Heterocycles with Nitrogen (N)

Impurity Abiraterone Impurity 7
Applications 3-(Diethylboryl)pyridine is an intermediate used to prepare inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. It is also used in the synthesis of trisubstituted pyrimidines from polyhalopyrimidines via Suzuki coupling.
References Charrier, J., et al.; J. Med. Pharm. Chem., 54, 2320 (2011); Large, J., et al.: Synlett., 861 (2006)

Applications An intermediate in the preparation of labelled Pipradrol Hydrochloride

Applications 4-[2-(1-Piperidinyl)ethoxy]-benzenemethanol is an intermediate in the synthesis of Pipendoxifene (P479850), a 2-Ph indole selective estrogen receptor modulator (SERM) that exhibits an excellent preclin. pharmacol. profile and was selected for further development as a treatment for metastatic breast cancer.
References Cotreau, M., et al.: J. Clin. Pharm., 42, 157 (2002); Greenberger, L., et al.: Clin. Cancer Res., 7, 3166 (2001)

Applications 2-Hydroxy-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of (E)-6-Amino-2-hexenoic Acid (A609990), used in the preparation of anti-collagenase active agent.
References Schmidt, A. M., et al: Org. Biomolec. Chem., 3, 2333 (2005);

Applications 4-[2-(1-Piperidinyl)ethoxy-d4]benzoic Acid, Hydrochloride Salt (cas# 1246815-60-0) is a compound useful in organic synthesis.

Applications 2-Cyano-3-chloropyridine (cas# 38180-46-0) is a compound useful in organic synthesis.

Applications Octahydro-6-(phenylmethyl)-1H-Pyrrolo[3,4-b]pyridine-d4 is an isotope labelled intermediate in the synthesis of moxifoxacin (M745000), a fluorinated quinolone antibacterial.
References Somisetti, N. et al.: Org. Chem. Indian J., 7, 123 (2011);

Applications 5-Nitro-1H-imidazole-1-ethanol-d4 (cas# 1794791-19-7) is a compound useful in organic synthesis.

Applications 1-Propylpiperazine dihydrobromide (cas# 64262-23-3) is a useful research chemical.

Applications A useful synthetic intermediate.
References Korosec, T., et al.: Bioorg. Med. Chem., 16, 209 (2008),

Applications (1-Benzyl-1H-imidazol-5-yl)(2,3-dimethylphenyl)methanone is an intermediate in the synthesis of 1-Benzyl-5-(1-(2,3-dimethylphenyl)vinyl)-1H-imidazole (B251400), an impurity of Medetomidine (M203250, HCl); an α2-adrenergic agonist, sedative, and analgesic.
References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987); Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987); Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988); Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996)

Applications (αS)-2-Chloro-α-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-nitro-1H-imidazole-1-ethanol is an intermediate in the synthesis of (S)-PA 824 (P122500), a novel anti-tuberculosis drug.
References Thompson, A. W., et al.: Biorg. Med. Chem. Lett., 25, 3804 (2015)

Applications 2-Butyl-d3-4-chloro-5-benzyloxymethyl-1H-imidazole (cas# 1189919-69-4) is a compound useful in organic synthesis.

Applications (4R)-3-(1-Oxo-3-buten-1-yl)-4-(phenylmethyl)-2-oxazolidinone is an intermediate in the synthesis of emericellamide A, a secondary metabolite of marine cyclic depsipeptide with antimicrobial properties.
References Ma, J. Y., et al.: Synlett., 8, 1307 (2009);

Applications N-Methyl-6-(4-nitrophenoxy)-4-pyrimidinamine is an intermediate in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.
References Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);

Applications 6-Chloro-4-(2,2,2-trifluoroacetyl)benzo[d]oxazol-2(3H)-one is an intermediate in the synthesis of 6-Chloro-4-[3-cyclopropyl-1-hydroxy-1-(trifluoromethyl)-2-propyn-1-yl]-2(3H)-benzoxazolone (C365790), a impurity of Efavirenz (E425000) which is a nonnucleoside HIV-1 reverse transcriptase inhibitor.
References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)

Applications 4-[4-(Trifluoromethoxy)phenoxy]piperidine is used in the preparation of 3,5-disubstituted isoxazolines as antituberculosis agents.
References Sun, D., et. al.: Eur. J. Med. Chem., 44, 460 (2009)

Applications (S)-1-Nitrosopiperidin-3-ol-d4 is an intermediate in synthesizing Ibrutinib-d4 (I124971), a labelled analogue of Ibrutinib (I124970). Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.
References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)

Applications A novel heterobifunctional linker for facile access to bioconjugates.
References Gait, M., et al.: Cell Mol. Life Sci., 60, 844 (2003), Hossany, R., et al.: Bioorg. Med. Chem., 12, 3743 (2004), Maurel, F., et al.: Bioorg. Med. Chem., 15, 5084 (2005),

Stability Stable
Applications 2,4,5-Triamino-6-pyrimidinol-13C2,15N is an intermediate in the synthesis of labelled Guanine (G836000). Guanine is on one of the five nucleobases incorporated into biological nucleic acids. Guanine, along with adenine and cytosine, is present in both DNA and RNA, whereas thymine is usually seen only in DNA, and uracil only in RNA.
References Geslain, R., et al.: J. Biol. Chem., 284, 27760 (2009); Manini, P., et al.: Toxicol. Lett., 190, 41 (2009); Gong, B., et al.: Biochem., 48, 11961 (2009); Sugimoto, M., et al.: J. Agric. Food Chem., 58, 374 (2010)

Applications 3-Bromo-2-cyanopyridine (cas# 55758-02-6) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-Amino-4,6-dihydroxypyrimidine-13C2 is an intermediate in the production of antimicrobial guanylsulfonamides.
References Barrett, O., et al.: ChemBioChem., 7, 1882 (2006), Patel, P., et al.: Bioorg. Med. Chem. Lett., 17, 6610 (2007), Gasser, L., et al.: Environ. Sci. Technol., 41, 2445 (2007)

Applications 5-Cyanopyrimidine (cas# 40805-79-6) is a compound useful in organic synthesis.

Applications (2-Pyrrolidinylethyl)triphenylphosphonium Bromide is an intermediate in the synthesis of in the synthesis of Pyrrobutamine Hydrochloride which is an antihistaminic.
References Casy, A.F., et al.: J. Pharm. Pharmacol., 22, 270 (1970),

Applications 2,4-Dinitro-3-pyridinol is an impurity in the synthesis of 2,6-Diamino-5-hydroxy-3-(phenylazo)pyridine which is a novel metabolite of Phenazopyridine (P313751).
References Bailey, K., et al.: Drug Metab. Dispos., 11, 277 (1983), Thomas, B. H., et al.: J. Pharm. Sci., 79, 321 (1990), Thomas, B.H., et al.: Xenobiotica, 23, 99 (1993),

Applications 5-Chloro-4-(3-pyridinyl)-2-pyrimidinamine is an intermediate in the synthesis of 3-((5-Chloro-4-(pyridin-3-yl)pyrimidin-2-yl)amino)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide (C179120), an impurity of Nilotinib (N465300), which might be useful in treatment of chronic myelogenous leukemia.
References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),

Applications 1-Benzoyl-4-(2,3-dichlorophenyl)piperazine 4-Oxide is an intermediate in the synthesis of Aripiprazole (A771000) related compound.
References Satyanarayana, Bollikonda. et al., Heterocyclic. Commun., 11, 485 (2005);

Applications An intermediate in the preparation of CDK inhibitors
References Jakobsen, P., et al.: Bioorg. Med. Chem., 8, 2803 (2000), Chu, X., et al.: J. Med. Chem., 49, 6549 (2006),

Applications 2-AMINO-4,6-DICHLOROPYRIMIDINE (cas# 56-05-3) is a useful research chemical.

Applications 5H,6H,7H-cyclopenta[b]pyridine-7-carboxylic acid hydrochloride (cas# 1610919-99-7) is a useful research chemical.

Applications 1-(1-Oxidobenzo[d]isothiazol-3-yl)piperazine 1-Oxide Hydrochloride is an intermediate in the synthesis of Ziprasidone (Z485010) related compounds.
References Huang, M., et al.: Clin. Pharmacol. Ther., 54, 257 (1993), Prakash, C., et al.: Drug Metab. Dispos., 25, 206 (1997), Brosen, K., et al.: Eur. J. Clin. Pharmacol., 44, 349 (1993),

Applications 3-Formyl-2,5-dihydro-2,2,5,5-tetramethyl-4-(3-pyridinyl)-1H-pyrrol-1-yloxy is an intermediate in the synthesis of highly active spin labelling reagents.
References Fawzi, N.L., et al.: J. Biomolec. NMR., 51, 105 (2011);

Applications 5,6-Diamino-2,4-dihydroxypyrimidine-13C2, Hydrochloride Salt (cas# 1346605-20-6) is a compound useful in organic synthesis.

Applications Can be used in the preparation of substances for treatment of dermatological conditions and skin protection.

Applications Used in the preparation of piperazine-1-carboxamide derivatives as fatty acid amide hydrolase (FAAH) inhibitors.
References Glorius, F., et al.: Org. Biomol. Chem., 3, 4171 (2005),

Applications 4-(4-Chlorophenyl)-1-imidazol-1-yl-(butan-d5)-2-ol (cas# 1185063-39-1) is a compound useful in organic synthesis.

Applications Labelled Anabaseine intermediate.

Applications N-(Benzyloxycarbonyl)-4-piperidone

Applications Ethyl 5-Methyl-1-phenyl-1H-pyrazole-4-carboxylate (cas# 89193-16-8) is a compound useful in organic synthesis.

Applications 2-Amino-4,6-dichloropyrimidine-13C2 (cas# 1346605-11-5) is a compound useful in organic synthesis.

Applications 2-Amino-4-chloro-5-nitropyridine (cas# 24484-96-6) is a compound useful in organic synthesis.

Applications Methyl 3-(Imidazol-4-yl) Propionate (cas# 31434-93-2) is a compound useful in organic synthesis.

Applications N-[2-(S)-Methyl-d3-butyryl]-4-(S)-phenylmethyl-2-oxazolidinone (cas# 1073232-99-1) is a compound useful in organic synthesis.

Applications Tris(p-tolyl)-1,3,5-triazine is an intermediate in synthesizing p-Cyanobenzoic Acid Trimer (C955200), which is used in the synthetic preparation of Terbium Triazinetribenzoate Formate Metal Organic Framework (MOF).
References Han, Y., et al.: J. Mater. Chem. A Mater. Energy Sustain., 3, 24525 (2015);

Applications 5-Iodo-N2,N4-bis(phenylmethyl)-2,4-pyrimidinediamine is an intermediate in the synthesis of Trimethoprim (T795615) related antibacterial agent.
References Pettit, G. R., et al.: J. Med. Chem., 48, 4087 (2005);

Applications Boronic acid derivatives and their binding affinities with diols.
References Yang, W., et al.: Bioorg. Med. Chem. Lett., 12, 2175 (2002), Yang, W., et al.: Med. Res. Rev., 23, 346 (2003),

Applications (S)-Benzyl 2-(5-Bromo-1H-indole-3-carbonyl)pyrrolidine-1-carboxylate is an intermediate in the synthesis of ent-Eletriptan (E505005), an enantiomeric impurity of the serotonin 5-HTIB/ID receptor agonist Eletriptan (E505000).
References Orita, A., et al.: Green Chem., 3, 13 (2001);

Applications Used in ointments for treatment of psoriasis.
References Wetterau, J., et al.: Biochim. Biophys Acta, 1345, 136 (1997), Sorbera, L., et al.: Drugs Future, 25, 1138 (2000), Robl, J., et al.: J. Med. Chem., 44, 851 (2001), Theuns, J., et al.: Neurolog. Aging, 25, S85 (2004),

Applications 4-Amino-6-hydroxypyrimidine (cas# 1193-22-2) is a compound useful in organic synthesis.

Applications 2-(Tetrazol-1-yl)acetic Acid-13C2,15N is a reactant used in the preparation of labelled β-lactam antibiotics.
References Nys, P. et al.: App. Biochem. Biotech., 88, 221 (2000); Won, J. et al.: App. Biochem. Biotech., 69, 1 (1998); Kostadinov, M. et al.: App. Biochem. Biotech., 33, 177 (1992)

Applications 2-Butyl-5-hydroxy-1H-imidazole (cas# 1026802-97-0) is a compound useful in organic synthesis.

Applications Intermediate in the preparation of (+/-)-Iso Myosmine (I821350).

Applications 1-(N,N-Dimethylsulfamoyl)-1H-imidazole-15N2 is a labelled imidazole (I350202) derivative, used in the preparation of Histamine H3 Receptor Agonists and druglike angiotensin II compounds with affinity for the AT2 receptor.
References Wijtmans, M. et al.: J. Med. Chem., 51, 2944 (2008); Georgsson, J. et al.: J. Med. Chem., 50, 1711 (2007)

Applications Precursor to chelating agents.

Applications 4-Bromo-3-hydroxypyridine (cas# 161417-28-3) is a compound useful in organic synthesis.

Applications 4-Piperidineethanol have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAK
References Tomita, N., et al.: Bioorg. Med. Chem., 23, 1779 (2013); Negoro, K., et al.: Bioorg. Med. Chem., 20, 6442 (2012); Giang, H.N., et al.: Macromole. Chem. Phy., 213, 982 (2012);

Applications 2-(n-Butyl-d9-amino)-4-chloro-6-cyclopropylamino-1,3,5-triazine (cas# 1189997-37-2) is a compound useful in organic synthesis.

Applications 2-Chloro-3-cyanopyridine (cas# 6602-54-6) is a compound useful in organic synthesis.

Stability Moisture Sensitive
Applications 4-Piperidinopiperidine-1-carbonyl Chloride is used as a reagent in the synthesis of Irinotecan Hydrochloride Trihydrate (I767500); a DNA topoisomerase inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kunimoto, T., et al.: Cancer Res., 47, 5944 (1987); Shimada, Y., et al.: J. Clin. Oncol., 11, 909 (1993)

Applications 3-Bromo-4-formyl-2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxy is an intermediate in the synthesis of highly active spin labelling reagents.
References Kalaim, T., et al: Synthesis., 10, 1702 (2010); Fawzi, N.L., et al.: J. Biomolec. NMR., 51, 105 (2011);

Applications 4-Chloro-2,6-dimethoxypyrimidine (cas# 6320-15-6) is a compound useful in organic synthesis.

Applications 5-Methylpyrimidine (cas# 2036-41-1) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 1-(2-Chloroethyl)-2-imidazolidinone (cas# 2387-20-4) is a compound useful in organic synthesis.

Applications 6-[[2-(tert-Butyldimethylsilyloxy)ethyl]methylamino]pyridin-3-ol (cas# 326496-02-0) is a compound useful in organic synthesis.

Applications Ethyl (5-Ethyl-2-pyridinyl)-1,1-d2-acetate (cas# 1189654-25-8) is a compound useful in organic synthesis.

Applications 5-{4-[2-[(5-Benzyloxypyridin-2-yl)methylamino]ethoxy]benzylidine}thiazolidine-2,4-dione (cas# 1076199-05-7) is a compound useful in organic synthesis.

Applications Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Colby, J., et al.: Biochem. J., 165, 395 (1977), Damani, L., et al.: Xenobiotica, 12, 527 (1982), Balzarini, J., et al.: J. Antimicrob. Chemother., 55, 135 (2005),

Applications 4-Chloropyridine-2-carboxamide, is a versatile building block used in synthesis of various chemical compounds.

Applications Ethyl N-Boc-piperidine-4-carboxylate is used as a reagent to synthesize 3-amino-1-(5-indanyloxy)-2-propanol derivatives as sodium channel blockers to treat stroke patients. Ethyl N-Boc-piperidine-4-carboxylate is also used as a reagent to prepare inhibitors of tumour necrosis factor alpha-converting enzyme.
References Levin. J.: Heterocycles, 70, 691 (2006); Seki, M., et al.: Chem. Pharm. Bull., 60, 488 (2012)

Applications 1,1-Dimethylethyl 4-(2-Hydroxyethyl)piperazine-1-carboxylate-d4 is an isotope labelled intermediate in the synthesis of labelled Flupentixol.
References Panteleev, J., et al.: Synlett., 26, 953 (2015); Liang, Y.K., et al.: Euro. J. Med. Chem., 84, 505 (2014);

Applications 2,5-Dihydro-3-(hydroxymethyl)-2,2,5,5-tetramethyl-4-(3-pyridinyl)-1H-pyrrol-1-yloxy is an intermediate in the synthesis of highly active spin labelling reagents.
References Fawzi, N.L., et al.: J. Biomolec. NMR., 51, 105 (2011);

Applications Reagent used to synthesize many pyrrole derivatives

Applications 1,1'-(AZODICARBONYL)DIPIPERIDINE (cas# 10465-81-3) is a useful research chemical.

Applications 3-Chloropyridine N-Oxide (cas# 1851-22-5) is a compound useful in organic synthesis.

Applications 3-Cyanopyridine N-Oxide is a useful synthetic intermediate in the synthesis of Arimoclomol Maleic Acid (A771270); an orally administered drug used to treat amyotrophic lateral sclerosis.
References Kurthy, M., et al.: New. York. Acad. Sci., 967, 482 (2002); Kalmar, B., et al.: Exp. Neurol., 184, 636 (2003)

5-Bromo-6-chloro-1H-indole is a fine chemical that is used as a building block for research chemicals, reagents, and speciality chemicals. It is soluble in chloroform and benzene, but insoluble in water. This product can be used as a reaction component or a useful intermediate in the production of complex compounds. 5-Bromo-6-chloro-1H-indole has been reported to be an effective scaffold for the synthesis of many novel compounds with potential applications such as pharmaceuticals, agrochemicals, and dyes.

2-Bromo-1H-imidazole is an environmental pollutant that has been detected in the atmosphere, water, and soil. It is used as a pesticide and has been found to be an impurity in biphenyl. 2-Bromo-1H-imidazole can be used as a substrate for the Suzuki coupling reaction or as a starting material for the synthesis of imidazole derivatives. The compound spontaneously fragments under acidic conditions to form nitric acid and hydrogen bromide. 2-Bromo-1H-imidazole has been shown to inhibit hepatitis C virus (HCV) replication and induce cancer cell apoptosis in vitro.
2-Bromo-1H-imidazole is also known to cause DNA fragmentation in cells through oxidation by reactive oxygen species or through spontaneous decomposition of the molecule into acid, bromine radicals, and ammonia.

Please enquire for more information about Pentachloropyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

4-(1-Piperidylmethyl)phenylboronic acid is a fine chemical that is used as a versatile building block in the synthesis of complex compounds. It has been used as a reagent and speciality chemical in research. 4-(1-Piperidylmethyl)phenylboronic acid is also a useful intermediate in organic synthesis, and can be used as a reaction component or scaffold for the preparation of other chemicals.

2-Chloro-3-fluoropyridine is a chemical compound that is classified as an allosteric modulator. It has a profile of physicochemical and spectrometric properties, which includes a pyridine ring with two chloro substituents and one fluorine atom. 2-Chloro-3-fluoropyridine can be transported by organic solvents such as benzene or chloroform, but not by water. This chemical reacts with copper chloride to form a cross-coupling reaction, which may be useful for the synthesis of complex organic molecules. 2-Chloro-3-fluoropyridine also has biological properties that include being a ligand for some receptors in the brain and central nervous system, as well as having antioxidant activity.