.

<p>6-Bromo-7-azaindole is a homologous molecule. It is an electron deficient compound with a piperidine moiety at the 6 position and a nitrogen atom at the 7 position. The nitrogen atom substitutes for an oxygen atom, making this molecule reactive. The electron deficient nature of this molecule makes it suitable for use in transistors and other physicochemical devices. 6-Bromo-7-azaindole has been shown to be effective against carcinoma cells in vitro, as well as to inhibit tumor growth in vivo. This drug also causes homologous recombination by interacting with DNA in mammalian cells. 6-Bromo-7-azaindole binds to DNA, forming a covalent bond with the guanine base of DNA through the nitrogen atom, which is electron deficient.</p>

<p>4-(Piperidin-1-ylmethyl)benzaldehyde is a benzyl compound that has been shown to inhibit the activity of some imidazole compounds. It has been shown to have an agonistic effect on h3 receptors, and can be used for the treatment of anxiety disorders. This compound can be used in drug design as a linker or pharmacophore for other compounds. 4-(Piperidin-1-ylmethyl)benzaldehyde can be synthesized from commercially available materials, which makes it worth further exploration.</p>

<p>Intermediate in the synthesis of nelarabine</p>

<p>2-Cyanopyridine is a chelate ligand that is structurally related to picolinic acid. It binds to the active site of IDO1 and prevents the enzyme from converting tryptophan into kynurenine. This leads to an increase in tryptophan levels, which can then be used for protein synthesis. 2-Cyanopyridine has been shown to have antimicrobial activity against Gram-positive bacteria in vitro and in vivo. It also inhibits the growth of Gram-negative bacteria, yeast, and fungi by binding to the iron atom of their heme molecules. 2-Cyanopyridine has shown potential as a pharmacological agent or as a biochemical probe for transfer reactions.</p>

Risedronic acid monohydrate is a bisphosphonate that inhibits bone resorption by inhibiting the activity of osteoclasts. It is used to treat postmenopausal women with osteoporosis and bowel disease, as well as to prevent bone loss in men with prostate cancer. Risedronic acid monohydrate has been shown to be more effective than alendronate for decreasing bone mineral density in women with breast cancer who have undergone chemotherapy. Risedronic acid monohydrate binds to the active site of the enzyme polymerase chain reaction (PCR) and blocks DNA synthesis, preventing the formation of new cells. Risedronic acid monerate also binds to the active site of nonsteroidal anti-inflammatory drugs (NSAIDs), thereby blocking their ability to inhibit cyclooxygenase enzymes, which are responsible for prostaglandin synthesis. This leads to reduced inflammation and pain.

<p>1-(4-Bromophenyl)piperazine is a chemical that is used in the synthesis of pharmaceuticals, such as antidepressants. It has been shown to inhibit monoamine neurotransmitter reuptake, including serotonin and dopamine. It also has an inhibitory effect on 5-hydroxytryptamine (5HT) release from nerve terminals and its binding to the 5HT7 receptor. 1-(4-Bromophenyl)piperazine can be used in chromatographic methods for validation of impurities, potential impurities, and other substances.</p>